Clinical trials: Nitrite
Blood Pressure
Dietary Nitrate Intake in Vegetarians and Omnivores
Vegetarian diets are commonly associated with lower blood pressure levels. This has been related to greater consumption of inorganic nitrate, since vegetables are the main source of this anion.
- Trial name
- NO3 (NCT03871777)
- Testing
- Chlorhexidine mouthwash
- Where
- United Kingdom
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Plymouth
Nitric Oxide, Insulin Sensitivity
Nutritional Supplementation and Insulin Sensitivity
Type 2 diabetes mellitus (T2DM) is a progressive disease and early intervention and prevention strategies are therefore very important. An important early hallmark in the development of T2DM is insulin resistance.
- Conditions
- Nitric Oxide, Insulin Sensitivity, Vascular Function, L-arginine
- Trial name
- NCT04239482
- Testing
- L-arginine + Nitrate / Nitrite
- Where
- Netherlands
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Cardiovascular Disease
Sex Differences in Oral Bacteria
Females have a lower incidence of hypertensive and cardiovascular disorders that may relate to differences in nitrogen oxides in the blood and saliva.
- Trial name
- NCT01583803
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Dietary Supplements: Beetroot Juice Acute Supplementation, Dietary Supplement: Placebo Acute Supplementation
Acute Effects of Beetroot Juice Ingestion on Cognitive Function and Neuromuscular Performance in Elite Female Taekwondo Athletes
Beetroot juice is a good source of nitrate (NO3-), which is a precursor of nitric oxide (NO) through the NO3- to nitrite (NO2-) to NO pathway (Lundberg et al., 2008).
- Trial name
- BEET_TAEKWONDO (NCT06675305)
- Testing
- Beetroot juice (James White, UK)
- Where
- Spain
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Universidad Pontificia Comillas
Aging
Nitrate and Exercise Performance in Middle to Older Aged Adults
Research with young healthy individuals has shown that beetroot juice beverages that contain large amounts of nitrate can improve exercise performance.
- Trial name
- NCT03371966
- Testing
- High Nitrate Beetroot Juice, Low Nitrate Beetroot Juice
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Wake Forest University
Nitric Oxide, Endothelium-Derived Relaxing Factor
Effects of Nitrite on Blood Vessel Dilation in Normal Volunteers
Nitric oxide gas is important in regulating blood vessel dilation, and consequently, blood flow. This gas is continuously produced by endothelial cells, which line the blood vessels.
- Conditions
- Nitric Oxide, Endothelium-Derived Relaxing Factor, Healthy
- Trial name
- NCT00048477
- Testing
- L-NMMA and Sodium Nitrite
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiovascular Diseases in Old Age
Efficacy Long-term Dietary Nitrate Consumption to Plasma Nitrite Conversion
The objective of this study was to determine the chronic effects of beetroot juice supplementation on the acute (90-minute post nitrate consumption) efficacy of converting dietary nitrate to plasma nitrate and plasma nitrite in…
- Trial name
- NCT05380167
- Testing
- BRJ Nitrate
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Wake Forest University
Healthy Volunteers
The Haem and Nitrite Study - The Effects of Haemoglobin NO-blockade on Nitrite-induced Forearm Vessel Dilatation
The study is a pharmacodynamic random order cross-over trial investigating the physiological effects of intra-arterial infusion of nitrite following a haemolysed autologous blood transfusion.
- Trial name
- NCT03077763
- Testing
- Sodium Nitrite
- Where
- United Kingdom
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Type 2 Diabetes, Ageing
Effects of Nitrate on Liver Perfusion and Sugar Control
Rationale: Mediterranean style diets and diets rich in green leafy vegetables protect against the risk of developing type 2 diabetes and a wide range of cardiovascular disease. These diets are rich in nitrate.
- Trial name
- DiMPLe (NCT02195856)
- Testing
- Beetroot juice
- Where
- 2 sites in United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Exeter
High Intensity Intermittent Sports Performance
Nitrate for High Intensity Intermittent Exercise
The objective of the current study is to assess the effect of 6-day dietary nitrate ingestion on high intensity intermittent sports performance in recreational soccer players.
- Trial name
- NITR-ITE (NCT02436629)
- Testing
- Nitrate-rich concentrated beetroot juice, Nitrate-depleted concentrated red beetroot juice
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy, Gastrointestinal Cancer
Dietary Nitrate and Nitrite Intake and Phosphate Biomarkers and Risk of Chronic Diseases
Nitrate, nitrite, and phosphate (NO3, NO2, P) are at all age stages ubiquitous in our everyday foods, including naturally occurring and as food additives, and in our drinking water.
- Conditions
- Healthy, Gastrointestinal Cancer, Cardiovascular Diseases, Chronic Obstructive Airway Disease
- Trial name
- NCT07746310
- Where
- Sweden
- Volunteers
- 86,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Time-trial Performance, Submaximal Exercise Performance
Nitrate Supplementation; Duration
The main aim of the current study will be to find the optimal duration of supplementation to enhance sports performance.
- Conditions
- Time-trial Performance, Submaximal Exercise Performance, Nitrite, Nitrate
- Trial name
- NO-how (NCT02115893)
- Testing
- Sodium Nitrate, Sodium Chloride
- Where
- 2 sites in Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Focus of Study of Healthy Adults
Oral Nitrite and Nitrate in Healthy Normal Volunteer Adults
This proposal hypothesizes that oral supplementation with sodium nitrite or nitrate will result in in vivo conversion of nitrate to nitrite and nitrite to nitric oxide with limited toxicity in the doses proposed in healthy adult…
- Trial name
- NCT01681836
- Testing
- 15Nitrogen(15N)-labeled sodium nitrite, 15Nitrogen(15N)-labeled sodium nitrate
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Gladwin, Mark, MD
Cyanide Poisoning
Study of SIAN Nasal Spray in Healthy Adults
This study is designed to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of single ascending doses of Stabilized Isoamyl Nitrite (SIAN) nasal spray in healthy subjects.
- Trial name
- NCT05194358
- Testing
- Stabilized Isoamyl Nitrite (SIAN)
- Where
- 2 sites in United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Emergent BioSolutions
Primary Hypertension
Dietary Nitrate and the Oral Microbiome in Children With Primary Hypertension
Children and adolescents with primary hypertension (high blood pressure without an underlying secondary cause) are at increased risk of cardiovascular disease in adulthood.
- Trial name
- NCT07236125
- Testing
- No active intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Yelda Kasımoğlu
Heart Failure
Oral Nitrite for Older Heart Failure Patients
Studies have demonstrated nitrite therapy increases adenosine triphosphate (ATP) synthesis in skeletal muscle mitochondria concomitant with reduced whole-body oxygen cost during steady state exercise.
- Trial name
- ONTx+HF (NCT02457260)
- Testing
- 14 N Sodium Nitrite
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Gladwin, Mark, MD
Blood Pressure Regulation
The Effects of Nitrate-Rich Mouthwash on Vascular Tone
High blood pressure (hypertension) is a major risk factor for cardiovascular disease. One important contributing factor to high blood pressure is reduced availability of nitric oxide (NO).
- Trial name
- NITRATONE (NCT07602764)
- Testing
- Nitrate-rich mouth rinse, Nitrate-rich drink
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Vascular Aging
Sodium Nitrite to Treat Arterial Aging
The proposed research will determine the effectiveness of nitrite, a naturally occurring compound in the body, for improving the health and function of arteries in middle-aged and older adults.
- Trial name
- NCT02022670
- Testing
- Sodium Nitrite
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Blood Pressure, Sports Physical Therapy
Oral Nitrite Synthesis and Post-exercise Hypotension
Exercise is probably the most effective approach to reduce blood pressure. In fact, a single bout of exercise induces a physiological response known as Post-Exercise Hypotension (PEH) where a prolonged decrease in resting blood…
- Trial name
- NCT03904394
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Plymouth
Healthy
The Effect of Sodium Nitrite on Renal Function and Blood Pressure in Healthy Humans. A Dose-response Study
The purpose of this study is to investigate the effect of different doses of sodium nitrite infusion in 12 healthy subjects. The effects on renal handling of nitrite, nitrate, sodium and water, plasma concentrations of vasoactive…
- Trial name
- NCT02078908
- Testing
- Sodium nitrite, 40 micrograms/kg/hour, Sodium nitrite, 120 micrograms/kg/hour, Sodium nitrite, 240 micrograms/kg/hour
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Erling Bjerregaard Pedersen