Clinical trials: Noninvasive Ventilation
Acute Respiratory Failure
CORALINE - Correlation Between Physiological and Clinical Variables and Failure of Non-Invasive Respiratory Support in Patients With Acute Respiratory Failure
This observational study aims to evaluate the relationship between clinical and physiological variables and the failure of non-invasive respiratory support (NIRS), including high-flow nasal oxygen (HFNO) and non-invasive…
- Trial name
- CORALINE (NCT06989385)
- Testing
- This is an observational study. Interventions are standard of care and include: High-flow nasal oxygen (HFNO) Non-invasive ventilation (NIV) Pnose monitoring
- Where
- Italy
- Volunteers
- 325 people
- Sponsor
- University of Modena and Reggio Emilia
Respiratory Insufficiency, Respiratory Failure
Vela Generation II: Usability and Performance of a Non-Invasive Ventilation Mask.
Study Overview The goal of this clinical trial is to learn whether an improved non invasive ventilation mask with airway washout can reduce how often people need to breathe and perform as well as standard NIV masks when used with…
- Trial name
- NCT07484802
- Testing
- NIV interface with airway washout
- Volunteers
- 60 people
- Sponsor
- Fisher and Paykel Healthcare
Acute Hypercapnic Respiratory Failure
Clinical Efficacy of a Cephalic Mask for Noninvasive Ventilation During Acute Hypercapnic Respiratory Failure
Noninvasive ventilation (NIV) is now a major therapeutic option to manage patients with acute hypercapnic respiratory failure (AHRF).
- Trial name
- NCT00213395
- Testing
- Interface for noninvasive ventilation
- Where
- France
- Sponsor
- University Hospital, Rouen
Respiratory Insufficiency, Acute Respiratory Insufficiency
NIV-NAVA vs NIV-PS/PC in Respiratory Insufficiency
This study evaluates the difference between Non Invasive Ventilation with Neurally Adjusted Ventilatory Assist (NIV-NAVA) and Conventional Non Invasive Ventilation with Pressure Support (PS) or Pressure Control (PC).
- Trial name
- NCT02592512
- Testing
- NIV-NAVA, NIV-PS/PC
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Vejle Hospital
Gas Exchange
High-Flow Nasal Cannula Versus Conventional Oxygen Therapy After Extubation in Liver Transplantation
Humidified oxygen therapy via high-flow nasal cannula (HFNC) is a recently available technique delivering heated and humidified high flow oxygen through simple nasal prongs.
- Trial name
- NCT03441854
- Testing
- HFNC group
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Healthy Volunteers
Airway Occlusion Measured During Non-invasive Ventilation to Assess Respiratory Effort
Non-invasive ventilation (NIV) is extensively used in critical care settings and emergency departments for a variety of aetiologies but specially for acute respiratory failure (ARF).
- Trial name
- NCT05576246
- Testing
- airway pressure occlusion measurement
- Where
- Argentina
- Volunteers
- 12 people
- Sponsor
- Clinica Olivos SMG
Hypertension, COVID-19
Coronavirus (COVID-19) ACEi/ARB Investigation
Coronavirus disease 2019 (COVID-19) is a pandemic infection caused by a virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
- Trial name
- CORONACION (NCT04330300)
- Testing
- Thiazide or Thiazide-like diuretics, Calcium Channel Blockers, ACE inhibitor
- Where
- Ireland
- Volunteers
- 2,414 people
- Sponsor
- National University of Ireland, Galway, Ireland
Acute Hypoxemic Respiratory Failure
Predicting High-Flow Nasal Cannula Failure in Acute Hypoxemic Respiratory Failure Using Metabolomics and Clinical Data
The goal of this observational study is to determine whether metabolomic profiles combined with clinical data can predict high-flow nasal cannula (HFNC) failure and help optimize respiratory support in adult patients with acute…
- Trial name
- META-RESPIRE (NCT07607080)
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Hospital del Mar Research Institute (IMIM)
Acute Respiratory Failure
The Use of Palliative Non Invasive Ventilation in Acute Respiratory Failure. OVNI Study.
The purpose of this study is: to estimate the frequency of the use of non invasive ventilation to estimate the frequency of the use of palliative non invasive ventilation to evaluate the impact of non invasive ventilation to…
- Trial name
- OVNI (NCT01449331)
- Where
- France
- Volunteers
- 1,450 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Respiratory Failure
Patient-ventilator Synchronisation Study for Intensive Care Unit Patients
This cross-over study will compare the asynchrony index between standard manual ventilator settings, optimized manual ventilator settings, and automated ventilator setting in intensive care patients ventilated in non-invasive…
- Trial name
- SyncAutoVNI (NCT03787173)
- Testing
- Optimized, Automated
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Chronic Obstructive Pulmonary Disease (COPD)
Effect of Exercise Ventilatory Support Pressure on Endurance in Patients With Severe Chronic Obstructive Pulmonary Disease - AVE-BPCO
Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease characterized by progressive obstruction of the airways.
- Trial name
- AVE-BPCO (NCT07125989)
- Testing
- non-invasive ventilation
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Bronchiolitis, Pneumonitis
Utility of Lung Clearance Index Score as a Noninvasive Marker of Deployment Lung Disease
The purpose of this study is to learn more about new noninvasive ways of detecting lung disease in US Military personnel and people who worked as contractors during military operations in Iraq and Afghanistan.
- Conditions
- Bronchiolitis, Pneumonitis, Dyspnea
- Trial name
- LCI (NCT03012958)
- Testing
- Lung clearance index (LCI)
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- National Jewish Health
Cancer
Non-invasive Ventilation in Terminally Ill Cancer Patients
The occurrence of acute respiratory failure (ARF) is often seen by oncologists as a terminal phase of the disease, this view being based on studies reporting limited survival at considerable costs in such patients.
- Trial name
- NCT00533143
- Testing
- non invasive ventilation (NIV)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
COPD
NIV-Training in Hypercapnic COPD Patients
The aim of the study is to investigate the additional effects of the use of NIV during exercise within a 3-week PR program on exercise capacity in COPD patients with chronic hypercapnic respiratory failure.
- Trial name
- NCT03803358
- Testing
- exercise training with non-invasive ventilation, standard exercise training without NIV
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Schön Klinik Berchtesgadener Land
Chronic Obstructive Pulmonary Disease Exacerbation, Obstructive Sleep Apnea Exacerbation
Non-invasive Ventilation or CPAP in OSA-COPD Following Admission for an Acute Hypercapnic Respiratory Failure
Chronic obstructive pulmonary disease (COPD) is a major public health problem with 212.3 million prevalent cases of COPD worldwide and 3.3 million deaths related to COPD in 2019.
- Trial name
- NCT07047092
- Testing
- Non-invasive Ventilation (NIV), Continous Positive Airway Pressure (CPAP)
- Where
- France
- Volunteers
- 386 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Infant, Newborn, Diseases, Intubation Complication
Noninvasive Positive Pressure Ventilation During Neonatal Nasal Intubation
The goal of this study is to perform a quality control assessment of our local intubation protocol in any newborn infant requiring endotracheal intubation in the delivery room or neonatal intensive care unit at the Department of…
- Trial name
- IntubAID (NCT06139809)
- Testing
- Intubation
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Hypercapnic Respiratory Failure
High Flow Oxygen and Non Invasive Ventilation for Hypercapnic Respiratory Failure
this study evaluates high flow oxygen therapy in addition to non invasive ventilation (NIV) to treat hypercapnic respiratory failure.
- Trial name
- NCT03627598
- Testing
- HFNC, standard
- Where
- Tunisia
- Volunteers
- 100 people
- Sponsor
- University Hospital, Mahdia
Prematurity
Nasal Cannula Versus Single Nasal Prong for Non-Invasive Ventilation in Preterm Infants
Preterm infants frequently require non-invasive ventilation (NIV) to treat respiratory distress after birth. The effectiveness of NIV may be influenced by the interface used to deliver respiratory support.
- Trial name
- NCT07725614
- Testing
- Experimental, Intervention Name: Nasal Cannula, Active comparator: single nasal prong
- Where
- Indonesia
- Volunteers
- 140 people
- Sponsor
- Universitas Indonesia
COPD
Analyse the Correlation Between sEMG and EMGdi
The most significant pathophysiology change of COPD patients is persistent incompletely reversible airflow obstruction and increased lung volume. As a result, the work of breathing(WB) and neural respiratory drive (NRD)increased.
- Trial name
- NCT03268616
- Testing
- inspiratory threshold load device and NPPV
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Healthy
Effects of High Flow Nasal Cannula on Breathing and the Respiratory System Parameters
The aim of this study is a detailed investigation of the effect of High Flow Nasal Oxygenation (HFNO) on respiratory system characteristics and ventilation parameters in healthy adult subjects and the subsequent use of measured…
- Trial name
- HaFo (NCT04004247)
- Testing
- High Flow Nasal generator (AirVO2)
- Where
- Czechia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Czech Technical University in Prague