Clinical trials: Non-Opioid Pain Management
Pain
Opioid Sparing Potential of Light-Induced Analgesia
This is a pilot trial testing the potential opioid-sparing analgesic effect of a novel non-pharmacological treatment using visualized light spectrums. Preclinical findings have shown such treatments to alter pain perception.
- Trial name
- NCT03890419
- Testing
- Green light, Clear light, Blue Light
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Duke University
Chronic Pain, Analgesia
QSPainRelief-STRAT
Investigating the clinical outcomes of drug combinations (opioid + medication acting on the central nervous system) in patients suffering from persistent pain (pain lasting for at least three months) through patient-reported…
- Conditions
- Chronic Pain, Analgesia, Adverse Drug Event, Drug Interaction
- Trial name
- QSPR-STRAT (NCT06244706)
- Testing
- Opioid drug + CNS-acting add-on drug
- Volunteers
- 150 people
- Sponsor
- Université Catholique de Louvain
Systemic Inflammatory Response Syndrome, Postoperative Pain, Acute
Opioid Free Anaesthesia-Analgesia Strategy on Surgical Stress and Immunomodulation in Elective VATS-Lobectomy for NSCLC
Lobectomy is a major, high-risk surgical procedure that in addition to one-lung ventilation (OLV) exerts a potent surgical stress response.
- Conditions
- Systemic Inflammatory Response Syndrome, Postoperative Pain, Acute, Postoperative Pain, Chronic, Infections Postoperative
- Trial name
- NCT05172739
- Testing
- Opioid-Based Anesthesia-Analgesia Strategy, Opioid-free Anesthesia-Analgesia Strategy
- Where
- Greece
- Volunteers
- 70 people
- Sponsor
- University of Crete
Pain; Cancer
An Efficacy and Safety Study of Transdermal Therapeutic System (TTS)-Fentanyl in Cancer Participants With Inadequately Controlled Pain by Non-Narcotic Analgesics
The purpose of this study is to evaluate the efficacy and safety of Transdermal Therapeutic System (TTS)-fentanyl D-Trans (transdermal patch containing a drug that is put on the skin so the drug will enter the body through the…
- Trial name
- NCT01060124
- Testing
- Fentanyl D-trans
- Volunteers
- 103 people
- Sponsor
- Janssen Korea, Ltd., Korea
Caudal Analgesia for Lumosacral Spine Surgeries
Caudal Epidural With Non Opioid Adjuvants in Lumbosacral Spine Surgery
Lumbosacral spine surgeries are accompanied with severe postoperative pain which has a negative effect on patients' recovery. Preemptive analgesia before lumbosacral spine surgeries should be implemented to prevent CNS plasticity…
- Trial name
- NCT04411329
- Testing
- Bupivacaine, Dexamethasone, Dexmedetomidine
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Surgical Wound, Post-Op Complication
CLoWI Versus PCA Morphine for Pain Control After Major Abdominal Surgery
Major abdominal surgery is associated with significant complications which may lead to morbidity and mortality. Pain experienced after surgery affects the recovery from surgery.
- Conditions
- Surgical Wound, Post-Op Complication, Opioid Use
- Trial name
- CLoWI (NCT04503720)
- Testing
- CLoWI, PCA
- Where
- 2 sites in Singapore
- Volunteers
- 52 people
- Sponsor
- JurongHealth
Postoperative Pain
Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation
This study is a prospective randomized trial examining the effect of tranexamic acid (TXA) and aminocaproic acid (ε-Ahx) with local anesthetics and thrombin in all electively created surgical wound beds in hand surgery to provide…
- Trial name
- NCT07644923
- Testing
- Bupivacaine, Lidocaine, Thrombin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- NYU Langone Health
Post Operative Pain
Trial of Extended Release Bupivacaine for Pain Relief After Surgery
This is a research study of SABER® -Bupivacaine, an experimental medication designed to reduce pain for up to 3 days after surgery.
- Trial name
- PERSIST (NCT02574520)
- Testing
- SABER-Bupivacaine (Part 1), SABER-Bupivacaine (Part 2), Bupivacaine HCl
- Where
- 21 sites in United States
- Volunteers
- 399 people
- Sponsor
- Durect
Postoperative Pain
Analgesic Efficacy of an Opioid-free Postoperative Pain Management Strategy Versus a Conventional Opioid-based Strategy Following Video-assisted Thoracoscopic Lobectomy
Investigators have designed a randomized controlled trial. Utilizing an open-label, randomized, controlled study methodology, this trial aims to explore a opioid-free, safe, and effective analgesic approach for thoracic surgery.
- Trial name
- NCT06570538
- Testing
- Ropivacaine, Sufentanil
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Affiliated Cancer Hospital & Institute of Guangzhou Medical University
Analgesia, Donor Nephrectomy
PQLB vs TFPB in HALDN
This prospective randomized non-inferiority trial is designed to compare postoperative analgesic effect of transversalis fascia plane block and posterior quadratus lumborum block in hand assisted laparoscopic donor nephrectomy.
- Conditions
- Analgesia, Donor Nephrectomy, Postoperative Pain, Fascial Plane Block
- Trial name
- NCT07852663
- Testing
- Quadratus Lumborum Block type 2, Transversalis Fascia Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Koc University Hospital
Opioid-use Disorder, Opioid Use Disorder, Mild
Effect of Standard of Care Reduced Dose Versus Full Dose Buprenorphine/Naloxone in the Perioperative Period on Pain Control and Post-Operative Opioid Use Disorder Symptoms
The purpose of this research study is to compare two ways of managing pain in people who are taking buprenorphine and are scheduled to undergo surgery.
- Trial name
- NCT04091009
- Testing
- Buprenorphine/naloxone
- Sponsor
- Massachusetts General Hospital
Acute Pancreatitis
Initial Pain Management in Pediatric Pancreatitis: Opioid vs. Non-Opioid
This will be a phase 2, single-center, unblinded randomized controlled pilot trial of two arms comparing opioid-sparing analgesia to the current Boston Children's Hospital institutional practice which has been reported to…
- Trial name
- PATIENCE (NCT04291599)
- Testing
- Ketorolac, Opioid
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Boston Children's Hospital
Sickle Cell Disease
Assessment of Opioid Analgesia in Sickle Cell
To develop and validate a non-invasive, in vivo, phenotyping method for CYP2D6 using the non-injurious neuroselective electrical stimulation technique: pain perception threshold/pain tolerance threshold (PPT/PTT) in children and…
- Trial name
- NCT00513864
- Testing
- Dextromethorphan, Codeine, Morphine
- Where
- United States
- Sponsor
- Children's National Research Institute
Arthritis, Pain
Non-cancer Pain and Cognitive Impairment: A Disabling Relationship
To compare the efficacy of long-acting oxycodone to extended-release acetaminophen in older persons with no and mild to moderate cognitive impairment and persistent moderate or higher intensity non-cancer lower extremity…
- Conditions
- Arthritis, Pain, Cognitive Impairment
- Trial name
- NCT01264965
- Testing
- long acting oxycodone, extra strength acetaminophen
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Chicago
Analgesia
Total Knee Arthroplasty (TKA) Study of HTX-011 in an Multimodal Analgesic Regimen (MMA) Regimen
Phase 3b, open-label single-arm study in which all subjects receive HTX-011 as part of a scheduled non-opioid MMA regimen.
- Trial name
- NCT03974932
- Testing
- HTX-011, Ibuprofen, Acetaminophen
- Where
- 6 sites in United States
- Volunteers
- 116 people
- Sponsor
- Heron Therapeutics
Non Small Cell Lung Cancer, Lung Cancer Stage 1
Exparel and Marcaine for Pain Management in Thoracoscopic Lobectomy Patients
The purpose of this study is to assess pain management after elective thoracoscopic lobectomy. The study will compare two local anesthetics that are given intra-operatively during lobectomy to see which one helps in better pain…
- Trial name
- BEMP (NCT03682224)
- Testing
- Liposomal Bupivacaine, Bupivacaine-Epinephrine
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Southern Illinois University
Tonsillectomy, Pharyngoplasty
Suzetrigine in Tonsillectomy for Opioid-sparing Pain Management
The goal of this clinical trial is to learn if a non-opioid pain medicine called suzetrigine can lower how much opioid pain medicine adults need after tonsil surgery (tonsillectomy) or a similar throat surgery.
- Conditions
- Tonsillectomy, Pharyngoplasty, Suzetrigine, Opioid
- Trial name
- STOP (NCT07821931)
- Testing
- Suzetrigine, Acetaminophen, oxycodone
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Stanford University
Total Knee Arthroplasty Postoperative Pain, Opioid Reduction After TKA
NEUROCUPLE™ as an Opioid Alternative Following Total Knee Arthroplasty
The goal of this clinical trial is to learn if the NEUROCUPLE device can reduce pain and opioid use after primary unilateral total knee arthroplasty (TKA) in adults.
- Trial name
- NCT07439666
- Testing
- NEUROCUPLE™ Patch, Enhanced Recovery After Surgery (ERAS) Standard of Care
- Where
- 3 sites in United States
- Volunteers
- 274 people
- Sponsor
- Jacques E. Chelly
Pain, Postoperative, Opioid Use
Transcutaneous Auricular Neurostimulation After Lumbar Surgery
The purpose of this study, entitled "Delivering Transcutaneous Auricular Neurostimulation as an Adjunct Non-Opioid Pain Management Therapy for Patients Undergoing Lumbar Surgery", is to demonstrate whether transcutaneous…
- Conditions
- Pain, Postoperative, Opioid Use, Lumbar Spine Injury
- Trial name
- NCT06100172
- Testing
- Sparrow Ascent Transcutaneous Auricular Neurostimulation (tAN)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Texas Southwestern Medical Center
Non-malignant Chronic Pain
Opioid Rotation From Morphine to Methadone in Treatment of Non-malignant Pain
Patients with non-malignant pain are switched from morphine to methadone with a nine-months' follow-up.
- Trial name
- NCT00356083
- Testing
- Methadone
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology