Clinical trials: Noncardiac Surgery
Hip Fractures
Hip Fracture Impact on Vascular Events In Noncardiac Surgery patIents: a cOhort evaluatioN (Hip VISION): Pilot Study
Hip VISION (Pilot Study) is a Prospective Observational Cohort Study to evaluate the incidence of overall and cause-specific mortality among consecutive patients aged ≥ 18 years presenting with hip fracture to the Juravinski…
- Trial name
- NCT01984385
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Population Health Research Institute
Atrial Fibrillation, Atrial Flutter
DETECTion of PeriOperative Atrial Fibrillation After Noncardiac Surgery
This is a multicentre prospective cohort study where patients will receive up to 14 days of continuous ECG monitoring by wearing a portable monitoring device, starting within 72 hours after noncardiac surgery.
- Trial name
- DETECT-POAF (NCT06519747)
- Testing
- Cardiac monitoring device
- Where
- 6 sites in Canada
- Volunteers
- 750 people
- Sponsor
- Population Health Research Institute
Elderly Patients, Major Surgery
Anesthesia-handover Checklist and Perioperative Outcomes in Elderly
With the increasing number of surgical cases, intraoperative handover of anesthesia care is common and inevitable. Verbal handover from one anesthesiologist to another during surgery are being used in many hospitals.
- Conditions
- Elderly Patients, Major Surgery, Anesthesia; Adverse Effect, Prevention
- Trial name
- NCT04377633
- Testing
- Oral handover, Checklist handover
- Where
- China
- Volunteers
- 1,421 people
- Sponsor
- Peking University First Hospital
Anesthesia, Blood Pressure
Norepinephrine Prevent Post-induction Hypotension in High-risk Patients
The investigators aimed to investigate the effects of continuous infusion of norepinephrine before and after general anesthesia induction on the occurrence of post-induction hypotension.
- Conditions
- Anesthesia, Blood Pressure, Norepinephrine
- Trial name
- NCT06028256
- Testing
- Norepinephrine Hydrochloride
- Volunteers
- 180 people
- Sponsor
- First Affiliated Hospital of Kunming Medical University
Predictive Model
A Prediction Model of Postoperative Anxiety Symptom in Elderly Patients Undergoing Major Noncardiac Surgery
A multicentre, prospective observational study to develop and validate a predictive model for postoperative anxiety symptoms in elderly Chinese patients undergoing non-cardiac major surgery.
- Trial name
- NCT06641986
- Where
- China
- Volunteers
- 5,551 people
- Sponsor
- Chinese PLA General Hospital
Myocardial Injury After Noncardiac Surgery (MINS)
Myocardial Injury Noncardiac Surgery in Geriatric Patients
In inpatients aged 45 years and older, the approximate peri-operative mortality rate after non-cardiac surgery is around 1% to 2%. Half of these deaths are attributed to cardiovascular complications of surgery.
- Trial name
- NCT06957106
- Where
- Turkey (Türkiye)
- Volunteers
- 117 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Patients With History of Ischemic Heart Disease With LV Dysfunction Undergoing Noncardiac Surgery
ACTIONS - Aortic Counterpulsation to Improve Outcomes in Noncardiac Surgery
The use of the IABP, in addition to standard care, in high-risk cardiac patients undergoing major noncardiac surgery is feasible and may result in improved perioperative outcomes at 30 days compared with standard care alone…
- Trial name
- ACTIONS (NCT01253356)
- Testing
- IABP
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Datascope Corp.
Mortality Following Noncardiac Surgery
South African Surgical Outcomes Study
We will conduct a 7 day cohort study of consecutive patients aged 16 years and older undergoing inpatient noncardiac surgery. Patients will be followed up for a maximum of 30 days.
- Trial name
- SASOS (NCT02141867)
- Where
- South Africa
- Volunteers
- 3,927 people
- Sponsor
- University of KwaZulu
Perioperative Stroke
Neurological Impact of Vascular Events In Noncardiac Surgery patIents cOhort evaluatioN Pilot Study
Two hundred million adults worldwide have major surgery every year. A million of these patients will have an obvious stroke after their surgery. Another 10 million patients may have "silent" strokes.
- Trial name
- NCT01369537
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- McMaster University
Patients ASA I, II, III
Postoperative Cognitive Dysfunction After Propofol Anesthesia for Noncardiac Surgery
Background: Postoperative cognitive dysfunction (POCD) in elderly patients after noncardiac surgery is a common problem. Therefore,this study was designed to assess POCD after closed-loop coadministration of propofol and…
- Trial name
- POCD ELA (NCT02841423)
- Testing
- neuropsychological test battery
- Where
- France
- Volunteers
- 204 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Aged, Surgical Procedures, Operative
Dexmedetomidine and Long-term Outcome in Elderly Patients After Surgery
Delirium is a frequent postoperative complication. Its occurrence is associated with worse long-term outcomes. In a previous randomized controlled trial, prophylactic low-dose dexmedetomidine infusion during the early…
- Conditions
- Aged, Surgical Procedures, Operative, Delirium, Dexmedetomidine
- Trial name
- NCT02809937
- Testing
- dexmedetomidine
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Peking University First Hospital
Hypotension, Postoperative Complications
Biomarkers, Blood Pressure, BIS: Risk Stratification/Management of Patients at Cardiac Risk in Major Noncardiac Surgery
Major adverse cardiovascular events (MACE) are a leading cause of serious complications and death following major noncardiac surgery.
- Conditions
- Hypotension, Postoperative Complications, Acute Coronary Syndrome, Heart Failure
- Trial name
- BBB (NCT02533128)
- Testing
- Liberal blood pressure management, Tight blood pressure management
- Where
- Switzerland
- Volunteers
- 458 people
- Sponsor
- Miodrag Filipovic, Prof. Dr. med.
SURGICAL PROCEDURES, OPERATIVE, Aged
The Impact of Perioperative Geriatric Care on Outcomes After Elective Noncardiac Surgery
The investigators will conduct a population-based study using health administrative data to evaluate the impact of preoperative geriatric consultation on postoperative outcomes in older patients having elective, non-cardiac…
- Conditions
- SURGICAL PROCEDURES, OPERATIVE, Aged, Epidemiology, Mortality
- Trial name
- NCT02975375
- Testing
- Preoperative geriatric consult or assessment, No Preoperative geriatric consult or assessment
- Where
- Canada
- Volunteers
- 266,499 people
- Sponsor
- Ottawa Hospital Research Institute
Perioperative Myocardial Infarction, Disability
Troponin Elevation After Major Noncardiac Surgery 2
Major adverse cardiac events (MACE) are a leading cause of mortality in patients undergoing noncardiac surgery. Patients with perioperative myocardial injury (PMI), defined as either myocardial infarction and lower elevations in…
- Conditions
- Perioperative Myocardial Infarction, Disability, Perioperative/Postoperative Complications
- Trial name
- TEAMS2 (NCT03408522)
- Where
- 3 sites in Canada, Netherlands
- Volunteers
- 1,000 people
- Sponsor
- UMC Utrecht
Hip Fracture, Perioperative Myocardial Injury
Nerve Block and Perioperative Myocardial Injury in Elderly Hip Fracture
This single-center, retrospective cohort study evaluates whether a single preoperative peripheral nerve block can reduce the risk of perioperative myocardial injury in elderly patients undergoing delayed hip fracture surgery…
- Conditions
- Hip Fracture, Perioperative Myocardial Injury, Myocardial Injury After Noncardiac Surgery
- Trial name
- PNB-CARD (NCT07751146)
- Testing
- PNB, Non-PNB
- Volunteers
- 500 people
- Sponsor
- Tongji Hospital
Antiplatelet Agents, Perioperative Care
Optimal PERioperative Antiplatelet Therapy Investigation ON Abdominal Surgery After Coronary Stent Implantation
The purpose of this study is to evaluate the impact of perioperative aspirin continuation on clinical outcomes in patients with a history of coronary stent implantation who are scheduled for abdominal surgery.
- Trial name
- OPERATION (NCT06723145)
- Testing
- Aspirin, Aspirin interruption
- Where
- Japan
- Volunteers
- 1,200 people
- Sponsor
- Kyoto University
Complication of Surgical or Medical Care
Incidence, Predictors and Validation of Risk Scores to Predict Myocardial Infarction After Noncardiac Vascular Surgery
Evaluate the incidence and predictors of post-operative mortality after noncardiac Vascular Surgery and compare the performance of existing risk scores.
- Trial name
- NCT04051749
- Testing
- Noncardiac Vascular Surgery
- Volunteers
- 306 people, healthy volunteers welcome
- Sponsor
- Centro Hospitalar De São João, E.P.E.
Perioperative/Postoperative Complications, Risk Factor, Cardiovascular
Myocardial Injury in Noncardiac Surgery in Sweden
The purpose of this multicentre, prospective, observational study is to identify robust biochemical markers that predict adverse cardiovascular outcomes and mortality in patients undergoing major abdominal surgery.
- Trial name
- MINSS (NCT03436238)
- Where
- 7 sites in Sweden
- Volunteers
- 1,269 people
- Sponsor
- Linkoeping University
Interdisciplinary Communication, Postoperative Complications
Effects of Preoperative Multidisciplinary Team Meetings for High-risk, Adult, Noncardiac Surgical Patients
The current multicenter stepped wedge randomized cluster trial study aims to assess whether implementation of preoperative multidisciplinary team (MDT) discussions is (cost)effective for high risk noncardiac surgical patients.
- Conditions
- Interdisciplinary Communication, Postoperative Complications, Noncardiac Surgery, Surgical Procedures, Operative
- Trial name
- PREPARATION (NCT05703230)
- Testing
- Structured preoperative multidisciplinary team meeting
- Where
- 14 sites in Netherlands
- Volunteers
- 1,200 people
- Sponsor
- Rijnstate Hospital
Atrial Fibrillation, Surgery
Single Dose Flecainide for Early Sinus Rhythm Conversion of Perioperative Atrial Fibrillation After Noncardiac Surgery
Investigator-initiated pilot study of single dose oral flecainide versus no flecainide for the early conversion of perioperative atrial fibrillation to sinus rhythm after noncardiac surgery.
- Trial name
- FLIP-AF (NCT06142604)
- Testing
- Flecainide
- Sponsor
- Population Health Research Institute