Clinical trials: Norepinephrine
Cardiogenic Shock, Myocardial Infarction
Clinical Outcome and Cost-effectiveness of Reduced Noradrenaline by Using a Lower Blood Pressure Target in Patients With Cardiogenic Shock From Acute Myocardial Infarction
Rationale: Pump failure due to acute myocardial infarction (AMI) can lead to cardiogenic shock (CS): a state of low blood flow to end-organs with subsequent multi-organ failure that is associated with high mortality rated.
- Trial name
- NORSHOCK (NCT05168462)
- Testing
- Reduced noradrenaline use
- Where
- Netherlands
- Volunteers
- 776 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Patients With Norepinephrine-refractory Vasoplegic Shock
Efficacy of Early Argipressin in the Management of Intensive Care Patients With Norepinephrine-refractory Vasoplegic Shock
Acute circulatory failure (shock) is defined as insufficient oxygen transport to meet the oxygen requirements of organs and tissues.
- Trial name
- Vaso²R (NCT07063680)
- Testing
- Argipressin, Chlorure de sodium, Collection of clinical data
- Where
- France
- Volunteers
- 390 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Spinal Induced-hypotension
Comparison of Phenylephrine and Norepinephrine for Spinal-induced Hypotension
Hypotension after spinal anaesthesia for cesarean deliveries is frequently encountered. Phenylephrine an α-agonist is commonly used for the prevention and treatment of spinal-induced hypotension.
- Trial name
- NCT04789005
- Testing
- Norepinephrine, Phenylephrine
- Where
- Nepal
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Parkinson's Disease, Gait Disorders, Neurologic
Study of Methylphenidate to Treat Gait Disorders And Attention Deficit In Parkinson's Disease (PARKGAIT-II)
Therapeutic management of gait disorders in very advanced Parkinson's disease (PD) patients can sometimes be disappointing, since dopaminergic drug treatments and subthalamic nucleus (STN) stimulation are more effective for…
- Conditions
- Parkinson's Disease, Gait Disorders, Neurologic, Dementia
- Trial name
- PARKGAIT-II (NCT00914095)
- Testing
- methylphenidate
- Where
- France
- Volunteers
- 69 people
- Sponsor
- University Hospital, Lille
Depression, Acute Kidney Injury
Serotonin-norepinephrine Reuptake Inhibitors and Acute Kidney Injury
The purpose of this study is to determine if there is an excess risk of acute kidney injury (AKI) with Serotonin-norepinephrine reuptake inhibitors (SNRIs) as compared to Selective serotonin reuptake inhibitors (SSRIs), two…
- Trial name
- SNRI-AKI (NCT02320240)
- Testing
- Duloxetine, Venlafaxine, Desvenlafaxine
- Where
- Canada
- Volunteers
- 3,255,526 people
- Sponsor
- Canadian Network for Observational Drug Effect Studies, CNODES
Hypotension
Management Arterial Hypotension During Planned Caesarean Section, Intravenous Ephedrine/Phenylephrine Mixture Versus Intravenous Baby Noradrenaline
Comparison of two practices of obstetrical services between the CHU of Clermont Ferrand and the HFME Lyon-Bron in the management of arterial hypotension during an elective cesarean section
- Trial name
- ARTEMIS (NCT05513066)
- Where
- 2 sites in France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Carotid Endarterectomy
Effects of Vasopressors on Cerebral Hemodynamics in Patients With Carotid Endarterectomy (TCD Part)
This study was a single-center, exploratory, randomized controlled trial. First, the effects of ephedrine, phenylephrine, or norepinephrine on cerebral blood flow hemodynamics in patients undergoing carotid endarterectomy were…
- Trial name
- NCT05665881
- Testing
- Ephedrine, Phenylephrine, Norepinephrine
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Beijing Tiantan Hospital
General Anxiety Disorder, Social Anxiety Disorder
A 10 Week Open-Label Pilot Study to Evaluate the Effectiveness and Safety of Memantine(Namenda) as Augmentation Therapy in Patients With Generalized Anxiety Disorder
This study is being conducted to evaluate the safety and effectiveness of memantine Add-On treatment of patients who are currently taking an SNRI or SSRI and who remain anxious and symptomatic despite treatment.
- Trial name
- NCT00411398
- Testing
- Namenda/Memantine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Septic Shock
The Construction and Application of Therapeutic System of Intelligent Decision-Oriented Hemodynamic Organized Therapy for Shock Patients
Patients with septic shock with norepinephrine >0.25ug/kg/min were enrolled. Informed consent was obtained for inclusion in the study and random assignment into the combination or norepinephrine group.
- Trial name
- NCT05886192
- Testing
- norepinephrine+vasopressin, Norepinephrine
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Down Syndrome, Autonomic Dysfunction
Exploring Sympathetic Nervous System Function in Individuals With Down Syndrome
Down syndrome (DS), the most common genetic cause of intellectual disability, is associated with widespread organ dysfunction, including abnormalities in the autonomic nervous system (ANS).
- Trial name
- DIVE (NCT07238465)
- Testing
- Cold Stress, Maximal Dynamic Exercise, Isometric Handgrip Exercise with Post-Exercise Muscle Ischemia
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Adverse Effect
ED90 of Norepinephrine and Phenylephrine Boluses Under Intensive Treatment
The objective of this study is to investigate the ED90 of norepinephrine and phenylephrine boluses for treating postspinal anesthesia hypotension under intensive treatment during cesarean section
- Trial name
- NCT06158009
- Testing
- Norepinephrine, Phenylephrine
- Volunteers
- 80 people
- Sponsor
- General Hospital of Ningxia Medical University
Cardiac Surgery, Cardiopulmonary Bypass
Norepinephrine Infusion During Cardiopulmonary Bypass
The primary objective is to test the efficacy and safety of the accuracy of continuous intravenous infusion of norepinephrine during cardiopulmonary bypass (CPB) on the prevention of hyperlactatemia after cardiac surgery.
- Trial name
- Norcal (NCT04312971)
- Testing
- Norepinephrine, Increase infusion rate, Decrease infusion rate
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 80 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Shock
Vasopressin Versus Norepinephrine for the Management of Shock After Cardiac Surgery
Vasoplegic syndrome after cardiac surgery is a common complication after cardiac surgery, with negative impact on patient outcomes and hospital costs.
- Trial name
- VaNCS (NCT01505231)
- Testing
- Vasopressin, Norepinephrine
- Where
- Brazil
- Volunteers
- 300 people
- Sponsor
- University of Sao Paulo
Hypotension Drug-Induced
Norepinephrine Addition in Spinal Anesthesia of Caesarean Section
The objective is to compare efficacy of prophylactic norepinephrine bolus versus Infusion in prevention of hypotension which occurs frequently after spinal anesthesia for caesarean section.
- Trial name
- NASA (NCT03626454)
- Testing
- Norepinephrine Bolus, Norepinephrine infusion, Normal Saline Flush, 0.9% Injectable Solution
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Fayoum University Hospital
Adverse Effect
Prophylactic Norepinephrine Infusion for Spinal Hypotension and Inferior Vena Cava Collapsibility Index
The purpose of this study is to investigate the preventive effect of norepinephrine on post-spinal hypotension and the effect of norepinephrine on inferior vena cava collapsibility index (IVC-CI).
- Trial name
- NCT03997500
- Testing
- normal saline, Norepinephrine
- Where
- China
- Volunteers
- 195 people
- Sponsor
- General Hospital of Ningxia Medical University
Soccer Performance
Effects of Coordinative Warm-Up Exercise Protocols on the Technical and Cognitive Performance of Soccer Players
The aim of this study is to evaluate the effects of 12 weeks of warm-up protocols administered to elite soccer players on technical-coordination performance and levels of cortisol, adrenaline, noradrenaline, and dopamine…
- Trial name
- NCT06690853
- Testing
- Experimental Coordinative training, Traditional training (control group)
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Molise
Anesthesia, Spinal and Epidural, Adverse Effect
Intravenous Bolus of Phenylephrine vs. Norepinephrine in Preventing Hypotension After Spinal Anesthesia
The purpose of the study is to determine if an intravenous bolus of phenylephrine is more effective compared to an intravenous bolus of norepinephrine associated with crystalloid loading for maintaining blood pressure during a…
- Conditions
- Anesthesia, Spinal and Epidural, Adverse Effect, Hypotension, Complications, Cesarean Section
- Trial name
- NorPN (NCT02854787)
- Testing
- Phenylephrine, Norepinephrine
- Where
- Tunisia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
ADHD
A Study to Assess the Efficacy and Safety of Solriamfetol in Subjects With ADHD (FOCUS)
FOCUS (Forward Treatment of Attention Deficit and Hyperactivity Using Solriamfetol) is a Phase 3, multi-center, randomized, double-blind, placebo-controlled, parallel- group trial to assess the efficacy and safety of solriamfetol…
- Trial name
- NCT05972044
- Testing
- Solriamfetol 150 mg, Solriamfetol 300 mg
- Where
- 42 sites in United States
- Volunteers
- 516 people
- Sponsor
- Axsome Therapeutics, Inc.
Major Depressive Disorder
A Paroxetine- and Placebo-Controlled Study of 50 mg/Day and 100 mg/Day of EB-1010 Among Outpatients With Major Depressive Disorder Who Have Responded Inadequately to Prior Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)
The main research hypothesis for this study is that, among patients with Major Depressive Disorder (MDD) who have responded inadequately to treatment with SSRIs or SNRIs, the degree of improvement, as measured by the change from…
- Trial name
- NCT01318434
- Testing
- EB-1010 25mg BID, SSRI Active, EB-1010 50mg BID
- Where
- 43 sites in United States
- Volunteers
- 342 people
- Sponsor
- Euthymics BioScience, Inc.
Hypotension During Surgery
Pneumatic Leg Compression and Norepinephrine Requirements in Patients Having Non-cardiac Surgery
The PLANE trial is a randomized, single-center trial investigating whether pneumatic leg compression reduces the amount of norepinephrine needed to keep MAP above 65mmHg compared to routine care without PLC in patients having…
- Trial name
- PLANE (NCT06950606)
- Testing
- Pneumatic leg compression
- Where
- Germany
- Volunteers
- 238 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf