Clinical trials: Non Invasive Positive Pressure Ventilation
Bronchopulmonary Dysplasia
Study of Nasal Ventilation In Preterm Infants To Decrease Time on The Respirator
Very premature infants often cannot breathe on their own and require assistance with a respirator. Conventional respirators deliver air or oxygen via a breathing tube placed through the mouth to the airway (endotracheal tube).
- Trial name
- NCT01440647
- Testing
- Extubation to NIPPV, Extubation to CPAP
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Women and Infants Hospital of Rhode Island
De Novo Hypoxemic Acute Respiratory Failure (hARF)
Impact on Mortality of a Strategy Including Continuous Positive Airway Pressure Plus High Flow Nasal Cannula Oxygen Therapy Versus High Flow Nasal Cannula Oxygen Therapy Alone in Patients With de Novo Acute Hypoxemic Respiratory Failure: a Prospective, Randomized Controlled Trial.
De novo hypoxemic acute respiratory failure (hARF) is one of the main causes of intensive care unit (ICU) admission. In de novo hARF, intubation is associated with a dramatic increase in mortality rate.
- Trial name
- HighCPAP (NCT06213168)
- Testing
- HFNC, CPAP and HFNC
- Where
- 29 sites in France
- Volunteers
- 1,084 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Type II Respiratory Failure, Hypercapnic Respiratory Failure
Post-Extubation High-Flow Nasal Cannula Versus Non-Invasive Ventilation in Type II Respiratory Failure
Acute hypercapnic respiratory failure is characterized by elevated arterial carbon dioxide levels and commonly occurs in patients with chronic respiratory diseases.
- Trial name
- NCT06918288
- Testing
- High-Flow Nasal Cannula (HFNC), Non-Invasive Ventilation (NIV)
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Benha University
Acute Cardiogenic Pulmonary Edema
Helmet CPAP vs Facemask CPAP in ACPE (hCPAP vs fCPAP)
This study objectively held to compare the physiological outcomes in the non-invasive (NIV) treatment of Acute Cardiogenic Pulmonary Edema (ACPE) patients in the Emergency Department (ED) delivered by helmet CPAP (hCPAP) and…
- Trial name
- NCT04014088
- Testing
- hCPAP vs fCPAP
- Volunteers
- 164 people
- Sponsor
- Hospital Raja Permaisuri Bainun
Preoxygenation, Non Invasive Ventilation
Preoxygenation Method With a Calibrated Leak
During preoxygenation, imperfect seal between the face mask and patient's face can induce an inward air leak decreasing its effectiveness. We assume that noninvasive ventilation could cancel the effect of the leak.
- Trial name
- NCT03087825
- Testing
- preoxygenation without inward leak, preoxygenation with inward leak
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Non-Invasive Positive-Pressure Ventilation
Impact of Neurally Adjusted Ventilator Assist (NAVA) Mode on Patient Ventilator Asynchrony Using Helmet
Non invasive ventilation has been proposed to reduce the incidence of ventilatory dysfunction following abdominal aortic surgery.
- Trial name
- NAVAHELMET (NCT01161875)
- Testing
- Neurally Adjusted Ventilatory Assistance
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Pierre and Marie Curie University
Covid19
Early Use of Hyperimmune Plasma in COVID-19
The study assesses the efficacy of early administration of hyperimmune plasma in covid-19 patients who are on CPAP or intubated. Efficacy is measured as a 2 point decrease in the WHO scale
- Trial name
- COV-II-PLA (NCT04721236)
- Testing
- hyperimmune plasma
- Where
- Italy
- Volunteers
- 260 people
- Sponsor
- Catherine Klersy
Sleep, Cerebral Oxygenation
Respiratory Support and Brain Health in Preterm Infants
Premature babies often require breathing support during their neonatal intensive care unit stay. This is because their lungs are not fully developed to perform the work of breathing on their own.
- Trial name
- NCT05589831
- Testing
- Non-invasive Neurally Adjusted Ventilatory Assist
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Mount Sinai Hospital, Canada
Neonatal Respiratory Failure
A Study of Bi-Level Positive Airway Pressure (BIPAP) Versus Non Invasive Positive Pressure Ventilation (NIPPV) for Neonatal Respiratory Failure
To research the effect of Bi-Level Positive Airway Pressure (BiPAP) for neonatal respiratory failure.
- Trial name
- BIPAP (NCT01318824)
- Testing
- Nasal Intermittent Positive Pressure Ventilation (NIPPV), Bi-Level Positive Airway Pressure (BIPAP)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Chronic Obstructive Pulmonary Disease
Effects of Non-invasive Ventilation on Respiratory Mechanics and NRD in Patients With Stable COPD
Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease characterized by persistent respiratory symptoms and airflow limitation.
- Trial name
- NCT03555097
- Testing
- incremental pressure support
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Zhujiang Hospital
Neonatal Respiratory Distress Syndrome, Prematurity
Breathing Variability and NAVA in Neonates
The current study is a crossover trial, aiming at evaluating the effect of NAVA -NIV compared to Nasal Intermittent Positive Pressure Ventilation (PC-NIV) at the same level of peak inspiratory pressure, in terms of…
- Trial name
- BRAVe NANO (NCT04000568)
- Testing
- Respiratory support: NAVA -NIV and PC-NIV
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Pulmonary Disease, Chronic Obstructive, Hypercapnia
Adaptive Non-invasive Ventilation to Abolish Tidal Flow Limitation
This study aimed to evaluate the effects of a novel automatic non-invasive ventilation (NIV) mode that continuously adjusts expiratory positive airway pressure (EPAP) to the lowest value that abolishes tidal expiratory flow…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Hypercapnia, Ventilator Lung
- Trial name
- NCT04497090
- Testing
- fixed-EPAP, auto-EPAP
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- Politecnico di Milano
Acute Respiratory Failure
Third International Study on Mechanical Ventilation
The objective of this study is to obtain a better understanding of the spectrum of use of mechanical ventilation in intensive care units: 1.
- Trial name
- ISMV (NCT01093482)
- Where
- 477 sites in United States, Argentina and 36 more
- Volunteers
- 8,151 people
- Sponsor
- Hospital Universitario Getafe
Hypoxia, Respiratory Acidosis
FIRST-line Support for Assistance in Breathing in Children (FIRST-ABC) Feasibility Study
A feasibility study to inform the design and conduct of a randomised controlled trial of high flow nasal cannula (HFNC) versus continuous positive airway pressure (CPAP) for non-invasive respiratory support in critically ill…
- Conditions
- Hypoxia, Respiratory Acidosis, Moderate/Severe Respiratory Distress
- Trial name
- FIRST-ABC (NCT02612415)
- Testing
- Treatment strategy: Non-invasive respiratory support delivered via high flow nasal cannula, Treatment strategy: Non-invasive respiratory support delivered via continuous positive airway pressure
- Where
- 3 sites in United Kingdom
- Volunteers
- 121 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Respiratory Insufficiency
Brain Natriuretic Peptide (BNP) Levels in Patients in Non Invasive Mechanical Ventilation
The purpose of the study is to evaluate variation of BNP in non invasive mechanical ventilated patients with severe acute respiratory failure.
- Trial name
- NCT00453726
- Testing
- Non invasive mechanical ventilation
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Ospedale S. Giovanni Bosco
Infant,Premature, Respiratory Failure
Nasal High-frequency Jet Ventilation (nHFJV) Following Extubation in Preterm Infants
Very low birth weight infants are at increased risk of requiring prolonged duration of mechanical ventilation and multiple intubations, both of which are risk factors for ventilator-induced lung injury and BPD.
- Conditions
- Infant,Premature, Respiratory Failure, Respiratory Insufficiency, Respiratory Distress Syndrome in Premature Infant
- Trial name
- NCT03558737
- Testing
- Nasal high-frequency jet ventilation (nHFJV), Nasal intermittent positive pressure ventilation (NIPPV)
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- University of Utah
Chronic Obstructive Pulmonary Disease (COPD)
High Intensity Non-Invasive Positive Pressure Ventilation (HINPPV)
The purpose of this pilot study is to evaluate the effect of high intensity non-invasive positive pressure ventilation (HINPPV) for stable, hypercapnic COPD patients.
- Trial name
- HINPPV (NCT01214200)
- Testing
- Bilevel positive airway pressure (BiPAP)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Philips Respironics
BPD - Bronchopulmonary Dysplasia
Randomized Control Trial: Synchronized Non-invasive Positive Pressure Ventilation Versus Non Synchronized Non Invasive Positive Pressure Ventilation in Extremely Low Birth Weight Infants
Infants delivered weighing less than 1 kg at birth (ELBW) are at high risk for the development of bronchopulmonary dysplasia (BPD) and Ventilator-Induced Lung Injury (VILI), in part because of the need for mechanical ventilation…
- Trial name
- NCT03613987
- Testing
- NAVA technology to synchronize NIPPV
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- New York Medical College
Neuromuscular Disease
Long-Term Effect of LIAM on Respiratory Performance in NIV Patients Suffering From Neuromuscular Disease
The long-term effect of LIAM (Lung Insufflation Assist Maneuver) on respiratory performance in home non-invasively ventilated (NIV) patients suffering from neuromuscular disease will be assessed in a prospective, randomized…
- Trial name
- LIAM (NCT02288299)
- Testing
- non invasive mechanical ventilation
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Drowning
Drowning-related Acute Respiratory Failure
The purpose of this study is to assess the Non-Invasive Ventilation-Continuous Positive Airway Pressure efficacy (experimental group) for drowning related Acute Respiratory Failure compared to Oxygen Supply by face mask…
- Trial name
- CPAPDROWNING (NCT06183827)
- Testing
- Emergency Medical Service intervention : Oxygen Supply strategy, Emergency Medical Service intervention : Continuous Positive Airway Pressure strategy
- Where
- 9 sites in France
- Volunteers
- 210 people
- Sponsor
- Assistance Publique Hopitaux De Marseille