Clinical trials: Neurotoxicity Syndrome
Botulism
Tolerability and Immunogenicity of a Single 40-ug Dose of rBV A/B for the Production of BabyBIG®
This Phase 2, open-label, uncontrolled study designed to evaluate safety, tolerability, and immunogenicity of a single dose of rBV A/B in healthy participants previously immunized with pentavalent botulinum toxoid (or pentavalent…
- Trial name
- NCT06112834
- Testing
- rBV A/B
- Where
- 2 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- California Department of Public Health
Healthy
Study to Evaluate Safety and PK of a Single IM Dose of G03-52-01 vs Placebo in Adult Subjects
A Phase 1, randomized, double-blind, placebo-controlled dose escalation trial of four dose cohorts of 10 subjects (1: 10mg, 2: 25mg, 3: 50mg, 4: 100mg).
- Trial name
- NCT04171115
- Testing
- G03-52-01
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alachua Government Services, Inc.
Botulism
Phase 3, Randomized, Safety, Lot Consistency and Clinical Benefit Study of Recombinant Botulinum Vaccine A/B
This Phase 3 clinical trial is a double blind, placebo-controlled, randomized, multicenter investigation of rBV A/B in male and female healthy adults 18 to 55 years of age.
- Trial name
- rBV A/B (NCT01940315)
- Testing
- rBV A/B
- Volunteers
- healthy volunteers welcome
- Sponsor
- DynPort Vaccine Company LLC, A GDIT Company
Breast Cancer
HGWD Improve the Paclitaxel-related Neurotoxicity in Patients With BC
The current treatments for albumin-bound paclitaxel (nab-PTX) -related peripheral neurotoxicity (PN) mainly included cryotherapy and compression therapy , oral B group vitamin , and duloxetine.
- Trial name
- NCT05566457
- Testing
- Huangqi Guizhi Wuwu decoction (HGWD) infusion packs
- Where
- China
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences
Ecstasy (Drug), N-Methyl-3,4-Methylenedioxymethamphetamine
The NeXT Study; The Netherlands XTC Toxicity Study
The purpose of this study is to investigate the possible neurotoxic effects of the party-drug Ecstasy (MDMA)on brain and brain function in humans.
- Conditions
- Ecstasy (Drug), N-Methyl-3,4-Methylenedioxymethamphetamine, Psychopathology
- Trial name
- NCT00235768
- Where
- 3 sites in Netherlands
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Botulism
Phase I, Dose Escalation Study to Evaluate the Safety and Pharmacokinetics of NTM-1632
This is a Phase I, randomized, double-blind, placebo controlled dose escalation trial to evaluate NTM-1632 in three dose cohorts (A: 0.033 mg/kg, B: 0.165 mg/kg, and C: 0.33 mg/kg).
- Trial name
- NCT02779140
- Testing
- NTM-1632
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
General Anaesthesia During Pregnancy
Intelligence and Neurodevelopmental Disorders After Prenatal Exposure to General Anaesthesia
Every year in the European Union, thousands of babies are exposed to anaesthesia before they are born because their mothers need surgery during pregnancy.
- Trial name
- PAE-IQ (NCT06633406)
- Testing
- Age-appropriate Wechsler Intelligence Test, Disruptive Behavior Disorders Rating Scale, Social Responsiveness Scale
- Where
- 3 sites in Belgium
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Neuroinflammatory Response, Nerve Injury
Assessment of Nerve Damage Biomarkers in Acute and Chronic Organophosphate Toxicity
The aim of this observational study is to answer the following questions in individuals with acute and chronic exposure to organophosphates. The main questions to be addressed are 1.
- Conditions
- Neuroinflammatory Response, Nerve Injury, Nerve Damage, Neurotoxicity
- Trial name
- NCT06021262
- Testing
- exposure to organophosphates
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Alcohol Withdrawal Syndrome
The "Prediction of Alcohol Withdrawal Severity Scale" (PAWSS)
Although there are several tools that can be used to evaluate the severity of ongoing alcohol withdrawal syndrome (AWS), there is no available tool that can predict which patients are at risk for developing AWS at the time…
- Trial name
- PAWSS (NCT01637415)
- Where
- United States
- Volunteers
- 409 people, healthy volunteers welcome
- Sponsor
- Stanford University
Botulism
Phase 1 PK Study of XOMA 3AB
This is a phase I, single-center, placebo-controlled, double-blinded, dose escalation study of anti-botulinum toxin monoclonal antibodies in healthy adult volunteers.
- Trial name
- NCT01357213
- Testing
- XOMA 3AB
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
General Anesthetics Toxicity
Anesthetic Neurotoxicity: the Association Between General Anesthesia and the Level of Plasma Neurofilament Light
A prospective controlled single centre study designed to determine the association between the exposure to anesthetic agents and the pre and postoperative changes in plasma Neurofilament Light levels, biomarkers of neurological…
- Trial name
- ANESTOX-2019 (NCT04164329)
- Testing
- General anesthetic
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Cardiocentro Ticino
Neurotoxic Effect of Sevoflurane-Based Anaesthesia
Evaluation of Neurotoxic Effect of Sevoflurane-Based AnaesthesiaGuided by Short-Term Olfactory Identification
Nowadays there is increasing doubts about the safety of anesthesia . Anesthesiologists have to console the worried patients, who are anxious about the potential risks of anesthetic-induced brain damage, by suggesting that any…
- Trial name
- NCT03726580
- Testing
- Sevoflurane
- Where
- Egypt
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Tanta University
Arsenic Poisoning
High-selenium Lentils Versus Arsenic Toxicity
About 45 million people in Bangladesh are chronically exposed to unacceptable levels of arsenic in their drinking water. Chronic arsenic poisoning leads to cancers, and vascular diseases.
- Trial name
- NCT02429921
- Testing
- high-selenium lentils, Low-Se lentils
- Where
- Bangladesh
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Extrapyramidal Symptoms, Drug-induced Parkinsonism
A Computer-Assisted Tool for Objective Assessment of Extrapyramidal Symptoms
This prospective, single-center observational study aims to develop and validate a computer-assisted tool for the objective quantitative assessment of extrapyramidal symptoms (EPS).
- Conditions
- Extrapyramidal Symptoms, Drug-induced Parkinsonism, Akathisia, Drug-Induced, Tardive Dyskinesia (TD)
- Trial name
- NCT07715994
- Testing
- Computer-Assisted Objective Assessment of Extrapyramidal Symptoms
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Lead Poisoning, Neurotoxicity
Effects of Lead Exposure on Ferroptosis Pathway
The aim of this study was to investigate the effects of chronic lead exposure on iron metabolism and the Nrf2-dependent ferroptosis pathway in lead acid battery factory workers
- Trial name
- NCT05950386
- Testing
- Lead exposure
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Northern Jiangsu People's Hospital
Alcoholism, Alcohol Amnestic Disorder
From Uncomplicated Alcoholism to Korsakoff's Syndrome
This research project aims to identify factors that contribute to the heterogeneity observed in neuroradiological and neuropsychological signs of chronic alcoholism.
- Trial name
- ALCOBRAIN (NCT01455207)
- Testing
- Neuropsychological testing, blood draw, genetic testing
- Where
- France
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Arsenic Poisoning, Environmental Exposure
Table-Top Water Pitcher to Reduce Arsenic Exposure Among Well Users in New Hampshire
The goals of this clinical trial are to: 1. gather preliminary data on the effectiveness of a table-top water pitcher filtration system in reducing arsenic exposure among individuals using private wells with elevated (>5 μg/L)…
- Conditions
- Arsenic Poisoning, Environmental Exposure, Water-Related Diseases
- Trial name
- NCT07103356
- Testing
- Water Pitcher Filtration System
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Trustees of Dartmouth College
Breast Cancer, Chemotherapeutic Agent Toxicity
Effects of Chemotherapy on the Brain in Women With Newly Diagnosed Early-Stage Breast Cancer
RATIONALE: Gathering information over time from laboratory tests, imaging scans, and assessment tests may help doctors learn more about the side effects of chemotherapy and plan the best treatment.
- Conditions
- Breast Cancer, Chemotherapeutic Agent Toxicity, Cognitive/Functional Effects, Fatigue
- Trial name
- NCT00755313
- Testing
- trastuzumab, aromatase inhibition therapy, carboplatin
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Metallosis, Pain
Neurotoxicity and Cardiotoxicity in Total Joint Arthroplasty
The purpose of this research is to understand whether patients who previously had total hip or total knee replacement experience memory, thinking or heart problems.
- Conditions
- Metallosis, Pain, Total Hip Replacement, Total Knee Replacement
- Trial name
- NCT04166539
- Testing
- Questionnaires, Interviews, Blood draw
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Botulism
A Study to Evaluate the Safety and Pharmacokinetics of NTM-1633 vs Placebo Administered Intravenously in Healthy Adults
This is a Phase I, single-center, double-blind, placebo-controlled dose escalation trial of three dose cohorts (A: 0.033 mg/kg, B: 0.165 mg/kg, and C: 0.33 mg/kg).
- Trial name
- NCT03603665
- Testing
- NTM-1633
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)