Clinical trials: Nitrates
Radial Artery Spasm
Nitrate Use to Obtain Radial Spasm Embarrassment (NURSE - TTS Trial)
Transradial cardiac catheterization and percutaneous coronary intervention are increasingly being performed worldwide in elective and emergency procedures, with many centres adopting the transradial route as their first choice of…
- Trial name
- NURSE-TTS (NCT04766151)
- Testing
- Transdermal glyceryl trinitrate 10mg patches
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- 424 General Military Hospital
Respiratory Failure
Strength Testing After Nitrate Delivery (STAND) in ICU Patients
It is well documented that intensive care unit (ICU) patients have lower levels of skeletal muscle strength compared to non-ICU patients upon hospital discharge, and this weakness affects the patient's ability to perform basic…
- Trial name
- NCT02293616
- Testing
- Nitrate Rich Beetroot Juice
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Wake Forest University Health Sciences
no Medications
Dietary Nitrate and Cardiovascular Health
An expanding number of studies suggest a therapeutic role for nitrate and nitrite, most notably in treatment and prevention of cardiovascular disease including ischemia-reperfusion (IR) injury and hypertension.
- Trial name
- NCT01262521
- Testing
- Dietary nitrate, Water
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Lymphoma
Gallium Nitrate in Treating Patients With AIDS-Related Non-Hodgkin's Lymphoma
RATIONALE: Chemotherapy uses different ways to stop cancer cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of gallium nitrate in treating patients with AIDS-related…
- Trial name
- NCT00002578
- Testing
- cytarabine, gallium nitrate, leucovorin calcium
- Where
- 3 sites in United States
- Volunteers
- 35 people
- Sponsor
- Roswell Park Cancer Institute
Cardiovascular Health, Functional Health
Beetroot Extract and Quality of Life in Adults Aged 75 and Over
The increasing number of adults aged 75 years and older highlights the need for effective, low-cost interventions to preserve cardiovascular health, functional independence, and cognitive performance and to support healthy aging.
- Conditions
- Cardiovascular Health, Functional Health, Cognitive Function Decline, Physical Performance Decline in Older Adults
- Trial name
- BERS (NCT07666685)
- Testing
- Beetroot Extract Supplementation
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fundacion Miguel Servet
Post Menopausal
The Impact of Inorganic Nitrate-rich Beetroot Juice on Microvascular Blood Flow and Cognitive Function
Cardiovascular disease (CVD) is one of the leading causes of mortality worldwide. Inorganic nitrate found in beetroot and green leafy vegetables has been demonstrated to reduce cardiovascular disease risk factors including…
- Trial name
- NCT05810974
- Testing
- Concentrated beetroot juice, Nitrate depleted beetroot juice + potassium nitrate (KNO3), Nitrate depleted beetroot juice
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Reading
Cardio-Renal Syndrome
Nitrates In Combination With Hydralazine in cardiorEnal Syndrome (NICHE) Study
This is a single-blind, randomised, clinical trial assessing the efficacy of Hydralazine and Isosorbidedinitrate combination (oral agents) in HF patients with renal dysfunction.
- Trial name
- NICHE (NCT02343393)
- Testing
- Hydralazine, Isosorbide Dinitrate
- Where
- 3 sites in Singapore
- Volunteers
- 100 people
- Sponsor
- National University Hospital, Singapore
Adult
Hydroponic vs Conventional Spinach Smoothies: Effects on Salivary Nitrate Bioavailability and Blood Pressure
The goal of this clinical trial is to determine whether hydroponic spinach (HS) versus conventional spinach (CS) smoothies produce differential post-consumption effects on salivary nitrate availability and blood pressure in…
- Trial name
- SPIN-BP-NO (NCT07665944)
- Testing
- Hydroponic spinach smoothie, Conventional spinach smoothie
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Plymouth
Chronic Obstructive Pulmonary Disease
A 2 Week, Crossover Trial of Dietary Nitrate in Chronic Obstructive Pulmonary Disease
Acute consumption of dietary nitrate (as beetroot juice) has been shown to increase exercise and decrease systemic blood pressure in multiple populations, including COPD.
- Trial name
- NCT02521532
- Testing
- Dietary nitrate
- Where
- Ireland
- Volunteers
- 8 people
- Sponsor
- Royal College of Surgeons, Ireland
Bioavailability
Bioavailability Study of EVEGYN 600 mg/1000 mg/100 mg Vaginal Ovule
A single dose of the study drug will be administered to healthy female subjects in a single period to obtain pharmacokinetic parameters for each active ingredient.
- Trial name
- NCT05361369
- Testing
- EVEGYN 600 mg/1000 mg/100 mg Vaginal Ovule
- Where
- Turkey (Türkiye)
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Exeltis Turkey
Headache
Lokal Cold Application in Nitroglycerin-Induced Headache (NIH)
The study was planned to evaluate the effect of local cold application on headache severity in individuals who received intravenous nitroglycerin treatment, which mostly causes headache due to its vasoditator effect.
- Trial name
- NCT04707586
- Testing
- Cold Application
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Yasemin Kalkan Uğurlu
Postmenopausal Women
Effect of Beetroot Juice on Blood Pressure Regulation in Post Menopausal Women
In this study the investigators will test the hypothesis that acute consumption of inorganic nitrate (supplied in concentrated beetroot juice) reduces artery stiffness and resting blood pressure, and lessens the rise in blood…
- Trial name
- NCT03380000
- Testing
- Beetroot juice
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Penn State University
Cardiovascular Diseases in Old Age
Efficacy Long-term Dietary Nitrate Consumption to Plasma Nitrite Conversion
The objective of this study was to determine the chronic effects of beetroot juice supplementation on the acute (90-minute post nitrate consumption) efficacy of converting dietary nitrate to plasma nitrate and plasma nitrite in…
- Trial name
- NCT05380167
- Testing
- BRJ Nitrate
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Wake Forest University
Healthy
Beetroot Juice and Sleep
The purpose of this study is to investigate the effects of acute inorganic nitrate supplementation (with beetroot) on the regulation of sleep and neurovascular physiology.
- Trial name
- NCT05864521
- Testing
- Active Beetroot Juice Supplement (aBRJ)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Hypertension
The Acute Effect of Beetroot Juice in Normal and Hypertensive Subjects
Inorganic nitrate can be converted to nitrite and thence nitric oxide in humans. Nitric oxide is normally produced by the inner lining of blood vessels and helps keep blood vessels open and therefore blood pressure lower.
- Trial name
- NCT01236872
- Testing
- Beetroot juice, Water
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Queen Mary University of London
Medicaments Substances in Therapeutic Use
Potassium Nitrate and Post-bleaching Sensitivity
This study will determine the effectiveness of the use of desensitivity gels prior in office bleaching on risk and intensity of tooth sensitivity caused by in-office bleaching using 35% hydrogen peroxide and using different types…
- Trial name
- NCT03523598
- Testing
- Potassium Nitrate Gel + Normal Toothpaste
- Where
- Brazil
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Sergipe
Heart Failure With Reduced Ejection Fraction
Neuromuscular Fatigability in Individuals With Heart Failure
Brief summary The aims of this project are to 1) characterise muscle fatigue in individuals with chronic heart failure during exercise involving a smaller and larger muscle mass (Part I), 2) to determine the effect of nitrate…
- Trial name
- NCT06551012
- Testing
- Nitrate-rich beetroot juice, Beetroot juice with nitrate extracted
- Volunteers
- 28 people
- Sponsor
- Newcastle University
Interdigital Tinea Pedis
Comparative PK Study of Econazole Nitrate Foam and Econazole Nitrate Cream in Subjects With Interdigital Tinea Pedis Aged 12 Years to Less Than 18 Years
To compare the pharmacokinetics of Econazole Nitrate Foam with Econazole Nitrate Cream in subjects with interdigital tinea pedis aged 12 years to less than 18 years.
- Trial name
- NCT01696799
- Testing
- Econazole Nitrate
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- AmDerma
Inflammation, Oxidative Stress
Evaluation of the Beneficial Health Effects of an Additive-free Meat Product in Healthy Subjects (HIPOCARNE)
The purpose of this research is to test the hypothesis that the consumption of meat products without additives, in comparison with their analogues with additives, could be beneficial in terms of modifying health markers.
- Conditions
- Inflammation, Oxidative Stress, Food Toxicity
- Trial name
- NCT06392893
- Testing
- Meat product without additives and allergens, Commercial meat product
- Where
- Spain
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Universidad de Murcia
Oral Hygiene
Clinical Study to Investigate the Tooth Stain Removal Efficacy of Two Experimental Toothpastes Compared to a Standard Toothpaste When Used Twice Daily for 8 Weeks
The aim of this study is to investigate the stain removal efficacy of 2 experimental anti-dentin hypersensitivity (DH) dentifrices with four and eight weeks twice daily use.
- Trial name
- NCT05459558
- Testing
- Experimental Dentifrice 1, Experimental Dentifrice 2, Reference Dentifrice
- Where
- United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- HALEON