Clinical trials: Niche, open to volunteers
Isthmocele, Cesarean Scar Defect
Clinical Impact of Uterine Repair During Cesarean Section With Barbed Suture on the Incidence of Isthmocele
Pregnant women, irrespective of their pregnancy risk, who undergo a cesarean section for any reason will be randomized to one of two suturing techniques: conventional suture or barbed suture for uterine repair after the cesarean…
- Conditions
- Isthmocele, Cesarean Scar Defect, Pelvic Pain, Spotting
- Trial name
- CESARIS (NCT06691750)
- Testing
- Barbed suture, Conventional smooth suture
- Where
- Spain
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Glioblastoma
Feasibility of ORGAnoids in Routine Clinical Practice for Molecular Analysis of the GLIOvascular Niche in Patients With Primary Brain Tumors.
The main goal of ORGA-GLIO trial is to establish the feasibility in routine clinical practice of ex-vivo organoid cultures composed of tumor cells within their microenvironment (glioblastoma organoid - GBO) and intra- and…
- Trial name
- ORGA-GLIO (NCT07029100)
- Testing
- Ex-vivo organoid culture
- Where
- 3 sites in France
- Volunteers
- 30 people
- Sponsor
- Centre Henri Becquerel
Colon Carcinoma
Neoadjuvant Immune Checkpoint Inhibition and Novel IO Combinations in Early-stage Colon Cancer
In this exploratory study, patients with stage 1-3 adenocarcinoma of the colon with no signs of distant metastases will be treated with short-term immunotherapy + novel IO combinations (i.e.
- Trial name
- NICHE (NCT03026140)
- Testing
- Nivolumab, Ipilimumab, Celecoxib 200mg
- Where
- 6 sites in Netherlands
- Volunteers
- 353 people
- Sponsor
- The Netherlands Cancer Institute
Cesarean Scar Defect
Impact of a Bladder Flap on Cesarean Scar Niche Development
The goal of this trial is to examine if the completion or omission of a bladder flap impacts the location and formation of cesarean scar niche in women undergoing primary cesarean section.
- Trial name
- B-FIND (NCT07634679)
- Testing
- Bladder flap formation
- Where
- 2 sites in United States
- Volunteers
- 338 people
- Sponsor
- Montefiore Medical Center
Cesarean Section; Dehiscence, Uterine Bleeding
Impact of Single- Versus Double-layer Hysterotomy Closure on Cesarean Niche Development: a Randomized Controlled Trial
The objective of this randomized monocentric study is to assess potential variations in the incidence and severity of isthmocele morbidity among women undergoing cesarean section with either single or double-layer closure of the…
- Conditions
- Cesarean Section; Dehiscence, Uterine Bleeding, Uterus; Scar, Uterus Abnormal
- Trial name
- NCT06308172
- Testing
- Hysterotomy closure
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Scar Niche
Two Dimensional Versus Three Dimensional Transvaginal U/S With or Without SIS
Primary aim: To assess the diagnostic agreement between 2D vs 3D TV U/S with or without SIS for the evaluation of cesarean scar defects and its correlation with symptoms.
- Trial name
- NCT07704788
- Volunteers
- 100 people
- Sponsor
- Sohag University
Caesarean Scar Defect
Effectiveness of Transvaginal Niche Resection Versus Expectant Management in Patients with Secondary Infertility and a Large Uterine Caesarean Scar Defect
The goal of this clinical trial is to evaluate the efficacy and safety of transvaginal niche resection in improving pregnancy outcomes of a large uterine caesarean scar defect (niche) with secondary infertility.
- Trial name
- TVARES (NCT06599671)
- Testing
- Transvaginal niche resection
- Volunteers
- 100 people
- Sponsor
- International Peace Maternity and Child Health Hospital
Scar Niche, Infertility, Post Menstrual Spotting
The Relationship Between the Number of Ceserean Sections and Scar Niche Development
Aim of the work This study aims to investigate the relationship between the number of previous cesarean sections (CS) and the incidence of a cesarean scar niche.
- Trial name
- NCT07114705
- Testing
- Transvaginal ultrasound
- Volunteers
- 82 people
- Sponsor
- Sohag University
Hematological Malignancies
National Longitudinal Cohort of Hematological Diseases (NICHE) - CART
This is a multicenter, ambispective, longitudinal, observational cohort study investigating CAR-T cell therapy in Chinese patients with hematological malignancies.
- Trial name
- NCT06607289
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
CLL
Study of the Metabolism in the Lymphatic Niche of CLL
Chronic lymphoid leukemia (CLL) is the most common adult leukemia that is characterized by a malignant monoclonal accumulation of tumoral and quiescent B cells in the peripheral blood.
- Trial name
- NCT05610228
- Testing
- NO intervention
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Diffuse Large B Cell Lymphoma
Study of the Hematopoietic Niche and the Role of Inflammation in the Pathophysiology of Cytopenias After CAR-T Cell Therapy: Potential of Therapies Directed to Repair the Bone Marrow Microenvironment
Immunotherapy with chimeric antigen receptor T-cells (CAR-T) has revolutionized the treatment of oncohematological diseases and its applications in solid tumors and non-neoplastic diseases are advancing.
- Trial name
- NCT06439173
- Testing
- CAR-T cell therapy
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Instituto de Investigación Biomédica de Salamanca
Colon Cancer, Liver Tumors
A Study of Imaging, Blood, and Tissue Samples to Guide Treatment of Colon Cancer and Related Liver Tumors
The purpose of this study is to explore novel ways of diagnosing colon cancer and predicting its propensity to spread to other organs such as the liver.
- Trial name
- NCT03432806
- Testing
- blood draws, colectomy or hepatectomy, Fibroscan test
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Multiple Myeloma, Acute Myeloid Leukemia
National Longitudinal Cohort of Hematological Diseases
Background Hematological diseases are disorders of the blood and hematopoietic organs. The current hematological cohorts are mostly based on single-center or multi-center cases, or cohorts with limited sample size in China.
- Conditions
- Multiple Myeloma, Acute Myeloid Leukemia, Hemophilia, Hemophilia A
- Trial name
- NICHE (NCT04645199)
- Where
- China
- Volunteers
- 2,300 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Isthmocele, Cesarean Scar Diverticula
Comparing Decidual Inclusion vs. Exclusion in Uterine Suture Techniques During Cesarean Section to Improve Scar Thickness and Reduce Isthmocele Risk in Primiparous Women
This study compares two ways of closing the uterus during cesarean delivery. In one group, the decidual layer near the uterine cavity is included in the suture. In the other group, this layer is left out.
- Trial name
- DISSUC (NCT07608874)
- Testing
- Single-Layered Non-Locked Closure with Decidual Inclusion, Single-Layered Non-Locked Closure with Decidual Sparing
- Where
- Switzerland
- Volunteers
- 374 people
- Sponsor
- Kantonsspital Baden
Niche
Cesarean Scar Defect: a Prospective, Observational Study.
The study is conducted as part of the doctoral thesis of Natalia Mazur-Ejankowska, a medical doctor undergoing specialist training in obstetrics and gynecology at the Department of Obstetrics and Gynecology, Gynecologic Oncology…
- Trial name
- NCT07723157
- Testing
- Transvaginal ultrasonography examination
- Where
- Poland
- Volunteers
- 150 people
- Sponsor
- Medical University of Gdansk
Cesarean Scar Pregnancy
Effect of Methotrexate on Blood Loss During Laparoscopic Management of CS Scar Pregnancy
Effect of Preoperative Methotrexate on Intraoperative Blood Loss and Surgical Outcomes During Laparoscopic Management of Cesarean Scar Pregnancy: A Prospective Cohort Study.
- Trial name
- CSEP (NCT07886216)
- Volunteers
- 42 people
- Sponsor
- Assiut University
Cesarean Section Complications, Uterine Bleeding
Platelet Rich Plasma for Uterine Scar
When vessel wall injury occurs, platelets become activated, releasing more than 30 bioactive proteins, many of which have a fundamental role in hemostasis, inflammation and ultimate wound healing.
- Conditions
- Cesarean Section Complications, Uterine Bleeding, Pelvic Pain, Menstrual Irregularity
- Trial name
- AA-PRP (NCT05224726)
- Testing
- Platelet Rich Plasma
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Caesarean Scar Niche
Niche Investigated: Closure of Hysterotomy & Evaluation of 3 Suturing Techniques (Running, Interrupted, and Locked)
This study aims to explore the impact of three different suturing techniques (Running, Interrupted \& Locked) that used to close the uterine incision at the cesarean section on the formation of a cesarean scar niche
- Trial name
- NCT06695793
- Testing
- Interrupted Sutures, Locked Sutures, Running Continuous Sutures
- Where
- 5 sites in Egypt
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Cairo University
Cesarean Section Complications, Abnormal Uterine Bleeding
Combined Hystroscopic and Laparoscopic Repair of CS Scar Disorder
Combined hystroscopic and laparoscopic repair of symptomatic uterine Niche as new technique to maximize resolution of symptoms after niche repair with concomitant increase in RMT
- Trial name
- NCT07183501
- Testing
- Combined hystroscopic and laparoscopic repair
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University