Clinical trials: Nociceptive Pain, open to volunteers
Nociceptive Pain, Pain, Postoperative
Guiding Opioid Administration by Nociception Level Index (NOL) in Patients With Regional Anesthesia
General anesthesia consists of a combination of hypnotic drugs to achieve unconsciousness and opioid analgesics to ensure antinociception.
- Conditions
- Nociceptive Pain, Pain, Postoperative, Analgesia, Postoperative, Anesthesia Recovery Period
- Trial name
- NORA (NCT06905340)
- Testing
- NOL (Nociception Level Index), Control (Standard treatment)
- Where
- Germany
- Volunteers
- 240 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Nociceptive Pain, Axial Back Pain
Ultra Low Frequency Neuromodulation for Nociceptive Chronic Low Back Pain
The goal of this clinical trial is to learn if Ultra Low Frequency (ULF) neuromodulation works to treat nociceptive chronic low back pain in adults. It will also evaluate the safety of ULF therapy.
- Trial name
- NCT06763653
- Testing
- ULF therapy, CMM
- Where
- 3 sites in Australia
- Volunteers
- 303 people
- Sponsor
- Presidio Medical, Inc
Nerve Pain, Neuropathic Pain
PETMRI for Chronic Pain from Spinal or Peripheral Nerve Origin
The purpose of this study is to compare the uptake of [18F]FTC-146 in healthy volunteers to that of individuals suffering from chronic pain with Spinal or Peripheral Nerve Origin.
- Conditions
- Nerve Pain, Neuropathic Pain, Nociceptive Pain, MIxed Pain (Nociceptive and Neuropathic)
- Trial name
- NCT06599151
- Testing
- [18F]FTC-146
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Stanford University
Gastroparesis, Chronic Abdominal Pain
Gastric Electrical Stimulation for Abdominal Pain in Patients With Gastroparesis
Gastroparesis is a disorder characterized by delayed gastric emptying and symptoms including nausea, vomiting, and abdominal pain.
- Trial name
- HEAL (NCT07556237)
- Testing
- Enterra™ neurostimulator
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Louisville
Dysmenorrhea, Dysmenorrhea Primary
A Research Study Exploring How Musculoskeletal Function and the Autonomic Nervous System Relate to Visceral Pain in Women With and Without Dysmenorrhea (Painful Periods).
The purpose of this clinical trial is to determine if women with dysmenorrhea demonstrate an increased musculoskeletal and autonomic nervous system response to a painful visceral stimulus compared to controls.
- Conditions
- Dysmenorrhea, Dysmenorrhea Primary, Visceral Pain, Menstrual Pain
- Trial name
- NCT07209566
- Testing
- Visceral Pain Stimulus
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Azusa Pacific University
Migraine, Musculoskeletal Pain
Overlapping Pain Trajectory Study
The goal of this observational study is to learn about spatial and temporal nociceptive filtering in adolescents with chronic overlapping pain conditions (COPCs). The main questions it aims to answer are: 1.
- Conditions
- Migraine, Musculoskeletal Pain, Functional Abdominal Pain Disorders, Chronic Pain
- Trial name
- COPC (NCT05752396)
- Testing
- Conditioned Pain Modulation, Offset Analgesia, Spatial Summation
- Where
- United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cesarean Section (MeSH: D002585), Anesthesia
Evaluation of Consciousness Depth (qCON) and Analgesia Depth (qNOX) Indices in General Anesthesia
Objective: This prospective, single-center, observational clinical study aims to evaluate changes in qCON (hypnotic depth), qNOX (nociception/analgesia depth), EMG, and other parameters in patients undergoing elective cesarean…
- Conditions
- Cesarean Section (MeSH: D002585), Anesthesia, Intraoperative Awareness, Analgesia
- Trial name
- NCT07887919
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Kudret Dogru
Abdominal Pain
Objective Integrated Multimodal Electrophysiological Index for the Quantification of Visceral Pain
The objectives of the study are to 1) Conduct telemetric biosignals (EDA, ECG, and EMG) recording in healthy controls and IBS participants experiencing cutaneous and visceral pain; and 2) Validate the OIME index as a biomarker…
- Trial name
- OIME (NCT06381921)
- Testing
- IBS-PPSM intervention
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Visceral Pain, Analgesia
Intraoperative Autonomic Blockade for Laparoscopic Cholecystectomy
This study proposes infiltrating the hepatoduodenal ligament and the serosal reflection of the gallbladder cystic plate with a combination of Bupivacaine (a long-acting local anesthetic) and Dexamethasone (a corticosteroid).
- Conditions
- Visceral Pain, Analgesia, Opioid Use, Postoperative Nausea
- Trial name
- ANB (NCT06753500)
- Testing
- Autonomic neural blockade
- Where
- 2 sites in Colombia
- Volunteers
- 60 people
- Sponsor
- Universidad Simón Bolívar
Pain, Gender Identity
State of Hormones Impact Nociceptive Expression
The Investigators have recently published on differences in pain sensitivity measures between cis and trans individuals in the local area.
- Trial name
- SHINE (NCT05787470)
- Testing
- Quantative sensory testing, Blood Draw
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Postoperative Pain
Preventive Analgesia With Anrikefon in Laparoscopic Cholecystectomy
This study will determine the optimal timing for Anrikefon administration. It will also assess the quality of patient recovery. Laparoscopic cholecystectomy (LC) is a routine surgical procedure.
- Trial name
- ANIPAP (NCT07566663)
- Testing
- Anrikefon for Preventive Analgesia, Anrikefon for bridging analgesia
- Where
- China
- Volunteers
- 274 people
- Sponsor
- Xuanwu Hospital, Beijing
Monitoring Noxious Events Using EEG-Derived Pain Indices, Procedural Sedation and Analgesia
qNOX Response to Nociceptive Motor Events During Procedural Sedation
The goal of this observational study is to evaluate whether the CONOX monitor can detect pain during sedation in patients undergoing urological procedures.
- Conditions
- Monitoring Noxious Events Using EEG-Derived Pain Indices, Procedural Sedation and Analgesia, Monitored Anesthesia Care
- Trial name
- MO-NOX (NCT07413848)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ankara University
Laparoscopic Surgery, Visceral Pain, Postoperative
Anrikefon-based Patient-controlled Intravenous Analgesia Following Laparoscopic Surgery
Visceral pain following laparoscopic surgery is frequently underestimated, yet it is associated with a range of adverse outcomes.
- Conditions
- Laparoscopic Surgery, Visceral Pain, Postoperative, Anrikefon, Patient-controlled Intravenous Analgesia
- Trial name
- NCT07525986
- Testing
- High-dose anrikefon, Medium-dose anrikefon, Low-dose anrikefon
- Where
- 4 sites in China
- Volunteers
- 140 people
- Sponsor
- Peking University First Hospital
Chronic Pain, Mixed Pain (Nociceptive and Neuropathic)
S1R Imaging-Based Cryoneurolysis in Chronic Pain
The goal of this clinical trial is to determine whether a sigma-1 receptor PET/MRI scan can help identify the specific nerves responsible for chronic pain.
- Trial name
- NCT07768501
- Testing
- [18F]-FTC-146
- Volunteers
- 6 people
- Sponsor
- Davidzon, Guido, M.D.
Pain, Acute Post-Operative, Dexmedetomidine
Esmolol Versus Dexmedetomidine for Opioid-sparing in Laparoscopic Gynecological Surgery
The aim of this study is to investigate and compare the effects of a continuous infusion of low-dose esmolol and dexmedetomidine versus placebo on intraoperative and postoperative opioid consumption and analgesic efficacy in…
- Conditions
- Pain, Acute Post-Operative, Dexmedetomidine, Analgesia, Esmolol
- Trial name
- NCT07846722
- Testing
- Esmolol hydrochloride, Dexmedetomidine, Normal (0.9%) saline
- Where
- Greece
- Volunteers
- 90 people
- Sponsor
- Vasiliki Samartzi
Cancer Pain, Visceral Pain
Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes
Patients with digestive tract malignancy often experience severe and unremitting abdominal pain that negatively affects physical, emotional, and social function, as well as health related quality of life (HRQOL).
- Conditions
- Cancer Pain, Visceral Pain, Gastrointestinal Neoplasms, Cancer of Gastrointestinal Tract
- Trial name
- NCT04907643
- Testing
- PICO G2 4k
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Cedars-Sinai Medical Center
Nociceptive Pain, Neuropathic Pain
Unveiling Physiological and Psychosocial Pain Components with an Artificial Intelligence Based Telemonitoring Tool
The pAIn-sense study aims to revolutionize the monitoring and treatment of chronic pain, a major health concern that significantly impacts psychological well-being and quality of life.
- Trial name
- pAIn-sense (NCT06044584)
- Testing
- No intervention
- Where
- 4 sites in Italy, Switzerland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- ETH Zurich
Knee Osteoarthritis
Neurofeedback for Pain Sensitization in Knee Osteoarthritis
The goal of this clinical trial is to learn whether a training method called neurofeedback is safe and practical to use in people with knee osteoarthritis (knee OA).
- Trial name
- NCT07832682
- Testing
- FWR Down-Conditioning Neurofeedback
- Volunteers
- 50 people
- Sponsor
- Northeastern University
Obese Patients, Bariatric Surgical Pain
Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy
Regional anesthesia is a technique in which a local anesthetic is injected near a nerve or spinal cord to block sensation, motor stimulation, and pain.
- Conditions
- Obese Patients, Bariatric Surgical Pain, Bariatric Surgery (Sleeve Gastrectomy ), Non-Opioid Pain Management
- Trial name
- NCT07084753
- Testing
- Levobupivacaine, Dexamethasone contained in the solution for thoracic paravertebral block, Adrenaline
- Where
- Croatia
- Volunteers
- 36 people
- Sponsor
- IVO JURISIC
Bone Marrow Aspiration, Pain
Visual and Auditory Distraction for the Relief of Pain and Anxiety
Bone marrow (BM) examinations are performed in diagnostic workup of malignancies, in particular hematological diseases, and are frequently associated with significant pain, distress, and anxiety.
- Conditions
- Bone Marrow Aspiration, Pain, Anxiety, Hematologic Diseases
- Trial name
- NCT07023692
- Testing
- Distraction with VR (Virtual Reality) headsets
- Where
- Sweden
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Region Skane