Clinical trials: Nociception, open to volunteers
Postoperative Pain
Analgesia Nociception Index in Orthognathic Surgery
This study aims to determine whether goal-directed analgesia using ANI(Analgesia/Nociception Index) can improve the quality of postoperative recovery in patients undergoing maxillofacial surgery.
- Trial name
- NCT06205355
- Testing
- Analgesia/Nociception Index (ANI) monitoring, Standard monitoring
- Where
- South Korea
- Volunteers
- 86 people
- Sponsor
- Seoul National University Hospital
Chronic Pain
Analgesia Nociception Index In Pediatric Patients With Chronic Pain
The goal of this observational study is to learn about the analgesia nociceptive index (ANI) is associated with pain sensitivity in patients between the ages of 9-17 who are experiencing chronic pain.
- Trial name
- Chronic pain (NCT07145762)
- Testing
- Interventional Block
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Pain, Acute Pain
Pain Induced by m-Cresol as Preservative
Preservatives such as m-Cresol are essential components in many subcutaneously injected medications, including insulin or human growth hormone, to prevent bacterial growth.
- Conditions
- Pain, Acute Pain, Healthy Volunteer Study
- Trial name
- NCT07600814
- Testing
- m-Cresol 0.1%, m-Cresol 0.25%, Control Solution
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Supratentorial Brain Tumor Surgery
FASt Track in Elective Neurosurgery: the Role of Low Propofol Bis-NOL Guided General Anaesthesia for Full, Early and Safe Awakening
To evaluate the effect of intraoperative sedation dosage on awakening and recovery of consciousness after elective neurosurgical surgery.
- Trial name
- FasTrack (NCT06844838)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Propofol, Sevoflurane
Comparison of Sevoflurane and Propofol on ANI
The goal of this clinical trial is to compare the effect of sevoflurane and propofol on analgesia nociception index(ANI) in patients undergoing general anesthesia.
- Conditions
- Propofol, Sevoflurane, Analgesia Nociception Index
- Trial name
- NCT06907823
- Testing
- propofol, Sevoflurane
- Volunteers
- 30 people
- Sponsor
- Pusan National University Yangsan Hospital
Brachial Plexus Blockade
Nociception Level Index After Brachial Plexus Block In Upper Extremity Surgery
The present prospective within-subject observational study will evaluate whether unilateral brachial plexus block (BPB) induces measurable lateralized autonomic modulation, assesses using bilateral Nociception Level (NoL)…
- Trial name
- NCT07620002
- Where
- Israel
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Carmel Medical Center
Mastectomy
Biological and Clinical Underpinnings of Postoperative Pain - Mastectomy
Persistent pain after mastectomy remains a significant clinical challenge that can delay recovery, reduce quality of life, and increase long-term healthcare burden.
- Trial name
- BAC-UPP 1 (NCT07271589)
- Volunteers
- 86 people
- Sponsor
- University of Alabama at Birmingham
Surgical Stress Response, Inflammation
CoreSys Monitoring for Intraoperative Stress Management in Abdominal Hysterectomy
This randomized controlled trial evaluates whether intraoperative guidance using the CoreSys monitor reduces the surgical stress response in patients undergoing elective open abdominal hysterectomy.
- Conditions
- Surgical Stress Response, Inflammation, Anesthesia, Perioperative Care
- Trial name
- CORESTRESS (NCT07571473)
- Testing
- propofol, CoreSys Monitor, Remifentanil (Target-Controlled Infusion)
- Where
- Argentina
- Volunteers
- 30 people
- Sponsor
- Hospital Provincial de Rosario
Adjuvants, Anesthesia
Effects of Dexmedetomidine Target Controlled Infusion on Patient State Index Values and Electroencephalographic Spectrum During Total Intravenous Anesthesia With Propofol
Dexmedetomidine Target Controlled infusion (TCI, Dyck model) effects on Neuromonitoring during Total Intravenous Anesthesia (TIVA) with Propofol and Remifentanil TCI (Eleveld model) has not been investigate yet.
- Trial name
- NCT07259460
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Padova
Depth of Anesthesia, Nociception
Anesthesia Induction Scheme for Painless Gastrointestinal Endoscopy Patients Based on Nociceptive Stimulation Monitoring
Nociception is the encoding and processing of noxious stimulation and is considered an objective indicator for monitoring pain. Currently, a new clinically-applied medical-engineering integrated monitoring device for noxious…
- Conditions
- Depth of Anesthesia, Nociception, Painless Gastrointestinal Endoscopy
- Trial name
- NCT06604156
- Testing
- EEG monitoring
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Min Su
Intraoperative Analgesia
NOL Guided Analgesia During Elective Laparoscopic Surgery Under General Anesthesia
The aim of this study is to investigate the hypothesis that the intraoperative use of the nociception level index NOL can reduce opioid consumption in adult patients undergoing elective laparoscopic surgeries under general…
- Trial name
- NOLGADELS (NCT06104059)
- Testing
- Nociception level index (NOL™), Fentanyl
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Attikon Hospital
Laparoscopic Cholecystectomy, Postoperative Pain
Comparison of ANI Between Preoperative and Postoperative Ultrasound-guided TAP Block in Laparoscopic Cholecystectomy
The goal of this clinical trial is to learn if the timing of ultrasound-guided transversus abdominis plane block (US-TAP block) administration (preoperative vs.
- Trial name
- CholeANI (NCT07809009)
- Testing
- Preoperative US-TAP Block, Postoperative US-TAP Block
- Volunteers
- 120 people
- Sponsor
- Pusan National University Yangsan Hospital
Spinal Cord Injuries
Influence of Spinal Stimulation Frequency on Spasticity, Motor Control, and Pain After Spinal Cord Injury
The goal of this study is to identify the effect of different types of noninvasive spinal stimulation on spasticity (involuntary muscle activity), muscle strength, and pain in people with spinal cord injury.
- Trial name
- NCT06214208
- Testing
- Transcutaneous Spinal Stimulation
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Shepherd Center, Atlanta GA
Nociceptive Pain, Pain, Postoperative
Guiding Opioid Administration by Nociception Level Index (NOL) in Patients With Regional Anesthesia
General anesthesia consists of a combination of hypnotic drugs to achieve unconsciousness and opioid analgesics to ensure antinociception.
- Conditions
- Nociceptive Pain, Pain, Postoperative, Analgesia, Postoperative, Anesthesia Recovery Period
- Trial name
- NORA (NCT06905340)
- Testing
- NOL (Nociception Level Index), Control (Standard treatment)
- Where
- Germany
- Volunteers
- 240 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Minimally Invasive Surgical Procedures, Colon Cancer Patients
Pain Evaluation Across Robotic and Laparoscopic Surgery for Colorectal Procedures
Minimally invasive surgery for colorectal conditions, such as laparoscopic or robotic surgery, has been shown to offer benefits over traditional open surgery.
- Trial name
- PEARL (NCT07431892)
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Hospital Central de la Defensa Gómez Ulla
Chronic Knee Pain, Obesity, Morbid
Photobiomodulation in Chronic Knee Pain in Patients Who Are in PreRehabilitation for Bariatric Surgery
Chronic pain is a global public health problem, which intensifies even more in the obese population, reaching about 33% of these patients.
- Trial name
- NCT05816798
- Testing
- Photobiomodulation, Standard Physiotherapy Tretament
- Where
- Brazil
- Volunteers
- 62 people
- Sponsor
- University of Nove de Julho
General Anesthesia
Comparison of Sevoflurane and Desflurane on ANI in Patients Undergoing General Anesthesia: a Prospective Randomized Controlled Study
This prospective randomized controlled study will compare the effects of sevoflurane and desflurane on the Analgesia Nociception Index (ANI) in adult patients undergoing general anesthesia.
- Trial name
- NCT07511634
- Testing
- Desflurane, Sevoflurane
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Pusan National University Yangsan Hospital
Postoperative Pain, Lumbar Spine Surgery
Postoperative Pain Monitoring With ANI in Lumbar Spine Surgery
This study aims to compare two different pain management methods in patients undergoing elective lumbar spine surgery. Patients are randomly assigned to receive either an ultrasound-guided erector spinae plane block (ESPB) or…
- Trial name
- SPINE-ANI (NCT07455565)
- Testing
- Erector Spinae Plane Block, Intravenous Multimodal Analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Akdeniz University Hospital
Laparoscopic Gynecological Surgery
EEG and ANI Guided Anesthesia and Quality of Recovery
This study aims to assess whether electroencephalogram (EEG) and nociception level-guided anesthesia can improve quality of recovery after laparoscopic gynecological surgery compared with standard care.
- Trial name
- NCT05936671
- Testing
- EEG-and-ANI-guided anesthesia, standard anesthesia, Sevoflurane and remifentanil
- Where
- 2 sites in South Korea
- Volunteers
- 126 people
- Sponsor
- Gangnam Severance Hospital
Pain
Measuring Analgesic Interventions
It is generally recognized that pain assessment and management especially in newborns, children and other nonverbal populations is an unmet need.
- Trial name
- NCT03794362
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Julia Finkel