Clinical trials: Nitrate / Nitrite
Blood Pressure
Dietary Nitrate Intake in Vegetarians and Omnivores
Vegetarian diets are commonly associated with lower blood pressure levels. This has been related to greater consumption of inorganic nitrate, since vegetables are the main source of this anion.
- Trial name
- NO3 (NCT03871777)
- Testing
- Chlorhexidine mouthwash
- Where
- United Kingdom
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Plymouth
Dietary Supplements: Beetroot Juice Acute Supplementation, Dietary Supplement: Placebo Acute Supplementation
Acute Effects of Beetroot Juice Ingestion on Cognitive Function and Neuromuscular Performance in Elite Female Taekwondo Athletes
Beetroot juice is a good source of nitrate (NO3-), which is a precursor of nitric oxide (NO) through the NO3- to nitrite (NO2-) to NO pathway (Lundberg et al., 2008).
- Trial name
- BEET_TAEKWONDO (NCT06675305)
- Testing
- Beetroot juice (James White, UK)
- Where
- Spain
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Universidad Pontificia Comillas
Blood Pressure, Sports Physical Therapy
Oral Nitrite Synthesis and Post-exercise Hypotension
Exercise is probably the most effective approach to reduce blood pressure. In fact, a single bout of exercise induces a physiological response known as Post-Exercise Hypotension (PEH) where a prolonged decrease in resting blood…
- Trial name
- NCT03904394
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Plymouth
Aging
Exploring the Effect of Inorganic Nitrates on the Human Microvascular Physiology - a Pilot Study.
We conducted a randomised, placebo-controlled, double blind, cross-over, trial to examine the short-term effect of concentrated beetroot juice on vascular outcomes in a young (18-35 years) and older group (55-75 years).
- Trial name
- ENIH-MPS (NCT04276766)
- Testing
- Crossover intervention
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Sheffield Hallam University
Blood Pressure Regulation
The Effects of Nitrate-Rich Mouthwash on Vascular Tone
High blood pressure (hypertension) is a major risk factor for cardiovascular disease. One important contributing factor to high blood pressure is reduced availability of nitric oxide (NO).
- Trial name
- NITRATONE (NCT07602764)
- Testing
- Nitrate-rich mouth rinse, Nitrate-rich drink
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Cardiovascular Diseases, Endothelial Dysfunction
Investigation of the Effects of Dietary Nitrate and Sex on COVID-19 Vaccine Induced Vascular Dysfunction in Healthy Men and Women (DiNOVasc-COVID-19)
Inorganic nitrate can protect blood vessels from the damage that occurs during cardiovascular disease. Early experimental work suggests that nitrate-induced improvements in vascular function relate to the suppression of…
- Trial name
- NCT04889274
- Testing
- COVID-19 vaccine, Concentrate beetroot Juice, Nitrate-deplete beetroot juice
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Healthy
Determination of Variances in Exhaled Nitric Oxide Output in Normal Healthy Male Volunteers Consuming High and Low Nitrate/Nitrite Diets
This study will determine whether and how nitrites and nitrates in the diet affect the level of nitric oxide gas that is breathed out in air.
- Trial name
- NCT00027157
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiovascular Diseases in Old Age
Efficacy Long-term Dietary Nitrate Consumption to Plasma Nitrite Conversion
The objective of this study was to determine the chronic effects of beetroot juice supplementation on the acute (90-minute post nitrate consumption) efficacy of converting dietary nitrate to plasma nitrate and plasma nitrite in…
- Trial name
- NCT05380167
- Testing
- BRJ Nitrate
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Wake Forest University
Type 2 Diabetes, Ageing
Effects of Nitrate on Liver Perfusion and Sugar Control
Rationale: Mediterranean style diets and diets rich in green leafy vegetables protect against the risk of developing type 2 diabetes and a wide range of cardiovascular disease. These diets are rich in nitrate.
- Trial name
- DiMPLe (NCT02195856)
- Testing
- Beetroot juice
- Where
- 2 sites in United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Nitric Oxide, Insulin Sensitivity
Nutritional Supplementation and Insulin Sensitivity
Type 2 diabetes mellitus (T2DM) is a progressive disease and early intervention and prevention strategies are therefore very important. An important early hallmark in the development of T2DM is insulin resistance.
- Conditions
- Nitric Oxide, Insulin Sensitivity, Vascular Function, L-arginine
- Trial name
- NCT04239482
- Testing
- L-arginine + Nitrate / Nitrite
- Where
- Netherlands
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Diabetes, Hypertension
The Effect of Dietary Nitrate on Blood Pressure, Insulin Sensitivity, and Vascular Function in Type 2 Diabetes
Dietary nitrate supplementation has previously been shown to reduce blood pressure in healthy volunteers. The investigators wished to see whether this would be replicated in subjects with type 2 diabetes and age matched healthy…
- Trial name
- NCT04076007
- Testing
- Beetroot juice, Nitrate depleted beetroot juice
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Air Pollution
The Effect of Juice Types on the Responses to Air Pollution
The study hypothesis is that drinking different juices will affect the body's responses to air pollution. Subjects will be exposed to air pollution during a 2-hour car ride on the NJ (New Jersey) Turnpike.
- Trial name
- NCT02027415
- Testing
- Beet juice, Orange juice
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
High Intensity Intermittent Sports Performance
Nitrate for High Intensity Intermittent Exercise
The objective of the current study is to assess the effect of 6-day dietary nitrate ingestion on high intensity intermittent sports performance in recreational soccer players.
- Trial name
- NITR-ITE (NCT02436629)
- Testing
- Nitrate-rich concentrated beetroot juice, Nitrate-depleted concentrated red beetroot juice
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy
Blood Nitrate/Nitrite Concentrations Following Acute Ingestion of Resync in Men and Women
This study evaluates acute ingestion of the dietary supplement Resync on blood nitrate/nitrite concentrations in a sample of men and women.
- Trial name
- NCT04125940
- Testing
- Resync, Resync + Collagen
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Memphis
Resting Metabolic Rate
Modulation of Metabolic Rate by Inorganic Nitrate
The purpose of this study is to determine the effects of sodium nitrate on resting metabolic rate, glucose uptake and formation of reactive oxygen species in humans.
- Trial name
- NCT02022176
- Testing
- Glucose Uptake, Resting metabolic rate, Nitrite infusion
- Where
- Sweden
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Healthy, Menopause
Nitrate, Exercise and Vascular Function in Midlife Women
The purpose of this clinical study in women after menopause is to investigate whether the daily intake of nitrate from beetroot juice over 12 weeks enhances the positive effect of exercise training on vascular function, blood…
- Conditions
- Healthy, Menopause, Hypertension, Inflammation
- Trial name
- Women's-Beet (NCT06527248)
- Testing
- Nitrate group
- Where
- Austria
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Adult
Hydroponic vs Conventional Spinach Smoothies: Effects on Salivary Nitrate Bioavailability and Blood Pressure
The goal of this clinical trial is to determine whether hydroponic spinach (HS) versus conventional spinach (CS) smoothies produce differential post-consumption effects on salivary nitrate availability and blood pressure in…
- Trial name
- SPIN-BP-NO (NCT07665944)
- Testing
- Hydroponic spinach smoothie, Conventional spinach smoothie
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Plymouth
High Blood Pressure, Flow Mediated Dilation
Effect of Nitrate-rich Fruit and Vegetable Supplement on Blood Pressure
It is hypothesized that the daily supplementation of a nitrate-rich, two-ounce fruit and vegetable energy supplement (Isagenix International LLC) by healthy young adults with a would increase circulating nitrates and improve…
- Trial name
- NCT03486145
- Testing
- fruit and vegetable juice supplement
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Hypertension, Cardiovascular Diseases
Probiotic Effect on Dietary Nitrate to Plasma Nitrite Production ( OPEDNPN )
Nitric Oxide (NO) is an important molecule that is produced naturally in the body and that helps maintain healthy blood flow. Low availability of NO contributes to many diseases while administration of NO is therapeutic.
- Conditions
- Hypertension, Cardiovascular Diseases, Diabetes
- Trial name
- OPEDNPN (NCT06375694)
- Testing
- Herbiotics Oral + Ent Probiotic
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wake Forest University
Focus of Study of Healthy Adults
Oral Nitrite and Nitrate in Healthy Normal Volunteer Adults
This proposal hypothesizes that oral supplementation with sodium nitrite or nitrate will result in in vivo conversion of nitrate to nitrite and nitrite to nitric oxide with limited toxicity in the doses proposed in healthy adult…
- Trial name
- NCT01681836
- Testing
- 15Nitrogen(15N)-labeled sodium nitrite, 15Nitrogen(15N)-labeled sodium nitrate
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Gladwin, Mark, MD