Clinical trials: Non Invasive Ventilation (NIV)
Preterm
Effects of Non-Traumatic Nasopharyngeal Suction Technique in Infants
Background: Non-invasive ventilation (NIV) in preterm infants often leads to secretion-related airway obstructions, requiring suctioning.
- Trial name
- NCT07111611
- Testing
- Non-Traumatic Nasopharyngeal Suction Procedure
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Istanbul Bilgi University
Infant, Newborn, Diseases, Intubation Complication
Noninvasive Positive Pressure Ventilation During Neonatal Nasal Intubation
The goal of this study is to perform a quality control assessment of our local intubation protocol in any newborn infant requiring endotracheal intubation in the delivery room or neonatal intensive care unit at the Department of…
- Trial name
- IntubAID (NCT06139809)
- Testing
- Intubation
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Healthy Participants
EIT Study With Healthy Patients
Patients with severe respiratory diseases such as chronic obstructive pulmonary disease (COPD) or obesity-hypoventilation syndrome (OHS) can benefit from having non-invasive ventilation (NIV).
- Trial name
- EIT Step 1 (NCT02828007)
- Testing
- NIV Group
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Non-invasive Ventilation, High-frequency Ventilation
MRI of the Chest Under High Frequency Ventilation
The purpose of the study is to evaluate the benefit on image quality of MRI of the chest performed under high frequency non-invasive ventilation.
- Conditions
- Non-invasive Ventilation, High-frequency Ventilation, Healthy Volunteer
- Trial name
- NCT02973373
- Testing
- MRI with High-frequency non-invasive ventilation, MRI without High-frequency non-invasive ventilation
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Non-invasive Ventilation
VENTILATION DURING SPACEFLIGHT (PHASE 2)
Space flights expose astronauts to medical risks, particularly respiratory risks, which are exacerbated in microgravity. Devices such as standard oxygen therapy and non-invasive ventilation (NIV) are used, but their performance…
- Trial name
- VESPA-2 (NCT07435389)
- Testing
- non-invasive oxygenation strategies
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Diaphragm Issues, Respiratory Failure With Hypoxia
Ultrasonographic Evaluation of the Diaphragm During NHF Versus NIV Use in Respiratory Failure
This study will describe influence of NHF or NIV to different ultrasonographic parameters of the diaphragm. Therefor subjects will be randomized to the sequence NHF and than NIV or NIV and than NHF.
- Conditions
- Diaphragm Issues, Respiratory Failure With Hypoxia, Respiratory Failure With Hypercapnia, Non-invasive Mechanical Ventilation
- Trial name
- SENNI (NCT04962568)
- Testing
- DTEE, DTEI, DEx
- Where
- Germany
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Jens Bräunlich
Respiratory Failure, Non Invasive Ventilation on Healthy Volunteer
Comparison of Three Noninvasive Ventilation Modes: a Physiological Study in Healthy Volunteers
Noninvasive ventilation (NIV) is a well established, safe, and effective technique in improving gas exchange while reducing dyspnea and inspiratory effort in patients with either hypoxemic and hypercapnic acute respiratory…
- Trial name
- NCT01610960
- Testing
- Non invasive ventilation HELMET, Non invasive ventilation facemask (Respironics)
- Where
- France
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Respiratory Insufficiency
Effect of Non-invasive Ventilation (NIV) on Cerebral Oxygenation
SUMMARY AND AIM Background: The proper management of brain oxygenation is an essential component of all anaesthesiologic procedures.
- Trial name
- NCT02454582
- Testing
- Somanetics INVOS Cerebral Oxymeter 5100C
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ass.-Prof. PD Dr. Klaus Ulrich Klein
Preoxygenation, Non Invasive Ventilation
Preoxygenation Method With a Calibrated Leak
During preoxygenation, imperfect seal between the face mask and patient's face can induce an inward air leak decreasing its effectiveness. We assume that noninvasive ventilation could cancel the effect of the leak.
- Trial name
- NCT03087825
- Testing
- preoxygenation without inward leak, preoxygenation with inward leak
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Prematurity; Extreme, Feeding Patterns
To Determine the Best Feeding Practice in Preterm Infants on Non-invasive Ventilation.
To evaluate the duration to reach full feeds by comparing continuous gavage feeds versus bolus feeds in preterm infants who are on non-invasive respiratory support (RAM cannula - short binasal prongs).
- Conditions
- Prematurity; Extreme, Feeding Patterns, Ventilator Lung; Newborn
- Trial name
- NCT05824377
- Testing
- Continuous Feeds, Intermittent Bolus Feeds
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Rajeev Kumar
Aerosol Disease, Covid19
A Safety Assessment of the iZephyr Hood for NIV in COVID-19 Patients
This study is a safety assessment of the iZephyr hood a novel aerosol removal device in patients receiving non invasive ventilation for COVID-19.
- Conditions
- Aerosol Disease, Covid19, Noninvasive Ventilation
- Trial name
- iZephyr (NCT04904484)
- Testing
- iZephyr hood
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Imperial College Healthcare NHS Trust
Preterm Infant
Effects of Two Modalities of Non-invasive Ventilation After Extubation in Very Low Birth Weight Neonates
The objective of this study is to evaluate the effects of continuous positive airway pressure and nasal intermittent positive pressure ventilation on breathing pattern variables of very low birth weight neonates immediately after…
- Trial name
- NCT03551314
- Testing
- Nasal Intermittent Positive Pressure, Continuous Positive Airway Pressure
- Where
- 2 sites in Brazil
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Autonomic Nervous System Imbalance
Heart Rate Variability of Premature Newborn
To analyze the effects of two CPAP methods on the HRV of PTNBs during their routine routine in the HCUFU neonatal ICU. This is a randomized clinical trial, with controlled groups and cross over with healthy term newborns (RNT) as…
- Trial name
- HRV (NCT06217133)
- Testing
- CPAP
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Federal University of Uberlandia
COPD, Home Care
FiO2 in Chronic Obstructive Pulmonary Disease (COPD) Patient Normobaric O2 Versus NIV
The purpose of this study is to compare pharyngeal FiO2 in day time with nasal normobaric O2 with inhaled FiO2 in the night time with home care ventilator NIV at the same O2 flow.
- Conditions
- COPD, Home Care, Oxygen Therapy
- Trial name
- NIVLEAKS (NCT02599246)
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Breas Medical S.A.R.L.
Pulmonary Disease, Chronic Obstructive
Carbon Dioxide Rebreathing During Exercise Assisted by Non-invasive Ventilation
The purpose of this study was to evaluate whether CO2 rebreathing occurs in healthy subjects or patients with COPD ventilated during exercise assisted by the single-limb circuit with a plateau exhalation valve at a given…
- Trial name
- NCT02655484
- Testing
- BiPAP® Vision® ventilator（"Ventilator", "Philips Respironics™ BiPAP® Vision®" ）
- Where
- China
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Guangzhou Institute of Respiratory Disease
Neuromuscular Diseases, Neurologic Disorder
Multisystem and Autonomic Complications of NMD on Long-term NIV
This exploratory observational study evaluates autonomic function using measures including heart rate variability in adults with childhood-onset neuromuscular and neurological disorders (NMD) who use non-invasive ventilation…
- Trial name
- NCT04100993
- Testing
- No intervention used
- Where
- United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Healthy
Effects of High Flow Nasal Cannula on Breathing and the Respiratory System Parameters
The aim of this study is a detailed investigation of the effect of High Flow Nasal Oxygenation (HFNO) on respiratory system characteristics and ventilation parameters in healthy adult subjects and the subsequent use of measured…
- Trial name
- HaFo (NCT04004247)
- Testing
- High Flow Nasal generator (AirVO2)
- Where
- Czechia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Czech Technical University in Prague
Chronic Obstructive Pulmonary Disease (COPD), Decompensated COPD With (Acute) Exacerbation
Breathing-swallowing Interaction in Chronic Obstructive Pulmonary Disease Patients - Impact of Non Invasive Ventilation
In the investigators' knowledge there are no data about the impact of non invasive mechanical ventilation on the breathing-swallowing interaction.
- Trial name
- NCT01518075
- Testing
- Spontaneous Breathing, Non Invasive Mechanical Ventilation
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Respiratory Diseases, Lung Diseases
In Vitro Assessment of a Breath-synchronized Vibrating Mesh Nebulizer During Non Invasive Ventilation
Using an adult lung bench model of non invasive ventilation, the aim of the study is to compare an experimental system of breath-synchronized vibrating mesh nebulizer to a conventional vibrating mesh nebulizer during non invasive…
- Conditions
- Respiratory Diseases, Lung Diseases, Cystic Fibrosis, COPD
- Trial name
- Synchro-Neb (NCT02084043)
- Testing
- Nebulization of Amikacin during NIV (RR: 15 cycles/minute), Nebulization of Amikacin during NIV (RR: 25 cycles/minute)
- Where
- Belgium
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University Hospital St Luc, Brussels