Clinical trials: Norepinephrine
Liver Transplantation
The Effect of Norepinephrine on Cardiac Output in Patients Undergoing Liver Transplant .
Early administration of NE in liver transplant recipient might enhance cardiac output through an increase in cardiac preload .
- Trial name
- NCT04376281
- Testing
- Noradrenaline
- Where
- Egypt
- Volunteers
- 31 people
- Sponsor
- Cairo University
Hypotenstion, Cesarean Resection
Norepinephrine vs. Phenylephrine for Spinal Hypotension in Cesarean Section
This clinical trial was conducted to compare the effectiveness and safety of two medications-norepinephrine and phenylephrine-in treating low blood pressure (hypotension) that often occurs during spinal anesthesia for cesarean…
- Conditions
- Hypotenstion, Cesarean Resection, Anesthesia Spinal, Pregnancy Complications
- Trial name
- Norepinephrine (NCT07153601)
- Testing
- Norepinephrine 4mcg, Phenylephrine 50 mcg
- Where
- Indonesia
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Universitas Sumatera Utara
Maternal Hypotension
Norepinephrine on Maternal Hypotension After Combined Lumbar and Epidural Anaesthesia
Norepinephrine has emerged as a potential alternative for stabilizing blood pressure during spinal anesthesia for cesarean section, purportedly maintaining maternal heart rate and cardiac output more effectively than…
- Trial name
- NCT06498115
- Testing
- Norepinephrine
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Third People's Hospital of Bengbu
Ciprofol, Propofol
Comparing Ciprofol and Propofol for Sedation in Hypotensive ICU Patients: a Single Center Prospective Cohort Study
This study was a single-center, prospective, 2-year observational cohort study. The study subjects were ICU patients requiring vasopressor drugs and requiring sedation.
- Conditions
- Ciprofol, Propofol, Sedation, Low Blood Pressure
- Trial name
- NCT05971121
- Testing
- ciprofol
- Where
- China
- Volunteers
- 456 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Post Spinal Hypotension
Leg Wrapping and Norepinephrine for Prevention of Post Spinal Hypotension in C.S
Maternal hypotension after subarachnoid block is considered one of the most common complications that occurs during cesarean delivery, with an incidence of up to 70-80%.
- Trial name
- NCT06496061
- Testing
- Norepinephrine, Leg wrapping
- Where
- Egypt
- Volunteers
- 168 people
- Sponsor
- Fayoum University
Overtraining Syndrome
Changes in the Hormonal and Inflammatory Profile of Young Sprint- and Endurance-trained Athletes.
One essential element of athlete training is conditioning camps, where athletes undergo a rigorous and targeted training schedule to prepare for upcoming sporting events.
- Trial name
- CHIPYA (NCT06150105)
- Testing
- Exercise training
- Where
- Poland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Major Depressive Disorder
Major Depressive Disorder Study In Adults
A study to obtain safety and tolerability data
- Trial name
- NCT00049972
- Testing
- paroxetine CR
- Where
- 71 sites in United States
- Volunteers
- 646 people
- Sponsor
- GlaxoSmithKline
Mood Disorder, Substance-Related Disorders
Pharmacological Interaction Between Doxazosin and Methylenedioxymethamphetamine (MDMA)
The purpose of this study is to determinate the effect of a pre-treatment with doxazosin, a alpha1-adrenergic receptor blocker, on the pharmacodynamics and pharmacokinetics of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy").
- Conditions
- Mood Disorder, Substance-Related Disorders, Amphetamine-Related Disorders
- Trial name
- NCT01386177
- Testing
- 3,4-Methylenedioxymethamphetamine, Doxazosin
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Depression
Evaluation of the Initial Prescription of Ketamine and Milnacipran in Depression in Patients With a Progressive Disease
KetaPal is a placebo-controlled randomized trial designed to demonstrate the antidepressant action of ketamine in palliative care situations.
- Trial name
- KETAPAL (NCT02783430)
- Testing
- Ketamine, Milnacipran
- Where
- 9 sites in France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Lille
Fluid Challenge, Pharmakodynamic
EFFECT OF VASOPRESSORS ON FLUID CHALLENGE PERSISTENCE AN OBSERVATIONAL STUDY IN PATIENTS UNDERGOING LAPAROTOMY.
The hemodynamic effect of the fluid challenge administration (FC) depends on different variables related to the interplay between cardiac function and vascular tone response.
- Conditions
- Fluid Challenge, Pharmakodynamic, Norepinephrine, Surgery
- Trial name
- NORA_FC (NCT04934345)
- Testing
- Fluid challenge
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Humanitas Clinical and Research Center
Hepatorenal Syndrome
To Compare the Efficacy of Nor Adrenaline and Terlipressin vs Step up Terlipressin Therapy in Hepatorenal Syndrome
All consecutive patients with liver cirrhosis having Acute Kidney Injury at admission or during hospitalization will be included in the study.
- Trial name
- NCT01649037
- Testing
- nor adrenaline and terlipressin, step up terlipressin therapy
- Where
- India
- Sponsor
- Institute of Liver and Biliary Sciences, India
Symptomatic Neurogenic Orthostatic Hypotension, MSA
Phase 3 Clinical Effect Durability of TD-9855 for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure
A Phase 3, 22-week, Multi-center, Randomized Withdrawal Study of ampreloxetine in Treating Symptomatic Neurogenic Orthostatic Hypotension in Subjects with Primary Autonomic Failure
- Conditions
- Symptomatic Neurogenic Orthostatic Hypotension, MSA, Parkinson's Disease (PD), Pure Autonomic Failure (PAF)
- Trial name
- REDWOOD (NCT03829657)
- Testing
- ampreloxetine
- Where
- 82 sites in United States, Australia and 17 more
- Volunteers
- 203 people
- Sponsor
- Theravance Biopharma
Neural Crest Tumor, Neuroendocrine Tumors
18F-MFBG PET Imaging of the Norepinephrine Transporter in Neural Crest and Neuroendocrine Tumors
The aim of this study is to evaluate the potential and feasibility of 18F-metafluorobenzylguanidine (18F-MFBG) positron emission tomography (PET) in patients with neural crest and neuroendocrine tumors.
- Trial name
- NCT04258592
- Testing
- (18F)MFBG, PET/CT, Venous blood samples
- Where
- Belgium
- Volunteers
- 6 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Septic Shock
The Construction and Application of Therapeutic System of Intelligent Decision-Oriented Hemodynamic Organized Therapy for Shock Patients
Patients with septic shock with norepinephrine >0.25ug/kg/min were enrolled. Informed consent was obtained for inclusion in the study and random assignment into the combination or norepinephrine group.
- Trial name
- NCT05886192
- Testing
- norepinephrine+vasopressin, Norepinephrine
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Adverse Effect
ED90 of Norepinephrine and Phenylephrine Boluses Under Intensive Treatment
The objective of this study is to investigate the ED90 of norepinephrine and phenylephrine boluses for treating postspinal anesthesia hypotension under intensive treatment during cesarean section
- Trial name
- NCT06158009
- Testing
- Norepinephrine, Phenylephrine
- Volunteers
- 80 people
- Sponsor
- General Hospital of Ningxia Medical University
Septic Shock
Norepinephrine Weaning in Septic Patients
The weaning rate of vasopressors drugs is usually chosen empirically by the clinician in critically patients. The investigators applied fuzzy logic principles to modify intravenous norepinephrine infusion rates during…
- Trial name
- CATECHOFLOU (NCT00763906)
- Testing
- norepinephrine infused at the clinician's discretion, norepinephrine infused under computerized fuzzy logic control
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Association pour le Développement de la Recherche et de l'Enseignement en Médecine d'Urgence
Major Depressive Disorder With Excessive Daytime Sleepiness Symptoms
Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol
CLARITY (Clinical Assessment of Response in the Treatment of Depression with Daytime Sleepiness Using Solriamfetol) is a Phase 3, double-blind, placebo-controlled, multicenter randomized withdrawal trial in patients with major…
- Trial name
- CLARITY (NCT07484217)
- Testing
- Solriamfetol 150 MG
- Where
- 40 sites in United States
- Volunteers
- 508 people
- Sponsor
- Axsome Therapeutics, Inc.
Incidence of Post-spinal Hypotension
Norepinephrine With Ephedrine Versus Norepinephrine Alone During Spinal Anesthesia for Cesarean Delivery
We hypothesize that the addition of ephedrine to norepinephrine infusion could decrease the incidence of post spinal hypotension(PSH) in parturient undergoing C.S under spinal anesthesia and minimize the changes in heart rate
- Trial name
- NCT07379710
- Testing
- Ephedrine and Norepinephrine infusion, Norepinephrine infusion
- Where
- Egypt
- Volunteers
- 260 people
- Sponsor
- Cairo University
Multiple Sclerosis
Molecular Imaging of NET Using [C-11]MRB-PET in MS
This study aims to use [C-11]MRB PET (positron emission tomography) imaging to look at brain injury in patients with Multiple Sclerosis (MS) and healthy individuals.
- Trial name
- NCT03207464
- Testing
- [C-11]Methylreboxetine
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Orthostatic Hypotension, Pure Autonomic Failure
Norepinephrine Transporter Blockade as a Pathological Biomarker in Neurogenic Orthostatic Hypotension
The autonomic or automatic nervous system helps control blood pressure. Diseases of the autonomic nervous system may result in a drop in blood pressure on standing in many cases leading to fainting.
- Conditions
- Orthostatic Hypotension, Pure Autonomic Failure, Multiple System Atrophy, Parkinson's Disease
- Trial name
- 6103 (NCT01316666)
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- Vanderbilt University Medical Center