Clinical trials: Noncardiac Surgery
Noncardiac Surgery, Postoperative Myocardial Infarction
The Prognostic Capabilities Of A Preoperative Six-Minute Walk Test To Independently Inform Cardiovascular Risk After Major Noncardiac Surgery
This prospective cohort study aims to determine whether the addition of the 6MWT to the RCRI score improves the risk prediction of postoperative cardiovascular outcomes after noncardiac surgery.
- Conditions
- Noncardiac Surgery, Postoperative Myocardial Infarction, Postoperative Death, Risk Assessment
- Trial name
- NCT02860754
- Testing
- Six-minute walk test to perform before surgery
- Where
- Canada
- Volunteers
- 1,000 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Myocardial Injury After Noncardiac Surgery (MINS), Myocardial Ischemia
Ivabradine for Prevention of Myocardial Injury After Noncardiac Surgery Trial (PREVENT-MINS)
This study is a multicentre, randomized controlled trial of ivabradine versus placebo.
- Trial name
- PREVENT-MINS (NCT05279651)
- Testing
- Ivabradine
- Where
- 26 sites in Poland
- Volunteers
- 2,146 people
- Sponsor
- Jagiellonian University
Coronary Artery Disease, Noncardiac Surgery
Preoperative vs Postoperative Revascularization in Coronary Heart Disease Patients Undergoing Time-Sensitive Non-Cardiac Surgery (CHRONOS-PCI)
To compare the safety and efficacy of preoperative versus postoperative revascularization strategies in patients with coronary heart disease undergoing time-sensitive non-cardiac surgery.
- Trial name
- CHRONOS-PCI (NCT07175870)
- Testing
- Non-cardiac surgery followed by postoperative PCI, Preoperative PCI followed by delayed non-cardiac surgery ~3 months later
- Where
- China
- Volunteers
- 140 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Paediatric Surgery, Anaemia
South African Paediatric Surgical Outcomes Study 2
Preoperative anaemia has been shown to be associated with worse outcomes after surgery in both adults and children. Limited research has been done on how common preoperative iron-deficiency anaemia (IDA) is in children and how…
- Conditions
- Paediatric Surgery, Anaemia, Iron Deficiency Anemia, Iron
- Trial name
- SAPSOS2 (NCT05681871)
- Testing
- Ferrous gluconate syrup or ferrous fumarate/folic acid tablets
- Where
- 2 sites in South Africa
- Volunteers
- 755 people
- Sponsor
- University of Cape Town
Elderly, Noncardiac Surgery
Impact of Esketamine on Delayed Neurocognitive Recovery in Older Patients
Esketamine is frequently used during the perioperative period for supplemental analgesia. Small sample size trials showed that subanesthetic dose esketamine may decrease postoperative neurocognitive complications.
- Conditions
- Elderly, Noncardiac Surgery, Delayed Neurocognitive Recovery, Postoperative Delirium
- Trial name
- NCT07523334
- Testing
- Esketamine 1, Esketamine 2, Esketamine 3
- Where
- 2 sites in China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Stroke, Atrial Fibrillation
Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Atrial Fibrillation Occurring Transiently With Stress
Multinational, investigator-initiated study of oral anticoagulation versus no anticoagulation for the prevention of stroke and other adverse cardiovascular events in patients with transient atrial fibrillation occurring…
- Trial name
- ASPIRE-AF (NCT03968393)
- Testing
- Non-vitamin K oral anticoagulant (NOAC)
- Where
- 105 sites in United States, Argentina and 16 more
- Volunteers
- 2,270 people
- Sponsor
- Population Health Research Institute
Breast Cancer, Myocardial Injury After Noncardiac Surgery (MINS)
Impact of Propranolol Strategies on Myocardial Injury After Breast Cancer Surgery
This study aims to evaluate the impact of using propranolol, a non-selective beta-blocker, on preventing myocardial injury after non-cardiac surgery (MINS) in breast cancer patients who also have hypertension or angina.
- Trial name
- B-BIT (NCT07583134)
- Testing
- propranolol, Usual Care
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Chang-Ik Yoon
Aging, Postoperative Cognitive Dysfunction
Postoperative Cognitive Function and EEG
In the elderly patients undergoing elective non-cardiac major surgery, the differences of EEG parameters between those with and without postoperative cognitive dysfunction were observed to determine the characteristic changes of…
- Conditions
- Aging, Postoperative Cognitive Dysfunction, EEG With Periodic Abnormalities
- Trial name
- POEM (NCT04219033)
- Testing
- EEG(Electroencephalogram) change
- Where
- 18 sites in China
- Volunteers
- 1,250 people
- Sponsor
- Air Force Military Medical University, China
Noncardiac Surgery
Prediction of Vascular Events After Major Non-Cardiac Surgery : an Observational Prospective Cohort Study
This observational study includes patients at medium-to-high cardiovascular risks undergoing major noncardiac surgery, measures their baseline demographic and clinical characteristics, preoperative cardiac biomarkers and…
- Trial name
- PREVENGE-CB-2 (NCT05812248)
- Testing
- Perioperative cardiac biomarker measurement
- Where
- China
- Volunteers
- 20,000 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Noncardiac Surgery
ZYNEX Cardiac Monitor in Patients Having Noncardiac Surgery
The trial groups will be: 1. Routine fluid management. Clinicians will be blinded to RI monitoring and use clinical judgement to determine how much fluids should be given, and when.
- Trial name
- NCT05536258
- Testing
- Fluid
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The Cleveland Clinic
Cardiovascular Disease
PeriOperative ISchemic Evaluation-2 Pilot
Major non-cardiac surgeries are common and major heart problems during or after such surgeries represent a large population health problem. Few treatments to prevent heart problems around the time of surgery have been tested.
- Trial name
- POISE2-pilot (NCT00860925)
- Testing
- active clonidine, active ASA
- Where
- 4 sites in Canada, China
- Volunteers
- 90 people
- Sponsor
- McMaster University
Neuromuscular Blockade
Postoperative Urinary Retention in Patients After Noncardiac Surgery and Reversal of Neuromuscular Block
The investigators propose a randomized trial comparing sugammadex and neostigmine for the reversal of neuromuscular blocks induced by rocuronium or vecuronium in adults having general anesthesia with muscular block for noncardiac…
- Trial name
- NCT05545280
- Testing
- Neostigmine with glycopyrrolate, Sugammadex
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The Cleveland Clinic
Intraoperative Hypotension
Hypotension Prediction Index for Blood Pressure Management
Design: Single-center randomized comparison of invasive arterial pressure monitoring vs. arterial pressure monitoring combined with Acumen Hypotension Prediction Index (HPI) software guidance on intraoperative hypotension…
- Trial name
- HPI (NCT03610165)
- Testing
- Acumen HPI-enabled EV1000 screen, Control
- Where
- United States
- Volunteers
- 214 people
- Sponsor
- The Cleveland Clinic
MYOCARD INFARCTUS, Non Cardiac Surgery
Myocardial Injury After Noncardiac Surgery (MINS) in Patients Undergoing Knee and Hip Arthroplasty
The aim of this study is to determine the incidence of myocardial injury after noncardiac surgery (MINS) in patients undergoing elective total knee or hip arthroplasty, and to identify the demographic, clinical, laboratory, and…
- Conditions
- MYOCARD INFARCTUS, Non Cardiac Surgery, ARTHROPLASTY, REPLACEMENT; ANESTHESIA
- Trial name
- MINS (NCT07098468)
- Where
- Turkey (Türkiye)
- Volunteers
- 323 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Elderly, Surgery
Dexmedetomidine and Outcomes of Elderly Admitted to ICU After Surgery
Sleep disorder and delirium are common problems in intensive care unit (ICU) patients, and may lead to poor prognosis. The investigators' previous study showed that nighttime infusion of low-dose dexmedetomidine improved the…
- Conditions
- Elderly, Surgery, Intensive Care Unit, Dexmedetomidine
- Trial name
- NCT04204798
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 1,410 people
- Sponsor
- Peking University First Hospital
Intraoperative Fluid Management
Advanced Monitoring to Inform and Guide Perioperative Hemodynamic Optimization 1 (AMIGO-1) Study
Serious complications occur in about 16% of major surgeries. Episode of hypotension during surgery may be a leading cause of these complications.
- Trial name
- AMIGO-1 (NCT03477617)
- Testing
- Intraoperative Hemodynamic Algorithm, Usual hemodynamic management
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
Perioperative Cardiac Complications
Perioperative Cardiac Complications in Noncardiac Surgery in Tibet, China
This observational study will describe the incidence and risk factors of perioperative cardiac complications (PCCs) in patients undergoing non-cardiac surgery in Tibet Autonomous Region.
- Trial name
- NCT04819698
- Testing
- Troponin I (cTnI ) monitoring
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Peking Union Medical College Hospital
Myocardial Injury, Non-cardiac Surgery
The Effect of Remote Ischemic Preconditioning on Myocardial Injury After Noncardiac Surgery
This is a multicentre, parallel-group, randomised, sham-controlled, observer blinded trial, assessing the efficacy of remote ischemic preconditioning on preventing myocardial injury after noncardiac surgery.
- Conditions
- Myocardial Injury, Non-cardiac Surgery, Remote Ischemic Preconditioning
- Trial name
- NCT05733208
- Testing
- Remote ischemic preconditioning
- Where
- China
- Volunteers
- 766 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Chronic Kidney Diseases, Acute Kidney Injury
Bleeding Reduction in Acute and Chronic Kidney Patients Having Surgery (BRACKETS) Pilot Trial
The BRACKETS pilot study is a multicentre, prospective, randomized controlled trial of prophylactic preoperative tranexamic acid (TXA) versus placebo and, using a partial factorial design, of prophylactic preoperative…
- Conditions
- Chronic Kidney Diseases, Acute Kidney Injury, Bleeding, Surgery
- Trial name
- BRACKETS (NCT06337838)
- Testing
- Desmopressin Injectable Solution, Tranexamic Acid Injectable Product
- Where
- 3 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Hamilton Health Sciences Corporation
Polypharmacy, Surgical Procedure, Operative
Polypharmacy and Outcomes After Elective Noncardiac Surgery
This study investigates the association of preoperative polypharmacy with outcomes and healthcare resource utilization in a population-based sample of older patients enrolled in a universal pharmacare program
- Conditions
- Polypharmacy, Surgical Procedure, Operative, Morality, Epidemiology
- Trial name
- NCT03133182
- Testing
- Polypharmacy
- Volunteers
- 266,499 people
- Sponsor
- Ottawa Hospital Research Institute