Clinical trials: Non-Suicidal Self-Injury
Suicidal Ideation, Suicide, Attempted
A Conditioning Paradigm to Increase Affinity for Sacredness of Life
Suicide-related experiences affect millions of people every year in the United States. Through decades of research, interventions targeting these experiences have developed with varied empirical support.
- Conditions
- Suicidal Ideation, Suicide, Attempted, Suicide and Self-harm, Non-suicidal Self-injury
- Trial name
- NCT05541900
- Testing
- TEC-Sacredness, TEC-Control
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Florida State University
Suicidal Ideation, Suicidal Behavior
Understanding and Acting to Regulate Suicidal Behavior
Data from Santé Publique France show that since the onset of the health crisis (covid-19), there has been an increase in emergency room visits for mood disorders among children under 15 years of age, with a notable rise in the…
- Conditions
- Suicidal Ideation, Suicidal Behavior, Self-harm Behavior, Adolescents
- Trial name
- CARES (NCT06689657)
- Testing
- Cognitive behavioral group therapy for adolescents and non violent resistance group for parents, Adolescent group therapy (CARES) and parent group therapy (RNV)
- Volunteers
- 108 people
- Sponsor
- University Hospital, Montpellier
Suicidal Intention
Suicidal Thought and Biological Markers
Thought Markers (Tm) and Biomarkers(Bm) to accurately predict the likelihood of a repeated suicide attempt.
- Trial name
- STM (NCT01992445)
- Where
- 3 sites in United States
- Volunteers
- 375 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Self-Harm, Deliberate, Non-Suicidal Self Injury
Aspects of Self-harm - Cognition, Imaging and Treatability
Deliberate self-harm (DSH) is a common symptom in psychiatric disorders. This study aim at increased understanding of parameters associated with DSH with the long term goal to potentially improve and possibly personalise its…
- Conditions
- Self-Harm, Deliberate, Non-Suicidal Self Injury, Attempt Suicide, Personality Disorders
- Trial name
- NCT04905797
- Testing
- Emotional Stop Signal Task, Magnetic Resonance Imaging, World Health Organizations Disability Assessment Schedule (WHODAS 2.0)
- Where
- Sweden
- Volunteers
- 316 people, healthy volunteers welcome
- Sponsor
- Region Skane
Non-suicidal Self-injury (NSSI)
Blended Unified Protocol in Chinese Adolescents With Non-Suicidal Self-Injury
This study utilizes the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Adolescents (UP-A) to address non-suicidal self-injury among Chinese adolescents.
- Trial name
- NCT06858540
- Testing
- Unified protocol for transdiagnostic treatment of emotional disorders in adolescents
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Jian-Jun Ou
Borderline Personality Disorder, Emotions
Emotional Reaction and Self Injury in Patients With Borderline Personality Disorder and Healthy Controls
The current study investigates the emotional response of patients with borderline personality disorder and healthy controls on stimuli associated with self-injury.
- Trial name
- NCT03149926
- Testing
- Stimuli presentation
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Katharina Bachmann
Depression Disorders, Non-suicidal Self-injury
The Impact of Beta-band Transcranial Alternating Current Stimulation (tACS) on Impulse Inhibition in Adolescents With Non-suicidal Self-injury
This clinical trial aims to determine whether beta-band transcranial alternating current stimulation (tACS) can improve impulse inhibition in adolescents with non-suicidal self-injury (NSSI) and to evaluate its safety.
- Trial name
- NCT07152925
- Testing
- Beta-frequency transcranial alternating current stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Anhui Medical University
Nonsuicidal Self-Injury, Self-Harm
Internet-delivered Emotion Regulation Individual Therapy or Adolescents (IERITA) With Self-injury Within Child and Adolescent Mental Health Services: Pilot Study
The overall purpose of the study is to implement and evaluate IERITA (Internet-delivered Emotion Regulation Individual Therapy for Adolescents) within child and adolescent mental health services for adolescents engaging in…
- Trial name
- NCT06817278
- Testing
- Adaptable IERITA, Standard IERITA, Treatment as usual
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
Deliberate Self Harm
Early Study of N-Acetylcysteine to Treat Deliberate Self-Harm in Adolescents
Deliberate Self-Harm (DSH) among adolescents is a serious behavioral problem associated with significant injury, impaired functioning, reduced quality of life, and high rates of psychiatric hospitalizations.
- Trial name
- NCT01111734
- Testing
- N-Acetylcysteine, fMRI
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Depression
A Study on the Intervention Effect of Therapeutic Horticulture Based on the Healing System on Non-suicidal Self-injury in Adolescent Patients With Depression
Non-suicidal self-harm is a serious issue. Adolescents with depression are among the high-risk groups for non-suicidal self-harm behavior.
- Trial name
- NCT07115381
- Testing
- Therapeutic Horticulture, Routine treatment and nursing
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Lei Huang
Self Harm
PsiloIMAGINE: A Psychedelic-augmented Mental Imagery-based Intervention for Young People With Self-harm
Approximately 20% of young people experience self-harm behaviour in their lives. Self-harm can occur across different mental health disorders, and lead to negative outcomes and risk of suicide.
- Trial name
- PsiloIMAGINE (NCT06798636)
- Testing
- Psilocybin 5 mg with cognitive behavioural therapy intervention
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Imperial College London
Temporal Interference Stimulation, Non Suicidal Self Injury
TIS for NSSI in Adolescent Depression
Temporal Interference Stimulation (TIS) has been successfully used to help patients with depression. However, its role in alleviating self injuries remained uncertain.
- Conditions
- Temporal Interference Stimulation, Non Suicidal Self Injury, Major Depressive Disorder
- Trial name
- NCT07554755
- Testing
- Active Temporal Interference Stimulation (TIS)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Second Hospital of Anhui Medical University
Suicidal Ideation, Suicide, Attempted
Safety Planning in Juvenile Justice for Suicidal Youth
This study will examine the feasibility and acceptability of a program designed to conduct safety planning with youth in the juvenile justice system who are at risk for a suicide attempt and/or self-injury and to increase the…
- Conditions
- Suicidal Ideation, Suicide, Attempted, Nonsuicidal Self-injury
- Trial name
- Safety (NCT03655470)
- Testing
- Safety Planning, Standard care
- Where
- 2 sites in United States
- Volunteers
- 59 people
- Sponsor
- Brown University
Self-Harm, Self-Harm, Deliberate
Group Treatment for Self-harming Adolescents and Their Parents: a Randomized Controlled Trial
Adolescent non-suicidal self-injury (NSSI) is common, strongly associated with psychiatric comorbidity and an increased risk of future suicide attempt.
- Conditions
- Self-Harm, Self-Harm, Deliberate, Self-harm Behavior, Non-Suicidal Self Injury
- Trial name
- ERA (NCT07720063)
- Testing
- Emotion Regulation Group Therapy for Self-harming Adolescents, ERA, Functional habits for mental health, FUNK
- Volunteers
- 180 people
- Sponsor
- Karolinska Institutet
Nonsuicidal Self-Injury, Self-Harm
Internet-delivered Emotion Regulation Individual Therapy or Adolescents (IERITA) With Self-injury Within Child and Adolescent Mental Health Services
The overall purpose of the study is to implement and evaluate IERITA (Internet-delivered Emotion Regulation Individual Therapy for Adolescents) within child and adolescent mental health services for adolescents engaging in…
- Trial name
- NCT07573085
- Testing
- Adaptable IERITA, Standard IERITA, Treatment as usual
- Where
- Sweden
- Volunteers
- 341 people
- Sponsor
- Karolinska Institutet
Self-Harm, Depression
Signatures of N-Ac for Non-Suicidal Self-Injury in Adolescents
To measure NAC-induced changes to concentrations of glutathione (GSH) in the anterior cingulate cortex (ACC) as measured by magnetic resonance spectroscopy (MRS) in 36 adolescents and young adults with NSSI (12 in each group…
- Conditions
- Self-Harm, Depression, Suicide
- Trial name
- NCT04005053
- Testing
- N-acetyl cysteine
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Minnesota
Self-Injurious Behavior
Self-Injury Treatment and Recovery in Veterans
Nonsuicidal self-injury (NSSI) refers to the intentional destruction of one's own body tissue without suicidal intent and for purposes that are not socially sanctioned.
- Trial name
- STRIVe (NCT05969080)
- Testing
- Treatment for Self-Injurious Behaviors, Treatment As Usual
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- VA Office of Research and Development
MDD, Major Depressive Disorder (MDD)
Inhaled DMT for Major Depressive Disorder
This Phase 2b, randomized, double-blind, active-controlled clinical trial will evaluate the efficacy and safety of inhaled N,N-dimethyltryptamine (DMT) in adults with Major Depressive Disorder (MDD).
- Conditions
- MDD, Major Depressive Disorder (MDD), Major Depression, Suicidal Ideation
- Trial name
- DMT-MDD (NCT07562191)
- Testing
- N,N-Dimethyltryptamine (15 mg + 60 mg), N,N-Dimethyltryptamine (1 mg + 4 mg)
- Where
- 5 sites in Brazil
- Volunteers
- 140 people
- Sponsor
- Universidade Federal do Rio Grande do Norte
Nonsuicidal Self Injury, Pain Empathy
Altered Neural Pain Empathic Reactivity in NSSI Adolescents
Nonsuicidal self-injury (NSSI) is defined as direct, deliberate bodily harm without suicidal intention. In recent years, growing evidence suggests that NSSI has become a worldwide public health issue.
- Trial name
- NCT05968313
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Self-injurious Thoughts and Behaviours, Borderline Personality Disorder
Development and Initial Testing of a Couple-Based Intervention to Optimize Suicide and Self-Injury Treatment: COMPASS (Connecting, Overcoming, and Moving Past Suicide and Self-Injury)
Self-injurious thoughts and behaviors (SITBs), including suicide, thinking about suicide, and self-injury without intent to die, are major public health crises, with variably effective, and sometimes long and expensive…
- Trial name
- COMPASS (NCT04737252)
- Testing
- Sage (formerly known as COMPASS)
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- York University