Clinical trials: Norepinephrine
Septic Shock
Methylene Blue in Early Septic Shock
Septic shock is a subset of sepsis characterized by a decrease in vascular tone, which contributes to impaired regional blood flow distribution, and leads to organic failure.
- Trial name
- SHOCKEM-Blue (NCT04446871)
- Testing
- 0.9% sodium chloride, Methylene Blue
- Where
- Mexico
- Volunteers
- 91 people
- Sponsor
- Hospital Civil de Guadalajara
Adverse Effect
ED90 of Norepinephrine and Phenylephrine Infusions in Preeclamptic Patients
The objective of this study is to investigate the ED90 of norepinephrine and phenylephrine infusions for preventing postspinal anesthesia hypotension under intensive treatment in preeclamptic patients during cesarean section
- Trial name
- NCT06158022
- Testing
- Norepinephrine, Phenylephrine
- Where
- China
- Volunteers
- 60 people
- Sponsor
- General Hospital of Ningxia Medical University
Adverse Effect
Prophylactic Norepinephrine and Phenylephrine Boluses for Postspinal Anesthesia Hypotension
The purpose of this study is to investigate the potency between prophylactic norepinephrine and phenylephrine boluses for postspinal anesthesia hypotension in patients undergoing caesarean section.
- Trial name
- NCT05035888
- Testing
- Phenylephrine, Norepinephrine
- Where
- China
- Volunteers
- 80 people
- Sponsor
- General Hospital of Ningxia Medical University
Cesarean Delivery Affecting Newborn, Acidosis
Ephedrine Versus Norepinephrine and Fetal Acid-Base Status During Cesarean Delivery Under Spinal Anesthesia
This study compares ephedrine and norepinephrine for the treatment of low blood pressure (hypotension) that may occur during cesarean delivery under spinal anesthesia.
- Conditions
- Cesarean Delivery Affecting Newborn, Acidosis, Maternal Hypotension, Spinal Aneshtesia
- Trial name
- NEO-FET (NCT06921473)
- Testing
- Norepinephrine, Ephedrine
- Where
- Turkey (Türkiye)
- Volunteers
- 155 people
- Sponsor
- mehmet özkılıç
Adverse Effect
Comparison of Hydroxyethyl Starch and Crystalloid Coload Combined With Norepinephrine Infusion for Hypotension
The purpose of this study is to investigate the ED50 and ED90 for an effective 6% Hydroxyethyl starch (130/0.4) or crystalloid coload combined with prophylactic norepinephrine infusion dose for postspinal anesthesia hypotension…
- Trial name
- NCT05475990
- Testing
- Hydroxyethyl starch, Crystalloid
- Where
- China
- Volunteers
- 80 people
- Sponsor
- General Hospital of Ningxia Medical University
Depression, Major Depressive Disorder
The Effects of Wellbutrin (Bupropion) on Residual and Cognitive Symptoms in SSRI-treated Depression
Many people with depression are treated with a serotonin-specific reuptake inhibitor anti-depressant (SSRI) and feel 'better'. Although many people feel 'better', they do not feel completely 'well'.
- Conditions
- Depression, Major Depressive Disorder, Unipolar Depression
- Trial name
- NCT00125957
- Testing
- Wellbutrin
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Mclean Hospital
Septic Shock
Norepinephrine Equivalent Dose of Vasopressin, Phenylephrine and Epinephrine in Septic Shock
Septic shock is the most common form of circulatory shock encountered in patients admitted in intensive care unit. The initial management involves fluid resuscitation but if hypotension does not get resolved solely by it, then…
- Trial name
- NCT06499467
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Anxiety Disorders, Panic Disorder
Initial Severity and Antidepressant Efficacy for Anxiety Disorders: an Individual Patient Data Meta-analysis
Anxiety disorders are common disorders, which pose a major burden to society and the individual. An anxiety disorder may be treated with medication, in particular with antidepressants such as the selective serotonin reuptake…
- Conditions
- Anxiety Disorders, Panic Disorder, Obsessive-compulsive Disorder, Post-traumatic Stress Disorder
- Trial name
- NCT02476136
- Testing
- paroxetine, duloxetine, fluoxetine or venlafaxine
- Volunteers
- 8,800 people
- Sponsor
- prof. Peter de Jonge
Adverse Effect
Coload Optimization Guided by Inferior Vena Cava Collapsibility Index
The purpose of this study is to investigate the optimal coload guided by inferior vena cava collapsibility index in parturients with prophylactic norepinephrine infusion undergoing cesarean section.
- Trial name
- NCT04272632
- Testing
- 4 ml/kg group, 8 ml/kg group, 12 ml/kg group
- Where
- China
- Volunteers
- 168 people
- Sponsor
- General Hospital of Ningxia Medical University
Acute Kidney Injury, Liver Failure
Renal Perfusion, Filtration and Oxygenation After Liver Transplantation -Effects of av Postoperative Blood Pressure
Comparing the effects of MAP 60, 75 and 90 mmHg, respectively, on renal blood flow, glomerular filtration rate and renal oxygen demand in patients with terminal liver failure directly after liver transplantation.
- Trial name
- NCT02455115
- Testing
- Alternating mean arterial pressure, Norepinephrine, Chromium ethylenediaminetetraacetic acid
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Sahlgrenska University Hospital
Role of the Noradrenergic System in the Regulation of Learning Dynamics, No Disease or Condition is Being Studied
Role of the Noradrenergic System in the Regulation of Learning Dynamics: Evaluation of the Effect of a Low-dose Selective Noradrenaline Reuptake Inhibitor (NOISYXETINE)
Administration of low-dose selective noradrenaline reuptake inhibitor (sNRI) (e.g. atomoxetine) to healthy subjects is a validated model of increasing cortical noradrenaline levels which, combined with computational modelling of…
- Trial name
- NOISYXETINE (NCT07239791)
- Testing
- Atomoxetine
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Spinal Anesthesia
Norepinephrine for Spinal-induced Hypotension
Norepinephrine (NE) infusion is used prophylactically to counteract the vasodilator effect of spinal anesthesia. prophylactic use of NE infusion is expected to decrease bouts of hypotension, vomiting and increase patient…
- Trial name
- NE in spianl (NCT03308708)
- Testing
- Norepinephrine infusion
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mansoura University
Septic Shock, Norepinephrine Adverse Reaction
Norepinephrine Administration Through a Midline Catheter in an Intermediate Care Unit
This is a single-center study retrospectively evaluating a local clinical routine to administer norepinephrine in midline catheters, with regard to complications and patient outcomes
- Conditions
- Septic Shock, Norepinephrine Adverse Reaction, Hypotension and Shock
- Trial name
- NCT06121115
- Testing
- Norepinephrine
- Where
- Sweden
- Volunteers
- 473 people
- Sponsor
- Region Skane
Shock, Mechanical Ventilation
Norepinephrine as Early Vasopressor Therapy in Children Undergoing Mechanical Ventilation
The purpose of this study is to assess the effectiveness from early infusion of norepinephrine in pediatric patients submitted to mechanical ventilation for the use of sedative and analgesics drugs.
- Trial name
- NCT00894621
- Testing
- Norepinephrine
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Unidade de Terapia Intensiva
Hypotension, Orthostatic, Hypotension
Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury
The goal of this study is to determine the efficacy of the drug Droxidopa (Northera) in increasing blood pressure in subject with hypotension, low blood pressure, which is classified as blood pressure less than 110/70 in males…
- Conditions
- Hypotension, Orthostatic, Hypotension, Spinal Cord Injuries
- Trial name
- NCT03602014
- Testing
- Northera
- Where
- 2 sites in United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Arterial Hypertension
Measurement of Noradrenaline Concentrations Using Different Dilution Methods
Norepinephrine is the vasopressor of choice for the treatment of peri-anesthetic arterial hypotension. The use of this drug at significantly lower concentrations (dilution factor between 40 and 200) than the commercial…
- Trial name
- NCT04772599
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Depression
Evaluation of the Initial Prescription of Ketamine and Milnacipran in Depression in Patients With a Progressive Disease
KetaPal is a placebo-controlled randomized trial designed to demonstrate the antidepressant action of ketamine in palliative care situations.
- Trial name
- KETAPAL (NCT02783430)
- Testing
- Ketamine, Milnacipran
- Where
- 9 sites in France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Lille
ADHD
An Open-Label Study to Assess the Long-Term Safety of Solriamfetol in Children and Adolescents With ADHD
This study is a Phase 3, multi-center, open-label trial to evaluate the long-term safety of solriamfetol in children and adolescents with ADHD.
- Trial name
- NCT07773883
- Testing
- Solriamfetol
- Where
- 7 sites in United States
- Volunteers
- 300 people
- Sponsor
- Axsome Therapeutics, Inc.
Chronic SSRI/SNRI Use and Intraoperative Propofol Requirements
The Effect of Chronic ssrı/snrı Antidepressant Treatment on Propofol Consumption in Elective Spine Surgery
The goal of this observational study is to learn whether long-term use of selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressants is related to the amount of propofol…
- Trial name
- NCT07822295
- Where
- Turkey (Türkiye)
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Kocaeli City Hospital
Hypnosis, Endocannabinoids
The Effect of Hypnosis on Blood Concentrations of Endocannabinoids
Introduction: Many interventions such as hypnosis, mindfulness meditation, conditioned pain modulation and placebos have been shown to effectively reduce pain both in the laboratory and in clinical settings.
- Conditions
- Hypnosis, Endocannabinoids, Analgesia
- Trial name
- NCT03407937
- Testing
- Hypnosis, Meditation, Conditioned pain modulation
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke