Clinical trials: Normal Drug Tolerance
Pediatric Obesity, Insulin Resistance
Metabolic Effect of Metformin in Obese Insulin Resistant Adolescents With Normal Glucose Tolerance
The primary objective of this randomized, parallel group, double-blind, placebo-controlled study is to determine whether treatment with metformin enhances insulin sensitivity in a group of ethnically diverse obese…
- Conditions
- Pediatric Obesity, Insulin Resistance, Hyperinsulinemia
- Trial name
- NCT00667498
- Testing
- Metformin
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Yale University
Diabetic Macular Edema
Intra-individual Variability and Circadian Rhythm of VEGF Levels and Interaction With Biomarkers
The study evaluates the intra-individual variability of VEGF levels over a period of 6 months as well as the circadian variation of VEGF levels, both under standardized conditions in patients with type 2 diabetes without DME and…
- Trial name
- NCT02325271
- Testing
- Frequent blood and urine sampling and blood pressure measurement
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- GWT-TUD GmbH
Atopic Dermatitis / Eczema
To Evaluate the in Use Tolerance of E45 Eczema Repair Emollient in Babies and Children With (Very(Dry/Atopic Skin
The investigation will evaluate, under dermatological control, the cutaneous in-use tolerance of E45 Eczema Repair Emollient with two or three times daily application, over a period of two weeks on children and babies with…
- Trial name
- NCT02857062
- Testing
- E45 Eczema Repair Emollient
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Reckitt Benckiser Healthcare (UK) Limited
Obesity
Evaluation of the Effect of Moderate-intensity Physical Activity on Glycemic Variability
Obesity is a major public health problem on the world and Mexico too, in addition the obesity develops chronic non-communicable diseases (NCD) such as type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD).
- Trial name
- NCT02620670
- Testing
- Physical activity of moderate intensity for 3 days
- Where
- Mexico
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Guadalajara
Healthy
A 24 Hour Occlusive Single Patch Test to Assess Acute Tolerance of Pre Lubricated Condom on a Panel of Healthy Adult Subjects
This is a 24 hour patch test to determine the acute tolerance of 3 variants of condom on a panel of healthy adult subjects. The patches will be affixed to the back and remain under occlusion for 24 hours.
- Trial name
- NCT02864966
- Testing
- Condom
- Where
- United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Reckitt Benckiser Healthcare (UK) Limited
Fine Lines, Wrinkles
A Clinical Study Evaluating the Efficacy and Tolerability of a Topical Facial Treatment For Facial Rejuvenation
This single-center clinical trial was conducted to evaluate the efficacy and tolerability of a topical facial treatment when applied by a license esthetician in clinic in a series of 3 sessions with 1 month intervals, in…
- Conditions
- Fine Lines, Wrinkles, Laxity; Skin
- Trial name
- NCT06629792
- Testing
- Gentle Cleanser, Facial Moisturizer, sunscreen SPF 30
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Revision Skincare
Neoplasms, Medication Toxicity
Study of Orally-Administered AMXT 1501 Dicaprate in Normal Healthy Volunteers
This is a Phase 1 study, which will assess the safety, PK, and pharmacodynamics (PD) of orally-administered AMXT 1501 dicaprate in normal healthy male volunteers.
- Conditions
- Neoplasms, Medication Toxicity, Tolerance
- Trial name
- NCT03077477
- Testing
- AMXT 1501
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Aminex Therapeutics, Inc.
Sjogren's Syndrome
The Functioning of Immune and Hormonal Systems in Patients With Sjogren's Syndrome and in Healthy Volunteers
This study aims to learn more about how the immune and hormonal systems function in patients with Sjogren's syndrome, a disease in which the immune system does not function properly.
- Trial name
- NCT00001953
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Impaired Glucose Tolerance
Postprandial Fatty Acid Metabolism in the Natural History of Type 2 Diabetes (T2D)
Lipotoxicity-causing fatty acid overexposure and accretion in lean tissues leads to insulin resistance and impaired pancreatic β-cell function - the hallmarks of T2D - contributing to associated complications such as heart…
- Trial name
- AGL11 (NCT02808182)
- Testing
- Nicotinic acid, [7,7,8,8-2H]-palmitate, [U-13C]-palmitate
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Rosacea, Redness
Evaluation of the Efficacy and Tolerance of Two Cosmetic Products in Subjects With Rosacea
Multicentric and double-blind randomised comparative clinical study in Argentina and Brazil. Under dermatological and ophthalmological control 4 visits: inclusion [Day(D)0], D28, D56, D84 Ethical committee required.
- Conditions
- Rosacea, Redness, Telangiectasia, Flushing
- Trial name
- NCT06582043
- Testing
- SCARCr tester 1
- Where
- 2 sites in Argentina, Brazil
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- NAOS Argentina S.A.
Mucopolysaccharidosis Type II, Metabolic Diseases
A Study of the Tolerance, Safety, and Pharmacokinetics of GNR-055 in Healthy Volunteers
It is a phase I open-label single-dose, dose-escalation cohort study to evaluate of the tolerance, safety, and pharmacokinetics of GNR-055 in healthy volunteers
- Trial name
- NCT06475404
- Testing
- verenafusp alfa 6 mg/kg, verenafusp alfa 9 mg/kg, verenafusp alfa 12 mg/kg
- Where
- Russia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- AO GENERIUM
Cystic Fibrosis, Pancreatic Insufficiency
Beta-cell Response to Incretin Hormones in Cystic Fibrosis
In recent years, diabetes has emerged as one of the most significant co-diseases that many Cystic Fibrosis (CF) patients develop.
- Trial name
- NCT01851694
- Testing
- GLP-1, GIP
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Skin Cancer, Heat Tolerance
Title: ICARUS - Psycho-physiological Profiling of Low and High Heat-resilient Individuals
The escalating environmental heat-stress associated with global warming is a societal challenge with large and potential harmful consequences for humans.
- Conditions
- Skin Cancer, Heat Tolerance, Heat-related Illness, Hyperthermia
- Trial name
- ICARUS (NCT07510061)
- Testing
- Controlled Heat and Ultraviolet Radiation Exposure Protocol
- Where
- 2 sites in Denmark, Greece
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Rheumatic Diseases
Tolerance and Pharmacokinetics of T0001 in Healthy Adult Chinese Volunteers
The purpose of this study to assess the MTD and Pharmacokinetics of T0001 in Healthy Adult Chinese Volunteers.
- Trial name
- NCT02291471
- Testing
- T0001，10mg, T0001，20mg, T0001，35mg
- Where
- China
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.
Skin Laxity, Skin Roughness
Aesthetic Performance and Tolerance of an Injective Intradermal Treatment for the Skin Roughness and Laxity of Back of the Hands
People lose collagen all over the body, not just in the face; skin roughness and laxity of the dorsum of the hands can result from chrono and photo-aging.
- Trial name
- NCT05590364
- Testing
- Profhilo® Body
- Where
- Italy
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- IBSA Farmaceutici Italia Srl
Skin Aging
Comparison of Redermic, Rejuva-A and Combination of Both Redermic and Rejuva-A in Subjects With Signs of Aging
Facial skin aging is a complex process combining factors such as sun exposure, smoking and those that are believed to be inherited.
- Trial name
- NCT00974480
- Testing
- Redermic, Tretinoin (Rejuva-A)
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Normal, Healthy Volunteers
A Study to Evaluate the Safety, Tolerance, and Pharmacokinetic and Pharmacodynamic Profile Of 1 SR Formulation of EB-1020
To investigate whether there is a food-effect with oral administration with EB-1020 as well as to obtain information on the safety, and tolerability of EB-1020 in a range of doses.
- Trial name
- NCT01744808
- Testing
- EB-1020 IR, EB-1020 SR1, EB-1020 SR2
- Where
- Australia
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Mucopolysaccharidosis Type II, Metabolic Diseases
A Multi-cohort Study of the Tolerance, Safety, and Pharmacokinetics of GNR-055 in Healthy Volunteers
It is a phase I open-label single-dose, dose-escalation cohort study to evaluate of the tolerance, safety, and pharmacokinetics of GNR-055 in healthy volunteers
- Trial name
- NCT04539340
- Testing
- GNR-055
- Where
- Russia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- AO GENERIUM
Type 2 Diabetes Mellitus, Impaired Glucose Tolerance
Effects of Colesevelam HCl On Bile Acid Kinetics
This project will compare the amount of bile acids and their kinetics in overweight and obese people with normal glucose metabolism, impaired glucose tolerance and frank type 2 diabetes.
- Trial name
- NCT00476710
- Testing
- Colesevelam HCl
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- KineMed
Acne Vulgaris
Effectiveness and Tolerance of Effaclar Serum in Women With Mandibular Acne
The role of "dermocosmetics" in acne management is increasingly important, as many patients and even physicians now resort to them as first-line management in mild-to-moderate acne.
- Trial name
- NCT05457621
- Testing
- Effaclar serum
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International