Clinical trials: Norepinephrine
Major Depressive Disorder
A Paroxetine- and Placebo-Controlled Study of 50 mg/Day and 100 mg/Day of EB-1010 Among Outpatients With Major Depressive Disorder Who Have Responded Inadequately to Prior Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)
The main research hypothesis for this study is that, among patients with Major Depressive Disorder (MDD) who have responded inadequately to treatment with SSRIs or SNRIs, the degree of improvement, as measured by the change from…
- Trial name
- NCT01318434
- Testing
- EB-1010 25mg BID, SSRI Active, EB-1010 50mg BID
- Where
- 43 sites in United States
- Volunteers
- 342 people
- Sponsor
- Euthymics BioScience, Inc.
Hypotension
Vasopressor Outcomes in Spine Surgery
This is a prospective, randomized control trial comparing norepinephrine versus phenylephrine for vasopressor support in patients undergoing elective spinal fusion surgery.
- Trial name
- V-SPINE (NCT06053398)
- Testing
- Phenylephrine, Norepinephrine
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- University of Texas Southwestern Medical Center
Adverse Effect
Coload Optimization Guided by Inferior Vena Cava Collapsibility Index
The purpose of this study is to investigate the optimal coload guided by inferior vena cava collapsibility index in parturients with prophylactic norepinephrine infusion undergoing cesarean section.
- Trial name
- NCT04272632
- Testing
- 4 ml/kg group, 8 ml/kg group, 12 ml/kg group
- Where
- China
- Volunteers
- 168 people
- Sponsor
- General Hospital of Ningxia Medical University
Depressive Disorder
Comparison of Esketamine Nasal Spray vs.Aripiprazole in Treat.Resistant Major Depressive Disorder in Elderly Patients
Phase III, open label, randomised, multicentre, blind for evaluators clinical trial to evaluate the efficacy of esketamine nasal spray at flexible dosis compared to aripiprazole in elderly participants (>60 years) who suffer from…
- Trial name
- CESAR (NCT07153406)
- Testing
- Experimental regimen, Control regimen
- Where
- 9 sites in Spain
- Volunteers
- 220 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Cirrhosis With Septic Shock
To Assess the Efficacy of Early Introduction of a Combination of Low Dose Vasopressin Analogue in Addition to Noradrenaline as a Vasopressor in Patients of Cirrhosis With Septic Shock
The consecutive patients admitted to Intensive care unit of Hepatology department of ILBS and full filling all the eligibility criteria will be enrolled in 1:1 ration by the process of randomization.- The study is an open level…
- Trial name
- NCT02468063
- Testing
- Low dose terlipressin, Noradrenaline
- Where
- India
- Volunteers
- 184 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Hypotension
Norepinephrine and Phenylephrine, Which Better for Elderly?
this is a prospective, double-blinded and single-center study. this study is based on the Stroke volume variation fluid guided therapy, to compare the effects of norepinephrine and phenylephrine in treating perioperative…
- Trial name
- NCT04067817
- Testing
- norepinephrine, Phenylephrine
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Dalian Medical University
Spinal Shock
the Effect of Oral Vasopressors for Liberation From IV Vasopressors in Spinal Shock
the study is developed to evaluate the effect of use of oral vasopressors (midodrine versus minirin) on weaning ICU patients from IV vasopressors (noradrenaline) and compare between them for efficacy in shortage the duration of…
- Trial name
- NCT04586790
- Testing
- Midodrine Oral Tablet, Minirin oral tablet, Nor-Adrenaline
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ahmed talaat ahmed aly
Maternal Hypotension
Norepinephrine Consumption After Prophylactic Ondansetron
This study evaluates the effect of prophylactic ondansetron on the incidence of spinal hypotension and vasopressor consumption in caesarean section patients using norepinephrine treatment.
- Trial name
- NCT02928601
- Testing
- Ondansetron, Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Perioperative Myocardial Injury, Blood Pressure
NORepinephrine-Maintaining-individuaALIZEd Blood Pressure
This study compares the effect of individualized vs standard blood pressure management on postoperative myocardial injury in high-risk patients undergoing non-cardiac surgery by measuring the hs-cTnT levels.
- Conditions
- Perioperative Myocardial Injury, Blood Pressure, Non-cardiac Surgery
- Trial name
- NCT03715712
- Testing
- standardized blood pressure management, Individualized blood pressure management
- Where
- South Korea
- Volunteers
- 420 people
- Sponsor
- Seoul National University Hospital
Healthy Aging and Parkinson's Disease
In Vivo Noradrenergic System and Aging
The main goal of this research proposal is to provide, for the first time in humans, a wider understanding of the role of the noradrenergic system both in health and illness (here Parkinson's disease) through the use of a newly…
- Trial name
- NA2C-PET-MRI (NCT07569120)
- Testing
- PET/MRI scanning session, Neuropsychological examination, Olfactory screening
- Where
- France
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Adverse Effect
ED90 of Norepinephrine and Phenylephrine Infusions in Preeclamptic Patients
The objective of this study is to investigate the ED90 of norepinephrine and phenylephrine infusions for preventing postspinal anesthesia hypotension under intensive treatment in preeclamptic patients during cesarean section
- Trial name
- NCT06158022
- Testing
- Norepinephrine, Phenylephrine
- Where
- China
- Volunteers
- 60 people
- Sponsor
- General Hospital of Ningxia Medical University
Endotoxemia
Effects of Vasopressors on Immune Response
Noradrenaline is a catecholamine and the cornerstone treatment for the improvement of hemodynamic parameters in septic shock. Catecholamines exert profound immunomodulatory effects.
- Trial name
- NCT02675868
- Testing
- Norepinephrine, Phenylephrine, Vasopressins
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Shock, Septic
Multimodal Vasopressor Strategy in Septic Shock
The goal of this prospective randomized controlled trial is to compare the effects of classic stepwise vs. early balanced multimodal vasopressor strategies in septic shock.
- Trial name
- NCT06155812
- Testing
- Simultaneous administration of vasopressors, Successive administration of vasopressors
- Where
- 2 sites in Croatia, Slovenia
- Volunteers
- 79 people
- Sponsor
- University Medical Centre Maribor
Primary Fibromyalgia
Long-Term Safety and Efficacy Study of Milnacipran in Pediatric Patients With Primary Fibromyalgia
The purpose of this study is to evaluate the long-term safety and efficacy of milnacipran in pediatric patients aged 13 to 17 years with primary fibromyalgia.
- Trial name
- MyFi (NCT01331109)
- Testing
- Milnacipran
- Where
- 31 sites in United States
- Volunteers
- 57 people
- Sponsor
- Forest Laboratories
Hypotension During Cesarean Delivery, Blood Pressure Monitoring
Comparison of HPI-guided Norepinephrine Boluses, ClearSight-guided Norepinephrine Infusion, and Oscillometric-guided Norepinephrine Infusion for Blood Pressure Stability During Cesarean Delivery
Background: Post-spinal hypotension occurs in 50-80% of cesarean deliveries and causes maternal nausea, vomiting, and reduced neonatal vigor; norepinephrine (NE), as boluses or prophylactic infusion, is the mainstay of treatment.
- Trial name
- NCT07883265
- Testing
- Hypotension Prediction Index derived from the noninvasive arterial waveform, Continuous noninvasive arterial pressure monitoring (HPI blinded), Norepinephrine intermittent bolus
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- National Taiwan University Hospital
Adverse Effect
Norepinephrine Prophylaxis for Postspinal Anesthesia Hypotension
The purpose of this study is to investigate the suitable infusion dose of norepinephrine for prophylaxis against post-spinal anesthesia hypotension.
- Trial name
- NCT04272567
- Testing
- Norepinephrine, Normal saline
- Where
- China
- Volunteers
- 99 people
- Sponsor
- General Hospital of Ningxia Medical University
Painless Myocardial Ischemia
Painless Myocardial Ischemia in Diabetic Patients.
This study aims to investigate the relationship between the concentrations of blood orphanin, norepinephrine and the morbidity of painless myocardial ischemia in patients with diabetes mellitus.
- Trial name
- NCT04071808
- Testing
- ELISA Test
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Second Hospital of Shanxi Medical University
Septic Shock
Effect of Norepinephrine Administration on Ventricular Systolic Function in Septic Shock
This observational, pharmacological, prospective study aims to assess the improvement of ventricular systolic function mediated by norepinephrine (NE) administration in preload non-responders septic shock patients.
- Trial name
- NCT05355961
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Post-Traumatic Stress Disorder
Study of the Safety and Efficacy of Nabiximols Oromucosal Spray Versus Placebo in Patients With Post-traumatic Stress Disorder
This study will be conducted to evaluate the efficacy of nabiximols for the treatment of symptoms of post-traumatic stress disorder (PTSD) in participants receiving selective serotonin reuptake inhibitor (SSRI) or…
- Trial name
- NCT04592159
- Testing
- Nabiximols
- Sponsor
- Jazz Pharmaceuticals
Adverse Event, Hypotension (MeSH: D007022)
ED90 of Norepinephrine and Phenylephrine Infusion in Patients of Advanced Maternal Age
This study aims to estimate the 90% effective dose (ED₉₀) of norepinephrine and phenylephrine infusions for the prevention of maternal hypotension in patients of advanced maternal age undergoing cesarean section, using the…
- Trial name
- NCT07894783
- Testing
- Norepinephrine, Phenylephrine
- Volunteers
- 60 people
- Sponsor
- General Hospital of Ningxia Medical University