Clinical trials: Nicotine Dependence Prevention
Nicotine Dependence
Effectiveness of GW468816, an NMDA Glycine Site Antagonist, for Prevention of Relapse to Smoking
The purpose of this study is to evaluate the efficacy of the glycine antagonist, GW468816, compared with placebo on duration of abstinence and rates of relapse in recently quit female smokers in a randomized, double-blind…
- Trial name
- NCT00218465
- Testing
- GW468816
- Where
- 2 sites in United States
- Volunteers
- 264 people
- Sponsor
- Massachusetts General Hospital
Asthma, Tobacco
Efficacy of School-Based, Peer-Led Asthma and Smoking Prevention Program on CO1 Levels and Smoking Behavior Among Early Adolescents in Jordan
Study Hypotheses: 1. adolescents in intervention schools who are given Triple A program plus ASP will show more awareness in regards to cigarettee smoking health effects and less nicotine dependencethan those in the control…
- Conditions
- Asthma, Tobacco, Waterpipe, Cigarettes
- Trial name
- TAJPlus (NCT01938976)
- Testing
- TAJ Plus (Adolescent Asthma Action in Jordan) Plus the added class smoke free pledge
- Volunteers
- 815 people
- Sponsor
- University of Technology, Sydney
Tobacco Use Disorder, Tobacco Dependence
Equitable Smoking Relapse Prevention
The goal of this clinical trial is to test a GPS (Global Positioning System)-enabled smartphone app (QuitBuddy) in current smokers.
- Trial name
- NCT05625685
- Testing
- Quitbuddy, Control, SDoH Augmentation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Bryan W. Heckman
Nicotine Dependence
Study Two on the Effectiveness of Mindfulness Training for Smokers
The MTS2 study enrollment goal is N=240 adult smokers randomized to study treatments. The study design includes two randomized arms to compare matched intensive interventions and a third non-randomized option for participants who…
- Trial name
- MTS2 (NCT01299909)
- Testing
- Integrated Training for Smokers, Mindfulness Training for Smokers, Quitline
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- University of Wisconsin, Madison
E-cigarette Use/Vaping Prevention, Nicotine Dependence Prevention
A Virtual Reality E-cigarette Prevention and Emotion Regulation Intervention for Adolescents
This study will examine E-Invite Only VR, a novel school-based universal e-cigarette prevention intervention that uses virtual reality (VR) to deliver prevention and emotion regulation skills-building content to middle school…
- Conditions
- E-cigarette Use/Vaping Prevention, Nicotine Dependence Prevention, Adolescent Mental Health
- Trial name
- NCT07460622
- Testing
- Virtual Reality E-Cigarette Prevention Program
- Where
- United States
- Volunteers
- 1,251 people, healthy volunteers welcome
- Sponsor
- Yale University
Nicotine Dependence, Cigarettes
Online Lapse Management Intervention
The purpose of the trial is to test the adjunctive effect of adding a lapse management system to a best practices web- and mobile smoking cessation program.
- Trial name
- NCT03191825
- Testing
- Endre: a digital smoking cessation counsellor, Lapse management system triggered from web-page, Lapse management system triggered by SMS-textmessage
- Where
- 2 sites in Czechia, Norway
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Nicotine Dependence
Drug /Cue Interactions In Alcohol-Tobacco Comorbidity
The purpose of this study is to determine how people react to different combinations of alcohol and nicotine.
- Trial name
- NCT00816231
- Testing
- Tobacco, Alcoholic Beverage
- Where
- United States
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Nicotine Dependence
Effects of Chantix on Relapse Prevention for Smoking Cessation
The goal of the proposed study is to validate an experimental paradigm to assess medication effects on smoking relapse following a brief (3-day) monitored period of smoking abstinence and a programmed cigarette lapse.
- Trial name
- NCT00948649
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Nicotine Dependence, Tobacco Smoking
Smoking Cessation and Menstrual Cycle Phase
Tobacco use is a risk factor for at least 20 types of cancer and remains the leading preventable cause of cancer in Canada. Smoking cessation is an important cancer prevention strategy for the close to 2 million Canadian women…
- Conditions
- Nicotine Dependence, Tobacco Smoking, Smoking Cessation, Nicotine Use Disorder
- Trial name
- MC-NRT (NCT05515354)
- Testing
- Timing of nicotine replacement therapy start date, Nicotine Replacement Therapy Agent
- Where
- Canada
- Volunteers
- 1,200 people
- Sponsor
- Centre for Addiction and Mental Health
Nicotine Dependence, Schizophrenia
Extended Duration Nicotine Replacement Therapy and Bupropion in Smokers With Schizophrenia
After successfully quitting smoking, smokers with schizophrenia are vulnerable to relapse shortly after discontinuation of treatment.
- Trial name
- NCT01576640
- Testing
- NRT, Bupropion SR 150mg bid, Relapse Prevention-Oriented Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Massachusetts General Hospital
Nicotine Dependence
Prevention of Nicotine Abstinence in Critically Ill Patients After Major Surgery
The primary objective of this study is to determine whether the application of transdermal nicotine patches in critically ill patients after major surgery with nicotine abstinence condition is associated with a lower incidence of…
- Trial name
- NCT03847155
- Testing
- Nicotine patch
- Where
- Czechia
- Volunteers
- 52 people
- Sponsor
- University Hospital Ostrava
Cigarette Smoking, Tobacco Smoking
Mindfulness Training for Smoking Cessation
The purpose of this study is to assess the effects of mindfulness training (MT) compared to standard Smoking Cessation Therapy (SCT) on smoking cessation and stress provocation in individuals trying to quit smoking.
- Conditions
- Cigarette Smoking, Tobacco Smoking, Nicotine Dependence, Smoking Cessation
- Trial name
- NCT01144689
- Testing
- Mindfulness Training, Smoking Cessation Therapy
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Yale University
Nicotine Dependence
Effectiveness of GSK598809, a Selective D3 Antagonist, Added to CBT and NRT for Smoking Cessation and Relapse Prevention
The purpose of this research study is to find out if an investigational drug, GSK598809 can help people who have very recently quit smoking; the investigators want to find out if continuing to take GSK598809 over six weeks can…
- Trial name
- NCT01188967
- Testing
- GSK598809
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Massachusetts General Hospital
Tobacco Use, Tobacco Smoking
Evaluation of a Brief Tobacco Intervention in the US Military
While the military has taken steps to reduce tobacco use over the past two decades, over a quarter of new military recruits report regular tobacco use prior to enlistment.
- Conditions
- Tobacco Use, Tobacco Smoking, Smoking, Cigar, Smoking, Pipe
- Trial name
- NCT03196102
- Testing
- BTI, Cigarette smoking military tailored pamphlet, Standard smoking cessation intervention
- Where
- United States
- Volunteers
- 2,999 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Tobacco Use, Tobacco Use Cessation
CONNECT Cancer Survivors With Tobacco Treatment
The purpose of this study is to evaluate the comparative effectiveness of two different informatics-enabled implementation strategies on increasing tobacco treatment and improving smoking cessation rates for cancer control and…
- Conditions
- Tobacco Use, Tobacco Use Cessation, Smoking Cessation, Nicotine Addiction
- Trial name
- NCT07020273
- Testing
- ELEVATE, ELEVATE-S
- Where
- United States
- Volunteers
- 3,543 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Substance Dependence
Relapse Prevention Study in Newly Abstinent Smokers
The purpose of this study is to determine the effect of GSK598809 as compared to placebo in preventing recently-quit smokers from going back to smoking.
- Trial name
- NCT00793468
- Testing
- GSK598809, Nicotine Replacement Transdermal Patch
- Where
- 10 sites in United States
- Sponsor
- GlaxoSmithKline
Little Cigars and Cigarillos (LCC) Use
Little Cigar and Cigarillo Warnings for Youth
This study explores the effect of the little cigars and cigarillos (LCC) warnings on youth who currently use, have ever used, or are susceptible to using LCCs.
- Trial name
- NCT06413797
- Testing
- FDA warnings + Image, FDA Warnings Text-Only, Surgeon General Text-Only Warnings
- Where
- United States
- Volunteers
- 928 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center