Clinical trials: Neurosciences, open to volunteers
Low Back Pain, Recurrent
Effectiveness of a Pain Neuroscience Education Programme on Physical Activity in Patients With Chronic Low Back Pain
Proposing ways to effectively counter chronic low back pain through non-drug intervention is a major public health issue due to the prevalence and health costs of this condition.
- Trial name
- END-LC (NCT05840302)
- Testing
- Activity monitor, Questionnaire
- Where
- France
- Volunteers
- 82 people
- Sponsor
- University Hospital, Montpellier
Substance Use Disorders
Enhancing Addiction Treatment Through Psychoeducation
Addiction is a brain disorder characterized by a broad range of both apparent and subtle cognitive impairments in attention, memory, executive functions, and decision-making.
- Trial name
- NCT07178158
- Testing
- Installing the Metacognium software app, Continue treatment as usual
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Virginia Commonwealth University
Academic Anxiety, Test Anxiety
AVE-Neurofeedback for Academic Anxiety and Divergent Thinking
Academic anxiety is one of the most prevalent psychological challenges among adolescents and has been associated with impaired executive functioning, attentional control, autonomic dysregulation, and reduced creative performance.
- Conditions
- Academic Anxiety, Test Anxiety, Divergent Thinking
- Trial name
- AVE-NFB (NCT07745335)
- Testing
- Audiovisual Entrainment Neurofeedback (AVE-NFB), Neurofeedback Only, Audiovisual Entrainment
- Where
- 3 sites in Indonesia
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Daniswara Raditya Suprapto
Chronic Pain
Pain Neuroscience Education and Memory
Brief Summary: The goal of this observational study (case series) is to determine whether Pain Neuroscience Education (PNE) can influence memory function and sensory awareness in adults (18 years and older) experiencing chronic…
- Trial name
- PNE (NCT07252596)
- Testing
- Pain Neuroscience Education (PNE)
- Volunteers
- 50 people
- Sponsor
- Evidence In Motion
Child Development, Executive Functions (EF)
Sharing Tales That Teach: Shared Picturebook Reading for Early Childhood Emotional and Cognitive Development
Sharing Tales That Teach is a randomised study of a shared picturebook reading programme for 4- to 5-year-old children and their primary caregivers.
- Conditions
- Child Development, Executive Functions (EF), Emotion Regulation
- Trial name
- STTT (NCT07666802)
- Testing
- Emotion-Focused Shared Picturebook Reading, Standard Dialogic Picturebook Reading
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Greenwich
Rheumatic Diseases, Rheumatoid Arthritis (RA)
Pain Neuroscience Education and Vagus Nerve Stimulation on Recovery in Individuals With Rheumatoid Arthritis
In the context of this randomized controlled study, patients who are diagnosed with Rheumatoid arthritis in Cerrahpaşa Faculty of Medicine Hospital, will be taken into a rehabilitation program by a qualified physiotherapist to…
- Trial name
- NCT07274124
- Testing
- Pain Neuroscience Education, Vagal Nerve Stimulation, Structured Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Medipol University
Adults, Female
Pain Science Education for Labour and Postpartum Pain
This Delphi study aims to establish expert consensus on the role, content, and delivery of pain science education (PSE) for labour and postpartum pain management.
- Conditions
- Adults, Female, Labour Pain, Postpartum Pain
- Trial name
- PNE-DELPHI (NCT07096661)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bournemouth University
Depression, Bipolar Disorder
Neuro-computational Study of Thymic Fluctuations in Mood Disorders
Depression and bipolar disorder are frequent, debilitating conditions. Both are thought to be primarily caused by an impaired regulation of mood, which is why they are sometimes referred to as "mood disorders".
- Conditions
- Depression, Bipolar Disorder, Recurrent Depression, Mood Disorders
- Trial name
- MOODELING (NCT07033923)
- Testing
- Brain magnetic resonance imaging (MRI) with structural (anatomical) and functional sequences (optional), Computerized cognitive tests, Daily longitudinal monitoring by mobile MOODELING application
- Where
- 2 sites in France
- Volunteers
- 588 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Fibromyalgia
Effects and Mechanisms of Pain Neuroscience Education in Patients With Fibromyalgia
This randomized controlled trials study aims, first, to determine the effectiveness of a nurse-led PNE program designed by a multidisciplinary team, compared with an active control group on pain intensity, fibromyalgia (FM)…
- Trial name
- NCT06097091
- Testing
- Self-management education, pain neuroscience education
- Where
- Taiwan
- Volunteers
- 98 people
- Sponsor
- Taipei Medical University
Chronic Low-back Pain (cLBP), Chronic Low-back Pain
Effectiveness of a Multidisciplinary Treatment for Patients With Chronic Low Back Pain
PAINDOC is a treatment program that includes 4 disciplines that, separately, have demonstrated their effectiveness in the treatment of chronic low back pain: education in pain neuroscience, therapeutic education (Empowered…
- Conditions
- Chronic Low-back Pain (cLBP), Chronic Low-back Pain, Back Pain
- Trial name
- PAINDOC (NCT06679205)
- Testing
- Multidisciplinary and multimodal intervention, Usual Care
- Where
- 2 sites in Spain
- Volunteers
- 62 people
- Sponsor
- University of Barcelona
Acute Stroke Intervention, Acute Stroke
Using AI Systems to Optimize the Clinical Outcome of Stroke Patients
This project addresses the imminent challenge of providing adequate motor rehabilitation to a growing number of stroke survivors amidst the ageing population, decreasing age of stroke, and shortage of physical/occupational…
- Conditions
- Acute Stroke Intervention, Acute Stroke, Acute Ischemic Stroke
- Trial name
- NCT06828679
- Testing
- Acupuncture, control group, Robotic Training
- Where
- Hong Kong
- Volunteers
- 400 people
- Sponsor
- Chinese University of Hong Kong
Alcohol Use Disorder
Temporally-Resolved Electrophysiology of Acamprosate Treatment of Alcohol Use Disorder
Background: Chronic heavy drinking can cause alcohol use disorder (AUD). AUD changes how the brain works. People with AUD may drink compulsively or feel like they cannot control their alcohol use.
- Trial name
- NCT06269627
- Testing
- Acamprosate calcium
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Benzodiazepine Adverse Reaction, Depression, Anxiety
Benzodiazepine Impact on Cognitive Function: fNIRs and PET/MRI Study
This study explores the impact of long-term benzodiazepine (BZDs) use on cognitive function and associated neuroimaging markers.
- Conditions
- Benzodiazepine Adverse Reaction, Depression, Anxiety, Benzodiazepine Dependence
- Trial name
- NCT06250842
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
Malignant Central Nervous System Neoplasm
Study of Human Brain-Gut Axis and Gut Microbiome in Patients With Brain Lesions - Repository for Neuroscience Research
This study explores how microorganisms in the gut can affect the growth and progression of brain tumors.
- Trial name
- NCT06117930
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Anterior Cruciate Ligament Injury
Virtual Reality Mindfulness Meditation After ACL Reconstruction
To evaluate the effect of virtual reality mindfulness meditation on patients after ACLR, the investigators will determine the effect of virtual reality mindfulness meditation to 1) decrease self-reported injury-related fear, 2)…
- Trial name
- NCT05527171
- Testing
- Virtual Reality Mindfulness Meditation
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of North Carolina, Chapel Hill
Dissociation
Mechanistic Interventions and Neuroscience of Dissociation
The purpose of this study is to test the neurophysiological mechanisms of an intervention to reduce symptoms of dissociation in traumatized people.
- Trial name
- MIND (NCT04670640)
- Testing
- Vibration, Breath Focus, No Distractions
- Where
- 2 sites in United States
- Volunteers
- 350 people
- Sponsor
- Emory University
Hemophilia
Effectiveness of an Educational Program for Pain Management in Patients With Hemophilic Arthropathy
Introduction: Hemophilic arthropathy is a common complication of hemophilia, characterized by chronic pain, functional limitation, and impaired quality of life.
- Trial name
- NCT07420387
- Testing
- Educational group
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Investigación en Hemofilia y Fisioterapia
Promoting Active Inference of Healthy Older Adults With Language Activity
A Language-Based Training Intervention to Enhance Cognitive Health in Community-Dwelling Older Adults
Taiwan is fast approaching a super-aged society, making it urgent to bolster cognitive health in otherwise healthy older adults.
- Trial name
- NCT07132281
- Testing
- Language activities active inference, Language activities passive, Board Games
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Sports Related Concussion
Chiropractic Neuroscience Care in Sports Concussion
The goal of this study is to evaluate our study design and the potential effect of chiropractic-applied clinical neuroscience care on individuals with sports-related concussion (SRC) in individuals between the ages 18 and 40.The…
- Trial name
- SRC (NCT07175753)
- Testing
- chiropractic applied clinical neuroscience care
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Life University
Frozen Shoulder
The Combined Effect of Mulligan Mobilization, Pain Neuroscience-Based Training, and Core Stabilization Exercises in Frozen Shoulder Patients
The purpose of this randomized controlled study is to investigate the effects of a combined rehabilitation program consisting of Mulligan Mobilization with Movement (MWM), Pain Neuroscience Education (PNE), and core stabilization…
- Trial name
- NCT07667556
- Testing
- Pain Neuroscience Education (PNE), Mulligan Mobilization With Movement (MWM), Core Stabilization Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Yeditepe University