Clinical trials: Normal Volunteers
Breakthrough Pain
Staccato Fentanyl Single and Multidose PK
The Phase I clinical trial in approximately 50 healthy volunteers will be conducted at a single clinical center in two stages. Stage 1 is an open-label, cross-over comparison of a single dose of Staccato Fentanyl and an…
- Trial name
- NCT00402350
- Testing
- Inhaled Fentanyl 25 mcg, Intravenous Fentanyl 25 mcg, Inhaled Fentanyl 25 mcg x 2
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Alexza Pharmaceuticals, Inc.
Plaque-type Psoriasis
Safety Study of Ointment for the Treatment of Plaque-type Psoriasis
The purpose of this study is to determine how much drug is absorbed throughout the body after being applied to the skin.
- Trial name
- AN2728-PSR-104 (NCT01258088)
- Testing
- AN2728 Ointment, AN2728 Vehicle
- Where
- Australia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Pfizer
Normal Volunteers, Hepatitis
Protein Biomarker in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the fifth commonest cancer in the world with poor prognosis, as the annual mortality is almost equivalent to the incidence. This is mainly due to late diagnosis and co-morbid liver dysfunction.
- Conditions
- Normal Volunteers, Hepatitis, Liver Cirrhosis, Hepatocellular Carcinoma
- Trial name
- NCT00465842
- Where
- Singapore
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Asthma
Safety Study of a Vitamin E Supplement in Normal Volunteers and Those With Both Allergy and Asthma
Gamma tocopherol (gt) is a naturally occurring form of vitamin E that is found in many foods, and is also commercially available as a vitamin supplement.
- Trial name
- NCT00386178
- Testing
- Vitamin E supplement rich in gamma tocopherol
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Diabetes Mellitus, Type 2
A Clinical Study to Assess the Safety and Pharmacokinetics of SRT2379 in Normal Healthy Male Volunteers
The main purpose of this study is to assess the safety and pharmacokinetics of SRT2379 (25, 75, 250, 500, 1000, 2000, and 3000 mg/day [fasted] and 500 mg/day [fed]) in healthy male volunteers.
- Trial name
- NCT01018628
- Testing
- SRT2379
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy Volunteers, Impaired Renal Function
RI Study to Assess and Compare the Pharmacokinetic Parameters of MD1003 in Renal Impaired Patients and Healthy Subjects
This is a Phase 1, multicentric, open-label,two arms to assess and compare the effect of single oral administration of MD1003 on the pharmacokinetic parameters in renal impaired patients and healthy subjects with normal renal…
- Trial name
- NCT04252430
- Testing
- MD1003
- Where
- 5 sites in France, Hungary
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- MedDay Pharmaceuticals SA
Diabetes Mellitus, Type 2, Healthy Volunteer
A Clinical Study to Assess the Safety and Pharmacokinetics of SRT2104 in Normal Healthy Male Volunteers
The purpose of this study is to determine the safety and tolerability of SRT2104 (0.03, 0.1, 0.25, 0.5, 1.0, 2.0, and 3.0 g/day) in healthy male volunteers when administered after a single dose and once daily for 7 consecutive…
- Trial name
- NCT00933530
- Testing
- SRT2104
- Where
- United Kingdom
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Sirtris, a GSK Company
Nitric Oxide, Endothelium-Derived Relaxing Factor
Effects of Nitrite on Blood Vessel Dilation in Normal Volunteers
Nitric oxide gas is important in regulating blood vessel dilation, and consequently, blood flow. This gas is continuously produced by endothelial cells, which line the blood vessels.
- Conditions
- Nitric Oxide, Endothelium-Derived Relaxing Factor, Healthy
- Trial name
- NCT00048477
- Testing
- L-NMMA and Sodium Nitrite
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Diabetes, Wound Infection
Tedizolid Tissue Penetration in Diabetic Patients With Wound Infections and Healthy Volunteers Via In Vivo Microdialysis
This study will determine the tissue penetration of tedizolid (Sivextro, Merck \& Co.), a novel oxazolidinone antibiotic, into the extracellular, interstitial fluid of soft tissue in diabetic patients with lower limb wound…
- Conditions
- Diabetes, Wound Infection, Healthy Volunteers
- Trial name
- NCT02620787
- Testing
- Tedizolid, Microdialysis Catheter Insertion
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Atopic Dermatitis (AD)
A Phase 1/1b Study to Evaluate Safety, Tolerability and Pharmacokinetics of ZL-1503 in Healthy Volunteers and Participants With Moderate to Severe Atopic Dermatitis
This is a phase 1/1b randomized, double blind, placebo-controlled, single dose escalation (SAD) and multiple dose escalation (MAD) study to evaluate the safety, tolerability, and pharmacokinetics (PK) of ZL-1503 in healthy…
- Trial name
- NCT07235384
- Testing
- ZL-1503
- Where
- 14 sites in Australia, China and 1 more
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Zai Lab (Shanghai) Co., Ltd.
Healthy
Effects of Stress Hormones on Emotion and Cognition
The purpose of this study is to examine how hormonal changes that occur during stressful situations affect thought and emotions.
- Trial name
- NCT00032838
- Testing
- Yohimbine
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Atopic Dermatitis
Assessment of the Phototoxic Potential of LEO 29102 Cream
The purpose of this trial is to evaluate the phototoxic potential of a single application on healthy skin of LEO 29102 cream in different doses.
- Trial name
- NCT00958516
- Testing
- LEO 29102 cream
- Where
- France
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- LEO Pharma
Chronic Spontaneous Urticaria
A Trial of HRS-3095 in Healthy Volunteers
The purpose of this study is to assess safety, PK, Pharmacodynamic profile of a single dose of HRS-3095 in healthy participants
- Trial name
- NCT07686484
- Testing
- HRS-3095
- Where
- Australia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Atridia Pty Ltd.
Healthy Subjects
Study to Evaluate the Pharmacokinetics of Mucinex 600 mg Extended-release Bi-layer Tablet in Healthy Volunteers
Evaluate the Pharmacokinetics of Mucinex® 600 mg Extended-Release Bi-Layer Tablet in Normal Healthy Subjects
- Trial name
- NCT03644108
- Testing
- Mucinex® ER 600 mg
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Reckitt Benckiser Inc.
Imaging Data Collection From Dynamic Swallowing MRI in Healthy Volunteers, Create Operating Algorithms
Transposition of Dynamic MRI Data From Healthy Subjects to an in Vitro Swallowing Simulator
Swallowing is a complex process, involving a very fine synchronization of the pharyngo-larynx, with respiration, under the control of the central nervous system and numerous peripheral effectors.
- Conditions
- Imaging Data Collection From Dynamic Swallowing MRI in Healthy Volunteers, Create Operating Algorithms, Apply the Imaging Data of MRI to a Swallowing Simulator
- Trial name
- SWALL-E (NCT05178108)
- Testing
- Real-time MRI of swallowing
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Adrenal Insufficiency
Comparison of Intramuscular and Intravenous ACTH Stimulation Test in Normal Volunteers
Cosyntropin (synthetic ACTH) stimulation test is considered the optimal test for diagnosis of primary and long-standing secondary adrenal insufficiency.
- Trial name
- NCT03752190
- Testing
- Cosyntropin
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Healthy Human Volunteers With Fitzpatrick Skin Type III-V, Sunburn, Erythema
A Clinical Trial to Compare the Photoprotective Effects of Cucumber Seed Extract vs Placebo in Filipino Adults by Measurement of Minimal Erythema Dose
A monocentric, randomized, split-body, double-blind, controlled trial was conducted on 29 Filipino adults with Fitzpatrick skin types III-V.
- Trial name
- NCT07719413
- Testing
- 2% cucumber seed gel, 4% cucumber seed gel
- Where
- Philippines
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- DOH - Tondo Medical Center
Healthy Volunteer Study, Hepatic Impairment
Study of Bemnifosbuvir/Ruzasvir as a Fixed-dose Combination in Subjects With Normal or Severely Impaired Renal or Hepatic Function
To Assess the Effect of Severe Hepatic or Renal Impairment on the Pharmacokinetics of Bemnifosbuvir/Ruzasvir After a Single Dose
- Conditions
- Healthy Volunteer Study, Hepatic Impairment, Renal Impairment
- Trial name
- NCT06911320
- Testing
- Bemnifosbuvir (BEM)/Ruzasvir (RZR) as a fixed-dose combination
- Where
- 2 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Atea Pharmaceuticals, Inc.
Healthy
Nervous System Function in Normal Volunteers During Cycling Training
This study will identify changes that occur in the nervous system of healthy normal volunteers while they are learning a cycling task.
- Trial name
- NCT00055588
- Testing
- Locomotor training
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Condylomata Acuminata
Safety and Immunogenicity Study of the Recombinant Human Papillomavirus Virus Type 6/11 Bivalent Vaccine
This phase I clinical study was designed to evaluate the safety and immunogenicity of the novel recombinant HPV type 6/11 bivalent vaccine, manufactured by Xiamen Innovax Biotech CO., LTD., in healthy volunteers aged over 18-55…
- Trial name
- NCT02405520
- Testing
- low dosage HPV Vaccine, medium dosage HPV Vaccine, high dosage HPV Vaccine
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Jun Zhang