Clinical trials: Normal-weight Obesity
Obese
EARLY Assessment of MYOcardial Tissue Characteristics in OBESITY (EARLY-MYO-OBESITY)
EARLY-MYO-OBESITY-CMR is a prospective, three-center, cardiac imaging study to investigate cardiac morphology, function, and tissue phenotypes in a cohort of non-diabetic obese adults, and compare with metabolically healthy…
- Trial name
- NCT05277779
- Testing
- cardiac magnetic resonance(CMR)
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Obesity
Differences in Extracellular Vesicles From Adipose Tissue of Individuals With Obesity.
Our society is characterized by a strong increase in the prevalence of obesity, which often causes the development of cardiovascular and metabolic diseases such as type 2 diabetes.
- Trial name
- EVO (NCT06444646)
- Testing
- Adipose tissue biopsy, Blood sampling, Questionnaire
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Diabetes Mellitus, Hypertension
Evidence-based Laboratory Test Order Sets in Primary Care
Cluster randomised controlled trial to evaluate what the effect is of evidence-based order sets aimed at five indications on the appropriateness of laboratory test ordering in primary care.
- Conditions
- Diabetes Mellitus, Hypertension, Cardiovascular Diseases, Fatigue
- Trial name
- NCT02950142
- Testing
- CPOE with order sets for lab testing, CPOE without order sets for lab testing
- Where
- Belgium
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Obesity
A Comparison of the Metabolic Effects of Fructose, Glucose, High Fructose Corn Syrup and Sucrose at Normal Population Consumed Levels in Adults Aged 20-60 Years Old
The purpose of this study is to investigate the acute and chronic effects of consumption fructose containing sugars and glucose in a real word setting when consumed in a manner and amount typical in the American diet.
- Trial name
- NCT01797042
- Testing
- Dietary Compliance
- Where
- United States
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- Rippe Lifestyle Institute
Obesity, Normal Weigth
Comparative Analysis of Postprandial Effects in Healthy and Obese Individuals
After eating, blood composition changes, including increased triglycerides and glucose, which can trigger postprandial inflammation. Particularly with high-fat foods, pro-inflammatory lipopolysaccharide (LPS) increases.
- Trial name
- CAPE (NCT06645756)
- Testing
- Test meal
- Where
- Germany
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Hohenheim
Overweight and Obesity
A Research Study of How NNC0174-0833 Behaves in Chinese Volunteers Who Are Normal Weight, Overweight or With Obesity
The aim of this study is to look at how the study medicine behaves in participants body and how it is removed from their body. The study compares three different doses of the study medicine in Chinese healthy men.
- Trial name
- NCT05254158
- Testing
- NNC0174 0833
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Breast Cancer, Obesity
Exergaming Intervention and Breast Cancer Biomarkers in Black Women
Overview: This is a 6 month, two-arm randomized clinical trial using comparing exergaming to a control group. The investigators will randomize Black sedentary overweight/obese women to Wii Fit exercise (n=50) or the control arm…
- Trial name
- POWER (NCT02152462)
- Testing
- Exergaming
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Obesity
Celecoxib Inhibition of Aromatase Expression and Inflammation in Adipose Tissue of Obese Postmenopausal Women
The study plans to find out whether Celebrex may be potentially useful to decrease inflammation in fat tissues and thereby lower the production of substances such as estrogens that may increase the risk of developing breast…
- Trial name
- NCT01901679
- Testing
- Celebrex
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Obesity, Type 2 Diabetes
Maternal Adipose Tissue and Placental Dysfunction Programs the Fetus for Type 2 Diabetes (PlacentA-DM)
The purpose of this study is to discover the characteristics of pregnant women which increases risk for their babies to develop diabetes, later on in life.
- Trial name
- PlacentA-DM (NCT02211651)
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Breast Cancer, Obesity
Vitamin D, Diet and Activity Study
Experimental and human data suggests that vitamin D could protect against breast cancer. Overweight/obese individuals are at increased risk of low vitamin D levels.
- Conditions
- Breast Cancer, Obesity, Hypovitaminosis D
- Trial name
- ViDA (NCT01240213)
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Metabolic Syndrome, Obesity
An Exercise RCT Targeting African-American Women With Metabolic Syndrome and High Risk for Breast Cancer
Among African-American women, in whom metabolic syndrome (MetS) is very prevalent and breast cancer mortality rates are high, it is hypothesized that intervening on MetS to improve the MetS profile may prove to be a means to…
- Trial name
- NCT02103140
- Testing
- Facility-based Exercise, Home-based Exercise
- Where
- United States
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Breast Cancer, Health, Subjective
Role of Pro-Resolving Lipid Mediators in Obesity-Associated Diseases
The main objective of this project is to determine the possible association between the levels of certain bioactive lipids, which the body produces from dietary fatty acids, and tumor characteristics in breast cancer patients, as…
- Conditions
- Breast Cancer, Health, Subjective, Obesity
- Trial name
- RESOLBE (NCT07447440)
- Testing
- Observational study (baseline), Observational study (baseline and 1 year)
- Where
- 2 sites in Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Obesity & Overweight
A Pharmacokinetic Study of VCT220 With Moderate Renal Impairment Patients
This Phase 1 study is designed to evaluate the pharmacokinetics and safety of a single oral dose of VCT220 (other name: CX11) in subjects with moderate renal impairment compared with age-, sex-, and body mass index (BMI)-matched…
- Trial name
- NCT07347808
- Testing
- VCT220
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Vincentage Pharma Co., Ltd
Inflammation, Obesity
Impact of a High Saturated Fat Diet on Fasted Systemic and White Adipose Tissue Inflammatory Responses
This study will investigate the effect of a 7-day westernised high-fat (65% of kilocalories), high-calorie (150% of requirements) diet on markers of inflammation in the blood and white adipose tissue.
- Conditions
- Inflammation, Obesity, Inflammatory Response, Cardiovascular Diseases
- Trial name
- NCT03569189
- Testing
- High Fat Diet
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Kisspeptin Action on Insulin in Healthy Normal Men, Kisspeptin Action on Insulin in Obese Diabetic Men
KP-10 and Insulin Secretion in Men
Induction of insulin secretion by kisspeptin is observed in mouse, pig, rat, and human islets in vitro and in rats, mice and monkeys in vivo, but its mechanism is not fully clear.
- Trial name
- NCT03771326
- Testing
- Kisspeptin-10
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Quaid-e-Azam University
Obese, Normal Body Weight
Cold Induced Changes in White Adipose
An adaptation to a cold environment is a tendency to generate heat within our body. Some of this heat comes from our fat tissue.
- Conditions
- Obese, Normal Body Weight, Prediabetes, Metabolic Syndrome
- Trial name
- NCT02596776
- Testing
- Fat biopsy, Propranolol and fat biopsy, heavy water and fat biopsy
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Philip Kern
Pregnancy Complications, Maternal Obesity
Gasdermin-D and Pannexin-1 in Pregnancy
One -third of fertile women around the world are overweight or obese. This means increasing risk for both the mother and the child.
- Trial name
- NCT05475951
- Testing
- Biomarker measurement of pannexin-1 and gasdermin-D
- Where
- Turkey (Türkiye)
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Haseki Training and Research Hospital
Obesity, Body Weight
Comparing the Efficacy of a Dual-Frequency LLLT Device With a Sham Device as a Therapy for Adipose Tissue Loss
The trial was designed to provide empirical evidence with which to compare the efficacy and safety of the invisa-RED Technology Elite Low-level Laser Therapy (LLLT) device with a sham device as a placebo, when both are used in…
- Conditions
- Obesity, Body Weight, Fat Burn, Cellulite
- Trial name
- NCT03811093
- Testing
- Care as Usual Group
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- IR Technology, LLC
Pharmacokinetics
Comparison of Serum Contraceptive Hormone Levels Between Normal Weight and Obese Users of the NuvaRing®
There are over 60 million women of reproductive age in the U.S. and a majority of these women qualify as overweight or obese. Evidence suggests that there is an association between increased body weight and decreased…
- Trial name
- NCT00710606
- Testing
- NuvaRing
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Columbia University
Normal-weight Obesity, BMI
Effects of Body Composition on Vascular Health in Females With a Healthy Body Weight
Most of the time, body weight is evaluated by looking at the ratio of your weight to your height. This measurement is called body mass index or BMI.
- Conditions
- Normal-weight Obesity, BMI, Stress
- Trial name
- NCT06818500
- Testing
- high-fat meal, Stress
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ball State University