Clinical trials: OA
OA, TKA
A Randomized Study on Sagittal Angle Differences in Lower Limbs Between Normal Individuals and Osteoarthritis Patients
With China gradually entering an aging society, the proportion of the elderly population is gradually increasing, and the number of patients with knee disease is also increasing year by year.
- Conditions
- OA, TKA, EOS
- Trial name
- NCT06527924
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Osteearthritis, OA
Value of Adding T2 Mapping Routine MRI in Assessment of Knee Articular Cartilage Early Osteoarthritis
This work aims at elucidating the role of MRI complementary T2 mapping in assessment of the articular knee cartilage for improving sensitivity of detection of early stage of osteoarthritis
- Conditions
- Osteearthritis, OA, OA Knee
- Trial name
- T2 mapping OS (NCT07316257)
- Testing
- MRI
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Assiut University
Respiratory Syncytial Virus Infections
A Study on the Immune Response and Safety Elicited by a Vaccine Against Respiratory Syncytial Virus (RSV) When Given Alone and Together With a Vaccine Against Influenza in Adults Aged 60 Years and Above
The purpose of this study is to assess the immunogenicity, safety and reactogenicity of the RSVPreF3 OA investigational vaccine when co-administered with the seasonal quadrivalent influenza vaccine (FLU-QIV) in adults aged 60…
- Trial name
- NCT04841577
- Testing
- RSVPreF3 OA investigational vaccine, FLU-QIV
- Where
- 14 sites in New Zealand, Panama and 1 more
- Volunteers
- 976 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Osteoarthritis (OA)
Empowered Relief Study
"Empowered Relief" (ER) Intervention was developed by Beth Darnall, PhD at what is now the Stanford Pain Relief Innovations Lab. Our design is a randomized 3-arm study with test treatment, active control, and placebo arms.
- Trial name
- NCT07562750
- Testing
- Empowered Relief, "Self Management Strategies" handout
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Respiratory Syncytial Viruses, Respiratory Syncytial Virus Infections
A Study on Safety and Immune Response of Investigational RSV OA Vaccine in Combination With Herpes Zoster Vaccine in Healthy Adults
To assess the ability of RSVPreF3 OA investigational vaccine to generate an immune response when given in combination with HZ/su vaccine and its safety in older adults, aged >=50 years of age.
- Trial name
- RSV-OA=ADJ-020 (NCT05966090)
- Testing
- RSVPreF3 OA investigational vaccine, HZ/su vaccine
- Where
- 31 sites in United States, Canada
- Volunteers
- 530 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Rheumatoid Arthritis (RA) and Osteoarthritis (OA)
Serum IL-17 Correlated With Inflammatory Changes in Osteoarthritis and Rheumatoid Arthritis
The total number of the included subjects was 120 in 3 equal groups (RA, OA and control). All subject was subjected to serum IL17 level measurement.
- Trial name
- NCT04474912
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Hip Osteoarthritis
Ultrasound and CT to Measure Muscle in Hip OA
This study will examine alterations in muscle in individuals with hip osteoarthritis compared to individuals without hip arthritis.
- Trial name
- NCT04061499
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
The Primary Disease Process Being Studied is Shoulder OA and the Effect of an All Polyethelene Glenoid Component on Shoulder Arthroplasty
This is a 2 Year Follow up Clinical and Radiographic Analysis of a Novel All Polyethelene Glenoid Component in Standard Total Shoulder Arthroplasty.
Two hundred patients will be analyzed both clinically (via validated outcomes measures) and radiographically (via 2 sets of standard radiographs) to determine the survival and degree of bone in growth of a novel all polyethelene…
- Trial name
- NCT01313741
- Testing
- Shoulder arthroplasty with anchor peg glenoid
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Knoxville Orthopedic Clinic
Osteoarthritis
Duloxetine in Osteoarthritis (OA) Pain
This study aims to determine in people with knee Osteoarthritis (OA) if relief of pain after treatment with either duloxetine or placebo is associated with changes in brain anatomy.
- Trial name
- NCT01558700
- Testing
- Duloxetine, Sugar pill
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Osteoarthritis (OA) of the Hip, Osteoarthritis (OA) of the Knee
Effects of Different Relaxation Therapies on Pain and Sleep in Hip and Knee Arthroplasty Patients
Hip and knee replacement surgery is commonly performed in older adults. After surgery, many patients experience pain, limited movement, and sleep problems.
- Trial name
- NCT07354542
- Testing
- Virtual Reality-Based Relaxation, Traditional Relaxation Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Bartın Unıversity
Lower Back Pain, Facet Joint Pain; Low Back Pain
Bone Enhanced Ultrasound (BEUS) Data Library Development Project
A common treatment for low back pain involves fluoroscopy-guided spinal facet joint injections and/or medial branch nerve blocks.
- Conditions
- Lower Back Pain, Facet Joint Pain; Low Back Pain, Osteoarthritis (OA)
- Trial name
- NCT07036653
- Testing
- spinal ultrasound
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Queen's University
Musculoskeletal Diseases
IADAPT-Third Phase
The goal of this research study is to compare a booklet and a DVD for patients with knee osteoarthritis, osteoporosis, or rheumatoid arthritis.
- Trial name
- NCT01698762
- Testing
- Multimedia Patient Decision Aids (MM-PtDAs), Comparative Effectiveness Research Summary Guide (CERSG), Questionnaires
- Where
- 3 sites in United States
- Volunteers
- 676 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Analgesia, Pain Catastrophizing
Test Retest Reliability of OA and OH
The goal of this study is to measure the test retest reliability of offset analgesia (OA) and onset hyperalgesia (OH) across multiple study visits.
- Conditions
- Analgesia, Pain Catastrophizing, Pain
- Trial name
- NCT05487183
- Testing
- Medoc cutaneous probe, Quantitative sensory testing, Computer tasks
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Osteoarthritis, Knee
A Phase Ib/II Clinical Trial to Evaluate the Safety and Efficacy of LG00034053 in Patients With Knee OA
This study is a multi-center, randomized, placebo-controlled, double-blind clinical study, consisting of Part 1 (Phase 1b) in a sequential, dose-escalating design and Part 2 (Phase 2) in a parallel design.
- Trial name
- NCT05237752
- Testing
- LG00034053
- Where
- 2 sites in Australia, South Korea
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- LG Chem
Respiratory Syncytial Virus Infections
A Study on the Immune Response and Safety of Vaccine Against Respiratory Syncytial Virus (RSV) Given to Adults 18 to 49 Years of Age at Increased Risk for Respiratory Syncytial Virus Disease, Compared to Older Adults 60 Years of Age and Above
The aim of this study is to demonstrate the immune response and to evaluate the safety of the RSVPreF3 OA investigational vaccine in non-immunocompromised adults 18-49 years of age (YOA), who are at increased risk (AIR) for RSV…
- Trial name
- NCT06389487
- Testing
- RSVPreF3 OA investigational vaccine
- Where
- 52 sites in United States, Australia and 4 more
- Volunteers
- 1,459 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Osteoarthritis, Knee
Civamide in OA of the Knee(s)
The purpose of this study is to evaluate the safety of Civamide Cream 0.075% as a Treatment in Subjects with Osteoarthritis (OA) of the Knee(s).
- Trial name
- NCT00077935
- Testing
- Civamide
- Where
- 34 sites in United States
- Volunteers
- 351 people, healthy volunteers welcome
- Sponsor
- Winston Laboratories
Osteoarthritis, Knee, Patellofemoral Disorder
High Tibial Osteotomy With/Without Fulkerson Osteotomy in Knee OA
This study will compare Hight Tibial Osteotomy with or without Fulkerson Osteotomy performed on patients with early stages of Osteoarthritis with patellofemoral joint disorders.
- Trial name
- NCT05128864
- Testing
- High Tibial Osteotomy
- Where
- Poland
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Centre of Postgraduate Medical Education
Knee Osteoarthritis (Knee OA)
Neuromuscular Control and Motor Unit Behavior in Patients With Knee Osteoarthritis
This study aims to examine the effects of moderate-intensity strength training, performed with or without an unloading knee orthosis (valgus-corrective or sham mode), on muscle function, motor unit behavior, and force modulation…
- Trial name
- NCT07544693
- Testing
- the strengthening program
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Veterans General Hospital.
Hip Dysplasia, Femoroacetabular Impingement
Cam Type FAI is a Cause of Hip Pain in the Young Adult and a Precursor to OA
An abnormally formed hip joint (cam deformity) is a major cause of osteoarthritis (OA). Individuals may not experience any symptoms until OA is severe due to extensive cartilage loss and changes in underlying bone.
- Conditions
- Hip Dysplasia, Femoroacetabular Impingement, Osteoarthritis
- Trial name
- NCT04080466
- Testing
- Low-dose CT Scan, Blood/Urine Collection, Patient Reported Questionnaires
- Where
- Canada
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Osteoarthritis, Knee
Prehabilitation Using Aquatic Exercise
With aging population, total knee arthroplasty is performed with increasing frequency. Although the surgery is successful in general, significant number of patients suffers persistent pain and disability.
- Trial name
- NCT02773745
- Testing
- Aquatic Prehab
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences