Clinical trials: Nitrates
Pancreatitis
Does Glyceryl Nitrate Prevent Post-Endoscopic Retrograde Cholangiopancreaticography (ERCP) Pancreatitis?
Post-ERCP pancreatitis can be a serious complication to ERCP. Two studies have shown a promising preventive effect of glyceryl nitrate.
- Trial name
- NCT00121901
- Testing
- glyceryl nitrate
- Where
- 14 sites in Denmark, France and 2 more
- Volunteers
- 1,600 people
- Sponsor
- Hvidovre University Hospital
Myofascial Trigger Points
Topical Nitrates for Myofascial Trigger Points
The purpose of this study is to determine whether a topical nitroglycerine patch applied daily over a trapezius trigger point can improve patients' symptoms.
- Trial name
- NCT01675700
- Testing
- Nitroglycerin patch
- Volunteers
- 10 people
- Sponsor
- GF Strong Rehabilitation Centre
Post-ERCP Acute Pancreatitis
Rectal Indomethacin Versus Rectal Indomethacin and Sublingual Nitrate for PEP Prevention
Patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) are at risk for post-ERCP pancreatitis (PEP), which is associated with adverse outcomes.
- Trial name
- NCT04425993
- Testing
- Isosorbide Dinitrate 5 MG, Indomethacin 100 MG
- Where
- 4 sites in China
- Volunteers
- 2,700 people
- Sponsor
- Air Force Military Medical University, China
Contrast-induced Nephropathy Following Percutaneous Intervention (CIN)
Efficacy and Safety of a Beet-Derived Inorganic Nitrate-Based Food Product for the Prevention of Contrast-Induced Nephropathy in High-Risk Patients Undergoing Percutaneous Coronary Intervention
Contrast-induced nephropathy (CIN) is a common complication in high-risk patients undergoing percutaneous coronary intervention (PCI) due to exposure to iodinated contrast agents.
- Trial name
- BEET-CIN (NCT06984406)
- Testing
- Beet-Derived Inorganic Nitrate-Based Food Product
- Where
- Russia
- Volunteers
- 88 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Peripheral Arterial Disease, Walking, Difficulty
Passive Stretching in Peripheral Arterial Disease Patients
Peripheral artery disease (PAD) leads to higher mortality rates and strains healthcare systems due to increased costs. It causes leg pain during walking due to reduced blood flow.
- Conditions
- Peripheral Arterial Disease, Walking, Difficulty, Inflammation
- Trial name
- NCT06420752
- Testing
- Calf Plantar flexion, Dietary nitrate
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Wisconsin, La Crosse
Dentine Hypersensitivity
Three Different Topically Applied Materials as Non-invasive Treatment of Sensitivity in Permanent Teeth With Molar Incisor Hypomineralization
This clinical study main goal is to investigate the effectiveness of nano hydroxy apatite crystal varnish and potassium nitrate gel as a non invasive approach in managing Dentin Hypersensitivity in MIH-affected teeth.
- Trial name
- NCT07056855
- Testing
- nano hydroxy apatite varnish Intervention (1), Potassium Nitrate Gel, Varnishes, Fluorid
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Cairo University
Type 2 Diabetes Mellitus, Hypertension
Effect of Beetroot Juice on Cardiovascular and Autonomic Responses to Exercise in Adults With Type 2 Diabetes
This study will investigate whether a single dose of beetroot juice can improve cardiovascular responses and recovery after exercise in adults with Type 2 Diabetes.
- Conditions
- Type 2 Diabetes Mellitus, Hypertension, Autonomic Nervous System Diseases
- Trial name
- DiaBEET (NCT07560800)
- Testing
- Beetroot juice
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Oxford Brookes University
Health Adult Subjects
Dose-response Effects of Dietary Nitrate on Running Time-to-exhaustion and Neuromuscular Fatigue: a Randomized Crossover Exploratory Pilot Study
Background: Dietary nitrate is a natural compound found in vegetables such as beetroot and leafy greens. Previous research suggests that consuming nitrate before exercise may improve endurance and physical performance.
- Trial name
- Nitrate TTE (NCT07735455)
- Testing
- Dietary Nitrate
- Where
- Spain
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Madrid
Malignant Pleural Effusion
Safety and Effectiveness Study for Pleurodesis With Silver Nitrate in Malignant Pleural Effusion
The primary purpose of this study is to determinate the degree of chest pain on patients with malignant pleural effusion submitted to pleurodesis with silver nitrate in three different dosages and concentrations ( 30ml 0.5% …
- Trial name
- NCT01125124
- Testing
- Silver Nitrate
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Dietary Nitrate Supplementation
Evaluating the Metabolic Effects of Dietary Nitrate Supplementation
Dietary nitrate is found to enhance muscle fatty acid oxidation/glucose uptake and increase mitochondrial biogenesis, which in turn, aid in the prevention and management of metabolic diseases.
- Trial name
- NIMMI (NCT05579262)
- Testing
- Beetroot juice
- Where
- Singapore
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
Metabolic Syndrome
Nitrate Supplementation and Cerebrovascular and Cognitive Function in Metabolic Syndrome
The purpose of this study is to determine if beetroot juice consumption can improve cognitive performance and brain vascular function in individuals with metabolic syndrome
- Trial name
- NCT05532423
- Testing
- Beetroot Juice - Active
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Penn State University
Hypoxia
Exercise in Hypoxia and Nitrate Supplementation in Athletes: is the Whole Greater Than the Sum of Its Parts?
Determine the combined effect of training in hypoxia and nitrate supplementation on the performance and health of athletes at sea-level and altitude conditions.
- Trial name
- NCT06727656
- Testing
- Nitrate + Hypoxia, Control
- Where
- Portugal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Trás-os-Montes and Alto Douro
Aging
Dietary Nitrate and Physiological Aging
The main purpose/s of this study is to examine the effects of 4 weeks of dietary nitrate supplementation on peripheral chemoreceptor sensitivity, spontaneous baroreflex sensitivity, and blood pressure responsiveness to a variety…
- Trial name
- NCT02593305
- Testing
- Super Beets
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Darren P Casey
Erectile Dysfunction
The Effects of a Nitrate Supplementation on Erectile Function
Twenty (20) individuals to be recruited from Ballantyne Medical Associates in Charlotte, NC, without any significant chronic medical history. These patients are general patients for primary care that meet inclusion criteria.
- Trial name
- NCT06213077
- Testing
- Nitric Oxide, Tadalafil
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- RHA Investments Ltd
Diabetes Mellitus, Type 2
Contraction (Exercise) Mediated Glucose Uptake as a Therapeutic Target in Type 2 Diabetes
The purpose of this project is to determine whether glucose metabolism can be improved by administering a substance (nitric oxide donor) normally released by muscles during exercise.
- Trial name
- NCT00168519
- Testing
- nitroprusside, pentalong, imdur, AICAR, isoptin
- Where
- Australia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Baker Heart Research Institute
Males, Females
Interaction Between Inorganic Nitrate Supplementation and Metformin in Individuals With Prediabetes
This study is examining whether short-term supplementation with inorganic nitrate, in the form of beetroot juice, can enhance blood vessel health, insulin sensitivity, and exercise capacity in individuals with prediabetes.
- Conditions
- Males, Females, Sedentary, Metformin
- Trial name
- NO3-PreDM (NCT07131384)
- Testing
- Dietary Supplement: Inorganic Nitrate (Beetroot juice)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Virginia
Pulmonary Embolism (Diagnosis)
Inorganic Nitrates in Intermediate High-risk Pulmonary Embolism
Pulmonary embolism (PE) is a serious condition caused by blood clots blocking the blood vessels in the lungs. In some patients, PE leads to increased pressure in the lung circulation and strain on the right side of the heart.
- Trial name
- NITRATE-PE (NCT07431229)
- Where
- 2 sites in Sweden
- Volunteers
- 36 people
- Sponsor
- Karolinska Institutet
Periodontal Diseases, Periodontitis
Intake of Nitrate-rich Vegetables and Their Effect on Inflammatory Molecules and Oral Microbiota of Patients With Periodontitis
Vegetables, mainly green leafy ones and some others like beets, are a rich source of nitrate. Nitrate metabolism has shown benefits to the body and there are recent studies that agree that the consumption of nitrates from…
- Trial name
- NCT05232331
- Testing
- Intake of nitrate rich vegetables
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- University of Guadalajara
Dentine Hypersensitivity
Instant and Lasting Relief Effects of Strontium Chloride/Potassium Nitrate Dentifrice on Dentin Hypersensitivity
The objective of the present study was to compare the effects of a commercially available dentifrice containing 2% strontium chloride and 5% potassium nitrate in a silica base, versus a control dentifrice, containing exactly the…
- Trial name
- NCT01426360
- Testing
- control dentifrice, strontium chloride/potassium nitrate dentifrice
- Where
- China
- Volunteers
- 79 people
- Sponsor
- Sun Yat-sen University
Endothelial Dysfunction
Nitrate and Vitamin C on Vascular Health Oxidative Stress
The objective of this study is to examine whether the co-administration of dietary nitrate combined with vitamin C for 4 weeks in patients at risk for CVD would yield robust effects on endothelial function using blood measures…
- Trial name
- NCT04283630
- Testing
- Dietary nitrate in the form of beetroot juice for all participnats, Nature Made vitamin c 1000 mg
- Where
- 2 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- David Travis Thomas