Clinical trials: Nociception Monitoring
Anesthesia
Comparison of Different Analgesia-Monitors in Tracing Unconscious Pain Sensations
Until today there is no standard-monitoring to specifically reflect the analgesic component of general anesthesia. Quality and safety of general anesthesia are of major clinical importance and can be improved by limiting the…
- Trial name
- AMUPS (NCT02429960)
- Testing
- Analgesia monitor (PhysioDoloris®), Analgesia monitor (SPI®), Analgesia monitor (AlgiScan®)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Intraoperative Monitoring
The Effect of SPI (Surgical Pleth Index) - Guided Anaesthesia on Opioid Consumption in Gastric Sleeve Surgery
This is a unicentric, prospective randomised trial that aims to evaluate the role of intra-operative monitoring of nociception through SPI (Surgical Pleth Index) in guiding analgesia and reducing opioid consumption in obese…
- Trial name
- NCT05884229
- Testing
- Intra-operative analgesia guided by SPI
- Where
- Romania
- Volunteers
- 40 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Cesarean Section, Postoperative Pain After Cesarean Section
Nociception Level Index Monitoring During Cesarean Section
This prospective randomized controlled trial evaluated the effect of nociception level (NOL) index-guided intraoperative analgesia on postoperative pain management in patients undergoing elective cesarean section under general…
- Conditions
- Cesarean Section, Postoperative Pain After Cesarean Section, Pain Management
- Trial name
- NOL-CS (NCT07720440)
- Testing
- Nociception Level Index Monitoring, Standard Intraoperative Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istinye University
Pain
Validation of a Nociception Monitor in Healthy Volunteers
Anesthesiology daily practice consists in management of sedation, immobility and analgesia. The monitoring of this last component remains largely based on indirect signs with poor sensitivity and specificity such as heart rate…
- Trial name
- NCT02589093
- Testing
- Stimulation
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Maisonneuve-Rosemont Hospital
Rapide Sequence Induction, Tracheal Intubation
Pain Assessment During Rapid Sequence Induction
Rapid sequence induction (RSI) is a standard anesthesia technique used in patients at risk of aspiration. Although tracheal intubation following RSI is a frequent and painful procedure, no study has yet evaluated nociception…
- Conditions
- Rapide Sequence Induction, Tracheal Intubation, Nociception, General Anesthesia
- Trial name
- NARSI (NCT07588165)
- Testing
- No Intervention: Observational Cohort
- Where
- Monaco
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Princesse Grace
Regional Anesthesia, Pain
Nociception Index Level (NOL) Perioperative Monitoring During Regional Anesthesia
This prospective observational study was conducted to assess pain using NOL index under locoregional anesthesia for orthopedic surgery of the upper limb.
- Conditions
- Regional Anesthesia, Pain, Intraoperative Monitoring
- Trial name
- NOL and LRA (NCT06300606)
- Testing
- NOL monitoring
- Where
- France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- American Hospital of Paris
Stress Related Disorder, Pain
Analgesia Nociception Index for Pain Monitoring in Intensive Care Units
The aim of this study is to examine the usability of ANI in patients who will be treated in intensive care unit.
- Conditions
- Stress Related Disorder, Pain, Intensive Care Unit Syndrome
- Trial name
- NCT05313789
- Testing
- Analgesia Nociception Index (ANI)
- Volunteers
- 180 people
- Sponsor
- İstanbul Yeni Yüzyıl Üniversitesi
Pain, Acute, Anesthesia
Pupillary Dilation Reflex Assessment for Intraoperative Analgesic Titration.
In this double blinded randomized controlled study, the pupillary dilation reflex is used for as a nociceptive indicator for opioid administration during elective surgery under general anesthesia.
- Trial name
- PUP-AIT (NCT03248908)
- Testing
- Pupillary dilation reflex, Standard of care
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- University Hospital, Antwerp
Intensive Care, Surgical, Anesthesia, General
Nociception Level Index as Monitorization of Pain at the Intensive Care
The aim of our study is to evaluate the effectiveness of a nociception monitor in providing adequate postoperative analgesia for patients needing critical care after surgery.
- Trial name
- NCT05762666
- Testing
- nociception level index monitor
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Haseki Training and Research Hospital
Nociceptive Pain, Anesthesia
Comparison of the Skin Conductance Algesimeter and the Nociception Level Index in the Paediatric Population. An Observational Study.
Evaluation and comparison of the skin conductance algesimeter(SCA) and the nociception level index(NOL) in the paediatric population (1-12 years) during surgery with general anaesthesia with bispectral index(BIS) in a tertiary…
- Conditions
- Nociceptive Pain, Anesthesia, Pain
- Trial name
- NOLvsSCA (NCT05998564)
- Testing
- Connecting patients to both non-invasive monitors to observe and compare the monitor's capabilities.
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Radboud University Medical Center
Nociceptive Pain, Surgical Procedure, Unspecified
Monitoring Analgesia by ANI (Analgesia The Nociception Index)
The objective of this research is to study the variations of the ANI(Analgesia The Nociception Index) according to 2 periods: the "NoStim" period before surgical incision under general anesthesia and the period of hemodynamic…
- Trial name
- ANI-MICI (NCT03749304)
- Testing
- ANI monitor
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Lille
Analgesia, Nociceptive Pain
Effect of ANI on Intraoperative Opioid Consumption
The aim of the study is to compare the analgesic nociception index (ANI), which is used to determine the dose of analgesic agent needed in the intraoperative period, with the conventional method in patients with erector spinae…
- Conditions
- Analgesia, Nociceptive Pain, Nerve Block, Pain
- Trial name
- NCT05106452
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
Intraoperative Complications, Intraoperative Hypotension
The Use of Surgical Pleth Index in Guiding Anesthesia in Gastroenterological Surgery
Surgical Pleth Index (SPI) is an intraoperative monitor aimed into detection of nociception and guidance of intraoperative opioid administration.
- Conditions
- Intraoperative Complications, Intraoperative Hypotension, Intraoperative Hypertension
- Trial name
- NCT04519203
- Testing
- SPI, Standard
- Where
- Finland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Pain
BIS and Entropy Nociception Monitoring
Reports have been appearing in literature over the past years of various nociception-antinociception monitors, introduced and promoted from major manufactures.
- Trial name
- BIS4 (NCT02585466)
- Volunteers
- 50 people
- Sponsor
- Medical University of Graz
Nociceptive Pain, Pain, Postoperative
Guiding Opioid Administration by Nociception Level Index (NOL) in Patients With Regional Anesthesia
General anesthesia consists of a combination of hypnotic drugs to achieve unconsciousness and opioid analgesics to ensure antinociception.
- Conditions
- Nociceptive Pain, Pain, Postoperative, Analgesia, Postoperative, Anesthesia Recovery Period
- Trial name
- NORA (NCT06905340)
- Testing
- NOL (Nociception Level Index), Control (Standard treatment)
- Where
- Germany
- Volunteers
- 240 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Post Operative Pain, Opioid Use
The Effect of Nociception Level (NOL) Monitoring on Intraoperative Opioid Consumption in Hip Surgeries
Hip surgeries are one of the most painful surgical operations, and inadequate pain management increases postoperative morbidity and mortality.The incidence of chronic pain after hip surgery is quite high, at 11-40%.For this…
- Trial name
- NCT06558149
- Testing
- Those whose opioids were adjusted according to hemodynamic parameters, Those whose opioids were adjusted according to NOL monitoring
- Volunteers
- 60 people
- Sponsor
- Kocaeli University
Ovarian Neoplasm
Impact of Specific Monitoring of Intraoperative Analgesia Under General Anesthesia on Chronic Pain After Ovarian Cancer Surgery
This is a single-center, randomized, phase II, non-comparative, single-blind clinical study that will determine whether morphine reduction through intraoperative monitoring by ANI (Analgesia Nociception Index) significantly…
- Trial name
- MONIALC (NCT04906187)
- Testing
- Arm A : intraoperative ANI monitoring of nociception, Arm B : no specific monitoring of nociception
- Where
- France
- Volunteers
- 126 people
- Sponsor
- Institut Bergonié
Unconscious State, Pressure Ulcer
Nociception Monitoring in Intensive Care
Precisely, pain in the ICU is a multidimensional problem with a multivariate of reasons. Still, it would be simpler to manage it in unconscious palliative patients with less source of pain, but only if we can detect it…
- Trial name
- NCT06270264
- Testing
- the Nociception level index monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Haseki Training and Research Hospital
Cesarean Delivery
An Observational Study Measuring in a Non-invasive Approach the Nociception Level Index and Its Association With Pain and Anxieiy Perception Evaluated by Questionnaires, in Awake Women During Elective Cesarean Delivery Under Spinal Anesthesiaanxiety
The Nociception Level (NOL) Index is a multiparametric, non-invasive monitor that objectively assesses nociception by integrating several autonomic physiological signals.
- Trial name
- NCT07726316
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Michael Grach
Pain
Evaluation of NoL Index and ANI After Nociceptive Stimulation at Different Infusion Rates of Remifentanil Infusion
Contrary to "immobility" and, to a lesser extent, to the "hypnosis/unconsciousness" component of general anaesthesia, the monitoring of "analgesia" remains largely elusive, evaluated mainly through poorly sensitive and…
- Trial name
- NCT02602379
- Testing
- Tetanic stimulation
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Maisonneuve-Rosemont Hospital