Clinical trials: Non-Invasive Ventilation
Heart Failure
Necklace-Shaped Sensor for Non-Invasive Monitoring of Stroke Volume and Cardiac Output
Study will compare measurements made with Necklace device for stroke volume/cardiac output with values from a FDA-approved reference device. The gold standard that will be used is Cardiac MRI.
- Trial name
- NCT02719301
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Baxter Healthcare Corporation
Chronic Obstructive Pulmonary Disease, Pulmonary Rehabilitation
Effects of Nocturnal Non-invasive Ventilation on Energy Expenditure in Patients With Severe Chronic Obstructive Pulmonary Disease
It has been shown, that in patients with very severe chronic obstructive pulmonary disease (COPD) the additional use of non-invasive ventilation during pulmonary rehabilitation (PR) may enhance the benefits of PR.
- Conditions
- Chronic Obstructive Pulmonary Disease, Pulmonary Rehabilitation, Non-invasive Ventilation, Energy Expenditure
- Trial name
- NCT01961245
- Testing
- nocturnal non-invasive ventilation
- Where
- Germany
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Schön Klinik Berchtesgadener Land
Infant, Premature, Diseases, Infant, Newborn, Diseases
Pulmonary Function Using Non-invasive Forced Oscillometry
The purpose of this observational study is to measure pulmonary function in term and preterm infants with and without pulmonary disease including respiratory distress syndrome, bronchopulmonary dysplasia, transient tachypnea of…
- Conditions
- Infant, Premature, Diseases, Infant, Newborn, Diseases, Bronchopulmonary Dysplasia, Respiratory Distress Syndrome, Newborn
- Trial name
- PUFFOR (NCT03346343)
- Testing
- Non-invasive forced airway oscillometry
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Mechanical Ventilation Complication, Respiratory Distress Syndrome in Premature Infant
Effect of Implementing Evidence Based Practices on Prevention of Associated Nasal Pressure Injuries Among Preterm Neonates With Non-Invasive Respiratory Support
This study aims to evaluate the effect of implementing evidence based practices on prevention of associated nasal pressure injuries among preterm neonates with non invasive respiratory support
- Trial name
- NCT06642285
- Testing
- Non Invasive Respiratory Support bundle
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Diaphragm, Ultrasonography
Patient-ventilator Asynchrony During Noninvasive Ventilation Assessed Using Diaphragm Ultrasonography
Fifteen healthy subjects under non-invasive ventilation will be have a recording of surface electromyogram, measurements of airway flows and pressures as well as a continuous ultrasound.
- Trial name
- ADULT (NCT03114384)
- Testing
- Creation and detection of patient-respirator asynchronies
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Saint Joseph Saint Luc de Lyon
Healthy
Non-invasive Neurally Adjusted Ventilatory Assist in Healthy Volunteers
Neurally adjusted ventilatory assist (NAVA) is a new concept of mechanical ventilation. NAVA delivers assistance to spontaneous breathing based on the detection of the electrical activity of the diaphragm.
- Trial name
- NCT00941044
- Testing
- Neurally adjusted ventilatory assist
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Amyotrophic Lateral Sclerosis, Motor Neuron Disease
Effects of Long Term Ventilation Support on the Quality of Life of ALS Patients and Their Families
Amyotrophic lateral sclerosis (ALS) is a serious rapidly progressive disease of the nervous system. The average survival from the time of diagnosis is two to three years.
- Conditions
- Amyotrophic Lateral Sclerosis, Motor Neuron Disease, Nervous System Diseases, Spinal Cord Diseases
- Trial name
- ALS-LTMV (NCT05744310)
- Testing
- Long term mechanical ventilation support, No long term mechanical ventilation support
- Where
- 9 sites in Norway
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Healthy Adult, Cardiac Output
Effect of Systematic and Sequential Leg Elevation on Cardiac Output in Healthy Volunteers
Passive leg raising (PLR) transiently increases venous return and cardiac preload and is commonly used to predict fluid responsiveness in critically ill patients.
- Conditions
- Healthy Adult, Cardiac Output, Hemodynamic, Passive Leg Raising
- Trial name
- SYSLE-1 (NCT07860515)
- Testing
- Passive Leg Raising, Non-Invasive Ventilation
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Régional d'Orléans
COPD, Home Care
FiO2 in Chronic Obstructive Pulmonary Disease (COPD) Patient Normobaric O2 Versus NIV
The purpose of this study is to compare pharyngeal FiO2 in day time with nasal normobaric O2 with inhaled FiO2 in the night time with home care ventilator NIV at the same O2 flow.
- Conditions
- COPD, Home Care, Oxygen Therapy
- Trial name
- NIVLEAKS (NCT02599246)
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Breas Medical S.A.R.L.
High Altitude Pulmonary Edema, Non-Invasive Positive Pressure Ventilation
Non-Invasive Positive Pressure Ventilation Management of High Altitude Pulmonary Edema
Trial of Non-Invasive Positive Pressure Ventilation Management of High Altitude Pulmonary Edema
- Conditions
- High Altitude Pulmonary Edema, Non-Invasive Positive Pressure Ventilation, Hypoxia
- Trial name
- NCT04288219
- Testing
- Non-Invasive Positive Pressure Ventilation, Nifedipine, supplemental oxygen
- Where
- Nepal
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Neuromuscular Diseases, Neurologic Disorder
Multisystem and Autonomic Complications of NMD on Long-term NIV
This exploratory observational study evaluates autonomic function using measures including heart rate variability in adults with childhood-onset neuromuscular and neurological disorders (NMD) who use non-invasive ventilation…
- Trial name
- NCT04100993
- Testing
- No intervention used
- Where
- United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Respiratory Distress Syndrome In Premature Infants
Successful Extubation and Noninvasive Ventilation in Preterm ≤ 1500g Terms
Noninvasive ventilation has been used in preterm newborn with respiratory distress syndrome in an attempt to assist failure extubation.
- Trial name
- NCT02396693
- Testing
- NIPPV, Bubble NCPAP, Ventilator NCPAP
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Healthy
Non Invasive Ventilation Comfort Study
Patients who are suffering from a variety of respiratory conditions benefit from continuous positive airway pressure (CPAP) which is a form of Non-Invasive Ventilation (NIV).
- Trial name
- NCT02473068
- Testing
- CPAP
- Where
- New Zealand
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Fisher and Paykel Healthcare
Pulmonary Disease, Chronic Obstructive
Carbon Dioxide Rebreathing During Exercise Assisted by Non-invasive Ventilation
The purpose of this study was to evaluate whether CO2 rebreathing occurs in healthy subjects or patients with COPD ventilated during exercise assisted by the single-limb circuit with a plateau exhalation valve at a given…
- Trial name
- NCT02655484
- Testing
- BiPAP® Vision® ventilator（"Ventilator", "Philips Respironics™ BiPAP® Vision®" ）
- Where
- China
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Guangzhou Institute of Respiratory Disease
Respiratory Failure, Non Invasive Ventilation on Healthy Volunteer
Comparison of Three Noninvasive Ventilation Modes: a Physiological Study in Healthy Volunteers
Noninvasive ventilation (NIV) is a well established, safe, and effective technique in improving gas exchange while reducing dyspnea and inspiratory effort in patients with either hypoxemic and hypercapnic acute respiratory…
- Trial name
- NCT01610960
- Testing
- Non invasive ventilation HELMET, Non invasive ventilation facemask (Respironics)
- Where
- France
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Pleural Effusion
Not Invasive Monitoring of Pleural Drainage
This study investigates if data about monitoring the drainage of pleural effusion can be collected by non invasive sensors (feasibility).
- Trial name
- NCT01778270
- Testing
- Body Bioimpedance Sensor
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Fontan Physiology
Feasibility and Efficacy of Portable Non-invasive Negative Pressure Ventilation in Fontan Patients
The human heart has 4 chambers: 2 collecting chambers (atria) and 2 pumping chambers (ventricles) to allow blood flow within two distinct circuits: "pulmonary" and "systemic".
- Trial name
- FONTAN-CMR (NCT03251742)
- Testing
- Hayek RTX ventilator
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
CO2 Clearance, Mask Comfort
Noninvasive Ventilation Masks Carbon Dioxide Clearance in Normal Volunteers
This study will be a randomized crossover trial that will be conducted at Rush University. The study will be conducted with 20 healthy volunteers who will be placed on ICU ventilator operating in the NIPPV mode.
- Conditions
- CO2 Clearance, Mask Comfort, Rebreathing Exhaled Gas
- Trial name
- NCT03882723
- Testing
- Evaluated 4 masks used for NIV with mechanical ventilators
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Respiratory Failure
Comparison of Non-invasive Methods of Lung Ventilation in Patients With Respiratory Failure After Cardiac Surgery
Comparison of the effectiveness of three methods of non-invasive ventilation in patients with mild and moderate respiratory failure in the early postoperative period after cardiac surgery
- Trial name
- NCT04787666
- Testing
- Using of non-invasive mask ventilation, high-flow oxygen therapy through a nasal cannula (high-flow nasal oxygenation) and non-invasive ventilation with a helmet
- Where
- Russia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Petrovsky National Research Centre of Surgery
Spinal Cord Injuries
Non-Invasive Spinal Cord Stimulation After Injury
The goal of this study is to assess the function of the lungs and the muscles are used to breathe after individuals receive respiratory training, spinal cord stimulation, a combination of respiratory training and stimulation, a…
- Trial name
- NCT03998527
- Testing
- Transcutaneous Electrical Spinal Cord Stimulation (TcESCS)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Louisville