Clinical trials: Nonunion Fracture
Rheumatoid Arthritis, Osteoarthritis
A Multi-centre Study to Assess the Long-term Performance of the Summit™ Hip in Primary Total Hip Replacement
The purpose of this study is to monitor the performance of the Summit™ hip in the treatment of patients with hip joint disease requiring a total hip replacement.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Post-traumatic Arthritis, Collagen Disorders
- Trial name
- NCT00208390
- Testing
- Summit Tapered Hip System
- Where
- 5 sites in China, Hong Kong and 3 more
- Volunteers
- 275 people
- Sponsor
- DePuy International
Bone Nonunion
Clinical Study of Umbilical Cord Blood Mononuclear Cells (UCB-MNCs) in the Treatment of Traumatic Fracture Healing
The aim of this study is to explore the effectiveness and safety of umbilical cord blood mononuclear cells in promoting traumatic fracture healing.
- Trial name
- NCT04997590
- Testing
- Umbilical cord blood mononuclear cells, Staphylococcal Enterotoxin C
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Qianfoshan Hospital
Bone Fracture
Autologous BM-MSC Transplantation in Combination With Platelet Lysate (PL) for Nonunion Treatment
Nonunion of long bones would occur in almost 10% of fractures and because of its long term and complicated treatment, is known as a therapeutic challenge for both of the surgeons and patients.
- Trial name
- NCT02448849
- Testing
- Percutaneous injection
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Royan Institute
Femoral Neck Fractures, Avascular Necrosis
Femoral Neck Fracture in Adult and Avascular Necrosis and Nonunion
One of the most serious sequelae of femoral neck fractures (FNFs) is avascular necrosis (AVN) and nonunion, and this translates to a significant morbidity and mortality.
- Trial name
- NCT03666637
- Testing
- dynamic hip screw (DHS) and cannulated screw (CS)
- Where
- Saudi Arabia
- Volunteers
- 69 people
- Sponsor
- Security Forces Hospital
Orthopaedic Surgery
Results of "Four Not Techniques" in Delayed and Nonunion Fractures of Lateral Humeral Condyle in Children
Fracture of lateral humeral condyle in children is not uncommon.The nonunion means no healing of the fracture after 3 months from the injury.Delayed union means no healing from 6 weels to less than 3 months after injury.
- Trial name
- NCT03545230
- Testing
- :Four Not Techniques"
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- Mahidol University
Scaphoid Fracture Non Union
Arthroscopic Scaphoid Grafting Versus Open Grafting in Scaphoid Non Union
the investigators compare the arthroscopic grafting technique with the traditional open technique in th treatment of scaphoid non union as regards the union rate, time to union and functional outcomes to provide the best…
- Trial name
- NCT07320404
- Testing
- Arthroscopic grafting and k wires fixation, open scaphoid grafting with K wires fixation
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Mitigation of Fracture Non-union in Patients at Risk
Observational, Non-interventional Use of LIPUS to Mitigate Fracture Non-union in Patients at Risk
This study is one of three separate studies of the Bioventus Observational Non-interventional EXOGEN Studies (BONES) program. Eligibility for each study is determined by fractured bone.
- Trial name
- BONES (NCT03382483)
- Testing
- Low intensity pulsed ultrasound
- Where
- United States
- Volunteers
- 12,387 people
- Sponsor
- Bioventus LLC
Non-union of Fractures
Autologous Stem Cell Therapy for Fracture Non-union Healing
Do mesenchymal stem cells accelerate new bone formation in persistent non-unions.
- Trial name
- NCT02177565
- Testing
- carrier plus in vitro expanded autologous BMSCs
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust
Osteoarthritis, Post-traumatic Arthritis
A Randomised Single Centre Study to Compare the Long-term Performance of 4 Designs of the DePuy Ultima LX Stem in Primary Total Hip Replacement
The purpose of this study is to compare the performance of 4 designs of the DePuy Ultima LX hip stem in the treatment of patients with hip joint disease requiring a total hip replacement.
- Conditions
- Osteoarthritis, Post-traumatic Arthritis, Collagen Disorder, Avascular Necrosis
- Trial name
- NCT00208351
- Testing
- Ultima LX Collared Stem - Non-Polished/Blasted Finished, Ultima LX Collared Stem - Polished Finished, Ultima LX Collarless Stem - Non-Polished/Blasted Finished
- Where
- United Kingdom
- Volunteers
- 164 people
- Sponsor
- DePuy International
Nonunion Fracture
Treatment of Atrophic Nonunion Fractures by Autologous Mesenchymal Stem Cell Percutaneous Grafting
Bone fractures heal most of the time particularly well and without complications. The solidification takes rarely more than two to three months. The wound healing depends greatly on a good blood supply and needs several steps.
- Trial name
- NCT01429012
- Testing
- Mesenchymal Stem Cells, Culture medium without MSC.
- Where
- Belgium
- Sponsor
- University of Liege
Infection, Wound Healing Problem
Fluid Lavage of Open Wounds (FLOW): Pilot Trial
The purpose of this trial is to investigate whether irrigation solution (soap vs. saline solution), or irrigation pressure (high vs. low) will decrease the rate of infection among patients with open fracture wounds.
- Conditions
- Infection, Wound Healing Problem, Nonunion
- Trial name
- FLOW (NCT01069315)
- Testing
- Type of fluid lavage solution, Type of fluid lavage pressure
- Where
- 9 sites in United States, Canada and 1 more
- Volunteers
- 111 people
- Sponsor
- McMaster University
Scaphoid Fracture
Vascularized Bone Grafts for Treatment of Scaphoid Nonunion
To assess the effect of vascularized bone grafting on the functional, clinical and radiological outcomes of the scaphoid nonunion
- Trial name
- NCT05358015
- Testing
- vascularized bone graft for scaphois nonunion
- Volunteers
- 25 people
- Sponsor
- Assiut University
Fracture, Fracture Nonunion
Relationships Between Vitamin D and Orthopedic Trauma
Vitamin D is an essential hormone involved in bone metabolism, bone mineral density maintenance, and bone health. Vitamin D deficiency is putatively linked to poor pediatric orthopedic outcomes [1].
- Conditions
- Fracture, Fracture Nonunion, Fractures, Bone, Vitamin D
- Trial name
- NCT04564625
- Testing
- Vitamin D Assessment, Fracture
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Methodist Health System
Healing of Fracture
Mesenchymal Stem Cells; Donor and Role in Management and Reconstruction of Nonunion Fracture
The investigators hypothesized that mesenchymal stem cells can be isolated from fracture site, iliac crest, and tibial crest, and can be expanded to be used in the management of nonunion fracture.
- Trial name
- NCT01626625
- Testing
- stem cells + hydroxy apatite, autograft taken from iliac crest
- Where
- Indonesia
- Volunteers
- 10 people
- Sponsor
- Universitas Indonesia
Rheumatoid Arthritis, Osteoarthritis
A Single Centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Primary Hip Resurfacing Surgery
The purpose of this study is to monitor the performance and determine the metal ion release of the DePuy ASR™ System in the treatment of patients with hip joint disease requiring hip resurfacing surgery.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Post-traumatic Arthritis, Collagen Disorders
- Trial name
- NCT00872794
- Testing
- DePuy ASR™ Hip System
- Where
- South Africa
- Volunteers
- 50 people
- Sponsor
- DePuy International
Fracture Non Union, Fracture Healing
Prospective Validation Study of the CD8+TEMRA Cells As a Prognostic Biomarker of Healing Outcome After Fracture
In approx. 10-15% of all fracture patients, there is a prolonged healing time or even a complete absence of fracture healing (non-union).
- Conditions
- Fracture Non Union, Fracture Healing, Long Bone Delayed-Union Fracture, Humerus Shaft Fracture
- Trial name
- BioBone (NCT06658379)
- Testing
- CD8+TEMRA
- Where
- 7 sites in Germany
- Volunteers
- 640 people
- Sponsor
- Charite University, Berlin, Germany
Fracture, Bone Nonunion
Safety and Exploratory Efficacy Study of UCMSCs in Patients With Fracture and Bone Nonunion
The purpose of the present study is to evaluate the safety and exploratory efficacy of the umbilical cord mesenchymal stem cells for patients with fracture and bone nonunion.
- Trial name
- NCT02815423
- Testing
- UCMSCs, Percutaneous
- Volunteers
- 40 people
- Sponsor
- South China Research Center for Stem Cell and Regenerative Medicine
Fracture, Ununited, Pseudarthrosis
Feasibility Study of Aastrom Tissue Repair Cells to Treat Non-Union Fractures.
The purpose of this multi-center study is to obtain clinical data to substantiate that Aastrom TRC autologous bone marrow cells will regenerate bone in patients with established (appendicular skeletal) non union fractures, when…
- Trial name
- NCT00424567
- Testing
- Fracture surgery, Cultured Bone Marrow Tissue
- Where
- 4 sites in United States
- Volunteers
- 36 people
- Sponsor
- Vericel Corporation
Long Bone Nonunion
Use of Adult Bone Marrow Mononuclear Cells in Patients With Long Bone Nonunion
The aim of the study is to determine the safety and feasibility of autologous mononuclear stem cells in long bone nonunion; and moreover, to evaluate the efficacy of the treatment.
- Trial name
- NCT01581892
- Testing
- Osteosynthesis
- Where
- Spain
- Volunteers
- 7 people
- Sponsor
- Hospital Universitario Central de Asturias
Rheumatoid Arthritis, Osteoarthritis
Multi-Centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Resurfacing and Primary Total Hip Replacement
The purpose of this study is to monitor the performance of a large metal-on-metal bearing from the DePuy ASR™ System in the treatment of patients with hip joint disease requiring hip resurfacing surgery or a total hip…
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Post-traumatic Arthritis, Collagen Disorders
- Trial name
- NCT00872547
- Testing
- DePuy ASR™ Hip System, DePuy ASR™ XL Head / ASR™ Acetabular Cup System
- Where
- 8 sites in Austria, Czechia and 6 more
- Volunteers
- 329 people
- Sponsor
- DePuy International