Clinical trials: Non-traumatic Brain Injury
Intrusive Thoughts, Post Traumatic Stress Disorder
Reduction of Trauma-induced Intrusions and Amygdala Hyperreactivity Via Non-invasive Brain Stimulation
The study will focus on the modulation of intrusive memories via functional magnetic resonance imaging (fMRI)-guided repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex (dlPFC) directly after…
- Trial name
- COOL (NCT04325087)
- Testing
- iTBS
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Attention Deficit Hyperactivity Disorder (ADHD)
Methodology of Super-Early Training of Developer Engineers and Leading Analysts With a Diagnosis of ADHD/ASD for Ensuring the Engineering Sovereignty of the State: Time Horizon: 2026-2038-2050
This document outlines a clinical study focused on the transition from diagnosis to profession: the calibration of attention deficit hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) into a strategic sovereign…
- Trial name
- DOCUMENT (NCT07845292)
- Testing
- Voice of Sleep "MamaBee" training modules (Fairy Tales)
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Pisareva Citadel Group LLC
Brain Concussion, Mild Traumatic Brain Injury
Repetitive Transcranial Magnetic Stimulation for Post-concussion Headaches
This study aims to examine the long-term effect of repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, on chronic headaches following mild traumatic brain injury (mTBI).
- Conditions
- Brain Concussion, Mild Traumatic Brain Injury, Headache, Post-Concussion Symptoms
- Trial name
- NCT06112093
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Traumatic Brain Injury (TBI) Patients, Healthy Participants
Portable VR-based Chromatic Pupilloperimeter for Diagnosis and Monitoring of Traumatic Brain Injury
Accurate and non-invasive methods for objectively identifying and monitoring head injuries (such as a concussion) are still an unmet need.
- Conditions
- Traumatic Brain Injury (TBI) Patients, Healthy Participants, Non-TBI Trauma
- Trial name
- NCT07474987
- Testing
- Virtual Reality pupillometry test
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Traumatic Brain Injury
A Study to Evaluate the SENSE Device's Ability to Detect TBI
The study population will consist of 3 mutually-exclusive sets of patients and subjects: TBI patients with intracranial bleeding TBI patients without intracranial bleeding Control subjects with normal brain health.
- Trial name
- SENSE-007 (NCT06828107)
- Testing
- SENSE device
- Where
- 6 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Sense Diagnostics, LLC
Anxiety Disorders and Symptoms, Sensory Disorders
Assessing the Clinical Utility of tACS
The present study seeks to evaluate the clinical utility of repeated transcranial alternating current stimulation (tACS) by assessing long-term, lasting changes in oscillatory activity and subsequent changes in related behavioral…
- Conditions
- Anxiety Disorders and Symptoms, Sensory Disorders, Hypervigilance, Post Traumatic Stress Disorder
- Trial name
- NCT03305328
- Testing
- Transcranial Alternating Current Stimulation
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Florida State University
Traumatic Chronic Encephalopathy
Cerebral and Cognitive Impact of Female Professional SoccerPractice
The objective of this study is to evaluate, using MRI, the microstructural consequences and the onset of any cognitive impairment in female professional soccer players at the end of their career, who have experienced repeated…
- Trial name
- TCFOOT F (NCT06788262)
- Testing
- Cerebral MRI
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Traumatic Brain Injury
A Study to Test the SENSE Device in Military-Age Patients With Traumatic Brain Injury
The study population will consist of 3 mutually-exclusive sets of patients and subjects: TBI patients with intracranial bleeding TBI patients without intracranial bleeding Control subjects with normal brain health.
- Trial name
- Sense-005 (NCT05155800)
- Testing
- SDx3
- Where
- 2 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Sense Diagnostics, LLC
Brain Injuries, Traumatic, Concussion, Mild
Validation of Brain Function Assessment Algorithm for mTBI/Concussion
This study is Part 2 of data collection from 13-25 years old subject population for validation of previously derived algorithms.
- Conditions
- Brain Injuries, Traumatic, Concussion, Mild, Concussion, Severe, Concussion, Intermediate
- Trial name
- CAS13-25V (NCT03671083)
- Testing
- BrainScope Ahead 300iP
- Where
- 5 sites in United States
- Volunteers
- 309 people, healthy volunteers welcome
- Sponsor
- BrainScope Company, Inc.
All Cause Mortality, Cardiovascular Diseases
Advice of Moderate Drinking Pattern Versus Advice on Abstention on Major Disease and Mortality
The goal of this clinical trial is to test two advices on alcohol drinking in more than 10.000 Spanish adult drinkers (men of 50 or more years and women of 55 or more years).
- Conditions
- All Cause Mortality, Cardiovascular Diseases, Invasive Cancer, Liver Cirrhosis
- Trial name
- UNATI (NCT06338215)
- Testing
- Moderate Alcohol Drinking Pattern, Abstention
- Where
- Spain
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Traumatic Brain Injury, Post Traumatic Stress Disorder
Test and Evaluation of Non-Invasive Neuro-Assessment Devices (NINAD: Neurokinetics, Inc, iPAS
The long term goal for the Traumatic Injury Research Program (TIRP) is testing of novel devices for the identification and longitudinal assessment of traumatic brain injury (TBI).
- Trial name
- NINADiPAS (NCT03465995)
- Testing
- NKI i-PAS Diagnostic Protocol
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Traumatic Brain Injury, Intracerebral Hemorrhage
Near Infra-red Spectroscopy for Detection of Intracranial Haematoma
Fall with head injury is becoming an epidemic challenge especially with the ageing population. Contributing factors for mortality and poor functional outcome included development of cerebral contusion and delayed traumatic…
- Trial name
- NCT03653728
- Testing
- Near infrared spectroscopy
- Where
- Hong Kong
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Concussion, Mild
Non-invasive Brain Stimulation and Injury Risk Biomechanics
The goal of this clinical trial is to test the effects of repetitive transcranial magnetic stimulation (theta burst stimulation) on movement biomechanics (jump landing) among individuals with and without a concussion history.
- Trial name
- NCT06093295
- Testing
- Repetitive Transcranial Magnetic Stimulation (Theta Burst Stimulation)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Georgia
Brain Concussion
Mild Traumatic Brain Injury Discrimination
Evaluation of the utility of a multi-modal assessment tool in distinguishing between individuals with and without a history of mild traumatic brain injury.
- Trial name
- MTBID (NCT02453958)
- Testing
- Multi-modal assessment system
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Empirical Technologies Corporation
Chronic Musculoskeletal Pain, Posttraumatic Stress Disorder (PTSD)
Neurobiological and Psychological Benefits of Exercise in Chronic Pain and PTSD
The wars in Iraq and Afghanistan are creating a new generation of Veterans, including an increasing number of women Veterans, who present with comorbid PTSD and chronic pain conditions from recent deployment-related physical…
- Conditions
- Chronic Musculoskeletal Pain, Posttraumatic Stress Disorder (PTSD), Mild or Moderate Traumatic Brain Injury
- Trial name
- EXCPPTSD (NCT03283163)
- Testing
- Exercise Testing and Training
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
TBI
Non-invasive Measurement of Cerebrovascular Reactivity After Traumatic Brain Injury
The investigators will longitudinally measure cerebrovascular reactivity (CVR) by functional near-infrared spectroscopy (fNIRS) in acute (≤3 days from injury), subacute, and chronic phases after TBI as a biomarker of TCVI as…
- Trial name
- NCT02990078
- Testing
- Sildenafil citrate, Functional Near Infared Spectroscopy, Hypercapnia Challenge
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Depression, Anxiety
Enhancing the Effectiveness of Cognitive Behavioral Therapy Using Non-invasive Brain Stimulation
The purpose of the proposed study is to examine if a repeated treatment of High Definition Transcranial Direct Current Stimulation (HD-tDCS) can increase the functional connectivity between the left ventrolateral prefrontal…
- Conditions
- Depression, Anxiety, Stress Disorders, Post-Traumatic
- Trial name
- NCT05555056
- Testing
- MxN-9 HD-tES Stimulator (Soterix Inc.)
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Manitoba