Clinical trials: Nociception, active
Surgical Stress Response, Inflammation
CoreSys Monitoring for Intraoperative Stress Management in Abdominal Hysterectomy
This randomized controlled trial evaluates whether intraoperative guidance using the CoreSys monitor reduces the surgical stress response in patients undergoing elective open abdominal hysterectomy.
- Conditions
- Surgical Stress Response, Inflammation, Anesthesia, Perioperative Care
- Trial name
- CORESTRESS (NCT07571473)
- Testing
- propofol, CoreSys Monitor, Remifentanil (Target-Controlled Infusion)
- Where
- Argentina
- Volunteers
- 30 people
- Sponsor
- Hospital Provincial de Rosario
Nociceptive Pain, Pain, Postoperative
Guiding Opioid Administration by Nociception Level Index (NOL) in Patients With Regional Anesthesia
General anesthesia consists of a combination of hypnotic drugs to achieve unconsciousness and opioid analgesics to ensure antinociception.
- Conditions
- Nociceptive Pain, Pain, Postoperative, Analgesia, Postoperative, Anesthesia Recovery Period
- Trial name
- NORA (NCT06905340)
- Testing
- NOL (Nociception Level Index), Control (Standard treatment)
- Where
- Germany
- Volunteers
- 240 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Depth of Anesthesia, Nociception
Anesthesia Induction Scheme for Painless Gastrointestinal Endoscopy Patients Based on Nociceptive Stimulation Monitoring
Nociception is the encoding and processing of noxious stimulation and is considered an objective indicator for monitoring pain. Currently, a new clinically-applied medical-engineering integrated monitoring device for noxious…
- Conditions
- Depth of Anesthesia, Nociception, Painless Gastrointestinal Endoscopy
- Trial name
- NCT06604156
- Testing
- EEG monitoring
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Min Su
Patients Undergoing Laparoscopic Surgery
Quantitative Analysis of EEG Changes in Response to Nociception
This study will quantify the nociception using Analgesia Nociception Index (ANI) during general anesthesia and analyze the differences in EEG depending on the degree of nociception.
- Trial name
- NCT06342570
- Testing
- There is no Intervention name to describe.
- Where
- South Korea
- Volunteers
- 109 people
- Sponsor
- Gangnam Severance Hospital
Laparoscopic Cholecystectomy, Postoperative Pain
Subcostal TAP Block and EEG Dynamics in Laparoscopic Cholecystectomy
Laparoscopic cholecystectomy is a commonly performed minimally invasive surgical procedure. Despite its minimally invasive nature, surgical stimulation and pneumoperitoneum may cause pain-related physiological and…
- Conditions
- Laparoscopic Cholecystectomy, Postoperative Pain, Intraoperative Nociception
- Trial name
- NCT07818954
- Testing
- Remifentanil, Ultrasound-Guided Subcostal Transversus Abdominis Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Ventilator Weaning, Airway Extubation
Can a Pain Monitor Predict When Postoperative Intensive Care Unit Patients Are Ready to Breathe on Their Own? A Pilot Study
The goal of this observational study is to learn if a chest monitor that tracks heart rhythm can help predict whether adults on a breathing machine after surgery will be able to breathe on their own once the breathing tube is…
- Conditions
- Ventilator Weaning, Airway Extubation, Respiration, Artificial
- Trial name
- NCT07771101
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Chronic Pain
Analgesia Nociception Index In Pediatric Patients With Chronic Pain
The goal of this observational study is to learn about the analgesia nociceptive index (ANI) is associated with pain sensitivity in patients between the ages of 9-17 who are experiencing chronic pain.
- Trial name
- Chronic pain (NCT07145762)
- Testing
- Interventional Block
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Pain, Acute Pain
Pain Induced by m-Cresol as Preservative
Preservatives such as m-Cresol are essential components in many subcutaneously injected medications, including insulin or human growth hormone, to prevent bacterial growth.
- Conditions
- Pain, Acute Pain, Healthy Volunteer Study
- Trial name
- NCT07600814
- Testing
- m-Cresol 0.1%, m-Cresol 0.25%, Control Solution
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Median Sternotomy, Pain Management
Effect of Parasternal Plane Block on Intraoperative Nociception
Effective pain control during pediatric cardiac surgery remains a major clinical challenge, particularly in procedures involving median sternotomy, which is associated with intense nociceptive stimulation.
- Trial name
- NCT07354750
- Testing
- Parasternal Plane Block, Group without peripheral nerve block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Spine Surgery, Pain After Surgery
Impact of NOL - Nociception Level Index Intraoperative Monitoring on Perioperative Outcomes in Spine Surgery - a Quality Improvement Pilot
The objective of this study is to evaluate the clinical impact of the NOL nociception level index monitoring on intraoperative and post operative patient outcomes and institutional metrics when used to guide intraoperative…
- Conditions
- Spine Surgery, Pain After Surgery, Anesthesia , Analgesia
- Trial name
- NCT07608276
- Testing
- NOL guided intraoperative analgesia
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Medasense Biometrics Ltd
Healthy
The Effect of Nonverbal Vocalisations on Pain Tolerance
Humans produce non-verbal vocalizations (shouting, growling, screaming), laughter, ...) in various contexts that are likely to perform biological functions. and important social issues.
- Trial name
- VOCPAIN (NCT04425395)
- Testing
- Cold pressor task (CPT), Acoustic Recordings, Index measurement NOL™
- Where
- France
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Chronic Knee Pain, Obesity, Morbid
Photobiomodulation in Chronic Knee Pain in Patients Who Are in PreRehabilitation for Bariatric Surgery
Chronic pain is a global public health problem, which intensifies even more in the obese population, reaching about 33% of these patients.
- Trial name
- NCT05816798
- Testing
- Photobiomodulation, Standard Physiotherapy Tretament
- Where
- Brazil
- Volunteers
- 62 people
- Sponsor
- University of Nove de Julho
Analgesics, Antipyretics and Anti-Inflammatory Drugs Causing Adverse Effects in Therapeutic Use
Developing a Method to Objectively Measure Opioid Analgesia
Inappropriate prescribing is the fundamental upstream driver of the opioid epidemic. Objective measures to determine the appropriateness of an opioid intervention, provide monitoring of the therapy for adequacy of dose and…
- Trial name
- NCT03605966
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Julia Finkel
Colorectal Surgery
Biological and Clinical Underpinnings of Postoperative Pain - Colorectal Surgery
Persistent pain after colorectal surgery remains a significant clinical challenge that can delay recovery, reduce quality of life, and increase long-term healthcare burden.
- Trial name
- BAC-UPP 2 (NCT07219160)
- Volunteers
- 128 people
- Sponsor
- University of Alabama at Birmingham
Pain, Anesthesia
Impact of Intraoperative Non-invasive Analgesia Monitoring Using Nociception Level Index on Patient Management
This prospective randomised clinical trial aims to assess the impact of intraoperative nociception monitoring using NOL on anesthetic management during major abdominal surgery.
- Conditions
- Pain, Anesthesia, Perioperative Care
- Trial name
- NCT06804434
- Testing
- Lidocaine Intravenous Infusion, NOL
- Where
- Romania
- Volunteers
- 160 people
- Sponsor
- Osoian Cristiana
Rapide Sequence Induction, Tracheal Intubation
Pain Assessment During Rapid Sequence Induction
Rapid sequence induction (RSI) is a standard anesthesia technique used in patients at risk of aspiration. Although tracheal intubation following RSI is a frequent and painful procedure, no study has yet evaluated nociception…
- Conditions
- Rapide Sequence Induction, Tracheal Intubation, Nociception, General Anesthesia
- Trial name
- NARSI (NCT07588165)
- Testing
- No Intervention: Observational Cohort
- Where
- Monaco
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Princesse Grace
Adjuvants, Anesthesia
Effects of Dexmedetomidine Target Controlled Infusion on Patient State Index Values and Electroencephalographic Spectrum During Total Intravenous Anesthesia With Propofol
Dexmedetomidine Target Controlled infusion (TCI, Dyck model) effects on Neuromonitoring during Total Intravenous Anesthesia (TIVA) with Propofol and Remifentanil TCI (Eleveld model) has not been investigate yet.
- Trial name
- NCT07259460
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Padova
ENT Disease
Analgesia Nociception Index Monitoring in Trigeminal Cardiac Reflex During Nasal Septoplasty
This study aims to evaluate the utility of Analgesia Nociception Index (ANI) monitoring as a predictive and preventive tool for TCR during septoplasty.
- Trial name
- ANI (NCT07435870)
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Fayoum University Hospital
Supratentorial Brain Tumor Surgery
FASt Track in Elective Neurosurgery: the Role of Low Propofol Bis-NOL Guided General Anaesthesia for Full, Early and Safe Awakening
To evaluate the effect of intraoperative sedation dosage on awakening and recovery of consciousness after elective neurosurgical surgery.
- Trial name
- FasTrack (NCT06844838)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Pediatric Patients, Orthopedic Surgery
Nociception Level Index as a Verbal Tool of Pain in Children
60 children under 6 years old, scheduled for orthopedic surgery for limb fracture or neuromuscular and bone deformities will be randomized by closed envelope method into two groups (n=30) either receiving standard pain management…
- Conditions
- Pediatric Patients, Orthopedic Surgery, Extremity Fractures Lower, Extremity Fractures Upper
- Trial name
- NCT05716243
- Testing
- The nociception level index monitorization, The nociception level index measurement;postoperative
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Haseki Training and Research Hospital