Clinical trials: Normal Individuals
Diabetes Mellitus
for Adipose Tissue DIabetes VAriants (fATDIVA)
The adipose (fat) cells under the skin are where individuals store excess fat. The more excess fat they have, the more "strain" they put on these cells which then get bigger and don't work as well as they should.
- Trial name
- fATDIVA (NCT02505321)
- Testing
- Oral Triglyceride Tolerance Test (OTTT), Abdominal fat biopsy (optional)
- Where
- United Kingdom
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Hearing Aids, 3D Printing
Effectiveness Comparison of 3D-Printed and Conventional Ear Tip Comfort in Individuals With Hearing in the Normal Range
Access to affordable and timely hearing healthcare remains a major challenge for many individuals, partly due to the high cost and long turnaround time.
- Trial name
- NCT07216937
- Testing
- BTE hearing aid with compatible earmolds
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Healthy Individuals (Controls), Vascular Surgery Patients With Acute Thrombosis
Haemodialysis Alters Hypercoagulability of Blood in Dialysis Patients
Primary Objective: To develop a thrombotic event risk assessment model integrating serum biomarkers (TM, TAT, t-PAIC, PIC) with clinical data, systematically compare its predictive performance across healthy populations, vascular…
- Conditions
- Healthy Individuals (Controls), Vascular Surgery Patients With Acute Thrombosis, Dialysis Patients
- Trial name
- TAT-t-PAIC (NCT07098676)
- Where
- China
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Ai Peng
Atopic Dermatitis, Healthy
Cytokine Production Patterns in Patients With Systemic Mastocytosis Compared With Atopic Dermatitis and Healthy Individuals
Cytokine Production Patterns in Patients with Systemic Mastocytosis Compared with Atopic Dermatitis and Healthy Individuals Summary: This study will examine how mast cells (cells involved in allergic reactions) migrate and…
- Conditions
- Atopic Dermatitis, Healthy, Mastocytosis
- Trial name
- NCT00001760
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Metabolic Syndrome, Inflammation
Impacts of Aronia on Inflammation and the Gut Microbiome
The overall goal of this project is to determine the inflammation lowering impact of anthocyanin-rich Aronia berries. Inflammation is an underlying mechanism driving the development of several diseases.
- Conditions
- Metabolic Syndrome, Inflammation, Hypertriglyceridemia, Obesity
- Trial name
- NCT04128839
- Testing
- Aronia berry juice
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Montana State University
Smoking, Lung Diseases
Evaluation of Lungs of Normal Individuals by Lung Lavage, Brushing and Bronchial Wall Biopsy
The purpose of this study is to obtain biologic materials from the blood and lungs of normal individuals to establish a set of normal range for various parameters.
- Trial name
- NCT00224185
- Testing
- Bronchopulmonary Lung Lavage, Bronchial Brushing, Bronchial Wall Biopsy
- Where
- United States
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
OA, TKA
A Randomized Study on Sagittal Angle Differences in Lower Limbs Between Normal Individuals and Osteoarthritis Patients
With China gradually entering an aging society, the proportion of the elderly population is gradually increasing, and the number of patients with knee disease is also increasing year by year.
- Conditions
- OA, TKA, EOS
- Trial name
- NCT06527924
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Small Fiber Neuropathy
Small Fiber Assessment by Cutaneous Silent Period
Our primary objective in this study is to investigate the cutaneous silent period (CSP) in normal subjects in the Egyptian population, as it was not carried out before in Egypt.
- Trial name
- NCT04863820
- Testing
- cutaneous silent period
- Where
- Egypt
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Cairo University
Healthy
Test-Retest Variability of Quick Contrast Sensitivity Function Testing
The contrast sensitivity function (CSF) provides a comprehensive characterization of spatial vision and predicts functional vision better than visual acuity, but long testing times prevent its psychophysical assessment in…
- Trial name
- NCT02177669
- Testing
- quick Contrast Sensitivity Function test
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University
HİDRADENİTİS SUPPURATİVA
Periodontal Status and Disease Severity in Hidradenitis Suppurativa Patients
This cross-sectional study aims to evaluate the periodontal status of individuals diagnosed with hidradenitis suppurativa (HS) and to compare them with systemically healthy controls.
- Trial name
- NCT07294456
- Testing
- No intervention (observational study)
- Where
- Turkey (Türkiye)
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Infections, Herpesviridae
VALTREX Once Daily For Viral Shedding In Herpes Simplex Virus 2 (HSV-2) Seropositive Subjects. VALTREX® Tablet is a Trademark of GlaxoSmithKline Group of Companies.
Eligible subjects will be randomized to receive VALTREX® tablet 1g or placebo once daily for 60 days in a two-way crossover study with a washout period of 7 days between treatment periods.
- Trial name
- NCT00116844
- Testing
- Valaciclovir
- Where
- 17 sites in United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dynamic Knee Valgus, Force Production
Investigation of the Effect of Instrument Assisted Soft Tissue Mobilization Technique in Individuals With Asymptomatic Dynamic Knee Valgus
STUDY DESIGN: Randomized controlled study OBJECTIVES: To investigate the contribution of instrument assisted soft tissue mobilization (IASTM) applied to gluteus medius (GMed) to isokinetic strength, femoral internal rotation…
- Conditions
- Dynamic Knee Valgus, Force Production, Frontal Plan Projection Angle, Instrument-assisted Soft Tissue Mobilization
- Trial name
- NCT04660604
- Testing
- Graston Technique®
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Sjogren Syndrome, Healthy Volunteers
"Core Stabilization Strenght and Pelvic Floor Functions in Primary Sjogren's"
This study aims to explain the comparison of core stabilization strength and pelvic floor functions between individuals diagnosed with Sjogren syndrome and a healthy control group. (Sjogren syndrome group n=27; control group n=27)
- Trial name
- NCT06879444
- Testing
- Core Muscle testing and patient reported outcome measures
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Onchocerciasis
Safety of a Single Dose of Moxidectin Compared With Ivermectin in Individuals Living in Onchocerciasis Endemic Areas and in Individuals Living in Onchocerciasis Endemic Areas With High Levels of Lymphatic Filariasis Co-endemicity Receiving Concomitant Albendazole
The purpose of this phase 3b study is to determine the safety of a single dose of moxidectin, compared to a single dose of ivermectin, in individuals living in onchocerciasis endemic areas and in individuals living in…
- Trial name
- NCT04311671
- Testing
- Moxidectin, Ivermectin, Albendazole
- Where
- 2 sites in Côte d’Ivoire, Democratic Republic of the Congo
- Volunteers
- 12,979 people, healthy volunteers welcome
- Sponsor
- Medicines Development for Global Health
Normal Hearing
The RBANS-H in Older Adults With Normal Hearing or Age-related Hearing Loss
The present cross-sectional study aims to examine the cognitive capabilities of older adults, aged 50 to 89, with normal hearing or age-related hearing loss by means of the Repeatable Battery for the Assessment of…
- Trial name
- RBANS-H_ARHL (NCT03208608)
- Testing
- RBANS-H
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Periodontitis
Boron Levels, Oxidative Stress, and Inflammation in Periodontitis
This cross-sectional observational study aims to evaluate the relationship between boron levels and oxidative stress, antioxidant defense, and inflammatory markers in individuals with periodontitis.
- Trial name
- NCT07775378
- Testing
- Biochemical Assessment of Saliva and Gingival Tissue
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Marmara University
Inflammation, Obesity
Systemic and White Adipose Tissue Inflammatory Profile in Lean Versus Obese Individuals
This study will compare the systemic and white adipose tissue inflammatory profile of individuals who are classified as lean and obese.
- Conditions
- Inflammation, Obesity, Inflammatory Response, Cardiovascular Risk Factor
- Trial name
- NCT04078776
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Photobiomodulation
Effects of Led Photobiomodulation Therapy
Background: Photobiomodulation therapy (PBMT) has become an adjuvant therapeutic possibility in body remodeling procedures. Although this modality emerged in 1960, there are still few studies that demonstrate the real mechanism…
- Trial name
- LLLT (NCT05012514)
- Testing
- LLLT RED
- Where
- Brazil
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Indústria Brasileira Equipamentos Médicos - IBRAMED
Type 1 Diabetes Mellitus
Tissue-Specific Metabolic Reprogramming in Diabetic Complications
We will perform blood sugar studies to assess changes in metabolic (biochemical processes that occur within us) profiles associated with high blood sugar and diabetes.
- Trial name
- DP3 (NCT01823406)
- Testing
- Euglycemic clamp (normal blood sugar clamp) for 4 hours, hyperglycemic clamp (elevated blood sugar to 300) for 4 hours
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Obesity, Ageing
Brown Adipose Tissue Activity and Age
In this study the investigators aim to investigate whether the sympathetic stimulation of BAT, as assessed with a 123I-metaiodobenzylguanidine single-photon emission computed tomography computed tomography scan, differs between…
- Trial name
- NCT02130154
- Testing
- 18-FDG PET CT scan and 123I-MIBG SPECT scan
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)