Clinical trials: Normal Drug Tolerance
Melanoma
A Study of HX008 Plus LP002 for the Treatment of Patients With Advanced Melanoma
The subsequent treatment choices for the patients with advanced melanoma, who have failed the immune checkpoint inhibitor therapy of single agent. Evidences showed that PD-1 and PD-L1 signalling pathways are not redundant.
- Trial name
- NCT04756934
- Testing
- HX008, LP002
- Where
- China
- Volunteers
- 63 people
- Sponsor
- Taizhou HoudeAoke Biomedical Co., Ltd.
Psoriasis
A Study to Evaluate the Switch From Etanercept to Infliximab in Subjects With Moderate-to-Severe Psoriasis (Study P05133)
This study will evaluate the efficacy, tolerability, and effect on the quality of life of infliximab in adults with moderate-to-severe psoriasis who are resistant to etanercept after 12 weeks of treatment or have failed 24 weeks…
- Trial name
- TANGO (NCT00686595)
- Testing
- Infliximab
- Volunteers
- 48 people
- Sponsor
- Merck Sharp & Dohme LLC
Acne Vulgaris
Study to Determine and Compare the Tolerance and Irritation Potential of Topical Acne Medications
This is a randomized, half-face study. On 1 side of the face, the subject will apply 1 of the 2 test products, clindamycin and benzoyl peroxide or dapsone gel and the contra lateral side of the face will remain non-treated to…
- Trial name
- NCT00964366
- Testing
- clindamycin and benzoyl peroxide, Dapsone gel
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Stiefel, a GSK Company
Oncology, Glioma
Monitoring of Neurological Symptoms, Treatment Tolerance, and Quality of Life Using the Resilience PRO Electronic Patient-reported Outcome Application in Patients With IDH-mutated Glioma
Patients with IDH-mutant glioma frequently experience symptoms such as fatigue, seizures, headaches, cognitive impairments (primarily attentional), and mood changes, which can significantly affect their health-related quality of…
- Trial name
- NEURO-PRO-GLIO (NCT07439302)
- Testing
- Neurocognitive assessment, Questionnaries QoL, Resilience Pro Application
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hand and Face Allotransplantation
Search Tolerance Signature in Vascularised Composite Allograft
Composite tissue allotransplants (CTA) involve transplantation of various tissues including vessels, nerves, skin, bones, and immune cells and entail a significant antigenic load.
- Trial name
- BIOCTA (NCT02055521)
- Testing
- Blood sample, biopsy
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Hospices Civils de Lyon
Purpura, Thrombocytopenic, Idiopathic, Autoimmune Thrombocytopenia
The ITP-RITUX Cohort: Rituximab in Immune ThrombocytoPenia.
The primary purpose of the study is to describe by a prospective observational study the serious adverse events occurring in patients treated off-label by rituximab for Immune Thrombocytopenia.
- Trial name
- ITP-RITUX (NCT01101295)
- Where
- 2 sites in France
- Volunteers
- 250 people
- Sponsor
- Henri Mondor University Hospital
Acne Vulgaris
A Study to Evaluate the Efficacy and Tolerance of 2 Acne Treatment Regimens on Subjects With Mild to Moderate Acne
This study will compare two different acne treatment regimens for the treatment of acne. Half of participants will receive a cleanser and a light therapy mask, while half of the participants will receive a cleanser, a light…
- Trial name
- NCT03124381
- Testing
- Cleanser, Acne Mask, Cleanser, Gel-Cream, Acne Mask
- Where
- 2 sites in United States
- Volunteers
- 126 people
- Sponsor
- Johnson & Johnson Consumer Inc. (J&JCI)
Solar Lentigo, Senile Lentigo
Tolerance and Performance of Cyto-selective Difluoroethane-based Cryotherapy in the Treatment of Brown Spots (Solar and Senile Lentigines, Post-Inflammatory Hyperpigmentation)
CS5_7 study aim to evaluate the tolerance and to adjust the mode of administration of two conditions of cryotherapy treatment applied on the brown spots of the face and hands with 1 prototype (816-v1).
- Conditions
- Solar Lentigo, Senile Lentigo, Post Inflammatory Hyperpigmentation
- Trial name
- NCT05883657
- Testing
- Condition 1 : Prototypes (816-v1) every weeks, Condition 2 : Prototypes (816-v1) every two weeks
- Where
- South Africa
- Volunteers
- 80 people
- Sponsor
- Cryonove Pharma
Lice Infestations
Safety and Tolerability of a Novel Malathion Formulation in Infants and Toddlers With Head Lice
In a previous phase II study, the safety and efficacy of a novel formulation of malathion 0.5% was evaluated in patients 2 years of age and older.
- Trial name
- NCT00291057
- Testing
- MALG
- Where
- 5 sites in United States
- Volunteers
- 30 people
- Sponsor
- Sun Pharmaceutical Industries, Inc.
Type 2 Diabetes, Impaired Glucose Tolerance
Effects of Pinitol on Hidrocarbonated Metabolism Parameters in Diabetic, Impaired and Normal Fasting Glucose Subjects
The purpose of this study was to assess whether pinitol improves hidrocarbonated metabolism parameters, and evaluate its effect on oxidative stress and endothelial function in diabetic, impaired and normal fasting glucose…
- Conditions
- Type 2 Diabetes, Impaired Glucose Tolerance, Healthy
- Trial name
- NCT01754792
- Testing
- Pinitol
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Breast Cancer
GEriatric Determinants of Curative RAdiotherapy Scheme Choice for Breast Cancer ELderly Patient Treatment Compliance and Tolerance
This study proposes an onco geriatric evaluation (Activities of Daily Living, Instrumental Activities Of Daily Living, Mini Mental State Examination, mini Geriatric Depression Scale, Mini Nutritional Assessment, Cumulative…
- Trial name
- GERABEL (NCT02994914)
- Testing
- Onco Geriatric Evaluation
- Where
- 3 sites in France
- Volunteers
- 241 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Breast Cancer, Elderly
Gene Polymorphisms and Gene Products as Biological Markers of Aging and Correlation With Clinical Geriatric Assessment, Tolerance of Chemotherapy and Outcome in Elderly Breast Cancer Patients
The goal is to study the biology of aging in breast cancer patients, and to study the impact of chemotherapy on aging related blood biomarkers.
- Trial name
- EBS (NCT00849758)
- Where
- 2 sites in Belgium
- Volunteers
- 110 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Psoriasis, Pruritus
Evaluation of the Efficacy and Tolerance of the Medical Device RL3020-DP0364 in Adult Population With Stable Mild Plaque Psoriasis, Dry Skin and Pruritus
The product RL3020-DP0364 developed by Pierre Fabre Laboratories moisturizes durably and repairs dry or atopic skin, especially in the case of certain dermatoses (atopic dermatitis, ichthyosis, etc ...) and erythema induced by…
- Conditions
- Psoriasis, Pruritus, Dry Skin
- Trial name
- NCT06800755
- Testing
- Dexeryl (RL3020-DP0364)
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Pierre Fabre Dermo Cosmetique
Varicose Ulcer
Clinical Trial to Evaluate the Efficacy, Tolerance and Acceptability of URGO Dressing vs a Hydrofibre in the Local Management of Venous or Predominantly Venous Mixed Leg Ulcers.
The main objective of this trial is to demonstrate that a local care strategy using URGO 310 3082 dressing is not inferior to a reference therapeutic strategy using a hydrofibre dressing in the management of venous ulcers.
- Trial name
- NCT01449422
- Testing
- Dressing
- Where
- France
- Volunteers
- 159 people
- Sponsor
- Laboratoires URGO
Safety Issues
A Phase I Clinical Study of Hemay808
This is a first-in-human study in health volunteers. The purpose is the local tolerability and systemic safety of Hemay808, which is an ointment made of a novel small molecule Hemay028.
- Trial name
- NCT04100642
- Testing
- Hemay808
- Where
- China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Tianjin Hemay Pharmaceutical Co., Ltd
Glucose Intolerance
Dorzagliatin and 1st Phase Insulin and Beta-cell Glucose Sensitivity in IGT and NGT
Dorzagliatin, a novel dual allosteric activator of glucokinase. reduces blood glucose by increasing insulin secretion by enhancing sensitivity of beta cells to glucose.
- Trial name
- NCT05468229
- Testing
- Dorzagliatin
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Lentigo, Hyperpigmentation
Efficacy and Tolerance of D-pigment Versus Moisturizer in Hands' Lentigo Lesions With or Without Laser Therapy
Pierre Fabre Dermo-Cosmétique has commercialized a cosmetic product (D-pigment rich texture) for treatment of hyperpigmentation.
- Trial name
- NCT03457246
- Testing
- D-Pigment rich texture, Hydrance optimale riche
- Volunteers
- 40 people
- Sponsor
- Pierre Fabre Dermo Cosmetique
Solid Tumor
Treatment of Advanced Solid Tumors With Neo-T(GI-NeoT-02)
The primary objective of this study is to evaluate the safety of Neo-T in the treatment of advanced solid tumors. The secondary objective of this study is to evaluate preliminarily the effect of Neo-T in the treatment of advanced…
- Trial name
- NCT05798546
- Testing
- Neo-T, Cyclophosphamide, Fludarabine
- Where
- China
- Volunteers
- 21 people
- Sponsor
- BGI, China
Leukemia, Lymphoma
Bone Marrow Transplantation in Treating Patients With Hematologic Cancer
RATIONALE: Bone marrow transplantation may be able to replace immune cells that were destroyed by chemotherapy and radiation therapy used to kill tumor cells.
- Conditions
- Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes
- Trial name
- NCT00005854
- Testing
- cyclophosphamide, cyclosporine, methotrexate
- Where
- 4 sites in United States
- Sponsor
- Fred Hutchinson Cancer Center
Cystic Fibrosis, Impaired Glucose Tolerance
Cystic Fibrosis (CF) Exacerbation and Insulin Treatment
The purpose of the study is to evaluate whether insulin treatment during pulmonary exacerbation (PE) in patients with Cystic Fibrosis (CF)and normoglycemia improves their short term outcome by normalizing the glycemic profile and…
- Conditions
- Cystic Fibrosis, Impaired Glucose Tolerance, Pulmonary Exacerbation
- Trial name
- NCT01149005
- Testing
- novorapid / humalog short acting insulin, Novo Rapid Insulin (Novonordisk)
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Hadassah Medical Organization