Clinical trials: Non Invasive Ventilation (NIV)
Non-invasive Ventilation, High-frequency Ventilation
Evaluation of Prolonged Apnea Supported by High Frequency Non-invasive Ventilation.
The purpose of the study is to assess the efficacy of high-frequency non-invasive ventilation on apnea duration, carbon dioxide clearance and oxygen delivery in healthy subjets and patients with lung disease.
- Conditions
- Non-invasive Ventilation, High-frequency Ventilation, Healthy Volunteer, Lung Diseases
- Trial name
- ANIV (NCT02712190)
- Testing
- High-frequency non-invasive ventilation
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Care
Effect of Care Package on Duration of Stay and Physiological Parameters in Non-invasive Mechanical Ventilation
Temporary tachypnea of the newborn can be improved with minimal respiratory support and nursing care given to babies within the first 72 hours of life.
- Trial name
- NCT06189989
- Testing
- The group to which a care package was applied in addition to the clinical routine care protocol)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Okan University
Neonates, Respiratory Distress
Non-invasive Secondary Respiratory Support in Late Preterm and Term Infants
The aim of the present work is to compare between various modes of non-invasive respiratory support (including NCPAP, NIPPV, and NHFOV) as secondary respiratory support modes in late preterm and term neonates as regards the need…
- Conditions
- Neonates, Respiratory Distress, Non- Invasive Ventilation
- Trial name
- NCT07000071
- Testing
- NCPAP, NIPPV, NHFOV
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Diaphragm Issues, Respiratory Failure With Hypoxia
Ultrasonographic Evaluation of the Diaphragm During NHF Versus NIV Use in Respiratory Failure
This study will describe influence of NHF or NIV to different ultrasonographic parameters of the diaphragm. Therefor subjects will be randomized to the sequence NHF and than NIV or NIV and than NHF.
- Conditions
- Diaphragm Issues, Respiratory Failure With Hypoxia, Respiratory Failure With Hypercapnia, Non-invasive Mechanical Ventilation
- Trial name
- SENNI (NCT04962568)
- Testing
- DTEE, DTEI, DEx
- Where
- Germany
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Jens Bräunlich
Chronic Obstructive Pulmonary Disease, Sleep Related Hypoventilation
Health Outcomes With CPAP or NIV in Patients With COPD and a Sleep Related Breathing Disorder
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease affecting an estimated 1 in 10 Canadians. Symptoms include persistent shortness of breath, cough and sputum production.
- Conditions
- Chronic Obstructive Pulmonary Disease, Sleep Related Hypoventilation, Obstructive Sleep Apnea, Hypoventilation
- Trial name
- NCT05623709
- Testing
- Positive airway pressure with continuous positive airway pressure or noninvasive ventilation
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Infant, Newborn, Diseases, Intubation Complication
Noninvasive Positive Pressure Ventilation During Neonatal Nasal Intubation
The goal of this study is to perform a quality control assessment of our local intubation protocol in any newborn infant requiring endotracheal intubation in the delivery room or neonatal intensive care unit at the Department of…
- Trial name
- IntubAID (NCT06139809)
- Testing
- Intubation
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Acute Respiratory Failure
METEOR Think NIV Pilot
This study will pilot test three strategies designed to speed implementation of preventive post-extubation noninvasive ventilation (NIV): one control strategy (traditional online continuing medical education) and two novel…
- Trial name
- NCT04052542
- Testing
- Traditional online continuing education, Interprofessional education, Just-in-time education
- Where
- United States
- Volunteers
- 1,328 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Non-invasive Ventilation, High-frequency Ventilation
MRI of the Chest Under High Frequency Ventilation
The purpose of the study is to evaluate the benefit on image quality of MRI of the chest performed under high frequency non-invasive ventilation.
- Conditions
- Non-invasive Ventilation, High-frequency Ventilation, Healthy Volunteer
- Trial name
- NCT02973373
- Testing
- MRI with High-frequency non-invasive ventilation, MRI without High-frequency non-invasive ventilation
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Healthy Volunteers
Examining the Effects of Nasal High Flow Oxygen Therapy Compared to Non-invasive Ventilation in Health Volunteers
Respiratory failure is characterized by low levels of oxygen and high levels of carbon dioxide in the blood which causes difficulty breathing.
- Trial name
- NCT03902639
- Testing
- Phase 1 and 2, Phase 3
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Haemodynamic Rebound
Hemodynamic Repercussions of Noninvasive Ventilation
The noninvasive ventilation (NIV) is a method of ventilatory support that does not require artificial airway. Its application is associated with complex hemodynamic repercussions, therefore is important to identify them for…
- Trial name
- NCT02139631
- Testing
- Noninvasive ventilation
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Federal University of Uberlandia
Chronic Obstructive Pulmonary Disease, Pulmonary Rehabilitation
Effects of Nocturnal Non-invasive Ventilation on Energy Expenditure in Patients With Severe Chronic Obstructive Pulmonary Disease
It has been shown, that in patients with very severe chronic obstructive pulmonary disease (COPD) the additional use of non-invasive ventilation during pulmonary rehabilitation (PR) may enhance the benefits of PR.
- Conditions
- Chronic Obstructive Pulmonary Disease, Pulmonary Rehabilitation, Non-invasive Ventilation, Energy Expenditure
- Trial name
- NCT01961245
- Testing
- nocturnal non-invasive ventilation
- Where
- Germany
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Schön Klinik Berchtesgadener Land
Healthy
Non-invasive Neurally Adjusted Ventilatory Assist in Healthy Volunteers
Neurally adjusted ventilatory assist (NAVA) is a new concept of mechanical ventilation. NAVA delivers assistance to spontaneous breathing based on the detection of the electrical activity of the diaphragm.
- Trial name
- NCT00941044
- Testing
- Neurally adjusted ventilatory assist
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Amyotrophic Lateral Sclerosis, Motor Neuron Disease
Effects of Long Term Ventilation Support on the Quality of Life of ALS Patients and Their Families
Amyotrophic lateral sclerosis (ALS) is a serious rapidly progressive disease of the nervous system. The average survival from the time of diagnosis is two to three years.
- Conditions
- Amyotrophic Lateral Sclerosis, Motor Neuron Disease, Nervous System Diseases, Spinal Cord Diseases
- Trial name
- ALS-LTMV (NCT05744310)
- Testing
- Long term mechanical ventilation support, No long term mechanical ventilation support
- Where
- 9 sites in Norway
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
COPD, Home Care
FiO2 in Chronic Obstructive Pulmonary Disease (COPD) Patient Normobaric O2 Versus NIV
The purpose of this study is to compare pharyngeal FiO2 in day time with nasal normobaric O2 with inhaled FiO2 in the night time with home care ventilator NIV at the same O2 flow.
- Conditions
- COPD, Home Care, Oxygen Therapy
- Trial name
- NIVLEAKS (NCT02599246)
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Breas Medical S.A.R.L.
Neuromuscular Diseases, Neurologic Disorder
Multisystem and Autonomic Complications of NMD on Long-term NIV
This exploratory observational study evaluates autonomic function using measures including heart rate variability in adults with childhood-onset neuromuscular and neurological disorders (NMD) who use non-invasive ventilation…
- Trial name
- NCT04100993
- Testing
- No intervention used
- Where
- United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Respiratory Distress Syndrome In Premature Infants
Successful Extubation and Noninvasive Ventilation in Preterm ≤ 1500g Terms
Noninvasive ventilation has been used in preterm newborn with respiratory distress syndrome in an attempt to assist failure extubation.
- Trial name
- NCT02396693
- Testing
- NIPPV, Bubble NCPAP, Ventilator NCPAP
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Healthy
Non Invasive Ventilation Comfort Study
Patients who are suffering from a variety of respiratory conditions benefit from continuous positive airway pressure (CPAP) which is a form of Non-Invasive Ventilation (NIV).
- Trial name
- NCT02473068
- Testing
- CPAP
- Where
- New Zealand
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Fisher and Paykel Healthcare
Pulmonary Disease, Chronic Obstructive
Carbon Dioxide Rebreathing During Exercise Assisted by Non-invasive Ventilation
The purpose of this study was to evaluate whether CO2 rebreathing occurs in healthy subjects or patients with COPD ventilated during exercise assisted by the single-limb circuit with a plateau exhalation valve at a given…
- Trial name
- NCT02655484
- Testing
- BiPAP® Vision® ventilator（"Ventilator", "Philips Respironics™ BiPAP® Vision®" ）
- Where
- China
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Guangzhou Institute of Respiratory Disease
Respiratory Failure, Non Invasive Ventilation on Healthy Volunteer
Comparison of Three Noninvasive Ventilation Modes: a Physiological Study in Healthy Volunteers
Noninvasive ventilation (NIV) is a well established, safe, and effective technique in improving gas exchange while reducing dyspnea and inspiratory effort in patients with either hypoxemic and hypercapnic acute respiratory…
- Trial name
- NCT01610960
- Testing
- Non invasive ventilation HELMET, Non invasive ventilation facemask (Respironics)
- Where
- France
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Motor Neuron Disease, Amyotrophic Lateral Sclerosis
Telemonitoring in NIV MND (OptNIVent)
This is a feasibility study of telemonitoring system for people with MND/ALS, who are on NIV, via a call centre operated by a local clinical commissioning group.
- Trial name
- OptNIVent (NCT05299372)
- Testing
- Telemonitoring via Careportal®
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust