Clinical trials: Nitrate
Respiratory Failure
Strength Testing After Nitrate Delivery (STAND) in ICU Patients
It is well documented that intensive care unit (ICU) patients have lower levels of skeletal muscle strength compared to non-ICU patients upon hospital discharge, and this weakness affects the patient's ability to perform basic…
- Trial name
- NCT02293616
- Testing
- Nitrate Rich Beetroot Juice
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Wake Forest University Health Sciences
Exercise Performance, Supplementation
The Effect of Acute Beetroot Juice Supplementation on Anaerobic Performance in Football Players
The aim of this clinical trial is to examine the effects of two different natural fruit-vegetable blend beverages on short-duration, high-intensity exercise performance and muscle oxygenation in young male football players.
- Trial name
- NCT07048912
- Testing
- Beetroot Juice (BJ)
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Melike Nur Eroğlu
Dietary Supplements, Caffeine
Effect of Acute Caffeine and Beetroot Juice Intake on Strength, Power, and Muscular Endurance
Introduction: Several studies have evaluated and confirmed the ergogenic effect of acute caffeine and beetroot juice intake on sports performance.
- Conditions
- Dietary Supplements, Caffeine, Nitrates, Sports Performance
- Trial name
- CAF+BJ (NCT06596395)
- Testing
- Acute caffeine and beetroot juice, Acute caffeine, Acute beetroot juice
- Where
- Spain
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Alcala
Malignant Breast Tissue Neoplasm
Is Dietary Nitrate Effective in Reducing Aerobic Glycolysis in Breast Cancer?
Breast cancer is the most prevalent cancer affecting women, with 1 in 8 women in the UK developing breast cancer in their life time.
- Trial name
- BEET (NCT03944226)
- Testing
- Beetroot juice
- Where
- United Kingdom
- Volunteers
- 1 people
- Sponsor
- University of Aberdeen
Hypertension
Pharmacokinetics of Berkeley Life Oral Nitrate Supplementation
The purpose of the study is to examine the way that a nitric oxide supplement moves through the body. Specifically, the relationship between saliva and blood concentration of the supplement and the elapsed time since taking the…
- Trial name
- NCT06777108
- Testing
- Inorganic Nitrate
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Virginia
Dietary Nitrate Supplementation
Evaluating the Metabolic Effects of Dietary Nitrate Supplementation
Dietary nitrate is found to enhance muscle fatty acid oxidation/glucose uptake and increase mitochondrial biogenesis, which in turn, aid in the prevention and management of metabolic diseases.
- Trial name
- NIMMI (NCT05579262)
- Testing
- Beetroot juice
- Where
- Singapore
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
Dietary Modification, Blood Pressure
Effect of Lettuce With Different Nitrate Contents on Blood Pressure
Leafy vegetables are a natural source of dietary nitrate, which may reduce systolic blood pressure (BP). However, the evidence has been obtained from studies using nitrate solutions (i.e., potassium or sodium nitrate) or beetroot…
- Trial name
- LBP (NCT02701959)
- Testing
- High Nitrate Lettuce, Low Nitrate Lettuce
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Newcastle University
Dentin Sensitivity
Exploratory Clinical Study to Investigate the Ability of an Experimental Combination Dentifrice to Protect Sensitive Teeth
This proof of principle (PoP) study will evaluate the ability of an experimental combination toothpaste formulation to protect sensitive teeth from dentine hypersensitivity.
- Trial name
- NCT05243745
- Testing
- 3% PVM/MA + 5% KNO3 Combination, 3% PVM/MA only, 5% KNO3 Only
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- HALEON
Medicaments Substances in Therapeutic Use
Potassium Oxalate and Potassium Nitrate and Post-bleaching Sensitivity
Objectives: This study will determine the effectiveness of the use of desensitivity gels prior in office bleaching on risk and intensity of tooth sensitivity caused by in-office bleaching using 35% hydrogen peroxide.
- Trial name
- NCT02941653
- Testing
- Potassium nitrate 2% gel, Potassium oxalate 5% gel
- Where
- Brazil
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Sergipe
Aging, Aging Well
Adjuvant Nitrate to Boost Exercise-induced Health Benefits in Older Adults
Aging-related functional declines are thought to be caused by hallmark biological processes that ultimately manifest in physical, mental, and metabolic impairments to compromise intrinsic capacity and healthspan.
- Conditions
- Aging, Aging Well, Healthy Aging
- Trial name
- BOOST-X (NCT07572266)
- Testing
- Nitrate enriched beetroot juice, Nitrate depleted beetroot juice, 12 week of combined exercise training
- Where
- United States
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- Florida Institute for Human and Machine Cognition
Oral Health, Dietary Nitrate
Evaluating the Impact of Various Dietary Nitrate Supplements on Oral Health
This study aims to investigate the effects of different dietary nitrate supplements, versus placebo, on microbiological and immunological markers associated with oral health in people aged 18-65 years.
- Trial name
- NCT06956612
- Testing
- Juice (Active comparator), Crystals (Experimental)
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shatha Alhulaefi
Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis
Steroid Impregnated Tape in the Treatment of Over-granulating Peritoneal Dialysis Exit Sites
Kidney failure is a devastating illness requiring treatment with dialysis or transplantation to preserve life. Individuals unable to have transplants are managed by peritoneal dialysis (PD)or haemodialysis (HD).
- Conditions
- Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, End Stage Renal Failure, Chronic Renal Failure
- Trial name
- STOP (NCT01996930)
- Testing
- Haelan tape (steroid impregnated tape), Silver Nitrate
- Where
- 8 sites in United Kingdom
- Volunteers
- 32 people
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Colorectal Cancer
Does Dietary Nitrate Supplementation Improve Aerobic Performance
The purpose of this study is to determine whether dietary nitrate supplementation improves performance in cardiopulmonary exercise testing (CPET).
- Trial name
- NCT02319356
- Testing
- Beetroot juice
- Volunteers
- 70 people
- Sponsor
- Royal Surrey County Hospital NHS Foundation Trust
No Dental Disease, Non-smoking
Examination of the Distribution of Nitrate Reducing Bacteria in the Human Oral Cavity
Dietary nitrate have been shown to have health benefits including lowering blood pressure (Hobbs et al, 2012), improving endothelial function and inhibiting platelet aggregation in healthy humans (Lidder \& Webb, 2013).
- Trial name
- REBOC (NCT03068962)
- Testing
- beetroot Juice, Buxton water, antiseptic mouthwash then beetroot juice
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Reading
Myofascial Trigger Points
Topical Nitrates for Myofascial Trigger Points
The purpose of this study is to determine whether a topical nitroglycerine patch applied daily over a trapezius trigger point can improve patients' symptoms.
- Trial name
- NCT01675700
- Testing
- Nitroglycerin patch
- Volunteers
- 10 people
- Sponsor
- GF Strong Rehabilitation Centre
Lymphoma
Gallium Nitrate in Treating Patients With AIDS-Related Non-Hodgkin's Lymphoma
RATIONALE: Chemotherapy uses different ways to stop cancer cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of gallium nitrate in treating patients with AIDS-related…
- Trial name
- NCT00002578
- Testing
- cytarabine, gallium nitrate, leucovorin calcium
- Where
- 3 sites in United States
- Volunteers
- 35 people
- Sponsor
- Roswell Park Cancer Institute
Stroke, CVA
Acute Effects of Beetroot Juice on Locomotor Economy and Capacity in Chronic Stroke
The purpose of this study is to investigate if a beetroot juice supplement can improve oxygen capacity during walking tasks at a submaximal and maximal effort in people greater than 6 months following stroke.
- Trial name
- NCT05720013
- Testing
- Beetroot Juice supplement
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Indiana University
Dentin Sensitivity
Effectiveness of Arginin and Potassium Nitrate Dentifrices in Dentin Hypersensitivity Therapy
Introduction: Dentin hypersensitivity (DH) could be defined as a brief and sharp pain in response to thermical, chemical, tactile and osmotic stimuli, which cannot be attributed to any dental condition or pathology.
- Trial name
- NCT02829879
- Testing
- 8% arginine/1450ppm sodium monofluorophosphate dentifrice, 5% potassium nitrate/2500ppm sodium fluoride dentifrice
- Where
- Chile
- Volunteers
- 50 people
- Sponsor
- University of Chile
Hypertension
A 2 Week, Crossover Trial of Dietary Nitrate in HTN
Acute consumption of dietary nitrate (as beetroot juice) has been shown to decrease systemic blood pressure in multiple populations including newly diagnosed, untreated hypertensives.
- Trial name
- NCT02597010
- Testing
- Dietary nitrate
- Volunteers
- 20 people
- Sponsor
- Royal College of Surgeons, Ireland
Post Menopausal
The Impact of Inorganic Nitrate-rich Beetroot Juice on Microvascular Blood Flow and Cognitive Function
Cardiovascular disease (CVD) is one of the leading causes of mortality worldwide. Inorganic nitrate found in beetroot and green leafy vegetables has been demonstrated to reduce cardiovascular disease risk factors including…
- Trial name
- NCT05810974
- Testing
- Concentrated beetroot juice, Nitrate depleted beetroot juice + potassium nitrate (KNO3), Nitrate depleted beetroot juice
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Reading