Clinical trials: Nuclear Cataract
Cataract, Nuclear Progressive
The Post-Vitrectomy Lenstatin™ Study
To determine the efficacy of Lenstatin™, an over-the-counter nutritional supplement, in inhibiting the progression of nuclear cataract in eyes after pars plana vitrectomy.
- Trial name
- NCT02131194
- Testing
- Lenstatin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Lenstatin LLC
Epiretinal Membrane, Macular Edema (ME)
Minimal Vitrectomy Surgery for Epiretinal Membrane
This multicenter randomized controlled trial evaluates Minimal Vitrectomy Surgery (MVS) versus conventional vitrectomy for idiopathic epiretinal membrane (ERM).
- Conditions
- Epiretinal Membrane, Macular Edema (ME), Nuclear Cataract
- Trial name
- MVS-ERM (NCT07019896)
- Testing
- Minimal Vitrectomy Surgery, Conventional Vitrectomy
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Peking Union Medical College Hospital
Nuclear Sclerotic Cataract
Comparison of Scheimpflug Photos of the Crystalline Lens in Patients Who Have Undergone Vitrectomy Surgery and Controls
Progression of nuclear sclerotic cataract after pars plana vitrectomy has been recognized for many years The mechanism for the rapid progression of nuclear sclerotic cataract remains unclear.
- Trial name
- NCT00406263
- Testing
- Scheimpflug crystalline lens photographs
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Barnes Retina Institute
Cataract and IOL Surgery, Cataract Surgery Anesthesia
The Impact of Physiologic Cataract Surgery on Patient Comfort and Medication Usage
The study will pertain to investigating the impact of high vs low IOP on the intraoperative experience and comfort for the patient and surgeon.
- Conditions
- Cataract and IOL Surgery, Cataract Surgery Anesthesia, Cataract Surgery Experience, Nuclear Cataract
- Trial name
- NCT07223866
- Testing
- High IOP Setting, Low IOP Setting
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Matthew Rauen
Cataract, Nuclear Sclerosis
Evaluating the Need for the Pseudophakic Intraoperative Abberrometry in Toric IOL Implantation
To determine clinically significant difference in results obtained from cataract surgery using IA. One eye will receive aphakic measurements only and the fellow eye will receive aphakic and then pseudophakic measurements when…
- Conditions
- Cataract, Nuclear Sclerosis, Cortical Cataract, Posterior Subcapsular Cataract
- Trial name
- NCT03819842
- Testing
- Pseudophakic Measurement
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alterman, Modi, & Wolter Ophthalmic Physicians & Surgeons
Age Related Cataracts
The Safety and Efficacy Study of Ethylenediaminetetraacetic Acid (EDTA) Ophthalmic Solution in Patients With Loss of Contrast Sensitivity Due to Age-Related, Low-Grade Nuclear Cataract
The study objectives were: To evaluate the efficacy of EDTA 1.3% and 2.6% ophthalmic solution (C-KAD) in improving visual function as assessed by contrast sensitivity; To evaluate the safety and tolerability of two doses of EDTA…
- Trial name
- NCT06365762
- Testing
- EDTA Ophthalmic Solution 2.6%, EDTA Ophthalmic Solution 1.3%
- Where
- 6 sites in United States
- Volunteers
- 111 people
- Sponsor
- Livionex Inc.
Corneal Endothelial Cell Loss, Corneal Endothelial Damage Following the Hard Nuclear Cataract Surgery
A Study of CA201A Eye Drops to Prevent Corneal Endothelial Cell Loss in Patients Undergoing Cataract Surgery
This study is designed to assess whether an investigational eye drop called CA201A can help protect the cornea (the outer covering of the eye) and reduce damage to corneal endothelial cells following cataract surgery, without…
- Trial name
- NCT07694375
- Testing
- Ophthalmic solution (matching formulation without ascorbic acid), Ascorbic acid ophthalmic solution 5%
- Where
- 8 sites in Australia
- Volunteers
- 200 people
- Sponsor
- Caravel Oculus Pty Ltd
Nuclear Cataract
Dose-Ranging Study of an Ophthalamic Solution in Patients With Loss of Visual Function Due to Age-Related Nuclear Cataract
This study will evaluate the safety and efficacy of three doses of C-KAD Ophthalmic Solution in patients with loss of visual function due to age-related nuclear cataract
- Trial name
- NCT00825721
- Testing
- LiquiTears, C-KAD Ophthalmic Solution
- Where
- Nepal
- Volunteers
- 81 people
- Sponsor
- Chakshu Research, Inc.
Cataract, Cataract Mature
Study of the Efficiency and Workflow of Femtosecond Laser Assisted Cataract Surgery in a Spanish Public Hospital
Purpose: To assess the time-efficiency of a designated operation room (OR) workflow in the introduction of Femtosecond laser-assisted cataract surgery (FLACS, LenSx, Alcon®).
- Conditions
- Cataract, Cataract Mature, Cataract, Nuclear
- Trial name
- FLACS (NCT03931629)
- Testing
- CONVENTIONAL PHACO
- Volunteers
- 167 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Cataract
Comparison of Two Fragmentation Modalities in Femtosecond Laser-assisted Cataract Surgery
Femtosecond laser-assisted cataract surgery consists in nuclear lens fragmentation, followed by ultrasound phacoemulsification of nuclear lens, which is then removed.
- Trial name
- SLICES (NCT02898909)
- Testing
- nuclear lens fragmentation in 8 pieces, nuclear lens fragmentation in 16 pieces
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Nuclear Sclerosis of the Lens, Phacoemulsification Cataract Surgery
This Clinical Trial Compares Two Phacoemulsification Systems Used in a Bilateral Cataract Surgery Subjects in Order to Study CDE and Ultrasound Time During Cataract Removal
This clinical trial compares two phacoemulsification systems used in a bilateral cataract surgery subjects, in order to study CDE and Ultrasound time during cataract removal
- Conditions
- Nuclear Sclerosis of the Lens, Phacoemulsification Cataract Surgery, Cataract Bilateral
- Trial name
- CDE (NCT07468877)
- Testing
- Cataract extraction with phacoemulsification comparing two systems
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Nicole Fram M.D.
Nuclear Cataract
Phacoemulsification at High IOP and Physiologic IOP: Impact on Anterior and Posterior Segment Physiology
The purpose of this study is to investigate the anterior and posterior structure and functional changes and vascular alterations when performing phacoemulsification at high IOP vs low, more physiological IOP using Centurion®…
- Trial name
- NCT05765201
- Testing
- High IOP, Low IOP
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Matthew Rauen
Hard Nuclear Cataract, Corneal Endothelial Cell
To Compare the Progressive Cracking Technique and Conventional Chop Technique on Corneal Endothelial Cells in Patients With Hard Nucleus Cataract
Approximately 60 participants at Eye Hospital of Wenzhou Medical University during January,2017 to June 2021 will be enroll in our study.
- Conditions
- Hard Nuclear Cataract, Corneal Endothelial Cell, Progressive Cracking Technique
- Trial name
- NCT04828499
- Testing
- Progressive Cracking Technique, Conventional Chop Technique
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Yune Zhao
Nuclear Sclerosis of the Lens, Posterior Subcapsular Cataract
The Comparison of Cataract Lasers Using the Optimedica Catalys Laser and the Alcon LenSx Laser.
This study compares two FDA approved Cataract Lasers.
- Conditions
- Nuclear Sclerosis of the Lens, Posterior Subcapsular Cataract, Cortical Cataract
- Trial name
- NCT01878838
- Testing
- Femtosecond Laser Assisted Cataract Surgery w/ Catalys Laser, Femtosecond Laser Assisted Cataract Surgery w/ LenSx Laser
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Steven H. Linn, OD
Hard Nuclear Cataract, Phacoemulsification Cataract Surgery
Study on the Surgical Strategy of Corneal Endothelial Protection for Hard Nuclear Cataract Patients
In this study, we compared two types of phacoemulsification commonly used in cataract surgery to evaluate their effect on the prognosis of patients with hard nuclei.
- Conditions
- Hard Nuclear Cataract, Phacoemulsification Cataract Surgery, Endothelial Cell Density Loss, Central Corneal Thickness
- Trial name
- NCT06991374
- Testing
- combined burst mode, torsional mode
- Where
- China
- Volunteers
- 207 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Incipient Cataract, Senile Nuclear Sclerosis
Resident-Performed Laser-Assisted vs Manual Traditional Phacoemulsification Cataract Surgery
The study design will be a prospective study comparing laser-assisted cataract extraction cases and traditional manual phacoemulsification cases.
- Trial name
- NCT02561104
- Testing
- Laser-assisted cataract surgery., Traditional manual phacoemulsification
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- University of Texas Southwestern Medical Center
Nuclear Cataract
Less Discomfort and Less Pharmacology. Cataract Surgery at Physiologic Intraocular Pressure (IOP)
To investigate the impact of high vs low Intraocular Pressure (IOP) on the intraoperative experience for the patient and surgeon.
- Trial name
- NCT06325397
- Testing
- High Intraocular Pressure (IOP), Low Intraocular Pressure (IOP)
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Matthew Rauen
Cataract
Study of Phacodepth Required for Safe and Effective Chop During Phacoemulsification for Cataract.
There is a correlation between phacodepth required for full thickness nuclear crack and the various grades of cataract
- Trial name
- CALIBCHOP (NCT01256918)
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Dr. Ram Manohar Lohia Hospital
Cataract
Retained Lens Fragments After Phacoemulsification
The purpose of this study is to investigate postoperative events in patients noted to have retained nuclear fragments in the anterior vitreous during routine phacoemulsification and in those who did not.
- Trial name
- NCT02058394
- Testing
- Phacoemulsification
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Ophthalmic Consultants, Corneal and Refractive Surgery Associates, PC
Cataract
Evaluation of the Age-Related Eye Disease Study (AREDS) Clinical Lens Grading System
This study will evaluate a system developed to grade the severity of age-related cataract, a common cause of vision loss in older adults.
- Trial name
- NCT00078299
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Eye Institute (NEI)