Clinical trials: Non-surgical Periodontal Therapy
Periodontitis, Obesity
Effects of Adjunct Antimicrobial Photodynamic Therapy in Periodontal Treatment of Patients With Obesity
The goal of this clinical trial is to compare the effects of adjuvant antimicrobial photodynamic therapy (aPDT) as an adjuvant of scaling and root planing with scaling and root planing alone for periodontal treatment in patients…
- Trial name
- NCT06073704
- Testing
- antimicrobial photodynamic therapy (aPDT), Control
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- University of Sao Paulo
Periodontitis
Effect of Photodynamic Therapy as an Adjunct to Non-Surgical Treatment of Periodontitis
Photodynamic therapy (PDT) is an innovative technique that utilizes light-activated agents, known as photosensitizers, to produce reactive oxygen species capable of targeting and eliminating pathogens.
- Trial name
- PerioFPS (NCT07070453)
- Testing
- Non-surgical periodontal treatment, Scaling and root planing + aPDT
- Where
- 2 sites in Portugal
- Volunteers
- 20 people
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Periodontitis (Stage 3), Gremlin-1
Comparative Analysis of Gremlin-1, Syndecan-4 and IL-1 Beta Levels in Gingival Crevicular Fluid Among İndividuals With Periodontal Health and Stage III Periodontitis, Considering Both Smokers and Non-Smokers, Before and After Non-Surgical Periodontal Therapy
eriodontitis is a complex disease characterized by the inflammation and destruction of the tissues supporting the teeth, and smoking can adversely affect the pathophysiological changes in this process.
- Conditions
- Periodontitis (Stage 3), Gremlin-1, Syndecan 4, Interleukin 1-beta
- Trial name
- NCT06687005
- Testing
- non-surgical periodontal therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Tugba Aydin
Saliva, Cortisol
Comparison of Saliva Biomarkers in Two Different Geographical Regions of Turkey
Periodontitis is a multifactorial, chronic inflammatory disease caused by many factors such as pathogenic microorganisms, host response, environmental and systemic factors.
- Conditions
- Saliva, Cortisol, Smoking, Tobacco, Periodontal Bone Loss
- Trial name
- NCT06809439
- Testing
- Non-Surgical Intervention, Saliva Collection (Baseline), Probing
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Karabuk University
Periodontitis, Prolactin in GCF
The Effect of Non-surgical Periodontal Therapy on the Gingival Crevicular Fluid Levels of Prolactin Hormone in Patients With Periodontitis.
The present study will be conducted on fifty participants. All participants will receive a full-mouth clinical examination, and the following periodontal parameters will be recorded: Plaque Index (PI).
- Trial name
- NCT03726411
- Testing
- non-surgical periodontal therapy
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Eman Mohamed Amr
Periodontal Disease, Diabetes Mellitus, Type 2
Serum Hs-CRP in Periodontitis Patients With or Without Diabetes
the aim of this study was to assess serum levels of high sensitivity c reactive protein in periodontitis patients with and without type 2 diabetes in a trial to analyze its prognostic effect following non-surgical periodontal…
- Trial name
- NCT03908606
- Testing
- Scaling and root planing
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis (Stage 3), Periodontitis Stage IV
Application of a Fasting-mimicking Diet in Obese Patients With Periodontitis Stage III-IV
This study will evaluate whether a fasting-mimicking diet (FMD) can improve the systemic and periodontal response to non-surgical periodontal treatment in obese adults with severe periodontitis.
- Trial name
- NCT07549633
- Testing
- Fast mimicking diet group, Normal diet group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Periodontal Disease, Periodontal Disease Stage 2
ABX Versus CHX in NSPT
The study aims to compare the efficacy of a novel mouthwash based on microRepair ABX and an antibacterial complex with that of 0.12% chlorhexidine, both used as adjuncts to scaling and root planing.
- Conditions
- Periodontal Disease, Periodontal Disease Stage 2, Periodontal Disease, AVDC Stage 3
- Trial name
- ABXvsCHX (NCT07520968)
- Testing
- ABX Mouthwash as adjunctive to non surgical periodontal treatment, CHX as adjunctive to non surgical periodontal treatment
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Roma La Sapienza
Periodontitis, Periodontitis Stage III
Diode Laser-Assisted Periodontal Therapy Enhances Clinical Outcomes for Deep Periodontal Pockets in Smokers
This study investigated the adjunctive effects of diode laser therapy in smokers with severe periodontitis. Thirty-three patients were randomized to non-surgical periodontal therapy (SRP) with or without diode laser.
- Conditions
- Periodontitis, Periodontitis Stage III, Periodontal Disease, Diode Laser Therapy
- Trial name
- NCT07213752
- Testing
- Diode Laser Application in Deep Periodontal Pockets, Professional Mechanical Plaque Removal, Scaling and Root Planing
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Periodontitis, Gingivitis
Evaluation of Mandibular Bone Microstructure Changes After Periodontal Treatment (M-BONE Study)
This prospective study evaluates how non-surgical treatment for gum disease affects the bone of the mandible. Gum disease (periodontitis) can lead to changes in the bone supporting the teeth, but these changes are not always easy…
- Trial name
- NCT07488403
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Root Canal Therapy, Periapical Periodontitis
Comparision of Non Surgical Retreatment and Endodontic Surgery of Failed Root Canal Treated Teeth
To the best of our knowledge, only two studies are available which have provided a direct comparison between outcome of nonsurgical retreatment and endodontic surgery. The results of the two studies are contradictory in nature.
- Trial name
- NCT03918733
- Testing
- surgical treatment, Non surgical retreatment
- Where
- India
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Microbial Colonization, Periodontal Diseases
Impact of Non-surgical Periodontal Therapy on Oral and Gut Microbiome
Periodontitis is an inflammatory disease characterized by a dysbiotic microbiome which can lead to bone destruction and tooth loss.
- Conditions
- Microbial Colonization, Periodontal Diseases, Periodontal Inflammation
- Trial name
- NCT04580355
- Testing
- One-Stage Full Mouth Debridement, Amoxicillin 500mg, Metronidazole 400mg
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Campinas, Brazil
Periodontal Disease, Obesity & Overweight
Effect of GLP-1 Receptor Agonists on Periodontal Health and Response to Nonsurgical Periodontal Therapy
This study aims to evaluate the effects of glucagon-like peptide-1 receptor agonist (GLP-1 RA) use on periodontal health and the response to non-surgical periodontal therapy in individuals with obesity and periodontitis.
- Trial name
- GLP1-PERIO (NCT07770906)
- Testing
- non-surgical periodontal therapy
- Volunteers
- 40 people
- Sponsor
- Cukurova University
Periodontal Bone Loss, Periodontal Pocket
Treatment of Intraosseous Periodontal Defects With Hyaluronic Acid
The aim of the present investigation will be evaluate the healing of periodontal intraosseous defects following Minimally Invasive Non Surgical Debridement (MINSD) and application of a hyaluronic acid-based gel, compared to MINSD…
- Trial name
- NCT05188898
- Testing
- MINSD and Hyaluronic acid, MINSD
- Where
- Italy
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Federico II University
Social Phobia, Periodontal Diseases
Nonsurgical Periodontal Treatment in Patients With Social Phobia
Objective: To investigate the impact of nonsurgical periodontal treatment in patients with social anxiety disorder (SAD) and controls without phobia.
- Trial name
- NSPTSP (NCT03241277)
- Testing
- Non surgical periodontal treatment
- Where
- Brazil
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Periodontitis, Diabetes Mellitus
Subgingival Lactobacillus Reuteri as an Adjunct to Non-Surgical Periodontal Therapy in Diabetic Patients
This randomized controlled clinical trial evaluates the adjunctive effect of subgingival administration of Lactobacillus reuteri probiotics in diabetic patients with Stage III Grade B or higher periodontitis receiving…
- Trial name
- LREUTERI-DM (NCT07652255)
- Testing
- Lactobacillus Reuteri Oral Solution [BioGaia], saline control
- Where
- Vietnam
- Volunteers
- 5 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Intrabony Periodontal Defects
Minimally Invasive Non-Surgical Therapy Versus Single Flap Approach in Management of Periodontal Intrabony Defects
This study aims to evaluate the clinical and 3D radiographic effects of minimally invasive non-surgical periodontal therapy (MINST) compared to single flap approach (SFA) in management of intrabony defects in stage III or IV…
- Trial name
- NCT07822659
- Testing
- minimally invasive non-surgical therapy, minimally invasive periodontal surgery
- Volunteers
- 40 people
- Sponsor
- Cairo University
Peri-Implantitis
Adjunctive Benefit of Electrolytic Cleaning on Non-surgical Treatment of Peri-implantitis.
Evaluate the outcomes of non-surgical therapy of peri-implantitis with the adjunctive use of electrolytic cleaning (Galvo Surge®).
- Trial name
- NCT05179746
- Testing
- Implants are decontaminated with electrolytic cleaning, Implants are decontaminated without electrolytic cleaning
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Lisbon
Chronic Periodontitis, Diabetes Mellitus, Type 2
Effectiveness of Non-surgical Periodontal Treatment on HbA1c Levels in a Patient With Type 2 Diabetes Mellitus
This study evaluates the effectiveness of an intervention, non-surgical periodontal treatment (SPR), in patients with poorly controlled type 2 diabetes mellitus and moderate-severe periodontal disease aimed at reducing HbA1c…
- Trial name
- NCT04051866
- Testing
- Non-surgical periodontal treatment: Scaling and root planing (SRP), Oral hygiene instructions
- Where
- Spain
- Sponsor
- Gerencia de Atención Primaria, Madrid
Periodontitis
The Effect of I-PRF As An Adjunct to Non-Surgical Periodontal Therapy on Clinical Parameters in Smokers With Periodontitis
The aim of this clinical trial is to evaluate the effect of subgingival injectable platelet-rich fibrin (i-PRF) application on clinical periodontal parameters as an adjunct to non-surgical periodontal treatment (NSPT) in smokers…
- Trial name
- NCT06605547
- Testing
- Non-surgical periodontal treatment, Subgingival application of saline, Subgingival application of i-PRF
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Abant Izzet Baysal University