Clinical trials: Non-Smoker
Tobacco Use Disorder
Comparative Abuse Liability Among African American and White Smokers
The study is a randomized crossover trial. Current smokers will complete a session with each product: usual brand cigarette, e-cigarette, and heat-not-burn.
- Trial name
- NCT04646668
- Testing
- E-cigarette and Heat not burn
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Tobacco Smoking
Smoking Interventions in the General Population
The study takes up two problems: 1) Little research exists about general population interventions for smokers not ready to quit within the foreseeable future.
- Trial name
- NCT00678938
- Testing
- Smoking abstinence oriented expert system intervention, Smoking reduction oriented expert system intervention
- Volunteers
- 1,462 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
COPD
Chronic Obstructive Pulmonary Disease (COPD) Biomarker Identification Study
Chronic obstructive pulmonary disease (COPD) is a common inflammatory disease of the airway affecting approximately 10% of individuals aged 40 years or more with a smoking history.
- Trial name
- NCT01780298
- Where
- United Kingdom
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Healthy, Smoking, Cigarette
Investigation of Secreted Phosphoproteins and PiP3 (Phosphoinositolphospat 3) in Sputum
The aim of this study is to validate two new biomarkers in sputum samples. These are PiP3 (phosphoinositolphospat ) and phosphor proteins, representing important proteins within inflammatory situations of the lung.
- Trial name
- NCT03076086
- Testing
- Induced sputum procedure
- Where
- Germany
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Fraunhofer-Institute of Toxicology and Experimental Medicine
Immunity, Smoking, Cigarette
Impact of Solarplast® on Immunity in Active Smokers and Non-smokers
The purpose of this study is to determine the impact of Solarplast treatment on measures of oxidative stress, immune function, skin appearance, and associated measures in 60 men and women, consisting of both cigarette smokers and…
- Trial name
- NCT05162820
- Testing
- 100 mg Solarplast
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Memphis
Asthmatic Smokers, Non-asthmatic Smokers
The Effects of Montelukast on Smokers With Asthma
The purpose of this study is: 1. To compare neutrophilia, eosinophilic inflammatory markers and asthma symptom indices between smokers and non-smokers. 2.
- Trial name
- NCT00712335
- Testing
- Fluticasone Propionate, Montelukast, Salmeterol
- Where
- South Korea
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Inje University
Healthy Lifetime Non-smokers
Evaluation of Acute and Subacute Effects of Nicotine Free Electronic Cigarette(NCFE) Vapors
This aim will examine the acute and subacute exposures to electronic cigarette (EC) vapor generated from e-liquids without nicotine (NFEC) on life-time non smokers subjects by measuring changes in nasal ion transport and TGF-β…
- Trial name
- NCT02585791
- Testing
- Propylene Glycol, vegetable glycerin, PG+VG
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Miami
Erectile Dysfunction, Smoking
A Comparative Pharmacokinetic and Pharmacodynamic Study of Sildenafil in Adult Smokers and Non Smokers
Smokers are at higher risk of developing Erectile dysfunction (ED) independent of age and comorbidities. Sildenafil is a cytochrome p3A4 (CYP3A4) substrate used for enhancing the erectile function in males.
- Conditions
- Erectile Dysfunction, Smoking, Pharmacokinetics, Pharmacodynamics
- Trial name
- NCT04100759
- Testing
- Sildenafil 50 mg Oral Tablet
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Asthma, COPD
ATP/AMP Challenge in Healthy Non-smokers, Smokers, Patients With Asthma, and Patients With Chronic Obstructive Pulmonary Disease (COPD)
In this randomised, cross-over, controlled study, a total of 84 subjects will be included: 12 healthy non-smoking volunteers; 12 current smokers; 30 patients with mild steroid-naïve asthma; and 30 patients with mild-moderate…
- Conditions
- Asthma, COPD, Smoking
- Trial name
- NCT00159315
- Testing
- Inhalation Challenge with ATP, Inhalation Challenge with AMP
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Healthy Volunteers, Moderate to Heavy Smokers
Study to Evaluate the Food Effect of Single-dose Bioavailability of Pracinostat in Healthy Adult Subjects
Open label study of Pracinostat will be tested to assess the effect of food on the single-dose pharmacokinetics in healthy non-smoking and smoking adult subjects under fasted and fed conditions.
- Conditions
- Healthy Volunteers, Moderate to Heavy Smokers, Non-smokers
- Trial name
- HVFE (NCT02058784)
- Testing
- pracinostat
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Helsinn Healthcare SA
Healthy Volunteers, Non-smokers
Evaluate the Effects of Itraconazole and Ciprofloxacin on Single-Dose PK of Pracinostat in Healthy Nonsmoking Subjects
This study is designed as a 2-part, open-label study to assess the effect of pracinostat with itraconazole (part 1) and pracinostat with ciprofloxacin (part 2) on the bioavailability of pracinostat.
- Trial name
- NCT02118909
- Testing
- Pracinostat, Itraconazole, Ciprofloxacin
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Helsinn Healthcare SA
Healthy Participant
Different Modes of Universal Adhesive in Smokers and Non-Smokers
The aim of the study was to evaluate the influence of smoking on the clinical performance of a universal adhesive used with different application modes in non-carious cervical lesions.
- Trial name
- NCT04807465
- Testing
- G-Premio Bond in etch&rinse mode, G-Premio Bond in selective-etch mode, G-Premio Bond in self-etch mode
- Where
- Turkey (Türkiye)
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Tobacco Cessation
Intervention Study to Increase Smoking Cessation Rates Among Public Housing Residents
The purpose of this study is to determine whether public housing residents trained in Tobacco Cessation and Motivational Interviewing Techniques to become Tobacco Treatment Advocates(TTA) will be effective in increasing the quit…
- Trial name
- NCT01651611
- Testing
- Motivational interviewing, Smoking cessation counseling, Navigation to smoking cessation resources
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Boston University
Current Smoker, Never Smoker
Effects of Electronic Cigarette Use on the Lungs
This randomized pilot clinical trial studies the effects of electronic cigarettes on the lungs. Studying the effects of electronic cigarettes on the lungs may provide the Food and Drug Administration (FDA) and other government…
- Conditions
- Current Smoker, Never Smoker, Tobacco Use Disorder, Former Smoker
- Trial name
- NCT02596685
- Testing
- Bronchoscopy, Electronic Cigarette, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Cigarette Smoking, Smoking Behaviors
Switch or Quit R01
This study evaluates whether non-cigarette tobacco products (e-cigarettes) can help smokers quit smoking as compared to traditional quit methods (nicotine replacement therapy or varenicline/Chantix).
- Trial name
- NCT06373679
- Testing
- Switching to E-Cigarette, Switching using Medication
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Lung Cancer
LDCT Screening in Non-smokers in Taiwan
This study utilizes the low dose computed tomography(LDCT) to detect the occurrence of early lung cancer among non-smokers in Taiwan.
- Trial name
- NCT02611570
- Testing
- LDCT
- Where
- 17 sites in Taiwan
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Academia Sinica, Taiwan
Heated Tobacco, Respiratory Function
Acute Effects of a Heat-not-burn Tobacco Product on Pulmonary Function in Healthy Non Smokers.
IQOS ("I-Quit-Ordinary-Smoking,") is a type of "heat-not-burn" (HNB) tobacco product. There is evidence of a growing number of young people who try IQOS as a 'safe' alternative of cigarette.
- Conditions
- Heated Tobacco, Respiratory Function, Tobacco Toxicity
- Trial name
- NCT03995329
- Testing
- IQOS
- Where
- 2 sites in Greece
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Asthma, COPD
Blood Collection From Individuals With Lung Disease for Genetic Studies (Qatar)
This is a research study where researchers are collecting blood to evaluate the genetic characteristics of individuals with chronic lung diseases, including asthma, COPD (chronic obstructive pulmonary disease), interstitial lung…
- Conditions
- Asthma, COPD, Interstitial Lung Disease, Cystic Fibrosis
- Trial name
- Q-BC (NCT00504361)
- Where
- Qatar
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Periodontal Diseases, Tooth Loss
Effect of Periodontal Maintenance Therapy on Tooth Loss in Regular and Irregular Compliant Smokers and Non-Smokers: A Cohort Retrospective Analysis With a Follow-up Up to 40 Years
Periodontal diseases are infections cause by dental plaque (Socransky, 1970). Risk factors are present which modify the course of disease progression.
- Conditions
- Periodontal Diseases, Tooth Loss, Compliance, Smoking
- Trial name
- NCT04938089
- Testing
- Maintenance
- Where
- Lebanon
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Saint-Joseph University
COPD, Lung Cancer (NSCLC)
Tumors and Respiratory System Diseases Due to Air Pollution: New Biomarkers of Exposure and Effects
This study aims to examine the exposure to atmospheric pollutants in a group of non-smoking patients suffering from lung cancer, chronic obstructive pulmonary disease (COPD), and leukemia.
- Conditions
- COPD, Lung Cancer (NSCLC), Leukemia
- Trial name
- RECAP (NCT06800586)
- Where
- 3 sites in Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna