Clinical trials: Nitrates
Pregnancy
Pregnancy, Nitrate, Endothelial Function and Tissue Oxygen Saturation
Adequate macro and microvascular endothelial function during pregnancy is essential for the normal placental development and growing fetus.
- Trial name
- NCT03315806
- Testing
- Beetroot juice
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Stable Angina, Myocardial Ischemia
Clinical Impact of the Withdrawal of Nitrate in Patients With Stable Angina
Chronic treatment of stable angina with nitrates long and short action is extremely frequent. In clinical practice the most commonly observed is a combination of anti-anginal agents, usually including nitrates fixed in an attempt…
- Conditions
- Stable Angina, Myocardial Ischemia, Quality of Life
- Trial name
- NCT01769079
- Testing
- Nitrate
- Where
- Brazil
- Volunteers
- 95 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Nitrates, Placebo
Beetroot Juice Effects on Contractile or Neuromuscular Properties in Male Trained Sprinters
Beetroot juice is a rich source of nitrate (NO3-), which serves as a precursor to nitric oxide (NO) via the NO3- to nitrite (NO2-) to NO conversion pathway.
- Trial name
- BEET_SPRINT (NCT06675682)
- Testing
- Beetroot Juice (Beet-It Stamina Shot) and Exercise Training
- Where
- Spain
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universidad Pontificia Comillas
Alzheimer's Disease
An Investigation Into the Feasibility of Beetroot Juice Supplementation in People Living With Alzheimer's Disease.
The goal of this clinical trial is to learn if taking a beetroot juice supplement will work in people living with Alzheimer's disease.
- Trial name
- OMNI (NCT07258004)
- Testing
- Beetroot juice
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of the West of Scotland
Healthy
Inorganic Nitrate: Sex Differences in Muscle Contractile Function and Efficiency
Dietary inorganic nitrate, in the form of beet root juice, is a nutritional intervention, considered to be an exercise enhancer due to its capacity to increase Nitric Oxide (NO) bioavailability.
- Trial name
- NCT04588740
- Testing
- concentrated beet root juice
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Angina Pectoris
Blood Pressure Interaction Between Sildenafil and Sublingual Glyceryl Trinitrate (GTN) in Men With Angina
The purpose of the study is to determine for how long sildenafil potentiates the blood pressure reduction that occurs with glyceryl trinitrate in men with angina.
- Trial name
- NCT00479908
- Testing
- Sildenafil citrate, Glyceryl trinitrate
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Edinburgh
Long COVID, Cardiorespiratory Fitness
Nitrite Supplementation in Long COVID Patients
Potential benefits of a nitrate-rich juice supplement to improve skeletal muscle function and associated physical capacity will be studied in patients with Long COVID.
- Trial name
- NCT05618574
- Testing
- 140 ml per day of Beet-It nitrate beverage (James White Drinks Ltd., Ipswich, UK)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- VA Office of Research and Development
Healthy
Blood Nitrate/Nitrite Concentrations Following Acute Ingestion of Resync in Men and Women
This study evaluates acute ingestion of the dietary supplement Resync on blood nitrate/nitrite concentrations in a sample of men and women.
- Trial name
- NCT04125940
- Testing
- Resync, Resync + Collagen
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Memphis
Aging, Hypertension
Aging, Nitrate, Endothelial Function and Muscle Oxygenation
Aging has been associated with reduced bioavailability of nitric oxide (NO) and endothelial dysfunction. Beetroot consumption, a nitrate-rich food, has been associated with increased NO bioconversion, which may promote beneficial…
- Conditions
- Aging, Hypertension, Dyslipidemia, Abdominal Obesity
- Trial name
- NCT02772900
- Testing
- Beetroot-based nutritional gel
- Volunteers
- 25 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Heart Failure
The Inorganic Nitrate and eXercise Performance in Heart Failure (iNIX-HF)
The goals of this project are to determine the effectiveness of acute (2 hours after a single dose) and chronic (after 6 weeks of once-a-day dosing) KNO3 treatment (10mmol) vs.
- Trial name
- iNIX-HF (NCT05562167)
- Testing
- KNO3
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Washington University School of Medicine
Healthy Young, Older People With Cardiovascular Disease Risk
Watermelon and Beetroot Products on Endothelial Function
Cardiovascular disease is the main cause of death worldwide. Endothelial dysfunction is the first step to development of cardiovascular diseases.
- Trial name
- NCT04781595
- Testing
- Watermelon, Beetroot, Watermelon + beetroot
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Health, Vulvovaginal Candidiasis
Effect of Exercise on Spread of the Miconozole Nitrate OVULE in the Vagina
This study uses MRI to detect the spread of the Miconozole Nitrate OVULE within the vagina. The effect of moderate amounts of physical activity on the spread will be evaluated, and compared to no physical activity.
- Trial name
- NCT00194324
- Testing
- Miconazole nitrate, Magnetic resonance imaging, Moderate levels of exercise
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Dental Erosion
The Effect of Nitrate Supplement on the Oral Microbiome and Saliva in Dental Erosion
Dental erosion happens when teeth lose some of their parts because of acid from the things people eat and/or drink or even from their stomach. It can make their teeth hurt and become sensitive.
- Trial name
- NCT06156618
- Testing
- Nitrate
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Portsmouth
Exercise Performance, Supplementation
The Effect of Acute Beetroot Juice Supplementation on Anaerobic Performance in Football Players
The aim of this clinical trial is to examine the effects of two different natural fruit-vegetable blend beverages on short-duration, high-intensity exercise performance and muscle oxygenation in young male football players.
- Trial name
- NCT07048912
- Testing
- Beetroot Juice (BJ)
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Melike Nur Eroğlu
Hypertension
A 2 Week, Crossover Trial of Dietary Nitrate in HTN
Acute consumption of dietary nitrate (as beetroot juice) has been shown to decrease systemic blood pressure in multiple populations including newly diagnosed, untreated hypertensives.
- Trial name
- NCT02597010
- Testing
- Dietary nitrate
- Volunteers
- 20 people
- Sponsor
- Royal College of Surgeons, Ireland
Healthy
Determination of Variances in Exhaled Nitric Oxide Output in Normal Healthy Male Volunteers Consuming High and Low Nitrate/Nitrite Diets
This study will determine whether and how nitrites and nitrates in the diet affect the level of nitric oxide gas that is breathed out in air.
- Trial name
- NCT00027157
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronaropathy
Prevention and Comparison of Different Forms of Administration of Nitrates in the Risk of Radial Spasm During Coronary Angiography.
The radial approach for a coronary angiography is currently adopted by several centers because of its simplicity. The radial artery spasm is the main inconvenient.
- Trial name
- NCT02258620
- Testing
- dinitrate isosorbide, nitroglycerine
- Where
- Belgium
- Volunteers
- 442 people
- Sponsor
- Brugmann University Hospital
Cerebrovascular Circulation, Cognitive Impairment
Effects of Dietary Nitrate From Vegetable/Fruit Juice on Cerebral Blood Flow Parameters
Nitrate provides the body with an alternative source of Nitric Oxide which plays a large role in promoting blood flow and reducing blood pressure.
- Trial name
- NCT01169662
- Testing
- Vegetable/fruit juice
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Cardiovascular Diseases
Influence of Dietary Nitrate on Vascular Dysfunction and Inflammation
The principal research objective is to determine whether inorganic nitrate in the form of beetroot juice compared to placebo control prevents the systemic inflammation that underlies typhoid vaccine-induced endothelial dysfunction
- Trial name
- NCT02715635
- Testing
- Typhoid vaccine, Concentrate beetroot Juice
- Where
- United Kingdom
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Heart Failure, Systolic
Effects of Dietary Nitrate Supplementation on Cardiorespiratory Control in Chronic Heart Failure
The main purpose of this study is to determine whether dietary nitrate supplementation via concentrated beetroot juice improves central and peripheral cardiovascular control and physical capacity in patients with systolic heart…
- Trial name
- NCT02401126
- Testing
- Nitrate supplementation
- Volunteers
- 13 people
- Sponsor
- Queen's University