Clinical trials: Non-obstructive Coronary Artery Disease
Angina (Stable), Percutaneous Coronary Intervention (PCI)
Advanced Invasive Diagnosis Strategy for Post-PCI Patients With Stable Coronary Syndromes Undergoing Coronary Angiography
AID Post-PCI Angina is as an observational, prospective, single-cohort, multicenter study designed to investigate the causes and origins of post-PCI angina by using the advance invasive diagnosis (AID) strategy combining with…
- Conditions
- Angina (Stable), Percutaneous Coronary Intervention (PCI), INOCA (Ischemia With Non Obstructive Coronary Artery Disease), Chronic Coronary Syndrome
- Trial name
- NCT07638137
- Testing
- An advanced invasive diagnosis (AID) strategy combining with angiography derived physiology (ADP)
- Where
- 5 sites in Spain
- Volunteers
- 246 people
- Sponsor
- Fundacion Investigacion Interhospitalaria Cardiovascular
Non-Obstructive Coronary Atherosclerosis
Effect of Mental Stress on Myocardial Perfusion in Women
Mental stress-induced myocardial ischemia(MSIMI) has been recognized a significant clinical problem. Evidence has shown that individuals with MSIMI have 2 to 2.5 times higher risk to develop a major averse cardiovascular events…
- Trial name
- MS in women (NCT03982901)
- Testing
- Mental Stress Test
- Where
- China
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Guangdong Provincial People's Hospital
Angina Patients With Non-obstructive Coronary Artery Disease, Coronary Microvascular Dysfunction
Coronary Microvascular Dysfunction in Angina Patients With Non-obstructive Coronary Artery Disease (ANOCA-CMD)
The goal of this observational study is to explore the incidence and effect on prognosis of coronary microvascular dysfunction in patients present of stable anginal symptoms, a clinical indication for invasive coronary…
- Conditions
- Angina Patients With Non-obstructive Coronary Artery Disease, Coronary Microvascular Dysfunction, Index of Microvascular Resistance
- Trial name
- NCT06503640
- Where
- China
- Volunteers
- 100 people
- Sponsor
- China-Japan Friendship Hospital
Non-valvular Atrial Fibrillation
Antithrombotic Strategy Variability In ATrial Fibrillation and Obstructive Coronary Disease Revascularized With PCI - The AVIATOR 2 Registry
The purpose of this observational registry was to compare the safety and efficacy of an antithrombotic regimen comprising one single antiplatelet agent plus an oral anti-thrombotic versus those consisting of DAPT alone or DAPT…
- Trial name
- NCT02362659
- Where
- United States
- Volunteers
- 514 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Adherence, Medication
Prevalence and Determinants of Therapeutic Non-Compliance in Patients With Chronic Pathologies ( PDTNCCP)
Identify the prevalence and determinants related to therapeutic non adherence among patients with chronic pathologies and to design effective interventions optimizing treatment compliance.
- Trial name
- PDTNCCP (NCT07864532)
- Where
- Tunisia
- Volunteers
- 3,000 people
- Sponsor
- University of Monastir
Discrete Coronary Artery Stenosis, Coronary Angiography of Multiple Detectors
Implications of the Presence of Non-obstructive Atherosclerotic Plaques on Platelet and Vascular Reactivity
Approximately 50% of coronary events occur in previously asymptomatic patients. Thus, the early detection of the individuals at higher risk became an important research target within the current cardiology.
- Conditions
- Discrete Coronary Artery Stenosis, Coronary Angiography of Multiple Detectors, Platelet Aggregation, Spontaneous, Cardiovascular Risk Factor
- Trial name
- NCT03632785
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- University of Sao Paulo
Non-Obstructive Coronary Artery Disease
Retrospective Study to Estimate the Current Status of Patients With Non-Obstructive coroNary Artery Disease
The study will estimate the current status of participants with non-obstructive coronary artery disease confirmed via coronary angiography.
- Trial name
- RESPOND (NCT03584321)
- Where
- Germany
- Volunteers
- 1,600 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Myocardial Infarction With Nonobstructive Coronary Arteries
The Prognostic Role of Indices of Sympathetic Nervous System Overdrive in MINOCA
Myocardial infarction with non-obstructive coronary arteries (MINOCA) occurs in 1-13% of all patients with acute myocardial infarction (AMI).
- Trial name
- PRISMA (NCT04681612)
- Testing
- MSNA, Heart Rate Variability, Blood Pressure Variability
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- Hippocration General Hospital
Ischemia, Myocardial, Non-Obstructive Coronary Atherosclerosis
INOCA-NA a Local Prospective Registry
The present study has the following objectives: 1. To investigate the prevalence of INOCA in patients referring for a clinically indicated coronary angiography (CA) c/o Division of Cardiology - Federico II University Hospital; 2.
- Conditions
- Ischemia, Myocardial, Non-Obstructive Coronary Atherosclerosis, Microcirculatory Status, Coronary Microvascular Dysfunction (CMD)
- Trial name
- INOCA-NA (NCT06588244)
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Federico II University
Acute Lung Injury, Pneumonia
Gases Humidification During Noninvasive Ventilation : Heat and Moisture Exchanger or Heated Humidifier ?
To humidify gases during non invasive ventilation, both to heated humidifier (HH) and heat and moisture exchanger (HME) are routinely used.
- Conditions
- Acute Lung Injury, Pneumonia, Chronic Obstructive Pulmonary Disease, Acute Heart Failure
- Trial name
- NCT00221819
- Testing
- heated humidifier (device), Heat and moisture exchanger (device)
- Where
- France
- Sponsor
- University Hospital, Bordeaux
Myocardial Infarction
Internet-based Treatment of Stress and Anxiety in Myocardial Infarction With Non-obstructive Coronary Arteries
Patient with myocardial infarction with non-obstructive coronary arteries and takotsubo syndrome often have high levels of stress and anxiety. At present there are no treatment alternatives in this group of patients.
- Trial name
- e-SMINC (NCT04178434)
- Testing
- Internet-based CBT intervention
- Where
- Sweden
- Volunteers
- 64 people
- Sponsor
- Per Tornvall
Angina Pectoris, Coronary Heart Disease
Evaluate the Efficacy and Safety of MUSK Pill on Coronary Microvascular Dysfunction
Objective to evaluate the effect of Shexiang Baoxin Pill on myocardial ischemia in patients with coronary microvascular dysfunction (non obstructive coronary heart disease) through a randomized, double-blind, placebo-controlled…
- Conditions
- Angina Pectoris, Coronary Heart Disease, X Syndrome, Angina, Non Obstructive Coronary Artery Disease
- Trial name
- NCT04984954
- Testing
- MUSK pill
- Where
- China
- Volunteers
- 264 people
- Sponsor
- Shanghai Hutchison Pharmaceuticals Limited
Angina Attacks, Non Obstructive Coronary Artery Disease
The Anti-Anginal Effects of N-Acetylcysteine (NAC) in Patients with Angina and Non-Obstructive Coronary Arteries (ANOCA)
The goal of this clinical trial is to determine if N-acetylcysteine (NAC) can reduce angina frequency in women with Angina with Non-Obstructive Coronary Arteries (ANOCA).
- Trial name
- NANA (NCT06890507)
- Testing
- N-Acetylcysteine (NAC)
- Where
- Australia
- Volunteers
- 25 people
- Sponsor
- University of Adelaide
Myocardial Ischemia
MCG for Non-Obstructive Myocardial Ischemia
The aim of this prospective study is to identify Non-Obstructive Myocardial Ischemia of patients who have acute chest pain using Magnetocardiography.
- Trial name
- NCT07657546
- Testing
- Magnetocardiography
- Where
- China
- Volunteers
- 3,786 people
- Sponsor
- Qilu Hospital of Shandong University
Hypertrophic Cardiomyopathy
Coronary Sinus Reducer Objective Impact on SymptoMs, Ischaemia and miCrovascular Resistance in Non-obstructive Hypertrophic CardioMyopathy
Hypertrophic cardiomyopathy (HCM) is a common heart condition in which the heart muscle becomes abnormally thick. In non-obstructive HCM, blood flow out of the heart is not blocked, but many patients still experience chest pain…
- Trial name
- COSMIC-HCM (NCT07865364)
- Testing
- Coronary sinus reducer
- Where
- 8 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- Imperial College London
Obstructive Pulmonary Function, Restrictive Pulmonary Function
Study to Compare the Pharmacokinetics and Pharmacodynamics of ASA Powder for Oral Inhalation With Non-enteric-coated Chewable Aspirin in Adult Subjects With Obstructive or Restrictive Pulmonary Function
The goal of this clinical trial is to compare the pharmacokinetics (PK) pharmacodynamics (PD), safety and tolerability of acetylsalicylic acid powder for oral inhalation (I-ASA) with non-enteric-coated chewable aspirin (C-ASA) in…
- Trial name
- NCT05625347
- Testing
- single dose (100 mg) of ASA, single dose (162 mg) of non-enteric-coated chewable aspirin tablets
- Where
- 4 sites in United States
- Volunteers
- 4 people
- Sponsor
- Vectura, Inc.
Coronary Microvascular Dysfunction (CMD), Angina Pectoris With Normal Coronary Arteriogram
Endothelin Role In COronary Microcirculation
Coronary microvascular dysfunction is an important cause of angina in patients who do not have significant blockages in the major coronary arteries.
- Conditions
- Coronary Microvascular Dysfunction (CMD), Angina Pectoris With Normal Coronary Arteriogram, Microvascular Angina
- Trial name
- ERICOM (NCT07670091)
- Testing
- Cardiac MRI, Invasive Coronary Angiogram, Endothelin Receptor Antagonist
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Angina Patients With Non-obstructive Coronary Artery Disease, Coronary Microvascular Disease
Study Targeting Myocardial Perfusion and Symptom Relief in Women With SGLT2 Inhibitors (STRONG)
The goal of this clinical trial is to that Sodium-glucose cotransporter 2 inhibitors treatment will improve Coronary Microvascular Disease with anginal symptoms associated with non-obstructive coronary disease in women.
- Conditions
- Angina Patients With Non-obstructive Coronary Artery Disease, Coronary Microvascular Disease, Coronary Microvascular Dysfunction (CMD)
- Trial name
- STRONG (NCT06600178)
- Testing
- Brenzavvy (bexagliflozin), 20 mg Oral Tablet
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Virginia
Coronary Artery Disease
Safety and Efficacy Study of PB127 Ultrasound Contrast Agent for Diagnosis of Coronary Artery Disease
The purpose of this study is to determine if the use of PB127 with cardiac ultrasound assists in the diagnosis or exclusion of coronary artery disease.
- Trial name
- POINT II (NCT00584896)
- Testing
- PB127 for Injectable Suspension
- Where
- 40 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Point Biomedical
Myocardial Infarction With Non-Obstructive Coronary Arteries
Prognostic Value of Precision Medicine in Patients With MINOCA (PROMISE Trial).
The aim of our study is to evaluate if the use of a precision-medicine approach with a specific therapy tailored on the underlying pathogenic mechanism will improve the quality-of-life in MINOCA patients.
- Trial name
- PROMISE (NCT05122780)
- Testing
- Coronary angiography, OCT imaging, Percutaneous coronary intervention (PCI):
- Where
- 3 sites in Italy
- Volunteers
- 120 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS