Clinical trials: Nociception Level Index(NoL)
Erector Spina Plan Block, Preemptive Analgesia
Comparison of the Effect of Preemptive and Post-operative Erector Spina Plane Block on Intraoperative Opioid Consumption and Postoperative Analgesia in Patients Who Will Undergo Elective Thoracotomy Surgery, Guided by the Nociception Level Index (NoL)
The patients who will participate in the study will be determined and informed according to the inclusion and exclusion criteria, and the patients who signed the informed consent form will be included in the study.52 patients who…
- Conditions
- Erector Spina Plan Block, Preemptive Analgesia, Thoracotomy, Nociception Level Index(NoL)
- Trial name
- NCT05944523
- Testing
- Erector Spina Plan Block
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Ankara University
Target Controlled Infusion, Intracranial Neoplasm
Comparison of Opioid Consumption During TCI Guided by NOL Index or Standard Care Undergoing Intracranial Tumor Surgery
In this prospective, randomized controlled study, we hypothesized that nociception level index monitoring reduced opioid administration during surgery.
- Conditions
- Target Controlled Infusion, Intracranial Neoplasm, Opioid, Nociceptive Pain
- Trial name
- NOLopioid (NCT05732896)
- Testing
- Nociception Leve Indeks
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Turkish Society of Anesthesiology and Reanimation
Elective Laparoscopic Cholecystectomy
"Impact of NOciception Level (NOL) Index Intraoperative Guidance of REmifentanil Administration on Opioid Consumption and QoR in Ambulatory Patients Undergoing LAparoscopic Cholecystectomy."
Background: Laparoscopic cholecystectomy is a common surgical procedure which constitutes the standard treatment for symptomatic gallbladder disease.
- Trial name
- NORELACs (NCT07810894)
- Testing
- Remifentanil titration based on Nociception Level Monitor, Remifetanil guided by vital parameters and clinical assessment
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Svendborg Hospital
Nociception During Anesthesia in Patients Taking β1-adrenergic Antagonist Chronic Treatment
Impact of Chronic Treatment by β1-adrenergic Antagonists on Nociceptive-Level (NOL) Index Variation After a Standardized Noxious Stimulus Under General Anesthesia
The aim of the present study is to investigate the effect of chronic treatment with β1-adrenergic antagonist on the NOL index variation, the heart rate variation and the mean blood pressure variation after a standardized noxious…
- Trial name
- BetaNOL (NCT04060095)
- Testing
- standardized noxious stimulus under general anesthesia.
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Pain, Anesthesia
Evaluation of the Nociception Guided by NoL Index and PK of Fentanyl in Pediatric Patients Under General Anesthesia
Fentanyl is one of the most common used opioids for analgesia during general anesthesia, however there are few studies that describe the relationship between its pharmacokinetics and pharmacodynamics, especially in the pediatric…
- Conditions
- Pain, Anesthesia, Pediatric ALL
- Trial name
- NoLPedFenta (NCT04786275)
- Testing
- Fentanyl, Tetanic stimulation
- Where
- Chile
- Volunteers
- 25 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Nociception, NOL Index
Nociception Monitoring During Cardiac Surgery
Cardiac surgery is frequently a source of acute or chronic pain. According to the International Association for the Study of Pain (IASP), nociception is defined as "the neural mechanisms of encoding and processing harmful…
- Conditions
- Nociception, NOL Index, Cardiac Surgery
- Trial name
- MoNOLcard (NCT06817005)
- Testing
- Intervention arm
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Nociceptive Pain, Anesthesia
Comparison of the Surgical Pleth Index and the Nociception Level Index in the Pediatric Population
This observational study aims to compare two nociception monitoring methods. The Nociception Level (NOL) index and the Surgical Pleth Index (SPI) in the pediatric population during general anesthesia.
- Conditions
- Nociceptive Pain, Anesthesia, Pediatric Anesthesia, Nociception Monitoring
- Trial name
- NOLvsSPI (NCT07084935)
- Testing
- Connecting all patients to the nociception level index(NOL) and the surgical pleth index (SPI), All patient will receive a tetanic stimuli (60mA, 100hz) of 5 seconds before start of incision
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Supratentorial Brain Tumor Surgery
FASt Track in Elective Neurosurgery: the Role of Low Propofol Bis-NOL Guided General Anaesthesia for Full, Early and Safe Awakening
To evaluate the effect of intraoperative sedation dosage on awakening and recovery of consciousness after elective neurosurgical surgery.
- Trial name
- FasTrack (NCT06844838)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Prostate Cancer, Pain Management
Effect of Rectus Block Timing on Opioid Use
The aim of this study is to observe the effect of administering local anesthetic to the abdominal wall at the beginning or end of surgery under general anesthesia on opioid consumption during surgery.
- Conditions
- Prostate Cancer, Pain Management, Nociception Level Index(NoL), Nociception Monitoring
- Trial name
- PROSTIMERSBOP (NCT07433140)
- Testing
- Early bilateral rectus sheat block, Late bilateral rectus sheat block
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Koc University Hospital
Pain, Acute, Nociceptive Pain
The Nociception Level (NOL) Index for Pain Assessment in the Adult Intensive Care Unit
Assessing pain in the adult intensive care unit (ICU) is challenging because many patients are unable to communicate due to mechanical ventilation and sedation.
- Conditions
- Pain, Acute, Nociceptive Pain, Behavior, Critical Illness
- Trial name
- NOL-ICU (NCT05339737)
- Testing
- Nociception Level (NOL) Index
- Volunteers
- 411 people
- Sponsor
- McGill University
Spine Surgery, Pain After Surgery
Impact of NOL - Nociception Level Index Intraoperative Monitoring on Perioperative Outcomes in Spine Surgery - a Quality Improvement Pilot
The objective of this study is to evaluate the clinical impact of the NOL nociception level index monitoring on intraoperative and post operative patient outcomes and institutional metrics when used to guide intraoperative…
- Conditions
- Spine Surgery, Pain After Surgery, Anesthesia , Analgesia
- Trial name
- NCT07608276
- Testing
- NOL guided intraoperative analgesia
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Medasense Biometrics Ltd
Anesthesia
NoL Index Response to Stimulation in Anesthetized Children
The Nociception Level (NoL) is an index obtained via a non-invasive monitor, that is currently used to assess nociception in anesthetized adults. The NoL index varies from 0 to 100.
- Trial name
- STIMNOL (NCT05233449)
- Testing
- NoL monitor, Stimulation
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Lille
Intraoperative Pain, Postoperative Pain
PECS-II vs ESP in Nociception Level Index Guided Breast Surgery
Background: Breast surgery is often associated with significant perioperative pain. While systemic opioids are commonly used, their side effects (nausea, vomiting, respiratory depression, delayed recovery) have encouraged the…
- Trial name
- NOL (NCT07002541)
- Testing
- PECS II block, ESP block
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Koç University
Supratentorial Brain Tumor
Comparison of the Analgesic Effects of Scalp Nerve Block and Intravenous Ibuprofen Applications Under the Guidance of Nociception Level Index (NoL) in Patients Undergoing Elective Supratentorial Craniotomy
Introduction: Scalp incision is a powerful nociceptive stimulus that can exacerbate rapid changes in hemodynamic and sympathetic activity.
- Trial name
- NCT05763836
- Testing
- Ibuprofen 800 Mg in 8 mL INTRAVENOUS INJECTION [Caldolor], Scalp nerve block
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Ankara University
Intraoperative Analgesia
NOL Guided Analgesia During Elective Laparoscopic Surgery Under General Anesthesia
The aim of this study is to investigate the hypothesis that the intraoperative use of the nociception level index NOL can reduce opioid consumption in adult patients undergoing elective laparoscopic surgeries under general…
- Trial name
- NOLGADELS (NCT06104059)
- Testing
- Nociception level index (NOL™), Fentanyl
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Attikon Hospital
Critical Illness
Pupillometry and Nociception Level Index for the Evaluation of Pain in Intensive Care Unit.
Pain is a frequent symptom in the intensive care unit (ICU). Critical ill patients are often intubated and sedated which makes self-evaluation of pain impossible.
- Trial name
- NOCI-ICU (NCT05469841)
- Testing
- Systemic pain assessment
- Where
- 2 sites in France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Labor Pain, Nociceptive Pain
Nociception Level Index (NOL Index) for Obstetrical Pain Assessment Under Epidural Analgesia.
Pain has been defined by the International Association for the Study of Pain (IASP) as "an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage".
- Conditions
- Labor Pain, Nociceptive Pain, Epidural Analgesia, NOL Index
- Trial name
- NCT05898737
- Testing
- NOL-Index
- Where
- Belgium
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Pain
The Medasense Study
Despite various efforts there is still the need for adequate monitoring of pain and nociception during anesthesia. In a previous protocol the investigators measured pain responses during anesthesia based on single end-points, eg…
- Trial name
- NCT01912118
- Testing
- Propofol, Remifentanil
- Where
- Netherlands
- Volunteers
- 96 people
- Sponsor
- Leiden University Medical Center
Cesarean Section, Postoperative Pain After Cesarean Section
Nociception Level Index Monitoring During Cesarean Section
This prospective randomized controlled trial evaluated the effect of nociception level (NOL) index-guided intraoperative analgesia on postoperative pain management in patients undergoing elective cesarean section under general…
- Conditions
- Cesarean Section, Postoperative Pain After Cesarean Section, Pain Management
- Trial name
- NOL-CS (NCT07720440)
- Testing
- Nociception Level Index Monitoring, Standard Intraoperative Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istinye University
Regional Anesthesia, Pain
Nociception Index Level (NOL) Perioperative Monitoring During Regional Anesthesia
This prospective observational study was conducted to assess pain using NOL index under locoregional anesthesia for orthopedic surgery of the upper limb.
- Conditions
- Regional Anesthesia, Pain, Intraoperative Monitoring
- Trial name
- NOL and LRA (NCT06300606)
- Testing
- NOL monitoring
- Where
- France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- American Hospital of Paris