Clinical trials: Nicotine E-Cigarette Use
Smoking, Tobacco
A Study to Determine the Effects of ENDS Flavor Availability on Abstinence Within Smokers
The overall purpose of this study will be to assess primary combustible cigarette users' abstinence from smoking their usual brand of combustible cigarettes at the end of the study, when provided with an electronic nicotine…
- Trial name
- NCT07598136
- Testing
- P2613422, P2611222, P2615522
- Where
- 7 sites in United States
- Volunteers
- 1,280 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
E-cigarette, Vaping
Understanding Vape Marketing Study
The purpose of this study is to develop an electronic cigarette (e-cigarette) counter-marketing lesson for adolescents. The lesson will involve short videos designed to improve adolescents' cognition of e-cigarette marketing in…
- Conditions
- E-cigarette, Vaping, Tobacco, Nicotine
- Trial name
- NCT07129265
- Testing
- Working group, Focus group
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Role of Tobacco Harm Reduction in Smoking Cessation, Efficiency and Efficacy of E-cigarettes and Nicotine Pouches
Electronic Cigarettes and Nicotine Pouches for Smoking Cessation
Pakistan is one of the most vulnerable low- and middle-income countries with 29 million adult active tobacco users. Smoking cessation services are lacking as the tobacco control initiatives have largely failed to address the…
- Conditions
- Role of Tobacco Harm Reduction in Smoking Cessation, Efficiency and Efficacy of E-cigarettes and Nicotine Pouches, Adverse Effect of E-cigarettes and Nicotine Pouches
- Trial name
- NCT05715164
- Testing
- E-cigarettes device plus liquid, Nicotine Pouches, Basic care counseling about smoking cessation
- Where
- Pakistan
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Alternative Research Initiative
Electronic Cigarette Use
Effects of Nicotine Salt Aerosol on Cigarette Smokers
This grant compares the effects of cigarette smoking, protonated nicotine ("salt") aerosol through an Electronic Nicotine Delivery System (ENDS), and unprotonated nicotine aerosol through an ENDS on nicotine delivery, nicotine…
- Trial name
- NCT03974152
- Testing
- Subox Mini C with Avail 18 mg nicotine salt (protonated), Subox Mini C with Avail 18 mg nicotine (unprotonated), Own brand cigarette
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Eastern Virginia Medical School
Electronic Cigarette Use, Cigarette Smoking
Effects of e-Cigarettes on Perceptions and Behavior - Remote Substudy # 1
This study assess the ways in which e-cigarette product characteristics, such as marketing strategies, impact user experience to inform potential regulations.
- Conditions
- Electronic Cigarette Use, Cigarette Smoking, Cigarette Use, Electronic, Vaping
- Trial name
- NCT05958979
- Testing
- Control Marketing Strategies, Experimental Marketing Strategies
- Where
- United States
- Volunteers
- 601 people, healthy volunteers welcome
- Sponsor
- University of Southern California
E-cigarette Use
Feasibility of PET/CT to Detect the Oral/Pulmonary Distribution of Nicotine Following E-cigarette Use
The investigators aim to (1) establish a methodology for the evaluation of the biodistribution of radio-labeled nicotine following e-cigarette use, (2) determine the oral/pulmonary distribution of nicotine following e-cigarette…
- Trial name
- NCT03491059
- Testing
- C-11 labeled nicotine, PET/CT imaging
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Tobacco Dependence
Does Switching to Nicotine Containing Electronic Cigarettes Reduce Health Risk Markers
The overall goal of this project is to understand the likely health effects of cigarette smokers switching to a Standardized Research Electronic Cigarette (SREC) and to assess the role of nicotine delivery on switching and…
- Trial name
- NCT03625986
- Testing
- Nicotine-Containing Electronic Cigarette, Non-Nicotine Electronic Cigarette
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Smoking Behaviors, Smoking ( Cigarette)
A Study to Assess Nicotine Uptake From a Menthol Electronic Nicotine Delivery System Product
This will be a randomized, open-label, 2-way crossover, single-site study designed to evaluate elements of abuse liability (AL), including subjective effects and physiological measures (pharmacodynamics [PD]), and plasma nicotine…
- Conditions
- Smoking Behaviors, Smoking ( Cigarette), Tobacco Use, Abuse Liability
- Trial name
- NCT07881848
- Testing
- Menthol 5%, Combustible cigarette
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Nicotine Dependence
Evaluation of Short-term Safety and Use Patterns of an Electronic Nicotine Delivery System
Electronic Nicotine Delivery Systems (ENDS), commonly referred to as electronic cigarettes have gained in popularity over the last several years.
- Trial name
- NCT01898169
- Testing
- NJOY King 26 mg nicotine Electronic Nicotine Delivery System
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- LA Clinical Trials
Electronic Nicotine Delivery System Flavors
Potential Effects of Electronic Nicotine Delivery System Flavor Regulations on African American Menthol Smokers
This study aims to better understand how the availability of electronic nicotine delivery system (aka electronic cigarettes) flavors (e.g., menthol, tobacco) impacts tobacco use behaviors, toxicant exposure, and abuse liability…
- Trial name
- RVA Flavors (NCT05023096)
- Testing
- Tobacco product administration and assessment
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cigarette Smoking
Nicotine Pharmacokinetics From Research Electronic Nicotine Delivery System S-TA-U001 in Smokers and E-Cigarette Users
To better understand the PK and associated pharmacodynamic (PD) responses produced by the Research ENDS S-TA-U001 product, this study will compare the Research ENDS S-TA-U001 to The subject's own brand combustion (non-menthol)…
- Trial name
- NCT02792426
- Testing
- Research ENDS S-TA-U001, Nicorette Inhalator
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- NJOY, Inc.
Smoking, Smoking Behaviors
CSD190501: A Study to Determine Subject Puffing Patterns of an Electronic Nicotine Delivery System in an Ambulatory Setting
This study will be a single-center, controlled, open-label, parallel study to evaluate the puffing patterns of healthy adult consumers of tobacco products switching from a usual brand (UB) Electronic Nicotine Delivery Systems…
- Conditions
- Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
- Trial name
- NCT04226404
- Testing
- CSD1905-11, CSD1905-12, CSD1905-13
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
THC, Cannabis
Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration
This is a crossover, randomized, double-blinded clinical pharmacology study enrolling dual cannabis-tobacco smokers to better understand the combined effects of co-administering cannabis and tobacco.
- Conditions
- THC, Cannabis, Cannabis Use, Cannabis Smoking
- Trial name
- CANNIC (NCT05999383)
- Testing
- Cannabis, Nicotine, Pax Loose Leaf Vaporizer
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Nicotine, Vaping
Reduced HPHC Exposure in Cigarette Smokers Switching to P4M3 Gen. 2.0 Compared to Continuing Smoking, or Smoking Abstinence
To demonstrate the reduction of Biomarkers of Exposure (BoExp) to selected harmful and potentially harmful constituents (HPHC) in smokers switching from cigarette (CIG) to P4M3, an Electronic Nicotine Delivery System (ENDS)…
- Conditions
- Nicotine, Vaping, Nicotine Vaping
- Trial name
- NCT05487456
- Testing
- P4M3 CA35, P4M3 CM35, CIG
- Where
- United Kingdom
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Tobacco Use Disorder
Low Nicotine Content Cigarettes in Vulnerable Populations: Women of Reproductive Age
Despite marked reductions in cigarette smoking in the general population, smoking among economically disadvantaged women has increased.
- Trial name
- NCT04092387
- Testing
- Varying the nicotine content of cigarettes, E-Cigarettes
- Where
- 2 sites in United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Nicotine Administration & Dosage, E-cigarettes
Evaluating the Comparative Pharmacokinetics of Nicotine After Administration Via JUUL or Tobacco Cigarettes
This is an observational, crossover design that will examine the pharmacokinetics and pharmacodynamics of impact of smoking tobacco cigarettes or vaping the JUUL electronic cigarette.
- Conditions
- Nicotine Administration & Dosage, E-cigarettes, Vaping, E-Liquid
- Trial name
- NCT04053868
- Testing
- JUUL, Tobacco
- Where
- 2 sites in United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Smoking, Smoking Behaviors
CSD201201: Study to Assess Elements of Abuse Liability for Electronic Nicotine Delivery System P12
This is a randomized, open-label, 6-way crossover, multi-site study designed to evaluate elements of abuse liability (AL) including subjective effects and physiological measures (pharmacodynamics [PD]), and nicotine uptake…
- Conditions
- Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
- Trial name
- NCT05210699
- Testing
- Product A, Product B, Product C
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Smoking
User Acceptability of a Nicotine Lactate Delivery System (P3L)
This study will provide an initial assessment of the acceptability of the Nicotine Lactate Delivery System (P3L) after ad libitum use and the ability of combustible cigarette (CC) smokers to use P3L to maintain their customary…
- Trial name
- NCT02643693
- Testing
- P3L, VUSE, CC
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Nicotine Dependence, Nicotine Dependence, Cigarettes
Comparing the Pharmacokinetics of Nicotine Salt Based ENDS in Healthy Smokers
A Ten Sequence, Open Label, Randomized Crossover Study Comparing Nicotine Pharmacokinetics of JUUL 1.7% and JUUL 5% Nicotine Salt Based ENDS Products, in Healthy Adult Smokers.
- Conditions
- Nicotine Dependence, Nicotine Dependence, Cigarettes, Tobacco Use, Tobacco Smoking
- Trial name
- NCT03593239
- Testing
- Tobacco flavored JUUL 1.7% ENDS, Tobacco flavored JUUL 5% ENDS, Mint flavored JUUL 1.7% ENDS
- Where
- New Zealand
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Juul Labs, Inc.
Cigarette Smoking Toxicity, Nicotine
The Acute Cardiovascular Effects of Nicotine in E-cigarettes (ACE) Study
The goal of this project is to evaluate the nicotine induced acute cardiovascular changes in E-Cigarette users and also study the mechanism involved particularly with vascular impairment.
- Conditions
- Cigarette Smoking Toxicity, Nicotine, Acute Cardiovascular Disease
- Trial name
- ACE (NCT03010995)
- Testing
- Prazosin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Louisville