Clinical trials: Nitrates
Postmenopausal Female Patients, Vasomotor Symptoms
Exercise Training Intensity and Nitrate Supplementation in Post-Menopausal Females on Hormone Therapy
This study is examining whether short-term supplementation with inorganic nitrate in the form of beetroot juice can enhance vascular function in postmenopausal females taking hormone therapy compared to placebo.
- Conditions
- Postmenopausal Female Patients, Vasomotor Symptoms, Menopausal Hormone Therapy
- Trial name
- BEET-MHT (NCT07871396)
- Testing
- Moderate Intensity Exercise (MIE), High intensity exercise (HIE), Control (No exercise)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Virginia
Healthy Adults
Effect of Acute Nitrate Supplementation on Vascular Function in Hispanic, Black and White Population
The purpose of the study is to assess vascular function in African Americans, Hispanic and Caucasian Americans to better understand racial differences in cardiovascular health.
- Trial name
- NCT05188079
- Testing
- Beetroot juice
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Acute Heart Failure, Left Ventricular Dysfunction
Bi Treatment With Hydralazine/Nitrates Versus Placebo in Africans Admitted With Acute Heart Failure
To investigate the effect of hydralazine isosorbide dinitrate on clinical outcomes, symptoms, cardiac parameters and functional status of African patients hospitalized with AHF and left ventricular dysfunction during 24 weeks of…
- Trial name
- B-AHEF (NCT01822808)
- Testing
- Hydralazine, Isosorbide Dinitrate
- Where
- South Africa
- Volunteers
- 500 people
- Sponsor
- University of Cape Town
Arterial Hypertension, Resistant Hypertension
Effect of Nitrate Supplementation on Blood Pressure and Microvascular Function of Resistant Hypertensive Patients
Arterial hypertension (AH) has been identified as an important public health problem and considered a new epidemic with high mortality and morbidity.
- Conditions
- Arterial Hypertension, Resistant Hypertension, Microvascular Function, Nitrate Supplementation
- Trial name
- NCT06169241
- Testing
- Beetroot extract
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Mitochondrial Energetics, Dietary Nitrate
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men
Diminished use of skeletal muscle, such as occurs with many chronic diseases (e.g., heart failure or cancer cachexia), denervation, bedrest, immobilization (e.g., limb casting or bracing), etc., is a common clinical condition…
- Conditions
- Mitochondrial Energetics, Dietary Nitrate, Disuse Atrophy (Muscle) of Lower Leg
- Trial name
- NCT07161973
- Testing
- Beetroot Juice - Active
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Indiana University
Hypertensive Heart Disease Without (Congestive) Heart Failure
The Influence of Beetroot Powder at a Dose of 20 g on Blood Pressure, Microcirculation, and Biochemical Markers in Men With Arterial Hypertension.SVEKLA2025.
Objective: to evaluate the effectiveness of using a food product, dry finely dispersed beetroot powder in a dose of 20 g, containing 800 mg of nitrate (NO3-), in relation to the regulation of blood pressure in men with…
- Trial name
- NCT07270718
- Testing
- Plus SVEKLA
- Where
- Russia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Becker Muscular Dystrophy
Sodium Nitrate for Muscular Dystrophy
The investigators' previous work in males with Becker Muscular Dystrophy shows that functional sympatholysis is restored by acute inorganic nitrate supplementation.
- Trial name
- NCT02434627
- Testing
- Sodium Nitrate
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Cedars-Sinai Medical Center
Medicaments Substances in Therapeutic Use
Potassium Oxalate and Potassium Nitrate and Post-bleaching Sensitivity
Objectives: This study will determine the effectiveness of the use of desensitivity gels prior in office bleaching on risk and intensity of tooth sensitivity caused by in-office bleaching using 35% hydrogen peroxide.
- Trial name
- NCT02941653
- Testing
- Potassium nitrate 2% gel, Potassium oxalate 5% gel
- Where
- Brazil
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Sergipe
Hypertension
The Effect of Orally Administrated Nitrate on Renal Parameters and Systemic Haemodynamics
Treatment with nitrate has shown to lower blood pressure in both healthy subjects and hypertensive patients.Beside this nitrate have also shown to decrease arterial stiffness and improve endothelial function.But the effect of…
- Trial name
- APNI (NCT04755400)
- Testing
- isotonic saline 9%, Potassium nitrate, Potassium chloride
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Frank Mose
Early Childhood Caries
Effectiveness of Dental Caries Arrest Treatment in Primary Teeth Using AgNO3 Followed by NaF Varnish
Aim: This randomised controlled trial will systematically compare the efficacy of a 25% AgNO3 solution followed by 5% NaF varnish with that of a 38% SDF solution in arresting caries teeth among preschool children when applied at…
- Trial name
- NCT02019160
- Testing
- 25% AgNO3 solution followed by 5% NaF varnish
- Where
- China
- Volunteers
- 1,070 people
- Sponsor
- The University of Hong Kong
Healthy, Older Adults
The Combined Effect of Dietary Nitrate and Caloric Restriction on Cognitive and Vascular Function.
This pilot study will compare the effect of combining dietary nitrate and caloric restriction versus dietary nitrate alone. The participant will be contacted, having responded to an advertisement on social media and posters, to…
- Conditions
- Healthy, Older Adults, Overweight and Obesity
- Trial name
- CRNitrateMRI (NCT06151015)
- Testing
- Nitrate-rich beetroot juice plus calorie-restricted diet, Nitrate-rich beetroot juice plus weight-maintenance diet
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Moira Taylor
Nitrate, Nitrate/Citrulline
Nitrate Formulations and Exercise Performance
this study compares the acute effects of Nitrate and Nitrate plus citrulline supplementation on physical performance in recreationally trained males and females.
- Conditions
- Nitrate, Nitrate/Citrulline, Placebo
- Trial name
- NCT06531070
- Testing
- Nitrate
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Greenwich
Preeclampsia, Hypertension
Effects of Nitrate-rich Beetroot Juice in Pregnant Women With High Blood Pressure
BACKGROUND: Preeclampsia (PE) is a serious syndrome that affects 3-7% of all pregnant women. PE is characterized by hypertension and kidney problems after the 20th week of pregnancy and is associated with an increased risk of…
- Conditions
- Preeclampsia, Hypertension, Endothelial Dysfunction, Nitric Oxide
- Trial name
- NITBEETPE (NCT05241327)
- Testing
- Beetroot Juice
- Where
- Sweden
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Nitrate Vasodilator Adverse Reaction
Estimation of Dietary Nitrate Intake in a Representative UK cohort_V1
Dietary nitrate has been shown to have health benefits including lowering blood pressure and improving the health and elasticity of blood vessels. The main source of dietary nitrate in the human diet is vegetables.
- Trial name
- NCT05178875
- Where
- United Kingdom
- Volunteers
- 2,444 people
- Sponsor
- University of Reading
Diabetes Mellitus, Type 2
The Effect of Nitrate on Brown Fat
Type 2 diabetes mellitus (T2DM) is a metabolic condition characterized by chronic hyperglycemia and progressive insulin resistance, which progressively lead to macro- and microvascular damage.
- Trial name
- NCT05342012
- Testing
- Concentrated beetroot juice, Nitrate depleted beetroot juice
- Where
- 4 sites in United Kingdom
- Volunteers
- 13 people
- Sponsor
- Bournemouth University
Dyslipidemia
Beetroot Juice and Postprandial Vascular Activity
Increased postprandial lipemia may increase the risk for cardiovascular diseases. An important mechanistic link between lipemia following a high-fat meal and adverse cardiovascular events is lipid-mediated endothelial activation.
- Trial name
- NCT01559441
- Testing
- Beetroot Juice with oral fat load, Carbohydrate control drink with oral fat load
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Ergogenics
Effect of the Beetroot Juice in Portuguese Swimmers
Objective: To investigate whether an acute intake of beet juice (BJ) improved the factors of total and split times (performance), stroke frequency and CMJ (biomechanics), lactate and HR (physiology) and RPE-TQR…
- Trial name
- NCT05657093
- Testing
- Beetroot Juice
- Where
- Spain
- Volunteers
- 18 people
- Sponsor
- Universidad Francisco de Vitoria
Chronic Stable Angina
The Effects of Inorganic Nitrate on Cardiac Muscle in Angina
Previous studies have shown that interventions which modestly increase blood nitrite_ improve skeletal muscle function on exercise while sparing oxygen, and have been also shown to open up the blood flow during periods of oxygen…
- Trial name
- NCT02078921
- Testing
- Sodium Nitrate
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University of Aberdeen
Blood Pressure, Nutritional Physiological Phenomena
Nitrate Supplementation; Source
The main aim of the current study will be to compare the effects of ingesting different nitrate-rich sources on plasma nitrite concentrations.
- Trial name
- NO-what (NCT02271633)
- Testing
- Sodium nitrate, Beetroot juice, Spinach
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Blood Pressure
Effect of High Nitrate Vegetable Juice Supplementation on Plasma Nitrate and Blood Pressure in Healthy Adults
Aims: The aim of this study is to carry out a randomised crossover intervention study examining the effect of two different high nitrate vegetable juices on plasma nitrate levels and blood pressure (BP) in healthy adults.
- Trial name
- NIVJUS (NCT04736784)
- Testing
- Food-based - beetroot juice, Food-based - leafy green vegetable juice
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast