Clinical trials: Neurosurgery, open to volunteers
Glioma, Glioblastoma
Feasibility of Intra- and Post-operative Microdialysis During Neurosurgery for Central Nervous System Lesions
This clinical trial evaluates the use of microdialysis catheters during surgery to collect biomarkers, and studies the feasibility of intra- and post-operative microdialysis during neurosurgery for central nervous system…
- Conditions
- Glioma, Glioblastoma, Metastatic Malignant Neoplasm in the Brain
- Trial name
- NCT04047264
- Testing
- Microdialysis, Magnetic Resonance Imaging, Computed Tomography
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Patients Operated on at the Neurosurgery Department
Neurophysiological Intraoperative or Epilepsy Monitoring
The investigators record the outcome of patients whose surgery involved intraoperative neurophysiological monitoring Trial with surgical intervention
- Trial name
- nphysdocu (NCT01630785)
- Testing
- Intraoperative Neurophysiological Monitoring IONM
- Where
- Switzerland
- Volunteers
- 10,000 people
- Sponsor
- University of Zurich
Glioblastoma Multiforme
Trial of Anti-PD-1 Immunotherapy and Stereotactic Radiation in Patients With Recurrent Glioblastoma
The purpose of this study is to assess the safety/tolerability/feasibility of pembrolizumab and radiation therapy before surgical resection in patients with recurrent glioblastoma as defined by treatment-related AEs and the…
- Trial name
- NCT04977375
- Testing
- Pembrolizumab, Stereotactic Radiation Therapy, Surgical Resection
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Chirag G. Patil
Post Operative Delirium, Parkinson Disease
Association of EEG Parameters with Postoperative Delirium in Patient's with Parkinson's Disease
Patients with Parkinson's disease seem prone to developing postoperative delirium after surgery, the causes of which remain understudied and multifactorial.
- Trial name
- NCT06809556
- Testing
- EEG (electroencephalogram) monitoring of Parkinson's patients undergoing deep brain stimulation
- Volunteers
- 40 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Craniocervical Surgery
Improved Understanding of Venous Drainage at the Cranio-cervical Junction : Study of Postoperative Venous Remodeling Following Surgical Treatment of Lesions of the Posterior Fossa or Posterior Approach of the Upper Cervical Spine.
In the literature, a dichotomous view of cerebral venous drainage is most commonly found. Thus, two drainage pathways are most often considered: the jugular vein network and the vertebral artery plexus.
- Trial name
- VENAMAP 2 (NCT07206667)
- Testing
- T1 GRE GADO MRI sequence
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Brest
Disc Disease, Instabilities Lumbar
Determining Postoperative Recovery and the Impact of Adverse Events in Neurosurgery Based on Self-reported, App-based Longitudinal Assessment
Analyzing the impact of surgery and adverse events (AEs) on patients' well-being is of paramount importance as it provides essential information for benefit-risk assessment.
- Conditions
- Disc Disease, Instabilities Lumbar, Brain Tumor, Aneurysm
- Trial name
- NCT06352710
- Testing
- OP-Tracker App
- Where
- Switzerland
- Volunteers
- 400 people
- Sponsor
- Cantonal Hospital of St. Gallen
Ageing and Geriatric Health
Study of Functional Decline and Care Pathways in Neurosurgical Patients Over 65 Years of Age
The GENEUS 1 study addresses this gap by characterizing the real-world profiles, outcomes, and care pathways of adults aged 65 years and older hospitalized in neurosurgery across France, Spain, and Portugal.
- Trial name
- GENEUS 1 (NCT07506941)
- Where
- 6 sites in France, Portugal and 1 more
- Volunteers
- 209 people
- Sponsor
- University Hospital, Toulouse
Cerebrospinal Fluid Leak, Dural Tear
Safety and Efficacy Evaluation of ArtiFix® Sealant Graft in Subjects Requiring Dural Repair Following Neurosurgery
The purpose of this clinical study is to evaluate and establish the safety and efficacy of the ArtiFix® device in subjects scheduled for cranial or spinal surgery that requires Dural repair (membrane that covers the brain and…
- Trial name
- NCT07092267
- Testing
- ArtiFix® is a surgical dural sealant graft intended to close dural defects following cranial and spine surgeries.
- Volunteers
- 20 people
- Sponsor
- Nurami Medical Ltd
Epilepsy
Functional Brain Mapping for Patients with Epilepsy
We aim to determine the clinical utility of 'dynamic tractography': a novel method for visualizing electrical neural transfers that incorporates the underlying white matter tracts and supporting linguistic processing.
- Trial name
- NCT05755919
- Testing
- Epilepsy surgery
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Wayne State University
Pediatric, Neurosurgery
Remimazolam and Emergence Delirium in Pediatrics
Emergence delirium is a common complication in pediatrics undergoing neurosurgery. Previous study showed that a single bolus of remimazolam was associated with lower incidence of postoperative agitation.
- Conditions
- Pediatric, Neurosurgery, Sevoflurane Anesthesia, Remimazolam
- Trial name
- NCT07046364
- Testing
- Remimazolam, Normal Saline
- Where
- 2 sites in China
- Volunteers
- 248 people
- Sponsor
- Peking University First Hospital
Patients Treated at the Neurosurgery Department
Patient Registry of the Neurosurgery Department
The investigators record all indications, treatments and outcomes from patients treated at the Neurosurgery Department. Trial with surgical intervention
- Trial name
- patregNCH (NCT01628406)
- Testing
- Treatment at the neurosurgery departement
- Where
- Switzerland
- Volunteers
- 24,000 people
- Sponsor
- University of Zurich
Brain Diseases
Evaluation of the Feasibility of Camera Measurement of Colorimetric Parameters of the Brain During Neurosurgery Operations: Tissue Oximetry and Endogenous or Induced Fluorescence
The management of many brain pathologies involves obtaining a functional and histological diagnosis and performing neurosurgery when possible.
- Trial name
- NEUROVISION (NCT06651463)
- Testing
- Videorecording
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Craniocerebral Trauma, Stroke
Timing Impact of Early vs. Late Cranioplasty on Hemicraniectomy Outcomes
This prospective, randomized study aims to comprehensively evaluate the impact of cranioplasty timing on postoperative complications and long-term functional outcomes following decompressive hemicraniectomy (DHC).
- Conditions
- Craniocerebral Trauma, Stroke, Intracranial Hemorrhages
- Trial name
- TIMELY (NCT06632587)
- Testing
- Early cranioplasty, Standard-of-care cranioplasty
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Cranial Neurosurgery
Heart Rate Variability and Processed EEG Features as Predictors of Postoperative Outcomes After Cranial Neurosurgery
Patients undergoing cranial neurosurgery face a high-risk postoperative period, particularly during emergence from anesthesia and early recovery in the post-anesthesia care unit (PACU).
- Trial name
- HERO-PACU (NCT07443072)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Brain Tumor
Panitumumab-IRDye800 to Detect Pediatric Neoplasms During Neurosurgical Procedures
The objective of the study is to assess safety of panitumumab-IRDye800 in pediatric patients undergoing brain surgery to remove suspected tumors.
- Trial name
- NCT04085887
- Testing
- Panitumumab-IRDye800, Pinpoint-IR9000 endoscopic/handheld device, Explorer Air camera
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Stanford University
Neurological Complication
Transcranial Doppler, Optic Nerve Envelope Diameter and Quantitative Pupillometry Measurements
Non-invasive neuromonitoring tools such as transcranial doppler, optic nerve envelope diameter measurement and quantitative pupillometry are routinely used in acute brain injured patients as part of multimodal neuromonitoring…
- Trial name
- DOPPLER (NCT05843214)
- Testing
- Non-invasive neuromonitoring evaluation (transcranial doppler, optic nerve envelope diameter and quantitative pupillometry)
- Where
- Reunion
- Volunteers
- 230 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Neurosurgery, Delirium - Postoperative
Electroencephalogram Predicts Post-operative Delirium
The goal of this observational study is to investigate the predictive value of sub-hairline electroencephalography (EEG) during anesthesia recovery for postoperative delirium (POD).
- Conditions
- Neurosurgery, Delirium - Postoperative, Brain Tumor Adult
- Trial name
- EPOD (NCT06894238)
- Testing
- Sub-hairline EEG Monitoring
- Where
- 2 sites in China
- Volunteers
- 137 people
- Sponsor
- Beijing Sanbo Brain Hospital
Posterior Fossa Lesion
Comparison of Surgical Outcomes of Craniotomy and Craniectomy in Posterior Fossa Lesions
The purpose of this randomized controlled trial is to compare the surgical outcomes of craniotomy and craniectomy among patients with posterior fossa lesions.
- Trial name
- NCT06831695
- Testing
- Craniotomy, Craniectomy
- Volunteers
- 80 people
- Sponsor
- University of Health Sciences Lahore
Brain Stem Hemorrhage, Robotic Surgical Procedures
A Multicenter, RAndomIzed, coNtrolled, umBrella Trial fOr Minimally Invasive Neurosurgery With AI-assisted Robotic guidanCe for Hemorrhagic Stroke
The purpose of this clinical trial is to observe the improvements in clinical symptoms and imaging outcomes for brainstem hemorrhage using robot-assisted stereotactic puncture, evaluate the clinical efficacy and safety of this…
- Trial name
- RAINBOW-BSH (NCT06459427)
- Testing
- Robot-assisted minimally invasive puncture and aspiration surgery, Standard medical management
- Where
- 15 sites in China
- Volunteers
- 142 people
- Sponsor
- Yanbing Yu
Brain Tumor Adult
The Impact of Paramedic Training in Simulation on the Experience of Patients Treated for Malignant Brain Tumors in Neurosurgery (IPSIMANON)
The goal of this clinical trial is to demonstrate that simulation training for paramedical staff in neurosurgery departments, in announcing and accompanying patients with a brain tumor, improves patient satisfaction when a…
- Trial name
- IPSIMANON (NCT06962215)
- Testing
- Paramedic training
- Where
- 11 sites in France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Brest