Clinical trials: Non-Dystrophic Myotonia
Paramyotonia Congenita, Nondystrophic Myotonia
Using MRI in Patients With Non-dystrophic Myotonia to Access Muscle Contractility
The aim of this project is (1) to investigate whether or not structural muscle abnormalities could be a consequence of the disorder and (2) to provide further clinical description of this rare phenotype.
- Trial name
- NCT04808388
- Testing
- MRI
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Myotonia, Non-Dystrophic Myotonia
Effectiveness of Mexiletine for Treating People With Non-Dystrophic Myotonia
Nondystrophic myotonias (NDM) are neuromuscular disorders caused by genetic abnormalities in certain muscle cell membrane proteins. The proteins affect muscle contraction.
- Trial name
- NCT00832000
- Testing
- Mexiletine
- Where
- 7 sites in United States, Canada and 2 more
- Volunteers
- 59 people
- Sponsor
- Richard Barohn, MD
Non-Dystrophic Myotonia
MExiletine Versus Lamotrigine in Non-Dystrophic Myotonias
This is a clinical trial to determine if Lamotrigine is non-inferior to Mexiletine for the treatment of myotonia in patients with Non-Dystrophic Myotonia. Non-dystrophic Myotonia is a genetic condition for which there is no cure.
- Trial name
- MEND (NCT05017155)
- Testing
- Mexiletine, Lamotrigine 25Mg Oral Tablet, Extended Release
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University College, London
Myotonia
An Open-Label, Randomized, Cross-Over Study to Investigate the Efficacy and Safety of Mexiletine PR Compared to Mexiletine IR
An Open-Label, Randomized, Cross-Over Study to Investigate the Efficacy and Safety of Mexiletine PR compared to Mexiletine IR in Patients with Non-Dystrophic Myotonias (ACHILLES study)
- Trial name
- NCT07097701
- Testing
- Granular powder in unit dose foil-lined sachet Mexiletine (PR), Oral Capsule Mexiletine (IR)
- Where
- Belgium
- Volunteers
- 24 people
- Sponsor
- Lupin Ltd.
Non-Dystrophic Myotonia
Treatment of Myotonia - Lamotrigine Versus Namuscla
In this clinical study, the aim is to investigate whether there is a difference in treatment of myotonia using two drugs. A difference there can justify the significantly higher cost when treated by Namuscla versus Lamotrigine.
- Trial name
- NCT05639257
- Testing
- Lamotrigine, Namuscla
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- Grete Andersen, MD
Non Dystrophic Myotonia, Arrythmia, Cardiac
A Single Center Prospective Study in an Estimated 570 Patients Who Underwent Genetic Screening at UZ Brussel in the Context of a Primary Cardiac Arrhythmia. Patients Showing a Variant Class 3,4 or 5 in SCN4A or CLCN1 Will Undergo a Clinical and Electrophysiological Review After IC.
A prospective interventional single-center study will be conducted. The study includes clinically diagnosed Intramuros PCA-patients who underwent a PCA gene panel of 113 genes (see Appendix 1) in the UZ-Brussel since 2021.
- Trial name
- NCT07183059
- Testing
- Electromyography
- Volunteers
- 570 people
- Sponsor
- Universitair Ziekenhuis Brussel
Non-Dystrophic Myotonia
Pilot Study for the Development of an Activity and Quality of Life Questionnaire for the Follow-up of Patients With Non-dystrophic Myotonia
Non-dystrophic myotonias (MND) are rare neuromuscular diseases caused by mutations in the voltage-dependent channels of skeletal muscles, resulting in delayed muscle relaxation after voluntary contraction.
- Trial name
- MNDActivLife (NCT06136416)
- Testing
- Questionnaire for Non-dystrophic myotonias
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Non-Dystrophic Myotonia, Myotonia Congenita
Contractile Properties of Hypertrofic Muscles in Patients With Non-Dystrophic Myotonia
In myotonia congenita (MC), mutations in the CLCN1 gene coding a key chloride channel expressed in muscle cells cause myotonia. On examination, the myotonia can be demonstrated as delayed muscle relaxation of muscle contractions…
- Trial name
- NCT04799366
- Where
- Denmark
- Volunteers
- 36 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Non-dystrophic Myotonias, Paramyotonia Congenita
Mexiletine and Non Dystrophic Myotonias
Treatment strategies in non-dystrophic myotonias are based on selective case reports, clinical experience and theoretical benefit.
- Conditions
- Non-dystrophic Myotonias, Paramyotonia Congenita, Myotonia Congenita
- Trial name
- MYOMEX (NCT02336477)
- Testing
- Mexiletine
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Myotonic Dystrophy
An Observational Study in Adult Patients With Non-dystrophic Myotonic Disorders
This is a non-interventional, prospective, observational, multicentre study to evaluate the long-term safety and effectiveness of Namuscla in adult patients with NDM.
- Trial name
- NCT04616807
- Testing
- Mexiletine
- Where
- 6 sites in France, Germany and 1 more
- Volunteers
- 53 people
- Sponsor
- Lupin Ltd.
Non Dystrophic Myotonia
Combined N-of-1 Trials Mexiletine vs Placebo in Patients With Non-Dystrophic Myotonia (NDM)
The main objective of this study is to explore whether multiple trials with individual patients (N-of-1 trials) can produce a reliable evidence base for coverage decisions on clinical and cost-effectiveness of drug treatment for…
- Trial name
- NCT02045667
- Testing
- Mexiletine
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center