Clinical trials: Neuroplasticity
Anterior Cruciate Ligament Injuries
Neuromuscular Rehab for ACL Reconstruction: Knee Function & Brain Plasticity
This study focuses on patients with anterior cruciate ligament (ACL) rupture and reconstruction, aiming to systematically investigate the clinical efficacy and underlying mechanisms of neuromuscular training in restoring knee…
- Trial name
- NCT07243860
- Testing
- Neuromuscular Training, Conventional Rehabilitation
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Cognitive Control
Measuring Plasticity in SFC/dACC Following Theta-Burst-Stimulation Using TMS
This is a study to determine whether particular forms of brain-stimulation, applied to superior frontal cortex/preSMA can affect cognition and associated frontal theta oscillations.
- Trial name
- BTMS (NCT03946059)
- Testing
- iTBS then cTBS, cTBS then iTBS
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Low Intensity Focussed Ultrasound
Pharmacological Mechanisms of Low-intensity Focused Ultrasound for Motor Cortex Neuroplasticity
Low-intensity focused ultrasound (LIFUS) has been shown to be an effective and safe non-invasive brain stimulation technique, capable of reaching greater brain depth and a greater spatial resolution than other brain stimulation…
- Trial name
- LIFUS-Pharma (NCT04923659)
- Testing
- Carbamazepine, Lorazepam, Dextromethorphan
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Acute Pain, Neuroplasticity
HD-tDCS: Effects on the Somatosensory System
The purpose of this study is to investigate the efficacy of high definition tDCS on different cortical targets in modulating the nociceptive system in the healthy subjects.
- Conditions
- Acute Pain, Neuroplasticity, Brain Modulation, Somatosensory Function
- Trial name
- NCT04165876
- Testing
- Primary Motor Cortex Stimulation, Dorsolateral Prefrontal Cortex Stimulation, Multimodal Stimulation (DLPFC+M1)
- Where
- Denmark
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Stroke
Exercise and Genotype in Sub-acute Stroke
This study will investigate the impact of cardiovascular exercise on brain plasticity among patients in sub-acute stages after stroke, and whether genotype modulates the response to this intervention.
- Trial name
- NCT05076747
- Testing
- Cardiovascular training, Standard Therapy
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- McGill University
ADHD, ADD
ADHD Electrophysiological Subtypes and Implications in Transcranial Direct-current Stimulation
In the present study the aim is to examine whether transcranial direct-current stimulation (tDCS) generated excitability changes and induce modifications of functional cortical architecture in Attention Deficit Hyperactivity…
- Trial name
- tdcs&adhd (NCT01649232)
- Testing
- Active tDCS
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Spanish Foundation for Neurometrics Development
Neuroplasticity in Motor Learning
Neuroplasticity in Motor Learning in Young Adults Under Variable and Constant Practice Conditions
The project aims at providing a better understanding of motor skill acquisition and learning processes. The primary objectives of the study are to determine how practice conditions, i.e., variable and constant practice…
- Trial name
- NMLPC (NCT04921072)
- Testing
- Constant practice conditions, Variable practice conditions
- Where
- Czechia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Spinal Cord Injuries, Amyotrophic Lateral Sclerosis
Effects of Remote Ischemic Conditioning on Hand Use in Individuals With SCI and ALS
Rehabilitation interventions such as physical training and neural stimulation after spinal cord injury (SCI) have been shown to increase neural plasticity.
- Trial name
- NCT03851302
- Testing
- Active Remote Ischemic Conditioning, Isometric hand exercise
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Bronx VA Medical Center
Analgesia Disorder, Pain
Neuroplasticity:Melatonin and Transcranial Current Stimulation in Healthy Subjects.
Pain exerts a tremendous cost in healthy care, rehabilitation and lost productivity. It is is associated with a wide range of diseases and their social consequences is a public health problem.
- Trial name
- NCT02195271
- Testing
- Transcranial Direct Current Stimulation (tDCS), Melatonin
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Movement Disorders, Parkinson Disease
Non-invasive Assessment of Synaptic Plasticity
The pathophysiological mechanisms underlying Movement Disorders, including Parkinson's disease, have been related to altered synaptic plasticity affecting several structures of the central nervous system.
- Trial name
- NEUROPLAST (NCT05353517)
- Testing
- Device: focal muscle vibration and theta burst stimulation
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Stroke With Hemiparesis
Strategies for Recovery of Dexterity Post Stroke
Motor learning can be affected by the sensory difficulties that may be experienced as a result of a stroke. This study will help us better understand what kinds of sensory information can help with the re-learning of grasping…
- Trial name
- NCT01977027
- Testing
- Alternate Hand Training or Affected Hand Training
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Autism
TMS Measures of Plasticity and Excitatory/Inhibitory Ratio as Biomarkers: R-baclofen Effects in Normal Volunteers
Our overall objective is to apply Transcranial Magnetic Stimulation (TMS) to develop measures of human synaptic plasticity and of brain excitatory:inhibitory ratio (E:I ratio), which we propose as novel biomarkers and outcome…
- Trial name
- NCT01172509
- Testing
- R-baclofen
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Gonzalez-Heydrich, Joseph, M.D.
Nerve Growth Factor, Exercise
Cortical Neuroplasticity by Muscle Pain of Pain-induced Plasticity
The purpose of this study is to investigate the sensory-motor cortical excitability response to delayed onset muscle soreness (DOMS) on Extensor Carpi Radialis (ECR) muscle during muscle hyperalgesia provoked by nerve growth…
- Conditions
- Nerve Growth Factor, Exercise, Motor Activity, Abnormality of SSEPs
- Trial name
- NCT03354624
- Testing
- Sterile solutions of recombinant human nerve growth factor (NGF)
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Old Age; Dementia, Aging
Compensatory Brain Activity in Older Adults.
There are two important aspects in which the present project will allow to enrich our understanding of compensatory brain activity in older adults.
- Conditions
- Old Age; Dementia, Aging, Cognitive Decline
- Trial name
- BrainAct (NCT06235840)
- Testing
- working memory adaptive training, multi-domain non-adaptive control training
- Where
- Poland
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Kazimierz Wielki University
Prolonged Pain, Neuroplasticity
Modulatory Effects of Multichannel tDCS During Prolonged Experimental Pain
Corticomotor excitability, pain sensitivity, descending pain control and somatosensory evoked potentials (SEPs) is often altered in acute and chronic pain.
- Conditions
- Prolonged Pain, Neuroplasticity, Brain Modulation
- Trial name
- NCT04165980
- Testing
- transcranial direct current stimulation
- Where
- Denmark
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Hypoxia, Altitude, Exercise Tolerance
Direct and Cross Effects of Adaptation to Systemic Hyperthermia: Impact on Quality of Life, Neurohormonal and Psychophysiological Human Status
Life expectancy and quality of human life are important indicator of the sustainable development of the society. At the same time, the physical, functional, emotional and psychological components of the of the quality of life…
- Conditions
- Hypoxia, Altitude, Exercise Tolerance, Metabolic Disturbance, Quality of Life
- Trial name
- NCT04089410
- Testing
- Hyperthermic Fitness Treatment (HFT), Physical Examination, Assessment of Cardiorespiratory Fitness
- Where
- Russia
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Fibromyalgia
An Exploration of the Neuroplasticity of Endogenous Analgesia in Health and Chronic Pain
Transcranial magnetic stimulation (TMS) is a neurophysiological tool for studying cortical functions, and in addition, has an analgesic therapeutic effect whose underlying mechanism is unknown.
- Trial name
- NCT02572726
- Testing
- active repeated transcranial magnetic stimulation
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Neuronal Plasticity, Multiple Sclerosis
Brain Activity Changes Following Neuroproprioceptive Physiotherapy in Multiple Sclerosis
Imaging methods bring new possibilities for describing the brain plasticity processes that underly the improvement of clinical function after physiotherapy in people with multiple sclerosis (pwMS).
- Conditions
- Neuronal Plasticity, Multiple Sclerosis, Rehabilitation
- Trial name
- NCT04448444
- Testing
- Motor Program Activating Therapy, Vojta reflex locomotion
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Aging Well
Assessing Causality of the Association Between Exercise and Neurocognitive Gains
Brief Summary: The aim of this project is to examine: 1. The effects of a community based square stepping exercise programme on cognitive and physical functions in older adults. 2.
- Trial name
- NCT05511259
- Testing
- exercise
- Where
- Singapore
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Nanyang Technological University
Depression
(GluEsk) Glutamate and Esketamine
Esketamine is the S-enantiomer of racemic ketamine, a N-methyl-D-aspartate (NMDA) receptor antagonist. Esketamine and other antidepressant NMDA receptor antagonists are hypothesised to act by producing a rapid increase in brain…
- Trial name
- GluEsk (NCT06432322)
- Testing
- Esketamine nasal spray
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Oxford