Clinical trials: Nicotine Use, active
Smoking, Smoking Behaviors
Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction
The study will recruit an anticipated 256 adults who currently smoke cigarettes and report a willingness to try switching to alternative, non-combustible products.
- Conditions
- Smoking, Smoking Behaviors, Nicotine Dependence
- Trial name
- NCT06077240
- Testing
- E-cigarette with 2.4% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 2.4% Nicotine with Tobacco Flavor Only, E-cigarette with 5% Nicotine with Menthol and Tobacco Flavors
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- Yale University
Alcohol Use Disorder (AUD), Nicotine Use Disorder
Pharmaceutically-Enhanced Reinforcement for Reduced Alcohol and Smoking
Using a randomized controlled trial (RCT), the goal of this study is to evaluate the ability of evidence based behavioral treatment (contingency management: CM) to significantly decrease alcohol use and cigarette smoking among…
- Trial name
- PERRAS (NCT05181891)
- Testing
- Contingency Management, Non-contingent control
- Where
- United States
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Washington State University
Tobacco Use Disorder, Nicotine Dependence
Beta-Adrenergic Modulation of Drug Cue Reactivity
This study is designed to investigate the effects of a beta-adrenergic antagonist (Propranolol; 40 mg IR) and nicotine patch (14 mg) administered alone and in combination on neurobiological and behavioral responses to smoking…
- Conditions
- Tobacco Use Disorder, Nicotine Dependence, Cigarette Smoking
- Trial name
- NCT05587361
- Testing
- Propranolol, Nicotine Patch
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Smoking Cessation; Tobacco Dependence, E-Cig Use
BREATHE Free Curriculum
The purpose of this study is to evaluate whether BREATHE Free, an in-person faith-based smoking cessation program, can help people quit using tobacco products, including cigarettes, cigars, cigarillos, and e-cigarettes/vapes.
- Conditions
- Smoking Cessation; Tobacco Dependence, E-Cig Use, Nicotine Dependence, Other Tobacco Product
- Trial name
- NCT06862050
- Testing
- BREATHE Free Curriculum
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Augusta University
Smoking Cessation, Cigarette Smoking
Quit With Sense: Using Mindful Smoking and Wearable Device for Smoking Cessation
This pilot randomized controlled trial will test the feasibility of a smoking cessation intervention using mindful smoking practice and a smartphone-based sensor-band among adults who regularly smoke cigarettes.
- Conditions
- Smoking Cessation, Cigarette Smoking, Tobacco Use, Nicotine Dependence
- Trial name
- NCT07789496
- Testing
- Mindful Smoking and Sensor-Band Intervention, Smoking Cessation Information
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Tobacco Smoking, Harm Reduction
Smoking Harm Reduction Using E-cigarettes and Cytisine
Smoking remains the leading cause of preventable death globally, with high prevalence in disadvantaged populations despite access to free nicotine replacement therapy (NRT) and counseling through Ontario's STOP Program.
- Conditions
- Tobacco Smoking, Harm Reduction, Nicotine
- Trial name
- SHRECC (NCT07274475)
- Testing
- E-cigarette e-liquid, Cytisine
- Volunteers
- 6,000 people
- Sponsor
- Centre for Addiction and Mental Health
Chronic Pain, Tobacco Use
Opioids, Low Nicotine Cigarettes, and Chronic Pain
The purpose of this study is to evaluate the effects of switching to very low nicotine content (VLNC) cigarettes versus normal nicotine content (NNC) cigarettes on craving, withdrawal, and pain among individuals with chronic pain…
- Conditions
- Chronic Pain, Tobacco Use, Opioid Substitution Treatment
- Trial name
- NCT06747871
- Testing
- Very Low Nicotine Cigarettes (VLNC), Normal Nicotine Cigarettes (NNC)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Cigarette Smoking, mHealth Intervention
Smoking Cessation for Fathers of Sick Children
The project aims to develop and examine the feasibility, acceptability, and preliminary effectiveness of a proactive intervention model combined brief advice, nicotine replacement therapy sampling and mHealth-based individual…
- Trial name
- Quit-for-Love (NCT07014124)
- Testing
- Nicotine Replacement Therapy (NRT) Sampling, mHealth-based motivational counselling, Brief cessation advice and self-help material
- Where
- Hong Kong
- Volunteers
- 160 people
- Sponsor
- The University of Hong Kong
Adverse Childhood Experiences, Nicotine Dependence, Cigarettes
Neurobehavioral Mechanisms Linking Childhood Adversity to Increased Risk for Smoking
The purpose of this study is to evaluate how certain childhood experiences influences brain function and responses to nicotine exposure in a group of nonsmoking young adults.
- Trial name
- NCT05665465
- Testing
- Nicotine nasal spray 0.5 mg
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Duke University
Message Exposure (Sequence: Regular Then Flavor), Message Exposure (Sequence: Flavor Then Regular)
Neuroimaging Approaches to Improve Prediction of Smoking Initiation and Nicotine Escalation in Young Adult ENDS Users
180 young adult vapers who are not current smokers will participate in a baseline functional magnetic resonance imaging (fMRI) experiment, prospectively linked to a 1-year randomized controlled trial.
- Conditions
- Message Exposure (Sequence: Regular Then Flavor), Message Exposure (Sequence: Flavor Then Regular), No Message Exposure (Control Condition)
- Trial name
- NCT05447325
- Testing
- Exposure to Anti-Vaping Messages (generic themes then flavor-specific themes), Exposure to Anti-Vaping Messages (flavor-specific themes then generic themes), Exposure to Anti-Vaping Messages (no message exposure)
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Georgia
E Cigarette Use
Adapting an Intervention for Vaping in Young Veterans
The objective of this proposal is to adapt an evidence-based combustible tobacco counseling intervention following an evidence-based process to include e-cigarette use and update its components for emerging adults (EA). 1.
- Trial name
- NCT06196489
- Testing
- adapted vaping cessation intervention
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Veterans Medical Research Foundation
Thromboangiitis Obliterans (Buerger's Disease)
A First in Human Single Ascending Dose (SAD) Study of ATI-1013 in Healthy Smokers
This study is a first-in-human clinical trial of drug ATI-1013, in healthy adult cigarette smokers. The main questions it aims to answer are to learn about the safety of drug ATI-1013, how long drug ATI-1013 remains within the…
- Trial name
- NCT07215923
- Testing
- ATI-1013 (0.2 g), ATI-1013 (0.8 g), ATI-1013 (3.2 g)
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Antidote Therapeutics, Inc
Coronary Artery Disease, Coronary Atherosclerosis
Effects of Switching From Cigarettes to Tobacco Heating System on Coronary Atherosclerosis Progression
Objective: To evaluate the impact of heated versus combustion tobacco products on progression of atherosclerosis in patients with CAD unable(unwilling) to quit smoking.
- Conditions
- Coronary Artery Disease, Coronary Atherosclerosis, Nicotine Dependence
- Trial name
- SWITCH (NCT05660798)
- Testing
- heated tobacco - lifestyle intervention
- Where
- Poland
- Volunteers
- 180 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
E Cigarette Use, Cessation, Tobacco
Evaluation of Dependence and Nicotine Replacement Therapy-Supported Cessation Efforts Among Regular Electronic Cigarette Use
This study aims to improve understanding of how people who use electronic cigarettes (ECIGs or e-cigarettes) respond when they try to stop using them and whether nicotine replacement therapy (NRT) can make that process easier.
- Conditions
- E Cigarette Use, Cessation, Tobacco, Cessation, Nicotine
- Trial name
- NCT07786896
- Testing
- Nicotine Replacement Therapies, Brief Behavioral Counseling
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- West Virginia University
Schizophrenia
Value of Voxel-Based Morphometry in Schizophrenia
This cross-sectional observational study investigates structural brain abnormalities in schizophrenia and nicotine use disorder (NUD), with a focus on understanding how these abnormalities correlate with behavioral traits such as…
- Trial name
- NCT07108673
- Testing
- MRI
- Volunteers
- 96 people
- Sponsor
- Assiut University
Nicotine Use Disorder
Effects of Novel E-cigarette Constituents on Adults TCORS 3.0
This study is an examination of the influence of cooling components of WS-3, WS-23, and menthol on the appeal and addiction potential of nicotine-containing e-liquids among adults.
- Trial name
- NCT05932745
- Testing
- E-liquid coolant (No WS-3) for non-menthol (1), E-liquid coolant (No WS-3) for low (0.1%) menthol (1), E-liquid coolant (No WS-3) for high (2.0%) menthol (1)
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Yale University
Tobacco Dependence, COPD Asthma
Cytisine vs Nicotine Replacement Therapy
Tobacco is the most preventable cause of disease and death in Canada. Although the tobacco use rate has substantially gone down in the general population, significant differences exist between sub-populations in Canada, for…
- Conditions
- Tobacco Dependence, COPD Asthma, Mental Illness, Substance Use
- Trial name
- NCT03249428
- Testing
- Cytisine, Nicotine replacement therapy (NRT)
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
HIV/AIDS, Nicotine Dependence
Optimizing Tobacco Use Treatment for PLWHA
The advent of anti-retroviral therapy (ART) for people living with HIV/AIDS (PLWHA) substantially improved life expectancy but has also led to the critical need to address modifiable risk factors associated with cancer and…
- Trial name
- HTO (NCT04176172)
- Testing
- Varenicline, Nicotine patch, Standard treatment
- Where
- 2 sites in United States
- Volunteers
- 340 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Healthy Adult Participants
Understanding Oral Nicotine Pouch Use in Healthy Volunteers
The goal of this clinical trial is to understand how using oral nicotine pouches effects the body in healthy volunteers. The main questions it aims to answer are: 1.
- Trial name
- NCT07829939
- Testing
- 0 mg oral nicotine pouches, 3 mg oral nicotine pouches, 6 mg oral nicotine pouches
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
CBD, Stress
Effects of Cannabidiol on Stress and Nicotine Withdrawal
The purpose of this study is to examine the effect of doses of cannabidiol (CBD) during exposure to stress and nicotine withdrawal in nicotine users.
- Conditions
- CBD, Stress, Nicotine Dependence, Tobacco Smoking
- Trial name
- CREWS (NCT07001930)
- Testing
- Epidiolex
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Johns Hopkins University