Clinical trials: Non-invasive
Cancer of the Head and Neck
PET With [18F]HX4 in Head and Neck Cancer
The aim of this study is to (i) Determine if tumor hypoxia can be accurately visualised with [18F] HX4 PET imaging in head and neck tumors (ii) correlate the [18F] HX4 PET images with blood and tissue markers and (iii)…
- Trial name
- NCT01347281
- Testing
- Injection of [18F]HX4
- Where
- Netherlands
- Volunteers
- 23 people
- Sponsor
- Maastricht Radiation Oncology
Noninvasive Ventilation, Respiratory Insufficiency
A Feasibility Study Evaluating the Use of a Non-invasive Ventilation Mask
Evaluate the clinicians assessment of the use of an oro-nasal mask during non-invasive ventilation (non-intubated) with a feasibility study.
- Trial name
- mask (NCT02383719)
- Testing
- Oro-nasal Mask
- Volunteers
- 18 people
- Sponsor
- Convergent Engineering, Inc.
Musculoskeletal Pain, Musculoskeletal Injury
A New Experimental Model of Transient and Short-lasting Muscle Pain in Humans Based on Diathermy
This study evaluates the use of short-wave diathermy (SWD) as an novel experimental model to induce transient and intensity-controlled muscle pain by heating muscle tissue.
- Trial name
- NCT03573219
- Testing
- Short-wave diathermy
- Where
- Argentina
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- National Council of Scientific and Technical Research, Argentina
Non-Invasive Positive-Pressure Ventilation
Impact of Neurally Adjusted Ventilator Assist (NAVA) Mode on Patient Ventilator Asynchrony Using Helmet
Non invasive ventilation has been proposed to reduce the incidence of ventilatory dysfunction following abdominal aortic surgery.
- Trial name
- NAVAHELMET (NCT01161875)
- Testing
- Neurally Adjusted Ventilatory Assistance
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Pierre and Marie Curie University
Lung Adenocarcinoma, Lung Adenosquamous Carcinoma
Erlotinib Hydrochloride With or Without Carboplatin and Paclitaxel in Treating Patients With Stage III-IV Non-small Cell Lung Cancer
This randomized phase II trial studies how well erlotinib hydrochloride with or without carboplatin and paclitaxel works in treating patients with stage III-IV non-small cell lung cancer.
- Conditions
- Lung Adenocarcinoma, Lung Adenosquamous Carcinoma, Malignant Pericardial Effusion, Malignant Pleural Effusion
- Trial name
- NCT00126581
- Testing
- Carboplatin, Erlotinib, Erlotinib Hydrochloride
- Where
- 96 sites in United States
- Volunteers
- 188 people
- Sponsor
- National Cancer Institute (NCI)
Surgery in Elderly Patients, Hemodynamics
Evaluation of a Non-invasive Cardiac Output Monitoring System.
There are different methods for measuring cardiac output (CO) completely non-invasive, which are used today. Two of these should be used in the study to examine the CO in an older group of patients (> 65 years) undergoing major…
- Conditions
- Surgery in Elderly Patients, Hemodynamics, Pulse Wave Transit Time
- Trial name
- NCT03178162
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Schleswig-Holstein
Accuracy and Precision of Noninvasive Measurement
CNAP Accuracy Dependent on Hemodynamic Variables
Agreement of CNAP pressure with invasive pressure is evaluated dependent on hemodynamic variables achieved by a PICCO monitor. Hypothesis: Low cardiac output and volume status but not high vascular resistance affect the accuracy…
- Trial name
- NCT01743846
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University Hospital Schleswig-Holstein
Low Back Pain, Herniation, Disc
Non-surgical Spinal Decompression Therapy and Outcomes
This project will determine the clinical utility of non-surgical spine decompression for chronic low back pain (LBP). LBP is one of the highest incidence medical conditions that contributes to disability, decreased activities of…
- Conditions
- Low Back Pain, Herniation, Disc, Sciatic Radiculopathy, Intervertebral Disc Stenosis of Neural Canal
- Trial name
- RESTORE (NCT06525896)
- Testing
- NSSD
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- University of South Florida
Hypotension, Hemodynamic Instability
Perioperative Hypotension in Gynaecologic Oncologic Surgery: HPI-ClearSight Versus Arterial Waveform Analysis
Background Intraoperative hypotension is associated with increased morbidity and mortality. The Hypotension Prediction Index (HPI) is an advancement of the arterial waveform analysis to predict intraoperative hypotension minutes…
- Conditions
- Hypotension, Hemodynamic Instability, Gynecologic Cancer
- Trial name
- NCT05354661
- Testing
- Hypotension Prediction Index
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Acute Asthma Exacerbations
Asthma Exacerbations & Respiratory Management International Survey
Asthma is a chronic health condition that affects 300 million humans worldwide and is thought to cause around 1.000 deaths per day.
- Trial name
- AERMIS (NCT06652542)
- Where
- 2 sites in Egypt, Spain
- Volunteers
- 93 people
- Sponsor
- Assiut University
Hereditary Diseases
Cell-based Non-invasive Prenatal Testing as an Alternative to Invasive Chorionic Villus Sampling
The study aims to evaluate cell-based non-invasive prenatal testing (cbNIPT) as an alternative to invasive chorionic villus sampling (CVS) in patients who achieve pregnancy following preimplantation genetic testing for hereditary…
- Trial name
- NCT05453474
- Testing
- Whole genome amplification
- Where
- Denmark
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Maternity, Pregnancy
Passive Leg Raising in Term Pregnancy on Hemodynamic Monitoring - Validating With Transthoracic ECHO (LG-ECHO)
This prospective observational validation study aims to evaluate the agreement and diagnostic accuracy of ClearSight™ compared with transthoracic echocardiography (TTE) during PLR in term pregnant women.
- Conditions
- Maternity, Pregnancy, Labor and Delivery, Hemodynamic Changes
- Trial name
- (LG-ECHO) (NCT07253818)
- Testing
- ClearSight™ System, Transthoracic Echocardiography, Passive Leg Raising (PLR) Maneuver
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ayse Zeynep Turan Civraz
Healthy Participants
Non-invasive Ultrasonic Auricular Vagus Nerve Stimulation
The Vagus nerve, one of 12 cranial nerves that connect the brain to the human body, controls specific involuntary functions such as breathing, heart rate, the digestive system and the immune system, and it is crucial to unlocking…
- Trial name
- SONIC (NCT07283913)
- Testing
- Ultrasound Vagus Nerve Stimulation (U-VNS)
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Menopause, Urinary Incontinence
Evaluation of the Safety and Performance of the MILTA GYNECO Vaginal Probe in Postmenopausal Women With Vaginal Atrophy
Vulvovaginal atrophy is common after menopause, with a significant negative effect on quality of life. Large cohort studies have reported the prevalence of vaginal dryness to be between 27% and 55% and dyspareunia between 32% and…
- Conditions
- Menopause, Urinary Incontinence, Atrophic Vaginitis
- Trial name
- SIVAM (NCT05058313)
- Testing
- Photobiomodulation
- Where
- 3 sites in France
- Volunteers
- 25 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Sepsis, Septic Shock
Non-invasive Hemodynamic Optimization of Sepsis in Internal Medicine: a Randomized Study Comparing Therapy Guided by Non-invasive Hemodynamic Indices Versus Standard of Care.
Background and Rationale Sepsis affects 20 to 30 million people globally each year, with an estimated 48.9 million cases in 2017. Despite medical advances, it still carries a high risk of death.
- Trial name
- NCT07863323
- Testing
- non-invasive hemodynamic assessment, Treatment per SSC Guidelines
- Where
- 2 sites in Italy
- Volunteers
- 430 people
- Sponsor
- Regione del Veneto - AULSS n. 7 Pedemontana
Cerebellar Ataxia
Cerebellar-spinal Transcranial Pulsed Current Stimulation (tPCS) for Treatment of Neurodegenerative Ataxia
Neurodegenerative ataxia represents a group of disabling diseases. Patients mainly present with imbalance during walking, speech problem and difficulty in co-ordination during working with hands.
- Trial name
- tPCS (NCT05625620)
- Testing
- Active Transcranial Pulse Current Stimulation
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Western University, Canada
Diabetes Mellitus, Type 2, Blood Pressure
Validating Non-invasive Measurements of Central Blood Pressure in Type 2 Diabetic Patients
The investigators want to validate two non-invasive devices for the determination of central blood pressure, i.e. blood pressure in the aorta (artery leaving the heart).
- Trial name
- IMPRESS (NCT01538290)
- Where
- Denmark
- Volunteers
- 34 people
- Sponsor
- University of Aarhus
Trisomy 13, Trisomy 18
Prenatal Non-invasive Aneuploidy Test Utilizing SNPs Trial
This prospective blinded study will assess the diagnostic capability of an informatics enhanced SNP based technology (Parental Support) to identify pregnant women who are carrying a fetus with an aneuploidy from fee floating DNA…
- Conditions
- Trisomy 13, Trisomy 18, Trisomy 21, Aneuploidy
- Trial name
- PreNATUS (NCT01545674)
- Testing
- Blood Draw
- Where
- 29 sites in United States, Canada and 4 more
- Volunteers
- 937 people, healthy volunteers welcome
- Sponsor
- Natera, Inc.
Bladder Cancer
Evaluation of ATO-101™ in Patients With Non-Muscle-Invasive Bladder Cancer (PERSEVERANCE EU)
Non-Muscle-Invasive Bladder cancer (NMIBC) tumours often recur despite TransUrethral Resection of Bladder (TURB) and Bacillus Calmette-Guerin (BCG) intravesical instillations, and have no effective conservative treatment options.
- Trial name
- PERSEVERANCE (NCT07260162)
- Testing
- ATO-101™
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Institut Cancerologie de l'Ouest
Reading Disability
Noninvasive Brain Stimulation to Enhance Reading Comprehension Ability in Adults
The goal of this project is to address the urgent need for effective, scalable adult literacy interventions by integrating breakthroughs in two separate fields: 1.) the brain network science of resilience to reading disorders and…
- Trial name
- NCT05523505
- Testing
- RLN real non-invasive brain stimulation intervention, RLN and CCN real non-invasive brain stimulation intervention
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
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