Clinical trials: Nicotine Vaping
- Condition Nicotine Vaping
- Funder type Industry (pharma, biotech, devices)
- Accepts healthy volunteers yes
Electronic Cigarette Use, Retina; Change
Nicotine Influence on the Retina Following the Use of Electronic Cigarette
The marketing of electronic cigarettes (e-cigarettes) in 2003 was initially intended to present a healthier alternative to smokers.
- Trial name
- NCT05801419
- Testing
- RETI-port/scan 21, Zilia Ocular, OCT-A
- Where
- Canada
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Christian Casanova
Smoking Cessation
Enhanced E-cigarette Coaching Intervention for Dual Users of Cigarettes and E-cigarettes
The purpose of this study is to develop and pilot test an enhanced behavioral coaching intervention for dual users of cigarettes and electronic nicotine delivery systems (ENDS) who call tobacco quitlines for help quitting smoking.
- Trial name
- NCT03575468
- Testing
- Enhanced E-cigarette Coaching, Quitline treatment as usual
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Consumer Wellness Solutions
Smoking Cessation, Harm Reduction
Assisting Smokers to Switch to a JUUL E-Cigarette by Devaluing Combustible Cigarettes
This study will evaluate a reward devaluation strategy in which smokers use the JUUL e-cigarette immediately before any combustible cigarettes (CCs) are smoked.
- Conditions
- Smoking Cessation, Harm Reduction, E-Cig Use, Cigarette Smoking
- Trial name
- RECON (NCT04188197)
- Testing
- JUUL
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
E-cigarette Use, Cigarette Smoking
BIDI Stick ENDS Abuse Liability and Puffing Topography Assessment
This study assessed the abuse liability (measured by assessing how much nicotine enters the body when the BIDI Stick is used, and how this makes users feel) and puffing topography (puff characteristics like volume and duration)…
- Trial name
- NCT05072925
- Testing
- Tobacco products
- Where
- Poland
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- BIDI Vapor
Electronic Cigarette Use
Characterization of Product Use in Smokers Switching From Cigarettes to a RELX Electronic Nicotine Delivery System
The study will assess product use behaviors, biomarkers of exposure, subjective effects, and safety in smokers who switch to a RELX ENDS over 8-weeks.
- Trial name
- NCT04708106
- Testing
- RELX ENDS Tobacco Flavor, RELX ENDS Menthol Flavor, RELX ENDS Tobacco and Menthol Flavors
- Where
- 5 sites in United States
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- Cheerain HK Limited
Vaping Cessation
Pilot Study of a Smartphone-Based Vaping Cessation Program
Prospective, open label, single center clinical study enrolling up to 100 participants to evaluate the effect of the Pivot vaping cessation program.
- Trial name
- NCT05642598
- Testing
- Pivot for Vape
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Pivot Health Technologies Inc.
Electronic Cigarette Use, Cigarette Use, Electronic
Evaluating Selected Constituents in the Exhaled Breath Samples
An Open-Label, Multi-Center Study to Evaluate Selected Constituents in the Exhaled Breath Samples From the Use of JUUL Nicotine Salt Pod System Product (5% and 3% Virginia Tobacco, Mint, Mango, Menthol) Users and Conventional…
- Conditions
- Electronic Cigarette Use, Cigarette Use, Electronic, Tobacco Use, Tobacco Smoking
- Trial name
- NCT04143256
- Testing
- JUUL ENDS 5% Virginia Tobacco, JUUL 3% Virginia Tobacco ENDS, JUUL 5% Mint ENDS
- Where
- 3 sites in United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Juul Labs, Inc.
Electronic Cigarette Use
Nicotine Uptake, Measures of Abuse Liability, and Puffing Topography With Use of RELX ENDS Products by ENDS Consumers
This study is being conducted to evaluate nicotine uptake, the potential abuse liability, and puffing topography associated with the use of an electronic nicotine delivery system (ENDS) with tobacco- and menthol-flavored…
- Trial name
- NCT04620616
- Testing
- RELX ENDS Tobacco Flavor, RELX ENDS Menthol Flavor, Subject Usual Brand ENDS
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Cheerain HK Limited
Second Hand Tobacco Smoke
Study to Evaluate Constituents in Exhaled Breath and Room Air From Use of E-vapor Products and Conventional Cigarettes
An open-label, single center, three-arm observational study to examine emissions from e-cigarettes versus conventional cigarettes under three environmental settings of typical residential, office and hospitality facilities.
- Trial name
- NCT03605641
- Testing
- JUUL, VUSE Solo, Conventional Cigarette
- Where
- Canada
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Juul Labs, Inc.
Nicotine Vaping, Nicotine
Nicotine Pharmacokinetics Following Use of the P4M3 Gen 2.0 E-Cigarette Compared to Smoking Cigarettes
This is a single-center, randomized, controlled, open-label, cross-over study with healthy adult smokers. The study will investigate the nicotine pharmacokinetic (PK) profiles of two e-liquid variants used with the P4M3 Gen 2.0…
- Conditions
- Nicotine Vaping, Nicotine, Vaping
- Trial name
- NCT05383508
- Testing
- CA35, CM35, Cig
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Electronic Cigarette Use, Tobacco Smoking
Characterize the Nicotine Uptake and Subjective Effects With Use of JUUL Electronic Nicotine Delivery Systems
The purpose of this study is to estimate nicotine uptake and assess subjective effects during ad libitum use sessions of 4 flavors of JUUL ENDS (also referred to as nicotine salt pod system; NSPS) products (i.e., Virginia…
- Trial name
- NCT04123041
- Testing
- JUUL ENDS, Combustible cigarette, comparator e-cigarette, Nicorette gum
- Where
- 2 sites in United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Juul Labs, Inc.
Electronic Cigarette Use, Cigarette Use, Electronic
Changes in Biomarkers of Cigarette Smoke Exposure After Switching Either Exclusively or Partly to JUUL ENDS
A Randomized, Open Label, Parallel Group Study in Adult Smokers to Evaluate Changes in Biomarkers of Cigarette Smoke Exposure After Switching Either Exclusively or Partly to using JUUL Electronic Nicotine Delivery Systems With…
- Conditions
- Electronic Cigarette Use, Cigarette Use, Electronic, Tobacco Use, Tobacco Smoking
- Trial name
- NCT04107779
- Testing
- Switch from UB of Combustible Cigarette to JUUL 5% Virginia Tobacco ENDS, Switch from UB of Combustible Cigarette to JUUL 3% Virginia Tobacco ENDS, Switch from UB of Combustible Cigarette to JUUL 5% Mint ENDS
- Where
- 5 sites in United States
- Volunteers
- 279 people, healthy volunteers welcome
- Sponsor
- Juul Labs, Inc.
Smoking, Tobacco Use
CSD201203: A Study to Determine Subject Puffing Patterns of a Non-cylindrical, Closed, Electronic Nicotine Delivery System at Three Nicotine Concentrations in an Ambulatory Setting
This is a multi-center, open-label, parallel, three-study-group investigation to evaluate the puffing patterns of healthy adult consumers of tobacco products switching from a usual brand (UB) Electronic Nicotine Delivery Systems…
- Conditions
- Smoking, Tobacco Use, Electronic Cigarette Use
- Trial name
- NCT05118139
- Testing
- P1211216, P1213416, P1213716
- Where
- 4 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Smoking Cessation
The Effects of Combination Zonisamide and Bupropion on Switching to an Electronic Cigarette
This three-group randomized double-blind placebo-controlled trial (N=180) will evaluate the impact of combination zonisamide and bupropion on the process of switching from combustible cigarettes (CCs) to an e-cigarette.
- Trial name
- NCT05205811
- Testing
- Bupropion, Zonisamide, E-cigarette
- Where
- 2 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Nicotine Addiction, Cigarette Smoking
Abuse Liability of Reduced Nicotine Content Cigarettes in the Context of Concurrent E-Cigarette Use
Three hundred-twenty (320) adult smokers of menthol or non-menthol combustible cigarettes will be recruited and randomly assigned to one of five groups (n=64/group), who will be asked to switch for 12 weeks to ad libitum use of…
- Trial name
- DUAL (NCT02870218)
- Testing
- Smoking research cigarettes with e-cigarette, Nicotine discrimination thresholds
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Electronic Cigarette Use
Nicotine Uptake, Measures of Abuse Liability, and Puffing Topography With Use of RELX ENDS Products by Smokers
This study is being conducted to evaluate nicotine uptake and exposure, the abuse liability, and puffing topography associated with the use of an electronic nicotine delivery system ENDS with tobacco- and menthol-flavored…
- Trial name
- NCT04640285
- Testing
- RELX ENDS Tobacco Flavor, RELX ENDS Menthol Flavor, Usual Brand Cigarette
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Cheerain HK Limited
Smoking
Comparison of Nicotine Plasma Concentrations and Subjective Effects for Three Menthol Electronic Cigarettes vs Combustible Menthol Cigarettes and Nicotine Gum
The purpose of this study is to measure plasma nicotine uptake parameters, physiological measures, and subjective effect measures in smokers during and following a single ad libitum use of three menthol electronic cigarettes…
- Trial name
- NCT02664012
- Testing
- Own Brand Menthol Cigarette, Electronic Menthol Cigarette #1, Electronic Menthol Cigarette #2
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- R.J. Reynolds Vapor Company
Smoking Cessation
Zonisamide/Bupropion Effects on Switching to Electronic Cigarettes
This single-group, small-scale, open-label study (N= 25 to 50) will evaluate the impact of combination zonisamide and bupropion on the process of switching from combustible cigarettes (CC) to an e-cigarette.
- Trial name
- BuZonE (NCT04388319)
- Testing
- Zonisamide, Bupropion, Halo G6 e-cigarette
- Where
- 2 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Nicotine, Vaping
Reduced HPHC Exposure in Cigarette Smokers Switching to P4M3 Gen. 2.0 Compared to Continuing Smoking, or Smoking Abstinence
To demonstrate the reduction of Biomarkers of Exposure (BoExp) to selected harmful and potentially harmful constituents (HPHC) in smokers switching from cigarette (CIG) to P4M3, an Electronic Nicotine Delivery System (ENDS)…
- Conditions
- Nicotine, Vaping, Nicotine Vaping
- Trial name
- NCT05487456
- Testing
- P4M3 CA35, P4M3 CM35, CIG
- Where
- United Kingdom
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Electronic Cigarette Use
Use Behavior, Nicotine Uptake, and Subjective Effects Comparison of Tobacco and Menthol e-Liquids by ENDS Consumers
This study is being conducted to evaluate the impact of within-flavor category (tobacco and menthol) differences in e-liquid flavors on product use behaviors, nicotine uptake, and subjective effects by current ENDS consumers when…
- Trial name
- NCT05134415
- Testing
- RELX ENDS Tobacco Flavor 1, RELX ENDS Tobacco Flavor 2, RELX ENDS Menthol Flavor 1
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cheerain HK Limited