Clinical trials: Next Generation Sequencing
Next Generation Sequencing (NGS), Breast Cancer
Research on the Heterogeneity of Taiwanese Breast Cancer Patients by Next Generation Sequencing (NGS) Tools
The objectives of this study are: 1. To determine the difference in genetic profiling of subjects with breast cancer recurrence 2. To determine the comprehensive genetic profiling of subjects with late stage breast cancer 3.
- Trial name
- NCT04626440
- Testing
- Diagnostic stage or the Clinical outcome
- Where
- Taiwan
- Volunteers
- 1,875 people
- Sponsor
- vghtpe user
Soft Tissue Sarcoma
Molecular Profiling of Advanced Soft-tissue Sarcomas
MULTISARC is a randomized multicenter study assessing whether high throughput molecular analysis (next generation sequencing exome - NGS) is feasible in advanced/metastatic soft-tissue sarcoma patients, that is, whether NGS can…
- Trial name
- MULTISARC (NCT03784014)
- Testing
- Nilotinib, Ceritinib, Capmatinib
- Where
- 17 sites in France
- Volunteers
- 603 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Holoprosencephaly
Retrospective Study Using Next Generation Sequencing (NGS) on Biological Samples to Improve Genetic Counseling for Patients With Previously Explored Craniofacial Midline Defects.
Holoprosencephaly, or HPE, is the most common congenital cerebral malformation in humans and the most severe of a group of pathologies related to a deficiency of the SHH signalling pathway (Sonic Hedgehog SHH-D).
- Trial name
- EXOMEDIANE (NCT04691414)
- Testing
- NGS
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Rennes University Hospital
NSCLC, NSCLC Stage IV
Molecular Landscape Analysis and Clinical Implications for NSCLC Patients With Rare Mutations
Lung cancer is the most common primary cancer of the lung and is responsible for the ever increasing number of cancer-related deaths worldwide.
- Conditions
- NSCLC, NSCLC Stage IV, NSCLC, Recurrent
- Trial name
- NCT05701787
- Where
- 2 sites in China
- Volunteers
- 500 people
- Sponsor
- Shanghai Chest Hospital
Sepsis, Severe
The Value of Full-targeted Pathogen Capture Metagenomics Next Generation Sequencing in Etiological Diagnosis of Sepsis
The etiological diagnosis of sepsis is the key to guide clinical treatment. Metagenomic sequencing (mNGS) is very suitable for the diagnosis of sepsis due to its rapid, accurate and not easy to be disturbed by the environment.
- Trial name
- NCT05540808
- Volunteers
- 86 people
- Sponsor
- Shenzhen Second People's Hospital
Gastritis, Atrophic, Gastric Cancer
System Biology of Spleen Deficiency Syndrome
Spleen Deficiency Syndrome(SDS)is a widely researched issue, but due to the limitations of the research methods, the scientific mechanism of SDS is biased and not comprehensive.
- Trial name
- SBSDS (NCT02915393)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Beijing University of Chinese Medicine
Respiratory Tract Infections (RTI), Respiratory Syndrome, Acute, Severe
Clinical Multimodal Surveillance of Respiratory Syndrome Pathogens
This nationwide, multicenter observational study will establish and improve a hospital-based clinical surveillance and early warning system for respiratory syndrome pathogens.
- Conditions
- Respiratory Tract Infections (RTI), Respiratory Syndrome, Acute, Severe, Acute Respiratory Infections (ARIs)
- Trial name
- NCT07694648
- Testing
- Tiered pathogen testing and multi-omics analysis
- Where
- 31 sites in China
- Volunteers
- 2,398 people
- Sponsor
- Huashan Hospital
Carcinoma, Non-small Cell Lung Cancer (NSCLC)
Next Generation Sequencing Method for the Detection of EGFR Gene Mutations in the Plasma of Patients With Lung Cancer
The study aims to evaluate the Plasma-SeqSensei™ Solid Cancer IVD Kit NGS diagnostic test (Sysmex) before its introduction into routine diagnostics.
- Trial name
- NCT06595498
- Testing
- Plasma- SeqSensei™ Solid Cancer IVD Kit (Sysmex), cobas® EGFR Mutation Test v2 (Roche)
- Where
- Italy
- Volunteers
- 130 people
- Sponsor
- Istituto Oncologico Veneto IRCCS
Coronavirus Infectious Disease 2019 (COVID-19)
COVID-19 in Baselland: Validation of Simple and Accurate Tests for COVID-19 Detection, Monitoring and Tracing (ACCURATE-BL-COVID-19)
This study is to establish an accurate, robust and easily scalable COVID-19 viral nucleic acid analysis platform from, but not limited to, saliva to help enable and support contact tracing in the canton of Baselland/ Switzerland.
- Trial name
- NCT04625257
- Testing
- Saliva based assay: crude RNA extraction, Validation of the NGS method, Validation of the LAMP assays
- Where
- Switzerland
- Volunteers
- 1,600 people
- Sponsor
- University Hospital, Basel, Switzerland
Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL)
Assessing Minimal Residual Disease by Next- Generation Sequencing to Minimize Exposure in People With CLL or SLL Who Have Been Treated With Venetoclax
This study will find out whether people with CLL or SLL who have received treatment with venetoclax, either alone or in combination with another drug, and who are found to be MRD-negative, can stop treatment with venetoclax and…
- Trial name
- NCT04419519
- Testing
- Venetoclax monotherapy, Venetoclax with anti CD20 monoclonal antibody
- Where
- 9 sites in United States
- Volunteers
- 81 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Human Papillomavirus
Multi-site HPV Screening by High-throughput Sequencing in Patients With Chronic HPV-HR Infection Followed by Gynecology
The main risk of developing cervical cancer is the persistence of an High risk human papillomavirus (HPV-HR) infection, the mechanisms of which are still not understood.
- Trial name
- DEP-HPV (NCT04901351)
- Testing
- Smear
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Toulouse
Breast Carcinoma, Neuropathy
Whole Exome Sequencing in Finding Causative Variants in Germline DNA Samples From Patients With Peripheral Neuropathy Receiving Paclitaxel for Breast Cancer
This research trial studies whole exome sequencing in finding causative variants in germline deoxyribonucleic acid (DNA) samples from patients with peripheral neuropathy receiving chemotherapy for breast cancer.
- Trial name
- NCT02610439
- Testing
- Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 575 people
- Sponsor
- National Cancer Institute (NCI)
Gastrointestinal Diseases, Colic
Effect of Lactobacillus Reuteri DSM17938 in Neonates Treated With Antibiotics
The aim of the study is to elucidate the relationship between postnatal antibiotic administration on development of gut microbiota and possible protective influence of simultaneously administration of probiotic during antibiotic…
- Trial name
- NCT02865564
- Testing
- Lactobacillus reuteri DSM 17938, ampicillin and gentamicin
- Where
- Slovenia
- Volunteers
- 98 people
- Sponsor
- University Medical Centre Ljubljana
Next Generation Sequencing, Pediatric Bacterial Meningitis
Application of Next Generation Sequencing Technique in Pediatric Bacterial Meningitis
Pathogen identification is of paramount importance for bacterial meningitis. At present, the pathogen of bacterial meningitis is still mainly based on Gram stain and bacterial culture.
- Trial name
- NCT03953638
- Testing
- Next Generation Sequencing
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Beijing Children's Hospital
Prosthetic Joint Infection
NGS vs Culture Outcomes for Treatment of PJI
This multicenter, randomized controlled trial will compare the use of NGS and traditional culture in directing antimicrobial treatment for patients with periprosthetic joint infection.
- Trial name
- NCT05247281
- Testing
- Culture-based treatment, Next Generation Sequencing (NGS) with Culture
- Where
- 9 sites in United States
- Volunteers
- 250 people
- Sponsor
- Center for Innovation and Research Organization
Acute Myeloid Leukemia
Prognostic Values of Next Generation Sequencing (NGS) in Acute Myeloid Leukemia Patients With Allo-HSCT
Acute myeloid leukemia (AML) is a genetically heterogeneous disease and allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment option for AML except for AML-M3.
- Trial name
- NCT03715621
- Where
- China
- Volunteers
- 500 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Colorectal Carcinoma, Soft Tissue Sarcoma
Molecular Profiling to Improve Outcome of Patients in Cancer. A Pilot Study
Next Generation Sequencing in cancer: a feasibility study in France to assess sample circuit and to perform analyzes within a limited time.
- Trial name
- MULTIPLI-0 (NCT03546127)
- Testing
- Next Generation Sequencing (NGS): exome, RNA seq
- Where
- 3 sites in France
- Volunteers
- 24 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Dental Pulp Necrosis, Pulpitis
Metagenomic Analysis and Postoperative Pain in Infected Root Canals Using Different Irrigation Protocols
Achieving effective root canal disinfection while minimizing postoperative pain is a critical goal in endodontic therapy. Advanced irrigation protocols, such as ultrasonic activation, laser activation, negative pressure…
- Trial name
- NCT07546773
- Testing
- Ultrasonic Irrigation Activation, Laser-Activated Irrigation, Mechanical Irrigation Activation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Suez Canal University
Major Fetal Anomaly
Development of an Optimal Approach to Return of Results for Next-generation Sequencing for Prenatal Diagnosis
To gain knowledge about how patients undergoing prenatal diagnosis for a fetal abnormality understand and react to Whole Genome Sequencing (WGS) testing, so that the investigators can develop more ethical and responsible approach…
- Trial name
- NCT02255825
- Testing
- Whole Genome Sequencing, Amniocentesis, Psychosocial assessment
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Diego
Prebiotics, Metagenomic Next Generation Sequencing
Assessing Changes in the Gut Microbiome of Non-Gastrointestinal Disordered Subjects Before and After Oral Prebiotic Supplementation Using the SIMBA Capsule
This is a randomized, double-blind, placebo-controlled, parallel-group clinical study. The primary objective is to assess the changes in the small intestinal (SI) metagenomic profile of healthy participants without any known…
- Conditions
- Prebiotics, Metagenomic Next Generation Sequencing, Microbiome, Small Intestine
- Trial name
- NCT07788924
- Testing
- FiberSmart
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Anderson Advanced Ingredients