Clinical trials: Neurosurgery
Neurosurgery
Neurosurgical Skill Enhancement Using Transcranial Stimulation
Recent changes in medical training environments and restrictive work-hour regulations have greatly impacted trainees, limiting the number of opportunities to gain proficiency in procedural skills.
- Trial name
- LETS-LEARN (NCT02987816)
- Testing
- Anodal tDCS
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Inflammation, Neutrophil
SIII and Spontaneous Regression in Lumbar Disc Herniation
This study aimed to investigate the role of the Systemic Immune-Inflammatory Index (SIII) in patients with lumbar disc herniation (LDH) and to evaluate its potential clinical relevance in relation to treatment modality.
- Conditions
- Inflammation, Neutrophil, Lymphocyte, Neurosurgery
- Trial name
- SIII-LDH (NCT07367503)
- Testing
- Lumbar disc herniation treatment, Lumbar disc herniation surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
Aging
Large-scale Multi-omics Analysis of Cerebrospinal Fluid
The aim of this study is to explore the role of cerebrospinal fluid (CSF) biomarkers in aging and neurodegenerative diseases.
- Trial name
- NCT06636201
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Surgical Education
Effect of Music on Surgical Performance During Artificial Intelligence-Based Simulation Training
At the Neurosurgical Simulation and Artificial Intelligence Learning Centre, we seek to provide surgical trainees with innovative technologies that allow them to improve their surgical technical skills in risk-free environments…
- Trial name
- NCT07111481
- Testing
- Mozart music exposure
- Where
- Canada
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- McGill University
Surgical Site Infection, Antibiotics Prophylaxis
Cefuroxime vs Ceftriaxone for SSI Prevention in Neurosurgery
BACKGROUND: Surgical site infection (SSI) is potentially catastrophic in neurosurgical procedures, causing poor in-hospital outcomes in more than half of those affected and significantly increased length of hospital stay.
- Trial name
- NCT05398081
- Testing
- Cefuroxime (Zinnat®), Ceftriaxone (Rocephin®)
- Where
- Nigeria
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Dr. Promise Tamunoipiriala Jaja
Surgical Education
Effect of Intelligent Tutor Induced Pausing on Learning Simulated Surgical Skills
Traditional training of surgical technical skills relies on mentorship from experienced surgeons, who continuously evaluate and change trainee performance to prevent errors and potential patient harm by providing verbal…
- Trial name
- NCT06235788
- Testing
- Experimental Group ICEMS verbal feedback with pause group, Experimental Group ICEMS audio feedback with pause and expert video
- Where
- Canada
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- McGill University
Brain Neoplasms
IORT After Surgical Resection of Brain Metastases
To evaluate the feasibility and efficacy of the Intraoperative Radiation Therapy (IORT) after the resection of a brain metastases to reduce the incidence of local relapse
- Trial name
- IORT_BRAINM1 (NCT05084092)
- Testing
- Intraoperative Radiotherapy (IORT), Brain surgery
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Institut Català d'Oncologia
Central Nervous System Disorder, Spine Disease
Neurological Surgery & Affiliated Services De-Identified Clinical Outcomes Database
The collection of data from the myriad of services described is significantly impacted by NIH guidelines defining medical research involving humans as well as the recent implementation of HIPAA constraints which further…
- Conditions
- Central Nervous System Disorder, Spine Disease, Peripheral Nerve Disorder
- Trial name
- MDAnalyze (NCT00593411)
- Where
- United States
- Volunteers
- 732 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Multidisciplinary Communication
Multidisciplinary Teamwork Perceptions When Mobilizing Ventilated Neurosurgery Patients
The purpose of this research study is to decide if using a nurse-led mobility protocol affects teamwork perceptions, when mobilizing ventilated neurosurgery patients.
- Trial name
- NCT05583487
- Testing
- Nurse-led progressive mobility protocol, Standard of Care
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Idiopathic Intracranial Hypertension
Idiopathic Intracranial Hypertension: Prognostic Factors and Multidisciplinary Management
Several studies have investigated factors associated with visual deterioration in BIIP patients. Severe papilledema, delayed diagnosis, high CSF opening pressure, obesity, and visual field defects have been associated with poor…
- Trial name
- NCT07707544
- Testing
- lumbo-peritoneal shunt, Conservative Management: Centered on lifestyle modifications for weight reduction, alongside targeted medical therapies including carbonic anhydrase inhibitors (e.g., acetazolamide) and/or topiramate.
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sohag University
Neurosurgery
Study of Antibiotics in Cerebrospinal Fluid Following Intravenous Injection
Three different antibiotics are used to prevent infection in case of neurosurgery - this study examines to which extent the antibiotics penetrate from the blood to the cerebrospinal fluid (surrounding the brain).
- Trial name
- NCT00925093
- Testing
- Vancomycin, Teicoplanin, Linezolid
- Volunteers
- healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Surgery, Surgery--Complications
Patterns and Outcomes of Neurosurgery in England Over a Five-year Period
Neurosurgical practice has seen many important changes over several decades with advances in treatments and the types of patients treated.
- Conditions
- Surgery, Surgery--Complications, Neurological Morbidity, Neurological Diseases or Conditions
- Trial name
- NCT05097066
- Testing
- Neurosurgical procedure
- Volunteers
- 371,418 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Epilepsy, Focal Cortical Dysplasia
First-in-human Experience Using Novel Ultraflexible Low-impedance Electrode Arrays: an IDEAL Stage 1 Study
The goal of this first-in-human study is to evaluate a novel ultraflexible microelectrode in children undergoing neurosurgery to remove tissue that causes epilepsy (seizures) in focal cortical dysplasia (FCD) or long-term…
- Trial name
- NCT06116279
- Testing
- Insertion of electrode during planned neurosurgery for epilepsy
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Informed Consent, Health Literacy, Risk, Spinal Puncture, Neurosurgery
Communicating Risks: Consent for Lumbar Puncture
The goal of this randomized control trial is to compare the effect of visual aids on the recall of probabilistic risks in healthy participants.
- Trial name
- NCT05717465
- Testing
- Anatomy diagrams, Standard informed consent
- Where
- United Kingdom
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University College London Hospitals
Meningioma
3D MRE-Based Evaluation of Meningioma Mechanical Properties and Histological Features
This prospective single-center study aims to evaluate the feasibility and clinical utility of three-dimensional magnetic resonance elastography (3D MRE) in assessing tumor stiffness and adhesion in patients with meningioma…
- Trial name
- NCT06955208
- Testing
- Magnetic Resonance Elastography, Intraoperative Assessment and Recording
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Shengjing Hospital
Craniocerebral Trauma, Stroke
Timing Impact of Early vs. Late Cranioplasty on Hemicraniectomy Outcomes
This prospective, randomized study aims to comprehensively evaluate the impact of cranioplasty timing on postoperative complications and long-term functional outcomes following decompressive hemicraniectomy (DHC).
- Conditions
- Craniocerebral Trauma, Stroke, Intracranial Hemorrhages
- Trial name
- TIMELY (NCT06632587)
- Testing
- Early cranioplasty, Standard-of-care cranioplasty
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Acute Kidney Injury
Effect of Vitamin E+Selenium on Kidney Function in Controlled Hypotension
The purpose of this study is to determine whether Kidney injury happens in controlled hypotension during brain operations by using Neutrophil Gelatinase Associated Lipocalin ELISA Kit and if so, does VitaminE+Selenium prevent it
- Trial name
- NCT01554345
- Testing
- vitamin E +Selenium
- Where
- Iran
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tehran University of Medical Sciences
Neurosurgery
Superficial Cervical Plexus Block for Postoperative Chronic Pain
The incidence of postoperative chronic pain after craniotomy is high. Postoperative chronic pain seriously affects patient's quality of life. Compound local scalp nerve block is a good choice for analgesia after craniotomy.
- Trial name
- NCT05108337
- Testing
- Superficial cervical plexus block, Control group
- Where
- 2 sites in China
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Deep Brain Stimulation, Parkinson Disease
Consensus Statements on Deep Brain Stimulation in Patients With Parkinson's Disease
Deep brain stimulation (DBS) has become a cornerstone therapy for advanced Parkinson's disease (PD), showing superior outcomes over best medical treatment in randomized clinical trials.
- Trial name
- DBS_Consensus (NCT07173660)
- Testing
- Delphi study
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Magna Graecia
300 Students of University of Milan School of Medicine
Psychological Assessment and Skills Training by Simulation in Neurosurgery
The subject of Safety in Health is assuming in time a predominant position with those of high social, economic and political relevance.
- Trial name
- PASSION (NCT06792669)
- Testing
- Simulation training to evaluate the participants' manual skill improvement
- Where
- Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta